National Norms for Entering College Freshmen—Fall 1969

This report presents national normative data on the characteristics of students entering colleges as first-time, full-time freshmen in 1969. It is the fourth such annual report developed as part of the Cooperative Institutional Research Program being conducted by the Office of Research of the American Council on Education. The major purpose of this ongoing research program is to determine how students are affected by the colleges they attend (Astin, Panos, and Creager, 1966). As evidenced by the wide response to the earlier normative reports (Astin, Panos, and Creager, 1967a, 1967b; Panos, Astin and Creager, 1967; and Creager, Astin,Boruch, and Bayer, 1968), the information provided has been valuable to those engaged in guidance, counseling, administration, educational research, and manpower studies

The First Year of College: A Follow-up Normative Report

The major purpose of this ongoing research program is to determine how students are affected by the colleges they attend (Astin, Panos, and Creager, 1966). Consequently, subsamples of the original groups of participating students have been periodically followed up. These follow-up surveys consist in part of post-tests on selected items administered previously in the Freshman Information Form and in part of items that cover the student\u27s experiences and achievements at his institution, his aspirations and plans for the future, his perceptions and evaluations of the college environment, and his educational outcomes and academic standing

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice