Brushless DC motor with dual windings

Motor has high starting torque and high running speeds. Control system consists of Hall effect generator/resolver and associated electronic amplifiers and switches. Motor operation is described

Optical-inertia space sextant for an advanced space navigation system, phase B

Optical-inertia space sextant for advanced space navigation syste

Roller gear drive development Final report, Oct. 1970 - Feb. 1971

Design, fabrication, and test of research model roller-gear drive consisting of transmission driven by dc moto

Comparison of decision methods to initiate fungicide applications against cercospora blight of carrot

Un modèle prévisionnel a été comparé, en 1991 et 1992, à d'autres méthodes pour son efficacité à déterminer le début des applications de fongicides utilisés pour lutter contre la brûlure cercosporéenne de la carotte, causée par le Cercospora carotae. Le premier traitement fongicide était appliqué lorsque : 1) les plants avaient atteint 15 cm de hauteur (méthode conventionnelle); 2) les feuilles intermédiaires de 50 % des plants présentaient des symptômes (méthode du 50 % d'incidence); 3) lorsque la valeur cumulative d'équivalence d'infection (CE) avait atteint 14 (méthode de prévision avec la valeur CIE = 14); 4) lorsque la valeur CIE avait atteint 18 (méthode de prévision avec la valeur CIE = 18). Pour toutes les méthodes, les applications subséquentes de fongicides ont été faites aux 10 jours lorsqu'il n'y avait pas de pluie, et aux 7 jours en présence de pluie. Les valeurs CIE ont été calculées en fonction de la durée d'humectation du feuillage et de la température durant cette période, tout en tenant compte des périodes d'humidité élevée et d'interruptions des périodes d'humectation du feuillage, et étaient cumulatives depuis l'émergence des plants. Pour les méthodes avec prévision, que ce soit pour une valeur CIE de 14 ou de 18, aucune perte de rendement n'a été observée et moins de traitements ont été nécessaires comparativement à la méthode conventionnelle et à celle du 50 % d'incidence. Dans une autre étude, les valeurs CIE ont été comparées aux pourcentages de champs qui avaient atteint des niveaux d'incidence de 50, 80 et 100% afin d'établir les seuils de risque léger (11 < CIE < 15) et de risque élevé (16 < CIE < 20). Seulement 3% des champs avaient déjà atteint l'incidence de 50 % lorsqu'une valeur CIE a atteint le seuil préconisé pour un risque faible et, 19 % des champs, une incidence de 80% pour un risque élevé.In 1991 and 1992, two thresholds of a forecasting model were compared with two other decision methods for effectiveness in timing the first fungicide application against Cercospora blight of carrot induced by Cercospora carotae. The first fungicide application was made when : 1) the plants reached 15 cm in height (conventional method); 2) the intermediate (middle) leaves of 50% of the plants were diseased (50% disease incidence threshold method); 3) the cumulative infection equivalence (CE) was 14 (forecasting model CE 14); and 4) the CE was 18 (forecasting model CE 18). In all four treatments, subsequent applications of fungicide were made at 10-d intervals when there was no rain, and at 7-d intervals when there was rain. The CE was calculated based on duration of leaf wetness and temperature during the wet period, corrected for high humidity and interrupted wet periods, and was cumulative starting at crop emergence. For thresholds of CE 14 and CE 18, no yield losses were observed and the total number of fungicide applications needed was lower compared to conventional and 50% disease incidence threshold methods. In a separate study, the CE thresholds were related to the percentage of commercial fields that reached disease incidence thresholds of 50, 80 and 100% to establish low risk (CE 11-15) and high risk (CE 16-20) thresholds. The forecasting of low and high risk CE thresholds were too late for 3 and 19% of the commercial fields because those fields had more than 50 and 80% of the plants diseased, respectively

Brood Provisioning And Nest Survival Of Ardea Herodias (Great Blue Heron) In Maine

From 1983–2009, the number of coastal breeding pairs of Ardea herodias (Great Blue Heron [GBHE]) in Maine declined by 64%, and the number of occupied islands on which these birds bred declined by 40%. The Maine Department of Inland Fisheries and Wildlife listed the GBHE as a species of special concern in 2007, and expanded its annual monitoring to include inland colonies in 2009. To assess regional demographic differences, we compared the relationship between brood provisioning and nest survival of GBHEs in 1 coastal and 1 inland colony. In terms of brood-provisioning within the 2 colonies, the inland colony had significantly greater rates for the first 2 weeks post-hatch, but the coastal colony had greater rates in subsequent weeks. These differences did not affect either nest fate (≥1 chick fledged) or daily nest survival at the inland or coastal colony. In both colonies, the maximum number of nestlings observed at a nest was positively correlated with the number that subsequently fledged. Daily nest survival was positively associated with an increasing number of nestlings, earlier hatch dates, and increased brood-provisioning rates for 1–2-week-old chicks. Our results suggest that the number of nestlings per nest can be used as a proxy for nest survival in GBHE colonies in the northeastern part of their range. Furthermore, because nest survival was influenced by brood-provisioning rates during the first 1–2 weeks post-hatch, our results suggest that the most sensitive time for disturbance of GBHEs in the northeastern part of their range may be earlier in the nesting stage than previously thought

Péritonite infectieuse chez une chatte

Auclair-Sémeré G., Groulade Paul. Péritonite infectieuse chez une chatte. In: Bulletin de l'Académie Vétérinaire de France tome 128 n°6-7, 1975. pp. 289-292

The Multifunctional Sorting Protein PACS-2 Regulates SIRT1-Mediated Deacetylation of p53 to Modulate p21-Dependent Cell-Cycle Arrest

SIRT1 regulates the DNA damage response by deacetylating p53, thereby repressing p53 transcriptional output. Here, we demonstrate that the sortingprotein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate the DNA damage response. PACS-2 knockdown cells failed to efficiently undergo p53-induced cell-cycle arrest in response to DNA damage. Accordingly, p53 acetylation was reduced both in PACS-2 knockdown cells and thymocytes from Pacs-2-/- mice, thereby blunting induction of the cyclin-dependent kinase inhibitor p21 (CDKN1A). The SIRT1 inhibitor EX-527 or SIRT1 knockdown restored p53 acetylation and p21 induction as well as p21-dependent cell-cycle arrest in PACS-2 knockdown cells. Traffickingstudies revealed that cytoplasmic PACS-2 shuttled to the nucleus, where it interacted with SIRT1 andrepressed SIRT1-mediated p53 deacetylation. Correspondingly, invitro assays demonstrated that PACS-2 directly inhibited SIRT1-catalyzed p53 deacetylation. Together, these findings identify PACS-2 as an invivo mediator of the SIRT1-p53-p21 axis that modulates the DNA damage response

Different prelamin A forms accumulate in human fibroblasts: a study in experimental models and progeria

Lamin A is a component of the nuclear lamina mutated in a group of human inherited disorders known as laminopathies. Among laminopathies, progeroid syndromes and lipodystrophies feature accumulation of prelamin A, the precursor protein which, in normal cells, undergoes a multi-step processing to yield mature lamin A. It is of utmost importance to characterize the prelamin A form accumulated in each laminopathy, since existing evidence shows that drugs acting on protein processing can improve some pathological aspects. We report that two antibodies raised against differently modified prelamin A peptides show a clear specificity to full-length prelamin A or carboxymethylated farnesylated prelamin A, respectively. Using these antibodies, we demonstrated that inhibition of the prelamin A endoprotease ZMPSTE24 mostly elicits accumulation of full-length prelamin A in its farnesylated form, while loss of the prelamin A cleavage site causes accumulation of carboxymethylated prelamin A in progeria cells. These results suggest a major role of ZMPSTE24 in the first prelamin A cleavage step

Probing the gravitational wave background from cosmic strings with LISA

Cosmic string networks offer one of the best prospects for detection of cosmological gravitational waves (GWs). The combined incoherent GW emission of a large number of string loops leads to a stochastic GW background (SGWB), which encodes the properties of the string network. In this paper we analyze the ability of the Laser Interferometer Space Antenna (LISA) to measure this background, considering leading models of the string networks. We find that LISA will be able to probe cosmic strings with tensions Gμ ≳ (10), improving by about 6 orders of magnitude current pulsar timing arrays (PTA) constraints, and potentially 3 orders of magnitude with respect to expected constraints from next generation PTA observatories. We include in our analysis possible modifications of the SGWB spectrum due to different hypotheses regarding cosmic history and the underlying physics of the string network. These include possible modifications in the SGWB spectrum due to changes in the number of relativistic degrees of freedom in the early Universe, the presence of a non-standard equation of state before the onset of radiation domination, or changes to the network dynamics due to a string inter-commutation probability less than unity. In the event of a detection, LISA's frequency band is well-positioned to probe such cosmic events. Our results constitute a thorough exploration of the cosmic string science that will be accessible to LISA

Tectonique et volcanisme sous-marin à l'arrière de l'arc des Nouvelles-Hébrides (Vanuatu, Pacifique sud-ouest) : résultats préliminaires de la campagne SEAPSO Leg II du N/O Jean-Charcot

L'arrière-arc des Nouvelles-Hébrides est caractérisé par deux régions structurées en horsts et grabens, au nord et au sud, encadrant une zone centrale clairement affectée par des compressions. Dans le nord, les grabens peu marqués dans la morphologie sont associés à d'importantes manifestations volcaniques récentes et actuelles. Localement, des dépôts manganèsifères témoignent d'une activité hydrothermale récente. Dans les fossés du Coriolis, les laves draguées sont de nature différente de celles des fossés nord ; en particulier, des basaltes ankaramitiques frais ont été recueillis au fond du fossé de Futuna. Ces structures et, plus spécialement, le fossé de Futuna au sud et le fossé de Vot Tande au nord, se sont mis en place sous l'effet d'une extension de direction N30° à N 40°, oblique par rapport à la direction de convergence des plaques. (Résumé d'auteur