mekoFUN für die Grundbildung: metakognitiv fundierte Bildungsarbeit mit Geringqualifizierten

Das neue Forschungsprojekt mekoFun beruht auf dem Konzept des metakognitiv fundierten Lernens. Dieser Ansatz wurde im Vorgängerprojekt KLASSIK bei älteren Lernern und dabei auch bei Lernenden mit eher niedrigen Intelligenzwerten erprobt und erfolgreich umgesetzt

Predicting Rising Follower Counts on Twitter Using Profile Information

When evaluating the cause of one's popularity on Twitter, one thing is considered to be the main driver: Many tweets. There is debate about the kind of tweet one should publish, but little beyond tweets. Of particular interest is the information provided by each Twitter user's profile page. One of the features are the given names on those profiles. Studies on psychology and economics identified correlations of the first name to, e.g., one's school marks or chances of getting a job interview in the US. Therefore, we are interested in the influence of those profile information on the follower count. We addressed this question by analyzing the profiles of about 6 Million Twitter users. All profiles are separated into three groups: Users that have a first name, English words, or neither of both in their name field. The assumption is that names and words influence the discoverability of a user and subsequently his/her follower count. We propose a classifier that labels users who will increase their follower count within a month by applying different models based on the user's group. The classifiers are evaluated with the area under the receiver operator curve score and achieves a score above 0.800.Comment: 10 pages, 3 figures, 8 tables, WebSci '17, June 25--28, 2017, Troy, NY, US

Separate girls\u27 and boys\u27 instruction sessions. Gender-aware education on trial in the classroom

Im niedersächsischen Schulversuch "Soziale Integration in einer jungen- und mädchengerechten Grundschule" wurde ein Modell der reflexiven Koedukation entwickelt, bei dem getrennte Stunden für Mädchen und Jungen eine zentrale Rolle spielen. Während der Praxiserprobung wurden verschiedene didaktische Modelle entwickelt. In einer Befragung haben Jungen und Mädchen diese Praxis positiv bewertet. (DIPF/Orig.)This article publishes the first results of Lower Saxony \u27s pilot classroom project "Social inclusion in a primary school tailored to the needs of boys and girls". It focuses on a model of reflective coeducation involving separatel girls\u27 and boys\u27 instruction sessions and its translation into practice. A number of didactic models has been elaborated. A survey has pointed out that boys and girl have a positive attitude towards this praxis. (DIPF/Orig.

High cadence observations of a global coronal wave by EUVI/STEREO

We report a large-scale coronal wave (so-called "EIT wave") observed with high cadence by EUVI onboard STEREO in association with the GOES B9.5 flare and double CME event on 19 May 2007. The EUVI instruments provide us with the unprecedented opportunity to study the {\it dynamics} of flare/CME associated coronal waves imaged in the extreme ultraviolet. The coronal wave under study reveals deceleration, indicative of a freely propagating MHD wave. Complementary analysis of the associated flare and erupting filament/CME hint at wave initiation by the CME expanding flanks, which drive the wave only over a limited distance. The associated flare is very weak and occurs too late to account for the wave initiation.Comment: Astrophysical Journal Letters (in press

Image-based dosimetry for 225Ac-PSMA-I&T therapy using quantitative SPECT

Purpose!#!After a decade of PET/MR, the case of attenuation correction (AC) remains open. The initial four-compartment (air, water, fat, soft tissue) Dixon-based AC scheme has since been expanded with several features, the latest being MR field-of-view extension and a bone atlas. As this potentially changes quantification, we evaluated the impact of these features in PET AC in prostate cancer patients.!##!Methods!#!Two hundred prostate cancer patients were examined with either !##!Results!#!High correlation and no visually perceivable differences between all evaluated methods (r > 0.996) were found. The mean relative difference in lesion uptake of !##!Conclusions!#!Based on these results and the encountered bone atlas registration inaccuracy, we deduce that including bones and extending the MR field-of-view did not introduce clinically significant differences in PSMA diagnostic accuracy and tracer uptake quantification in prostate cancer pelvic lesions, facilitating the analysis of serial studies respectively. However, in the absence of ground truth data, we advise against atlas-based methods when comparing serial scans for bone lesions

Genetic diversification of persistent Mycobacterium abscessus within cystic fibrosis patients

Mycobacterium (M.) abscessus infections in Cystic Fibrosis (CF) patients cause a deterioration of lung function. Treatment of these multidrug-resistant pathogens is associated with severe side-effects, while frequently unsuccessful. Insight on M. abscessus genomic evolvement during chronic lung infection would be beneficial for improving treatment strategies. A longitudinal study enrolling 42 CF patients was performed at a CF center in Berlin, Germany, to elaborate phylogeny and genomic diversification of in-patient M. abscessus. Eleven of the 42 CF patients were infected with M. abscessus. Five of these 11 patients were infected with global human-transmissible M. abscessus cluster strains. Phylogenetic analysis of 88 genomes from isolates of the 11 patients excluded occurrence of M. abscessus transmission among members of the study group. Genome sequencing and variant analysis of 30 isolates from 11 serial respiratory samples collected over 4.5 years from a chronically infected patient demonstrated accumulation of gene mutations. In total, 53 genes exhibiting non-synonymous variations were identified. Enrichment analysis emphasized genes involved in synthesis of glycopeptidolipids, genes from the embABC (arabinosyltransferase) operon, betA (glucose-methanol-choline oxidoreductase) and choD (cholesterol oxidase). Genetic diversity evolved in a variety of virulence- and resistance-associated genes. The strategy of M. abscessus populations in chronic lung infection is not clonal expansion of dominant variants, but to sustain simultaneously a wide range of genetic variants facilitating adaptation of the population to changing living conditions in the lung. Genomic diversification during chronic infection requires increased attention when new control strategies against M. abscessus infections are explored.Peer Reviewe

Cardiovascular effects of flavanol-rich chocolate in patients with heart failure

Aims Flavanol-rich chocolate (FRC) is beneficial for vascular and platelet function by increasing nitric oxide bioavailability and decreasing oxidative stress. Congestive heart failure (CHF) is characterized by impaired endothelial and increased platelet reactivity. As statins are ineffective in CHF, alternative therapies are a clinical need. We therefore investigated whether FRC might improve cardiovascular function in patients with CHF. Methods and results Twenty patients with CHF were enrolled in a double-blind, randomized placebo-controlled trial, comparing the effect of commercially available FRC with cocoa-liquor-free control chocolate (CC) on endothelial and platelet function in the short term (2 h after ingestion of a chocolate bar) and long term (4 weeks, two chocolate bars/day). Endothelial function was assessed non-invasively by flow-mediated vasodilatation of the brachial artery. Flow-mediated vasodilatation significantly improved from 4.98 ± 1.95 to 5.98 ± 2.32% (P = 0.045 and 0.02 for between-group changes) 2h after intake of FRC to 6.86 ± 1.76% after 4 weeks of daily intake (P = 0.03 and 0.004 for between groups). No effect on endothelial-independent vasodilatation was observed. Platelet adhesion significantly decreased from 3.9 ± 1.3 to 3.0 ± 1.3% (P = 0.03 and 0.05 for between groups) 2 h after FRC, an effect that was not sustained at 2 and 4 weeks. Cocoa-liquor-free CC had no effect, either on endothelial function or on platelet function. Blood pressure and heart rate did not change in either group. Conclusion Flavanol-rich chocolate acutely improves vascular function in patients with CHF. A sustained effect was seen after daily consumption over a 4-week period, even after 12 h abstinence. These beneficial effects were paralleled by an inhibition of platelet function in the presence of FRC only. Trial Registration ClinicalTrials.gov Identifier: NCT0053894

Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study

Aims Extracts from pine tree bark containing a variety of flavonoids have been used in traditional medicine. Pycnogenol is a proprietary bark extract of the French maritime pine tree (Pinus pinaster ssp. atlantica) that exerts antioxidative, anti-inflammatory, and anti-platelet effects. However, the effects of Pycnogenol on endothelial dysfunction, a precursor of atherosclerosis and cardiovascular events, remain still elusive. Methods and results Twenty-three patients with coronary artery disease (CAD) completed this randomized, double-blind, placebo-controlled cross-over study. Patients received Pycnogenol (200 mg/day) for 8 weeks followed by placebo or vice versa on top of standard cardiovascular therapy. Between the two treatment periods, a 2-week washout period was scheduled. At baseline and after each treatment period, endothelial function, non-invasively assessed by flow-mediated dilatation (FMD) of the brachial artery using high-resolution ultrasound, biomarkers of oxidative stress and inflammation, platelet adhesion, and 24 h blood pressure monitoring were evaluated. In CAD patients, Pycnogenol treatment was associated with an improvement of FMD from 5.3 ± 2.6 to 7.0 ± 3.1 (P < 0.0001), while no change was observed with placebo (5.4 ± 2.4 to 4.7 ± 2.0; P = 0.051). This difference between study groups was significant [estimated treatment effect 2.75; 95% confidence interval (CI): 1.75, 3.75, P < 0.0001]. 15-F2t-Isoprostane, an index of oxidative stress, significantly decreased from 0.71 ± 0.09 to 0.66 ± 0.13 after Pycnogenol treatment, while no change was observed in the placebo group (mean difference 0.06 pg/mL with an associated 95% CI (0.01, 0.11), P = 0.012]. Inflammation markers, platelet adhesion, and blood pressure did not change after treatment with Pycnogenol or placebo. Conclusion This study provides the first evidence that the antioxidant Pycnogenol improves endothelial function in patients with CAD by reducing oxidative stress. Clinical Trial Registration: ClinicalTrials.gov identifier: NCT0064175