It is a Small World: Global Medical Education for the Twenty-first Century

Last year’s epidemic of the Severe Acute Respiratory Syndrome (SARS) virus in Asia and the present world-wide concern about the spread of the H5N1 avian flu virus has brought international health concerns to the front pages of national and international newspapers, newsmagazines, and health journals around the world. Add to this the global Human Immunodeficiency Virus (HIV) epidemic, the global resurgence of tuberculosis (TB), and the disturbing increases in antibiotic-resistant bacteria, and it becomes difficult to imagine the compartmentalized world of even 30 years ago when diseases of different continents stayed in their place. Today, more than one million people cross international borders each day (not including refugees and displaced persons). Air transport guarantees a rapid transit of both person and pathogen well within the incubation period of many diseases. Body-heat detectors used recently at immigration points (e.g., Singapore and Hanoi) to detect febrile passengers are symbolic of the coarse screening attempts being used to control the movement of contagious diseases.

Using the Rosat Catalogue to find Counterparts for Unidentified Objects in the 1st Fermi/LAT Catalogue

There are a total of 1451 gamma-ray emitting objects in the Fermi Large Area Telescope First Source Catalogue. The point source location accuracy of typically a few arcminutes has allowed the counterparts for many of these sources to be found at other wavelengths, but even so there are 630 which are described as having no plausible counterpart at 80% confidence. In order to help identify the unknown objects, we have cross-correlated the positions of these sources with the Rosat All Sky Survey Bright Source Catalogue. In this way, for Fermi sources which have a possible counterpart in soft X-rays, we can use the, much smaller, Rosat error box to search for identifications. We find a strong correlation between the two samples and calculate that there are about 60 sources with a Rosat counterpart. Using the Rosat error boxes we provide tentative associations for half of them, demonstrate that the majority of these are either blazars or blazar candidates and give evidence that most belong to the BL Lac class. Given that they are X-ray selected and most are high synchrotron peaked objects, which indicates the presence of high energy electrons, these sources are also good candidates for TeV emission, and therefore good probes of the extragalactic background light.Comment: 9 pages, 1 figure; Accepted for publication in MNRA

Panel 2.11: Food Security and Nutrition

This is a summary of the presentations and discussion of Panel 2.11, Food Security and Nutrition of the Conference, Health Aspects of the Tsunami Disaster in Asia, convened by the World Health Organization (WHO) in Phuket, Thailand, 04-06 May 2005. The topics discussed included issues related to food security and nutrition as pertain to the responses to the damage created by the Tsunami. It is presented in the following major sections: (1) findings; (2) key questions; (3) discussion; and (4) recommendation

Identification of a gonadotropin-releasing hormone receptor orthologue in Caenorhabditis elegans

BACKGROUND: The Caenorhabditis elegans genome is known to code for at least 1149 G protein-coupled receptors (GPCRs), but the GPCR(s) critical to the regulation of reproduction in this nematode are not yet known. This study examined whether GPCRs orthologous to human gonadotropin-releasing hormone receptor (GnRHR) exist in C. elegans. RESULTS: Our sequence analyses indicated the presence of two proteins in C. elegans, one of 401 amino acids [GenBank: NP_491453; WormBase: F54D7.3] and another of 379 amino acids [GenBank: NP_506566; WormBase: C15H11.2] with 46.9% and 44.7% nucleotide similarity to human GnRHR1 and GnRHR2, respectively. Like human GnRHR1, structural analysis of the C. elegans GnRHR1 orthologue (Ce-GnRHR) predicted a rhodopsin family member with 7 transmembrane domains, G protein coupling sites and phosphorylation sites for protein kinase C. Of the functionally important amino acids in human GnRHR1, 56% were conserved in the C. elegans orthologue. Ce-GnRHR was actively transcribed in adult worms and immunoanalyses using antibodies generated against both human and C. elegans GnRHR indicated the presence of a 46-kDa protein, the calculated molecular mass of the immature Ce-GnRHR. Ce-GnRHR staining was specifically localized to the germline, intestine and pharynx. In the germline and intestine, Ce-GnRHR was localized specifically to nuclei as revealed by colocalization with a DNA nuclear stain. However in the pharynx, Ce-GnRHR was localized to the myofilament lattice of the pharyngeal musculature, suggesting a functional role for Ce-GnRHR signaling in the coupling of food intake with reproduction. Phylogenetic analyses support an early evolutionary origin of GnRH-like receptors, as evidenced by the hypothesized grouping of Ce-GnRHR, vertebrate GnRHRs, a molluscan GnRHR, and the adipokinetic hormone receptors (AKHRs) and corazonin receptors of arthropods. CONCLUSION: This is the first report of a GnRHR orthologue in C. elegans, which shares significant similarity with insect AKHRs. In vertebrates, GnRHRs are central components of the reproductive endocrine system, and the identification of a GnRHR orthologue in C. elegans suggests the potential use of C. elegans as a model system to study reproductive endocrinology

Sentinel-based Surveillance of Coyotes to Detect Bovine Tuberculosis, Michigan

Coyotes could be used as sentinels to detect Mycobacterium bovis in the wild

Transactional Sex among Youths in Post-conflict Liberia

This paper presents findings on sexual risk behaviours of Liberian youths based on five focus-group discussions conducted with 6th and 7th graders (n=36) attending an elementary/middle school in Monrovia, Liberia. The purpose of the focus-group discussions was to gain an understanding of the sexual behaviours of in-school Liberian adolescents. The focus-group discussions were part of a larger study to adapt an evi-dence-based HIV-prevention intervention—Making Proud Choices!—for in-school youths. Post-conflict conditions were discussed as a contributor to the emergence of high-risk sexual behaviours, including transactional sex, sexual violence, and lack of condom-use. Transactional sex was often described by the focus-group participants as occurring between young females and older, more financially-secure males to obtain cash, food, clothing, western commodities, and school-fees and was often encouraged by parents and promoted by peers. The findings also indicate that female adolescents make choices to engage in transactional sex to gain access to a continuum of material and consumer needs. These findings suggest that individual risk-taking behaviours are nested within complex sexual economies and that HIV-prevention interventions should be considered that leverage females’ agency and control

Angular Correlations in Top Quark Pair Production and Decay at Hadron Colliders

We show how to observe sizable angular correlations between the decay products of the top quark and those of the anti-top quark in top quark pair production and decay at hadron colliders. These correlations result from the large asymmetry in the rate for producing like-spin versus unlike-spin top quark pairs provided the appropriate spin axes are used. The effects of new physics at production or decay on these correlations are briefly discussed.Comment: 34 pages, revtex, including 12 uuencoded postscript figure

Spectroscopy of Broad Line Blazars from 1LAC

We report on optical spectroscopy of 165 Flat Spectrum Radio Quasars (FSRQs) in the Fermi 1LAC sample, which have helped allow a nearly complete study of this population. Fermi FSRQ show significant evidence for non-thermal emission even in the optical; the degree depends on the gamma-ray hardness. They also have smaller virial estimates of hole mass than the optical quasar sample. This appears to be largely due to a preferred (axial) view of the gamma-ray FSRQ and non-isotropic (H/R ~ 0.4) distribution of broad-line velocities. Even after correction for this bias, the Fermi FSRQ show higher mean Eddington ratios than the optical population. A comparison of optical spectral properties with Owens Valley Radio Observatory radio flare activity shows no strong correlation.Comment: Accepted for publication in Ap

QCD Corrections to Spin Correlations in Top Quark Production at Lepton Colliders

Spin correlations, using a generic spin basis, are investigated to leading order in QCD for top quark production at lepton colliders. Even though, these radiative corrections induce an anomalous gamma/Z magnetic moment for the top quarks and allow for single, real gluon emission, their effects on the top quark spin orientation are very small. The final results are that the top (or anti-top) quarks are produced in an essentially unique spin configuration in polarized lepton collisions even after including the O(alpha_{s}) QCD corrections.Comment: 32 pages, REVTeX, 13 Postscript figures, psfig.sty and here.sty are required. Several references added, Tables 3, 4 and 5 are change

Size Resolved Measurements of Springtime Aerosol Particles over the Northern South China Sea

Large sources of aerosol particles and their precursors are ubiquitous in East Asia. Such sources are known to impact the South China Sea (henceforth SCS), a sometimes heavily polluted region that has been suggested as particularly vulnerable to climate change. To help elucidate springtime aerosol transport into the SCS, an intensive study was performed on the remote Dongsha (aka Pratas) Islands Atoll in spring 2010. As part of this deployment, a Davis Rotating-drum Uniform size-cut Monitor (DRUM) cascade impactor was deployed to collect size-resolved aerosol samples at the surface that were analyzed by X-ray fluorescence for concentrations of selected elements. HYSPLIT backtrajectories indicated that the transport of aerosol observed at the surface at Dongsha was occurring primarily from regions generally to the north and east. This observation was consistent with the apparent persistence of pollution and dust aerosol, along with sea salt, in the ground-based dataset. In contrast to the sea-level observations, modeled aerosol transport suggested that the westerly flow aloft (w700 hPa) transported smoke-laden air toward the site from regions from the south and west. Measured aerosol optical depth at the site was highest during time periods of modeled heavy smoke loadings aloft. These periods did not coincide with elevated aerosol concentrations at the surface, although the model suggested sporadic mixing of this free-tropospheric aerosol to the surface over the SCS. A biomass burning signature was not clearly identified in the surface aerosol composition data, consistent with this aerosol type remaining primarily aloft and not mixing strongly to the surface during the study. Significant vertical wind shear in the region also supports the idea that different source regions lead to varying aerosol impacts in different vertical layers, and suggests the potential for considerable vertical inhomogeneity in the SCS aerosol environment