Study of Thermoacoustic Phenomenon in a Rijke Tube

AbstractThermoacoustics is concerned with the interactions between heat (thermo) and pressure oscillations in gases (acoustics). A “Rijke Tube”, named after its inventor, is a fundamental tool for studying thermoacoustic phenomenon. Rijke's tube turns heat into sound, by creating a self-amplifying standing wave. It is basically an open-ended tube with a properly placed heat source inside. To study the phenomenon a Rijke tube apparatus was designed and constructed with the facility to change the heat source position and the heat input of the source. Experiments were conducted by changing the heat input, the tube length and diameter. Effects of these parameters on the output sound level were studied. The heat source position was changed and the sound level was measured to estimate the optimal position of the heat source in Rijke tube and to compare it with Rayleigh's estimation. The input electrical power consumed by the heater and the output sound power was calculated. The conversion efficiency of sound power from heat input was calculated and found to be minimal. The focus of this paper is to quantitatively evaluate the performance of the apparatus designed and to explain the mechanism of thermoacoustic phenomenon in Rijke tube with the help of ‘Rayleigh's criterion’

Measurement and Monitoring of Microwave Reflection and Transmission Properties of Cement-Based Materials for Propagation Modeling

A non-destructive, contactless, free-space method is used for measuring and monitoring the properties of cement-based materials. We analyse the propagation factor, penetration depth and reflection and transmission coefficients of the plane wave interacting with the highly lossy specimen. Results are presented of the measurement and monitoring of the properties of cement-based materials during all stages of their lives and different curing conditions The expected applications of the results for propagation modelling are discussed

Measurement and Monitoring of Microwave Reflection and Transmission Properties of Cement-Based Specimens

The results of measurement and monitoring of reflection and transmission properties of cement-based specimens (blocks of mortar, concrete) during long time of their service lives, including hydration process, and different curing conditions at microwave frequencies (X-band) are presented. A simple and inexpensive measurement system that utilizes the nondestructive and contactless free space method is used. Dependencies of the reflection and transmission coefficients on water-to-cement ratio, preparing and curing conditions of the specimens are demonstrated. It is shown that the reflection coefficient is approximately stable after hydration process while the transmission coefficient changes during long time of the specimen\u27\u27s service life. The complex dielectric permittivity of the cement-based materials is calculated by a new method using only the amplitudes of the reflection and transmission coefficients. The expected applications of the results are discussed

Measurement and Monitoring of Microwave Reflection and Transmission Properties of Cement-Based Specimens

The results of measurement and monitoring of reflection and transmission properties of cement-based specimens (blocks of mortar, concrete) obtained by using a simple and an inexpensive measurement system at microwave frequencies (X-band) are presented. Dependencies of the reflection and transmission coefficients on water-to-cement (w/c) ratio, preparing and curing conditions of the specimens are demonstrated. It is shown that the amplitudes of reflection and transmission coefficients, together with thickness of the specimens, determine the complex dielectric permittivity of the hardened cement-based specimens. The expected applications of the results for the determination of physical properties of cement-based materials are discussed. The causes and effects of measurement errors and uncertainties are also discussed

Comparison of multi layer perceptron (MLP) and radial basis function (RBF) for construction cost estimation: the case of Turkey

In Turkey, for the preliminary construction cost estimation, a notice, which is updated and published annu­ally by Turkish Ministry of the Environment and Urbanism, known as “unit area cost method” (UACM) is generally employed. However, it’s known that the costs obtained through this method in which only construction area is taken into consideration have significant differences from actual costs. The aim of this study is to compare the cost estimations obtained through “multi layer perceptron” (MLP) and “radial basis function” (RBF), which are commonly used artificial neural network (ANN) methods. The results of MLP and RBF were also compared with the results of UACM and the validity of UACM was interpreted. Dataobtained from 232 public construction projects, which completed between 2003 and 2011 in different regions of Turkey, were reviewed. Consequently, estimated costs obtained from RBF were found to be higher than the actual costs with a 0.28% variance, while the estimated costs obtained from MLP were higher than actual values with a 1.11% variance. The approximate costs obtained from UACM are higher than actual costs with a 28.73% variance. It was found that both ANN methods were showed better performance than the UACM but RBF was superior to MLP. First published online: 24 Aug 201

Vertebrate Host Susceptibility to Heartland Virus

Heartland virus (HRTV) is a recently described phlebovirus initially isolated in 2009 from 2 humans who had leukopenia and thrombocytopenia. Serologic assessment of domestic and wild animal populations near the residence of 1 of these persons showed high exposure rates to raccoons, white-tailed deer, and horses. To our knowledge, no laboratory-based assessments of viremic potential of animals infected with HRTV have been performed. We experimentally inoculated several vertebrates (raccoons, goats, chickens, rabbits, hamsters, C57BL/6 mice, and interferon-α/β/γ receptor–deficient [Ag129]) mice with this virus. All animals showed immune responses against HRTV after primary or secondary exposure. However, neutralizing antibody responses were limited. Only Ag129 mice showed detectable viremia and associated illness and death, which were dose dependent. Ag129 mice also showed development of mean peak viral antibody titers \u3e8 log10 PFU/mL, hemorrhagic hepatic lesions, splenomegaly, and large amounts of HRTV antigen in mononuclear cells and hematopoietic cells in the spleen

Chloroquine as weekly chemoprophylaxis or intermittent treatment to prevent malaria in pregnancy in Malawi: a randomised controlled trial.

BACKGROUND: Sulfadoxine-pyrimethamine resistance threatens efficacy of intermittent preventive treatment of malaria during pregnancy, and alternative regimens need to be identified. With the return of chloroquine efficacy in southern Africa, we postulated that chloroquine either as an intermittent therapy or as weekly chemoprophylaxis would be more efficacious than intermittent sulfadoxine-pyrimethamine for prevention of malaria in pregnancy and associated maternal and newborn adverse outcomes. METHODS: We did an open-label, single-centre, randomised controlled trial at Ndirande Health Centre, Blantyre, in southern Malawi. We enrolled pregnant women (first or second pregnancy) at 20-28 weeks' gestation who were HIV negative. Participants were randomly assigned in a 1:1:1 ratio using a computer-generated list to either intermittent sulfadoxine-pyrimethamine (two doses of 1500 mg sulfadoxine and 75 mg pyrimethamine, 4 weeks apart), intermittent chloroquine (two doses of 600 mg on day 1, 600 mg on day 2, and 300 mg on day 3), or chloroquine prophylaxis (600 mg on day 1 then 300 mg every week). The primary endpoint was placental malaria in the modified intent-to-treat population, which consisted of participants who contributed placental histopathology data at birth. Secondary outcomes included clinical malaria, maternal anaemia, low birthweight, and safety. This trial is registered with ClinicalTrials.gov, number NCT01443130. FINDINGS: Between February, 2012, and May, 2014, we enrolled and randomly allocated 900 women, of whom 765 contributed histopathological data and were included in the primary analysis. 108 (14%) women had placental malaria, which was lower than the anticipated prevalence of placental malaria infection. Protection from placental malaria was not improved by chloroquine as either prophylaxis (30 [12%] of 259 had positive histopathology; relative risk [RR] 0·75, 95% CI 0·48-1·17) or intermittent therapy (39 [15%] of 253; RR 1·00, 0·67-1·50) compared with intermittent sulfadoxine-pyrimethamine (39 [15%] of 253). In protocol-specified analyses adjusted for maternal age, gestational age at enrolment, bednet use the night before enrolment, anaemia at enrolment, and malaria infection at enrolment, women taking chloroquine as prophylaxis had 34% lower placental infections than did those allocated intermittent sulfadoxine-pyrimethamine (RR 0·66, 95% CI 0·46-0·95). Clinical malaria was reported in nine women assigned intermittent sulfadoxine-pyrimethamine, four allocated intermittent chloroquine (p=0·26), and two allocated chloroquine prophylaxis (p=0·063). Maternal anaemia was noted in five women assigned intermittent sulfadoxine-pyrimethamine, 15 allocated intermittent chloroquine (p=0·038), and six assigned chloroquine prophylaxis (p>0·99). Low birthweight was recorded for 31 babies born to women allocated intermittent sulfadoxine-pyrimethamine, 29 assigned intermittent chloroquine (p=0·78), and 41 allocated chloroquine prophylaxis (p=0·28). Four women assigned intermittent sulfadoxine-pyrimethamine had adverse events possibly related to study product compared with 94 women allocated intermittent chloroquine (p<0·0001) and 26 allocated chloroquine prophylaxis (p<0·0001). Three women had severe or life-threatening adverse events related to study product, of whom all were assigned intermittent chloroquine (p=0·25). INTERPRETATION: Chloroquine administered as intermittent therapy did not provide better protection from malaria and related adverse effects compared with intermittent sulfadoxine-pyrimethamine in a setting of high resistance to sulfadoxine-pyrimethamine. Chloroquine chemoprophylaxis might provide benefit in protecting against malaria during pregnancy, but studies with larger sample sizes are needed to confirm these results. FUNDING: US National Institutes of Health

Diagnosis of placental malaria in poorly fixed and processed placental tissue

Abstract Background Placental histopathology has been considered the gold standard for diagnosis of malaria during pregnancy. However, in under-resourced areas placental tissue is often improperly fixed and processed; the resulting formalin pigment is difficult to distinguish from malaria pigment. This study examines two alternative diagnostic methods: polymerase chain reaction (PCR) and a novel immunohistochemistry (IHC)-based method using an antibody against histidine-rich protein 2 (HRP2). Methods Placental histopathology from 151 pregnant women in Kinshasa was assessed by two blinded microscopists and compared with peripheral blood PCR and IHC for HRP2. The Cohen’s kappa coefficients were calculated to assess the test agreement. The sensitivity and specificity of individual tests were calculated using PCR or IHC as the reference standard as well as latent class analysis (LCA). Results PCR and IHC correlated fairly well. The correlation between the two blinded microscopists was poor, as there was widespread formalin pigment. Using LCA, all of the tests had high specificities. The most sensitive test was IHC (67.7 %), with PCR as second-best (56.1 %). Conclusions PCR and/or IHC are suitable diagnostics when the presence of formalin pigment substantially compromises placental histopathology