An Effective Search Method for Gravitational Ringing of Black Holes

We develop a search method for gravitational ringing of black holes. The gravitational ringing is due to complex frequency modes called the quasi-normal modes that are excited when a black hole geometry is perturbed. The detection of it will be a direct confirmation of the existence of a black hole. Assuming that the ringdown waves are dominated by the fundamental mode with least imaginary part, we consider matched filtering and develop an optimal method to search for the ringdown waves that have damped sinusoidal wave forms. When we use the matched filtering method, the data analysis with a lot of templates required. Here we have to ensure a proper match between the filter as a template and the real wave. It is necessary to keep the detection efficiency as high as possible under limited computational costs. First, we consider the white noise case for which the matched filtering can be studied analytically. We construct an efficient method for tiling the template space. Then, using a fitting curve of the TAMA300 DT6 noise spectrum, we numerically consider the case of colored noise. We find our tiling method developed for the white noise case is still valid even if the noise is colored.Comment: 17 pages, 9 figures. Accepted to Phys. Rev. D, Note correction to Eq. (3-25), A few comments added and minor typos correcte

Search for astro-gravity correlations

A new approach in the gravitational wave experiment is considered. In addition to the old method of searching for coincident reactions of two separated gravitational antennae it was proposed to seek perturbations of the gravitational detector noise background correlated with astrophysical events such as neutrino and gamma ray bursts which can be relaibly registered by correspondent sensors. A general algorithm for this approach is developed. Its efficiency is demonstrated in reanalysis of the old data concerning the phenomenon of neutrino-gravity correlation registered during of SN1987A explosion.Comment: 29 pages (LaTeX), 4 figures (EPS

The mathematical theory of resonant transducers in a spherical gravity wave antenna

The rigoruos mathematical theory of the coupling and response of a spherical gravitational wave detector endowed with a set of resonant transducers is presented and developed. A perturbative series in ascending powers of the square root of the ratio of the resonator to the sphere mass is seen to be the key to the solution of the problem. General layouts of arbitrary numbers of transducers can be assessed, and a specific proposal (PHC), alternative to the highly symmetric TIGA of Merkowitz and Johnson, is described in detail. Frequency spectra of the coupled system are seen to be theoretically recovered in full agreement with experimental determinations.Comment: 31 pages, 7 figures, LaTeX2e, \usepackage{graphicx,deleq

Stochastic Background Search Correlating ALLEGRO with LIGO Engineering Data

We describe the role of correlation measurements between the LIGO interferometer in Livingston, LA, and the ALLEGRO resonant bar detector in Baton Rouge, LA, in searches for a stochastic background of gravitational waves. Such measurements provide a valuable complement to correlations between interferometers at the two LIGO sites, since they are sensitive in a different, higher, frequency band. Additionally, the variable orientation of the ALLEGRO detector provides a means to distinguish gravitational wave correlations from correlated environmental noise. We describe the analysis underway to set a limit on the strength of a stochastic background at frequencies near 900 Hz using ALLEGRO data and data from LIGO's E7 Engineering Run.Comment: 8 pages, 2 encapsulated PostScript figures, uses IOP class files, submitted to the proceedings of the 7th Gravitational Wave Data Analysis Workshop (which will be published in Classical and Quantum Gravity

A GFP-Tagged Gross Deletion on Chromosome 1 Causes Malignant Peripheral Nerve Sheath Tumors and Carcinomas in Zebrafish

Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive soft-tissue sarcomas, characterized by complex karyotypes. The molecular bases of such malignancy are poorly understood and efficient targeted molecular therapies are currently lacking. Here we describe a novel zebrafish model of MPNSTs, represented by the transgenic mutant line Tg(-8.5nkx2.2a:GFP)ia2. ia2 homozygous animals displayed embryonic lethality by 72 hpf, while the heterozygotes develop visible tumor masses with high frequency in adulthood. Histological and immunohistochemical examination revealed aggressive tumors with either mesenchymal or epithelial features. The former (54% of the cases) arose either in the abdominal cavity, or as intrathecal/intraspinal lesions and is composed of cytokeratin-negative spindle cells with fascicular/storiform growth pattern consistent with zebrafish MPNSTs. The second histotype was composed by polygonal or elongated cells, immunohistochemically positive for the pan-cytokeratin AE1/AE3. The overall histologic and immunohistochemical features were consistent with a malignant epithelial neoplasm of possible gastrointestinal/pancreatic origin. With an integrated approach, based on microsatellite (VNTR) and STS markers, we showed that ia2 insertion, in Tg(-8.5nkx2.2a:GFP)ia2 embryos, is associated with a deletion of 15.2 Mb in the telomeric portion of chromosome 1. Interestingly, among ia2 deleted genes we identified the presence of the 40S ribosomal protein S6 gene that may be one of the possible drivers for the MPNSTs in ia2 mutants.Thanks to the peculiar features of zebrafish as animal model of human cancer (cellular and genomic similarity, transparency and prolificacy) and the GFP tag, the Tg(-8.5nkx2.2a:GFP)ia2 line provides a manageable tool to study in vivo with high frequency MPNST biology and genetics, and to identify, in concert with the existing zebrafish MPNST models, conserved relevant mechanisms in zebrafish and human cancer development

Peak and end point of the relic graviton background in string cosmology

Using general arguments we determine the allowed region for the end point frequency and the peak energy density of the stochastic background of gravity waves expected in string cosmology. We provide an accurate estimate of the minimal experimental sensitivity required to detect a signal in the Hz to GHz range.Comment: 11 pages, LATEX, one figure included using eps. A complete collection of papers and references on the pre-big-bang scenario in string cosmology is available at http://www.to.infn.it/teorici/gasperini

Detection strategies for scalar gravitational waves with interferometers and resonant spheres

We compute the response and the angular pattern function of an interferometer for a scalar component of gravitational radiation in Brans-Dicke theory. We examine the problem of detecting a stochastic background of scalar GWs and compute the scalar overlap reduction function in the correlation between an interferometer and the monopole mode of a resonant sphere. While the correlation between two interferometers is maximized taking them as close as possible, the interferometer-sphere correlation is maximized at a finite value of f*d, where `f' is the resonance frequency of the sphere and `d' the distance between the detectors. This defines an optimal resonance frequency of the sphere as a function of the distance. For the correlation between the Virgo interferometer located near Pisa and a sphere located in Frascati, near Rome, we find an optimal resonance frequency f=590 Hz. We also briefly discuss the difficulties in applying this analysis to the dilaton and moduli fields predicted by string theory.Comment: 26 pages, Latex, 4 Postscript figures. Various minor improvements, misprint in eqs. 42, 127, 138 corrected, references adde

Final analysis of colorectal cancer patients treated with irinotecan and 5-fluorouracil plus folinic acid neoadjuvant chemotherapy for unresectable liver metastases

We have previously reported that neoadjuvant therapy with modified FOLFIRI enabled nearly a third of patients with metastatic colorectal cancer (mCRC) to undergo surgical resection of liver metastases. Here, we present data from the long-term follow-up of these patients. Forty patients received modified FOLFIRI: irinotecan 180 mg m−2, day 1; folinic acid, 200 mg m−2; and 5-fluorouracil: as a 400 mg m−2 bolus, days 1 and 2, and a 48-h continuous infusion 1200 mg m−2, from day 1. Treatment was repeated every 2 weeks, with response assessed every six cycles. Resected patients received six further cycles of chemotherapy postoperatively. Nineteen (47.5%) of 40 patients achieved an objective response; 13 (33%) underwent resection. After a median follow-up of 56 months, median survival for all patients was 31.5 months: for non-resected patients, median survival was 24 months and was not reached for resected patients. Median time to progression was 14.3 and 5.2 months for all and non-resected patients, respectively. Median disease-free (DF) survival in resected patients was 52.5 months. At 2 years, all patients were alive (8 DF), and at last follow-up, eight were alive (6 DF). Surgical resection of liver metastases after neoadjuvant treatment with modified FOLFIRI in CRC patients achieved favourable survival times

Testing the performance of a blind burst statistic

In this work we estimate the performance of a method for the detection of burst events in the data produced by interferometric gravitational wave detectors. We compute the receiver operating characteristics in the specific case of a simulated noise having the spectral density expected for Virgo, using test signals taken from a library of possible waveforms emitted during the collapse of the core of Type II Supernovae.Comment: 8 pages, 6 figures, Talk given at the GWDAW2002 worksho

The TIGA technique for detecting gravitational waves with a spherical antenna

We report the results of a theoretical and experimental study of a spherical gravitational wave antenna. We show that it is possible to understand the data from a spherical antenna with 6 radial resonant transducers attached to the surface in the truncated icosahedral arrangement. We find that the errors associated with small deviations from the ideal case are small compared to other sources of error, such as a finite signal-to-noise ratio. An in situ measurement technique is developed along with a general algorithm that describes a procedure for determining the direction of an external force acting on the antenna, including the force from a gravitational wave, using a combination of the transducer responses. The practicality of these techniques was verified on a room-temperature prototype antenna.Comment: 15 pages, 14 figures, submitted to Physical Review