2,294 research outputs found

    Dichromacy: Color Vision Impairment and Consanguinity in Heterogenous Population of Pakistan

    Full text link
    Background and Objectives: Dichromacy, an X-linked recessive disorder is identified worldwide, more in males than females. In European Caucasians, its incidence is 8% in males and 0.5% in females. In India, it is 8.73% in males and 1.69% in females, and in Iran, it is 8.18% in males and 0.43% in females. Population based epidemiological data about dichromacy in different ethnic groups in Pakistan is not available. The aim of this study was to find out the population prevalence of inherited red-green dichromacy in a heterogenous population of the district of Chiniot, Punjab, Pakistan, and to determine the impact of consanguinity and ethnicity. Methods: In this cross-sectional study, boys and girls of the higher secondary schools were examined in the three tehsils of district Chiniot. Pseudoisochromatic Ishihara Test has been employed for detection of dichromacy in the study population. The sample size was calculated statistically as 260, which was expanded to 705 and divided by population density of the three tehsils. Results: Screening of 359 males and 346 females revealed 19 (5.29%) dichromat males and only 2 (0.58%) females. The study population belonged to 23 castes / isonym groups. The consanguinity found in the district of Chiniot is 84.82% and in the dichromat families, it is 85.71%, of which 52.37% are first cousin. Interpretation & Conclusion: The study has shown that the incidence of dichromacy could be reduced through genetic counselin

    Enhanced Version of Multi-algorithm Genetically Adaptive for Multiobjective optimization

    Get PDF
    Abstract: Multi-objective EAs (MOEAs) are well established population-based techniques for solving various search and optimization problems. MOEAs employ different evolutionary operators to evolve populations of solutions for approximating the set of optimal solutions of the problem at hand in a single simulation run. Different evolutionary operators suite different problems. The use of multiple operators with a self-adaptive capability can further improve the performance of existing MOEAs. This paper suggests an enhanced version of a genetically adaptive multi-algorithm for multi-objective (AMAL-GAM) optimisation which includes differential evolution (DE), particle swarm optimization (PSO), simulated binary crossover (SBX), Pareto archive evolution strategy (PAES) and simplex crossover (SPX) for population evolution during the course of optimization. We examine the performance of this enhanced version of AMALGAM experimentally over two different test suites, the ZDT test problems and the test instances designed recently for the special session on MOEA?s competition at the Congress of Evolutionary Computing of 2009 (CEC?09). The suggested algorithm has found better approximate solutions on most test problems in terms of inverted generational distance (IGD) as the metric indicator. - See more at: http://thesai.org/Publications/ViewPaper?Volume=6&Issue=12&Code=ijacsa&SerialNo=37#sthash.lxkuyzEf.dpu

    Frequency of Clinical Symptoms of Gastroesophageal Reflux Disease in Asthmatic Patients

    Full text link
    Background: Gastroesophageal reflex is known as an acid reflex, is long term condition where stomach contents back into the oesophagus resulting in either symptoms or complications. GERD disease is caused by weakness or failure of the lower oesophageal sphincter. Symptoms include the acidic taste behind the mouth, heart burn, chest pain, difficult breathing and vomiting. Complication includes esophagitis, oesophageal strictures and barrettes oesophagus. Objective: The aim of this research was to introduce the symptoms of GERD disease in asthmatic patients and how these symptoms worsen the symptoms of asthma disease and what clinical pictures present with the asthmatic disease. Methodology: A designed performa was used to collect the data and after filling the performa, results were drawn and conclusion through the facts and the information given by patients. Results: In the present study among all 164 asthmatic patients, 70 (42.7%) patients showed dyspepsia, 58 (35.4%) were with chest burning, 23 (14%) were asking about chest pain, with acidic mouth taste were 39 (23.8%), 22 (13.4%) were feeling sore throat and 44 (26.8%) showed regurgitation reflex. Among these 164 patients 16 (9.8%) were smokers and 148 (90.2 %) were non-smokers. 47 (28.7%) were males and 117 (71.3%) were females. Conclusion: It is concluded that gastroesophageal reflux disease in asthmatic patients present symptoms of acidic mouth taste, chest burning, chest pain, dyspepsia, regurgitation reflex and sore throat

    Enhanced Luminescence in InGaN Multiple Quantum Wells with Quaternary AlInGaN Barriers

    Get PDF
    We report on the comparative photoluminescence studies of AlGaN/GaN, GaN/InGaN, and AlInGaN/InGaN multiple quantum well(MQW) structures. The study clearly shows the improvement in materials quality with the introduction of indium. Our results point out the localized state emission mechanism for GaN/InGaN structures and the quantum well emission mechanism for AlInGaN/InGaN structures. The introduction of indium is the dominant factor responsible for the observed differences in the photoluminescence spectra of these MQW structures

    Two Mechanisms of Blueshift of Edge Emission in InGaN-Based Epilayers and Multiple Quantum Wells

    Get PDF
    We present the results of a comparative photoluminescence(PL) study of GaN and InGaN-based epilayers, and InGaN/GaN multiple quantum wells(MQWs). Room-temperature PL spectra were measured for a very broad range of optical excitation from 10 mW/cm2 up to 1 MW/cm2. In contrast to GaN epilayers, all In-containing samples exhibited an excitation-induced blueshift of the peak emission. In addition, the blueshift of the emission in the InGaN epilayers with the same composition as the quantum well was significantly smaller. The comparison of the blueshift in the “bulk” InGaN and in the MQWs allowed us to separate two different mechanisms responsible for this effect: (i) filling of the localized states in In-rich areas and (ii) screening of the polarizationelectric field in strained MQW structures

    Indium-Silicon Co-Doping of High-Aluminum-Content AlGaN for Solar Blind Photodetectors

    Get PDF
    We report on an indium–silicon co-doping approach for high-Al-content AlGaN layers. Using this approach, very smooth crack-free n-type AlGaN films as thick as 0.5 μm with Al mole fraction up to 40% were grown over sapphire substrates. The maximum electron concentration in the layers, as determined by Hall measurements, was as high as 8×1017 cm−3 and the Hall mobility was up to 40 cm2/Vs. We used this doping technique to demonstrate solar-blind transparent Schottky barrierphotodetectors with the cut-off wavelength of 278 nm

    Indium–silicon co-doping of high-aluminum-content AlGaN for solar blind photodetectors

    Get PDF
    We report on an indium–silicon co-doping approach for high-Al-content AlGaN layers. Using this approach, very smooth crack-free n-type AlGaN films as thick as 0.5 μm with Al mole fraction up to 40% were grown over sapphire substrates. The maximum electron concentration in the layers, as determined by Hall measurements, was as high as 8×1017 cm−3 and the Hall mobility was up to 40 cm2/Vs. We used this doping technique to demonstrate solar-blind transparent Schottky barrierphotodetectors with the cut-off wavelength of 278 nm
    corecore