Presbyterian Imitation Practices in Zachary Boyd’s Nebuchadnezzars Fierie Furnace

The university administrator, preacher and poet Zachary Boyd (1585–1653) relied heavily on epithets and similes borrowed from Josuah Sylvester's poetry when composing his scriptural versifications Zion's Flowers(c. 1640?). The composition of Boyd's adaptation of Daniel 3, Nebuchadnezzars Fierie Furnace, provides an unusually lucid example of the reading and imitation practices of a mid-seventeenth-century Scottish Presbyterian in the years preceding civil war. This article begins by re-considering a manuscript transcription of Fierie Furnace held at the British Library previously described as an anonymous playtext from the early 1610s, then establishes the nature of Boyd's reliance on Sylvester by analyzing holograph manuscripts held at Glasgow University Library, a sermon Boyd wrote on the same theme, and the copy of Sylvester's Devine Weekes, and Workes that Boyd probably used.Arts and Humanities Research Counci

Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors.

Controversy exists regarding the potential regenerative influences of incretin therapy on pancreatic β-cells versus possible adverse pancreatic proliferative effects. Examination of pancreata from age-matched organ donors with type 2 diabetes mellitus (DM) treated by incretin therapy (n = 8) or other therapy (n = 12) and nondiabetic control subjects (n = 14) reveals an ∼40% increased pancreatic mass in DM treated with incretin therapy, with both increased exocrine cell proliferation (P < 0.0001) and dysplasia (increased pancreatic intraepithelial neoplasia, P < 0.01). Pancreata in DM treated with incretin therapy were notable for α-cell hyperplasia and glucagon-expressing microadenomas (3 of 8) and a neuroendocrine tumor. β-Cell mass was reduced by ∼60% in those with DM, yet a sixfold increase was observed in incretin-treated subjects, although DM persisted. Endocrine cells costaining for insulin and glucagon were increased in DM compared with non-DM control subjects (P < 0.05) and markedly further increased by incretin therapy (P < 0.05). In conclusion, incretin therapy in humans resulted in a marked expansion of the exocrine and endocrine pancreatic compartments, the former being accompanied by increased proliferation and dysplasia and the latter by α-cell hyperplasia with the potential for evolution into neuroendocrine tumors

Verifying the Kugo-Ojima Confinement Criterion in Landau Gauge Yang-Mills Theory

Expanding the Landau gauge gluon and ghost two-point functions in a power series we investigate their infrared behavior. The corresponding powers are constrained through the ghost Dyson-Schwinger equation by exploiting multiplicative renormalizability. Without recourse to any specific truncation we demonstrate that the infrared powers of the gluon and ghost propagators are uniquely related to each other. Constraints for these powers are derived, and the resulting infrared enhancement of the ghost propagator signals that the Kugo-Ojima confinement criterion is fulfilled in Landau gauge Yang-Mills theory.Comment: 4 pages, no figures; version to be published in Physical Review Letter

Transpositionally active episomal hAT elements

<p>Abstract</p> <p>Background</p> <p><it>hAT </it>elements and V(D)J recombination may have evolved from a common ancestral transposable element system. Extrachromosomal, circular forms of transposable elements (referred to here as episomal forms) have been reported yet their biological significance remains unknown. V(D)J signal joints, which resemble episomal transposable elements, have been considered non-recombinogenic products of V(D)J recombination and a safe way to dispose of excised chromosomal sequences. V(D)J signal joints can, however, participate in recombination reactions and the purpose of this study was to determine if <it>hobo </it>and <it>Hermes </it>episomal elements are also recombinogenic.</p> <p>Results</p> <p>Up to 50% of <it>hobo/Hermes </it>episomes contained two intact, inverted-terminal repeats and 86% of these contained from 1-1000 bp of intercalary DNA. Episomal <it>hobo/Hermes </it>elements were recovered from <it>Musca domestica </it>(a natural host of <it>Hermes</it>), <it>Drosophila melanogaster </it>(a natural host of <it>hobo</it>) and transgenic <it>Drosophila melanogaster </it>and <it>Aedes aegypti </it>(with autonomous <it>Hermes </it>elements). Episomal <it>Hermes </it>elements were recovered from unfertilized eggs of <it>M. domestica </it>and <it>D. melanogaster </it>demonstrating their potential for extrachromosomal, maternal transmission. Reintegration of episomal <it>Hermes </it>elements was observed <it>in vitro </it>and <it>in vivo </it>and the presence of <it>Hermes </it>episomes resulted in lower rates of canonical <it>Hermes </it>transposition <it>in vivo</it>.</p> <p>Conclusion</p> <p>Episomal <it>hobo</it>/<it>Hermes </it>elements are common products of element excision and can be maternally transmitted. Episomal forms of <it>Hermes </it>are capable of integration and also of influencing the transposition of canonical elements suggesting biological roles for these extrachromosomal elements in element transmission and regulation.</p

Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.

Low-dose antithymocyte globulin (ATG) plus pegylated granulocyte colony-stimulating factor (G-CSF) preserves β-cell function for at least 12 months in type 1 diabetes. Herein, we describe metabolic and immunological parameters 24 months following treatment. Patients with established type 1 diabetes (duration 4-24 months) were randomized to ATG and pegylated G-CSF (ATG+G-CSF) (N = 17) or placebo (N = 8). Primary outcomes included C-peptide area under the curve (AUC) following a mixed-meal tolerance test (MMTT) and flow cytometry. "Responders" (12-month C-peptide ≥ baseline), "super responders" (24-month C-peptide ≥ baseline), and "nonresponders" (12-month C-peptide &lt; baseline) were evaluated for biomarkers of outcome. At 24 months, MMTT-stimulated AUC C-peptide was not significantly different in ATG+G-CSF (0.49 nmol/L/min) versus placebo (0.29 nmol/L/min). Subjects treated with ATG+G-CSF demonstrated reduced CD4+ T cells and CD4+/CD8+ T-cell ratio and increased CD16+CD56hi natural killer cells (NK), CD4+ effector memory T cells (Tem), CD4+PD-1+ central memory T cells (Tcm), Tcm PD-1 expression, and neutrophils. FOXP3+Helios+ regulatory T cells (Treg) were elevated in ATG+G-CSF subjects at 6, 12, and 18 but not 24 months. Immunophenotyping identified differential HLA-DR expression on monocytes and NK and altered CXCR3 and PD-1 expression on T-cell subsets. As such, a group of metabolic and immunological responders was identified. A phase II study of ATG+G-CSF in patients with new-onset type 1 diabetes is ongoing and may support ATG+G-CSF as a prevention strategy in high-risk subjects

Impacts of environmental and socio-economic factors on emergence and epidemic potential of Ebola in Africa

Abstract: Recent outbreaks of animal-borne emerging infectious diseases have likely been precipitated by a complex interplay of changing ecological, epidemiological and socio-economic factors. Here, we develop modelling methods that capture elements of each of these factors, to predict the risk of Ebola virus disease (EVD) across time and space. Our modelling results match previously-observed outbreak patterns with high accuracy, and suggest further outbreaks could occur across most of West and Central Africa. Trends in the underlying drivers of EVD risk suggest a 1.75 to 3.2-fold increase in the endemic rate of animal-human viral spill-overs in Africa by 2070, given current modes of healthcare intervention. Future global change scenarios with higher human population growth and lower rates of socio-economic development yield a 1.63-fold higher likelihood of epidemics occurring as a result of spill-over events. Our modelling framework can be used to target interventions designed to reduce epidemic risk for many zoonotic diseases

Partial Discharge Localization Based on Received Signal Strength

Partial Discharge (PD) occurs when insulation containing defects or voids is subject to high voltages. If left untreated PD can degrade insulation until, eventually, catastrophic insulation failure occurs. The detection of PD current pulses, however, can allow incipient insulation faults to be identified, located and repaired prior to plant failure. Wireless technology has paved the path for PD detection and monitoring. Software Defined Radio (SDR) is a promising technology. Signals from two PD sources are received at six outdoors locations using an SDR USRP N200 which is connected to a laptop. PD sources, thereafter, are localized based on received signal strengths

Gated pipelined folding ADC based low power sensor for large-scale radiometric partial discharge monitoring

Partial discharge is a well-established metric for condition assessment of high-voltage plant equipment. Traditional techniques for partial discharge detection involve physical connection of sensors to the device under observation, limiting sensors to monitoring of individual apparatus, and therefore, limiting coverage. Wireless measurement provides an attractive low-cost alternative. The measurement of the radiometric signal propagated from a partial discharge source allows for multiple plant items to be observed by a single sensor, without any physical connection to the plant. Moreover, the implementation of a large-scale wireless sensor network for radiometric monitoring facilitates a simple approach to high voltage fault diagnostics. However, accurate measurement typically requires fast data conversion rates to ensure accurate measurement of faults. The use of high-speed conversion requires continuous high-power dissipation, degrading sensor efficiency and increasing cost and complexity. Thus, we propose a radiometric sensor which utilizes a gated, pipelined, sample-and-hold based folding analogue-todigital converter structure that only samples when a signal is received, reducing the power consumption and increasing the efficiency of the sensor. A proof of concept circuit has been developed using discrete components to evaluate the performance and power consumption of the system

DNA binding activities of the Herves transposase from the mosquito Anopheles gambiae

Determining the mechanisms by which transposable elements move within a genome increases our understanding of how they can shape genome evolution. Class 2 transposable elements transpose via a 'cut-and-paste' mechanism mediated by a transposase that binds to sites at or near the ends of the transposon. Herves is a member of the hAT superfamily of class 2 transposons and was isolated from Anopheles gambiae, a medically important mosquito species that is the major vector of malaria in sub-Saharan Africa. Herves is transpositionally active and intact copies of it are found in field populations of A gambiae. In this study we report the binding activities of the Herves transposase to the sequences at the ends of the Herves transposon and compare these to other sequences recognized by hAT transposases isolated from other organisms. We identified the specific DNA-binding sites of the Herves transposase. Active Herves transposase was purified using an Escherichia coli expression system and bound in a site-specific manner to the subterminal and terminal sequences of the left and right ends of the element, respectively, and also interacted with the right but not the left terminal inverted repeat. We identified a common subterminal DNA-binding motif (CG/AATTCAT) that is critical and sufficient for Herves transposase binding. The Herves transposase binds specifically to a short motif located at both ends of the transposon but shows differential binding with respect to the left and right terminal inverted repeats. Despite similarities in the overall structures of hAT transposases, the regions to which they bind in their respective transposons differ in sequence ensuring the specificity of these enzymes to their respective transposon. The asymmetry with which the Herves terminal inverted repeats are bound by the transposase may indicate that these differ in their interactions with the enzyme.https://doi.org/10.1186/1759-8753-2-

Natural growth rates in Antarctic krill (Euphausia superba): II. Predictive models based on food, temperature, body length, sex, and maturity stage

We used the instantaneous growth rate method to determine the effects of food, temperature, krill length, sex, and maturity stage on in situ summer growth of krill across the southwest Atlantic sector of the Southern Ocean. The main aims were to examine the separate effects of each variable and to generate a predictive model of growth based on satellite-derivable environmental data. Both growth increments in length on moulting (GIs) and daily growth rates (DGRs, mm d-1) ranged greatly among the 59 swarms, from 0.58–15% and 0.013–0.32 mm d-1. However, all swarms maintained positive mean growth, even those in the low chlorophyll a (Chl a) zone of the central Scotia Sea. Among a suite of indices of food quantity and quality, large-scale monthly Chl a values from SeaWiFS predicted krill growth the best. Across our study area, the great contrast between bloom and nonbloom regions was a major factor driving variation in growth rates, obscuring more subtle effects of food quality. GIs and DGRs decreased with increasing krill length and decreased above a temperature optimum of 0.5°C. This probably reflects the onset of thermal stress at the northern limit of krill’s range. Thus, growth rates were fastest in the ice edge blooms of the southern Scotia Sea and not at South Georgia as previously suggested. This reflects both the smaller size of the krill and the colder water in the south being optimum for growth. Males tended to have higher GIs than females but longer intermoult periods, leading to similar DGRs between sexes. DGRs of equivalent-size krill tended to decrease with maturity stage, suggesting the progressive allocation of energy toward reproduction rather than somatic growth. Our maximum DGRs are higher than most literature values, equating to a 5.7% increase in mass per day. This value fits within a realistic energy budget, suggesting a maximum carbon ration of ~20% d-1. Over the whole Scotia Sea/South Georgia area, the gross turnover of krill biomass was ~1% d-1