Researcher-led teaching:embodiment of academic practice

This paper explores the embodied practices of leading researchers(and/or leading scholars/practitioners), suggesting that distinctive‘researcher-led teaching’ depends on educators who are willing and able to be their research in the teaching setting. We advocate an approach to the development of higher education pedagogy which makes lead-researchers the objects of inquiry and we summarise case study analyses (in neuroscience and humanities) where the knowledge-making‘signatures’ of academic leaders are used to exhibit the otherwise hidden identities of research. We distinguish between learning readymade knowledge and the process of knowledge in the making and point towards the importance of inquiry in the flesh. We develop a view of higher education teaching that depends upon academic status a priori, but we argue that this stance is inclusive because it has the propensity to locate students as participants in academic culture

The schistosome egg: development and secretions

We have investigated the development of the schistosome egg and its secretions in order to understand how it migrates through gut tissues and also initiates pathology in the liver. We show by electron microscopy that the subshell envelope is absent in the newly deposited egg, but appears very early and differentiates as development progresses. In the mature egg, this nucleated envelope contains extensive endoplasmic reticulum, suggestive of a protein synthetic capacity. Furthermore, Reynolds' layer only appears between the envelope and the egg-shell in the mature egg and may represent its accumulated secretions. We have biosynthetically labelled and collected the secretions (ESP) released by mature but not immature eggs during culture. Their fractionation by SDS–PAGE reveals a simple pattern of 6 bands, differing markedly in composition from soluble egg antigen preparations. Electrophoresis in casein substrate gels demonstrates the presence of 2 distinct proteases in the egg secretions. By immunocytochemistry, ESP localized predominantly to the envelope of the mature egg, suggesting that this layer rather than the miracidium is the source of egg secretions

A study into situated learning through community legal companionship

Against the background of the current graduate skills agenda and its considered importance in relation to a UK law degree, this article considers the value of the CLOCK Community Legal Companion scheme, a collaborative social justice project involving law students, legal services providers, third sector advice agencies and law courts based in two areas of the country namely; Canterbury and Brighton. In recent years, the UK Government has significantly cut civil legal aid in areas such as housing, family and welfare benefits, with a view to easing the strain on the deficit. These cuts have been opposed by many, including lawyers, who have raised concerns that the most vulnerable within our communities could be left unrepresented in court and as a consequence an undue burden placed on our civil justice system. CLOCK therefore provides an opportunity for those within our communities who are caught in the so-called ‘justice gap’, to gain support and guidance from law students when they attend court unrepresented. The findings of a small-scale research project into the perceived benefits of Community Legal Companionship, conducted at two UK law schools; Canterbury Christ Church University and the University of Brighton, indicate that the socio-legal experiential learning opportunities for undergraduate law students presented by such initiatives, are also valuable in terms of legal skills acquisition. The research shows that the scheme not only enables law students to use their legal knowledge for the benefit of their local community, but also through analysis of their own perceptions, demonstrates how such a community-based project can provide undergraduate law students with valuable employability skills. Experiences of setting up a Community Legal Companion scheme, together with an overview of how the scheme operates in the Canterbury and Brighton County Courts, as well as students’ reflections of participating as Community Legal Companions drawn from the empirical qualitative research, are evaluated in this article

Situated learning through the CLOCK legal companion scheme

This paper introduces the CLOCK Community Legal Companion scheme, a collaborative social justice project involving law students, law firms, third sector advice agencies and law courts. Initiated by Keele University’s law school due to concerns over the rise in the number of self-represented litigants, following implementation of the Legal Aid Sentencing & Punishment of Offenders Act 2012 (LASPO Act) and the associated reduction in legal aid, the scheme is designed to assist self-represented litigants at courts local to the participating laws schools in the post-LASPO era. Law students acting as Community Legal Companions assist self-represented litigants with legal form-filling; bundle preparation; signposting to appropriate legal and third sector services and accompany litigants in person to hearings along McKenzie Friend principles by taking notes for them. Drawing on the experiences of the scheme at two of the participating universities: Canterbury Christ Church University and the University of Brighton, Ben Waters and Jeanette Ashton outline the role of the Community Legal Companion and how the scheme operates in their respective court centres. They share their experiences of setting up the scheme and of their students’ reflections on volunteering as Community Legal Companions. Situated within a pedagogical context of experiential learning and clinical legal education, the paper also reflects upon the project based research undertaken at both institutions. This includes the responses provided by the students to an initial questionnaire about their experiences as they embarked upon their Companionship role, and the responses received to a follow-up questionnaire after students had undertaken the role for the three-month period. When presenting the research findings, consideration is given to students’ perceptions of the Community Legal Companion role; their motivations for volunteering for the scheme; the preparation and training they received from academic leads, legal partners, third sector partners and the courts; the challenges presented by the role; the supportive link made to their academic studies and the opportunities for key skills acquisition. Perceptions of employability enhancement and the likely impact of the role in supporting students’ future careers are also considered. Whilst there is a considerable body of literature on the well-known and perhaps more established clinical legal education model i.e. that of the university-based law clinic, this paper contributes to the research from the perspective of experiential learning in the context of the court environment through situated learning opportunities. It is argued that such socio-legal active learning initiatives enable law students to learn about law in context, in this case by assisting self-represented litigants who are often at their most vulnerable, with some having poor levels of literacy and many being thoroughly bewildered by the court process. The findings of the study reveal that the CLOCK Community Legal Companion scheme, as well as bringing benefits to the wider community, enables law student volunteers to develop key skills, build links with legal and third sector partners and to feel part of a community of practice

EFFECTS OF PITUITARY PARS INTERMEDIA DYSFUNCTION AND PRASCEND\u3csup\u3e®\u3c/sup\u3e TREATMENT ON ENDOCRINE AND IMMUNE FUNCTION IN SENIOR HORSES

Pituitary pars intermedia dysfunction (PPID) is one of the most common endocrine diseases affecting senior horses. PPID causes abnormally high concentrations of adrenocorticotropic hormone (ACTH) in the plasma and a very distinct, long, shaggy haircoat (hypertrichosis). At present, the recommended treatment for PPID is daily oral administration of pergolide mesylate. Due to the increased ACTH levels associated with PPID, it is commonly thought that these horses are immunosuppressed and at increased risk of opportunistic infections, although current research in this area is sparse. Additionally, it is not well-understood how treatment with Prascend® (pergolide tablets) affects endocrine measures other than ACTH and if it also impacts the immune response. To better understand how PPID influences endocrine and immune function in the horse, Non-PPID horses (n=10), untreated PPID horses (n=9), and PRASCEND-treated PPID horses (n=9) were followed over 15 months. Endocrine measures assessed included basal ACTH, ACTH responses to thyrotropin-releasing hormone (TRH) stimulation tests, basal insulin, insulin responses to oral sugar tests (OST), total cortisol, and free cortisol. Systemic immune function measures included basal and stimulated whole blood and peripheral blood mononuclear cell (PBMCs) cytokine and receptor expression, plasma myeloperoxidase levels, and complete blood counts. Localized immune function measures within the lung included cytokine and receptor expression after stimulation of cells obtained via bronchoalveolar lavage (BAL), myeloperoxidase levels in BAL fluid, and BAL fluid cytology. We hypothesized that PPID would affect immune function, but that any alterations would be corrected by treatment with PRASCEND. Results for the endocrine analyses showed that basal ACTH was reduced in the PRASCEND-treated horses to the levels of the Non-PPID horses, but ACTH in response to TRH stimulation was only reduced in the PRASCEND-treated horses at non-fall timepoints. PPID did not affect basal insulin, insulin responses to OSTs, total cortisol, or free cortisol, and PRASCEND treatment did not appear to have an impact on these measures either. These results suggest that PPID and hyperinsulinemia/insulin dysregulation are distinct endocrine conditions, and that the excess ACTH in horses with PPID is inactive, as it is unable to stimulate a normal cortisol response. In the immune function analyses, PPID horses had decreased expression of interferon gamma (IFNγ) from PBMCs stimulated with Rhodococcus equi and Escherichia coli and increased transforming growth factor beta (TGFβ) expression from the E. coli-stimulated PBMCs. TGFβ was also increased in PPID horses in the unstimulated whole blood samples. These results suggest that PPID horses are unable to mount an appropriate Th1 response, and that the regulatory subset of T-lymphocytes may be contributing to this decreased Th1 response. Results for the localized immune function analyses may indicate altered Th2 responses within the lung of PPID horses, although these results were severely limited by the sample size available for analyses. PRASCEND did not appear to affect immune function as measured in this study. In summary, PRASCEND successfully reduces basal ACTH in PPID horses and remains the best choice for veterinarians in monitoring dosage and response to PRASCEND treatment. Insulin, total cortisol, and free cortisol were not affected by PPID status or PRASCEND treatment in this study. Immune function was altered in horses with PPID, and it is likely that these horses are indeed at increased risk of opportunistic infection. PRASCEND treatment did not correct the differences in immune function in this study. Additional research is needed to further understand which mechanisms are driving the alterations in immune function for horses with PPID

Constitutional Law—Due Process Requires that Limits Be Placed on Psychiatric Confinement Commensurate With the Procedural Safeguards Employed in Obtaining That Confinement.

McNeil v. Director, Patuxent Institution, 407 U.S. 245 (1972)

Three-body interactions in complex fluids: virial coefficients from simulation finite-size effects

A simulation technique is described for quantifying the contribution of three-body interactions to the thermodynamical properties of coarse-grained representations of complex fluids. The method is based on comparing the third virial coefficient $B_3$ for a complex fluid with that of an approximate coarse-grained model described by a pair potential. To obtain $B_3$ we introduce a new technique which expresses its value in terms of the measured volume-dependent asymptote of a certain structural function. The strategy is applicable to both Molecular Dynamics and Monte Carlo simulation. Its utility is illustrated via measurements of three-body effects in models of star polymer and highly size-asymmetrical colloid-polymer mixtures.Comment: 13 pages, 8 figure

Monte Carlo cluster algorithm for fluid phase transitions in highly size-asymmetrical binary mixtures

Highly size-asymmetrical fluid mixtures arise in a variety of physical contexts, notably in suspensions of colloidal particles to which much smaller particles have been added in the form of polymers or nanoparticles. Conventional schemes for simulating models of such systems are hamstrung by the difficulty of relaxing the large species in the presence of the small one. Here we describe how the rejection-free geometrical cluster algorithm (GCA) of Liu and Luijten [Phys. Rev. Lett 92, 035504 (2004)] can be embedded within a restricted Gibbs ensemble to facilitate efficient and accurate studies of fluid phase behavior of highly size-asymmetrical mixtures. After providing a detailed description of the algorithm, we summarize the bespoke analysis techniques of Ashton et al. [J. Chem. Phys. 132, 074111 (2010)] that permit accurate estimates of coexisting densities and critical-point parameters. We apply our methods to study the liquid--vapor phase diagram of a particular mixture of Lennard-Jones particles having a 10:1 size ratio. As the reservoir volume fraction of small particles is increased in the range 0--5%, the critical temperature decreases by approximately 50%, while the critical density drops by some 30%. These trends imply that in our system, adding small particles decreases the net attraction between large particles, a situation that contrasts with hard-sphere mixtures where an attractive depletion force occurs.Comment: 11 pages, 10 figure

Depletion potentials in highly size-asymmetric binary hard-sphere mixtures: Comparison of accurate simulation results with theory

We report a detailed study, using state-of-the-art simulation and theoretical methods, of the depletion potential between a pair of big hard spheres immersed in a reservoir of much smaller hard spheres, the size disparity being measured by the ratio of diameters q=\sigma_s/\sigma_b. Small particles are treated grand canonically, their influence being parameterized in terms of their packing fraction in the reservoir, \eta_s^r. Two specialized Monte Carlo simulation schemes --the geometrical cluster algorithm, and staged particle insertion-- are deployed to obtain accurate depletion potentials for a number of combinations of q\leq 0.1 and \eta_s^r. After applying corrections for simulation finite-size effects, the depletion potentials are compared with the prediction of new density functional theory (DFT) calculations based on the insertion trick using the Rosenfeld functional and several subsequent modifications. While agreement between the DFT and simulation is generally good, significant discrepancies are evident at the largest reservoir packing fraction accessible to our simulation methods, namely \eta_s^r=0.35. These discrepancies are, however, small compared to those between simulation and the much poorer predictions of the Derjaguin approximation at this \eta_s^r. The recently proposed morphometric approximation performs better than Derjaguin but is somewhat poorer than DFT for the size ratios and small sphere packing fractions that we consider. The effective potentials from simulation, DFT and the morphometric approximation were used to compute the second virial coefficient B_2 as a function of \eta_s^r. Comparison of the results enables an assessment of the extent to which DFT can be expected to correctly predict the propensity towards fluid fluid phase separation in additive binary hard sphere mixtures with q\leq 0.1.Comment: 16 pages, 9 figures, revised treatment of morphometric approximation and reordered some materia