Sensitivity of Bayes Estimates of Reliability and Reliable Life to a Non Standard Prior

Robustness of Bayes estimate of reliability function and the reliable life by employing Edgeworth-gamma class of priors for the unknown mean and precision of normal population of failure times, have been investigated. The effect of a moderately non-normal prior for Martz and Waller data has been noted to be insignificantly small

Kitozan male molekulske mase kao nosač hidrodinamički uravnoteženog sustava za usporenu isporuku ciprofloksacin hidroklorida

Chitosan has become a focus of major interest in recent years due to its excellent biocompatibility, biodegradability and non-toxicity. Although this material has already been extensively investigated in the design of different types of drug delivery systems, it is still little explored for stomach specific drug delivery systems. The objective of the present investigation was to explore the potential of low molecular mass chitosan (LMCH) as carrier for a hydrodynamically balanced system (HBS) for sustained delivery of water soluble drug ciprofloxacin hydrochloride (CP). Various formulations were prepared by physical blending of drug and polymer(s) in varying ratios followed by encapsulation into hard gelatin capsules. All the formulations remained buoyant in 0.1mol L1 HCl (pH 1.2) throughout the experiment. Effect of addition of xanthan gum (XG) or ethyl cellulose (EC) on drug release was also investigated. Zero order drug release was obtained from the formulations containing LMCH alone or in combination with XG, and in one instance also with EC. Our results suggest that LMCH alone or in combination with XG is an excellent material for stomach specific sustained delivery of CP from hydrodynamically balanced single unit capsules.Zbog svoje biokompatibilnosti, biorazgradljivosti i netoksičnosti kitozan je vrlo interesantan istraživačima u području farmaceutske tehnologije. Najviše se upotrebljavao u dizajniranju različitih sustava za isporuku lijekova ali vrlo malo za sustave za specifičnu isporuku u želucu. Cilj ovog rada bio je ispitati mogućnost upotrebe kitozana male molekulske mase (LMCH) kao nosača u hidrodinamički balansiranom sustavu (HBS) za usporenu isporuku vodotopljivog lijeka ciprofloksacin hidroklorida (CP). Pripravljene su različite formulacije stvaranjem fizičke smjese lijeka i polimera u različitim omjerima, koje su potom kapsulirane u želatinske kapsule. Svi su pripravci za vrijeme cijelog eksperimenta ostali plutati u 0,01mol L1 HCl (pH 1,2). Ispitivan je i učinak ksantan gume (XG) ili etilceluloze (EC) na oslobađanje lijeka. Oslobađanje lijeka nultog reda postignuto je iz formulacija koje sadrže samo LMCH ili LMCH u kombinaciji sa XG i u jednom slučaju s EC. Dobiveni rezultati pokazuju da je LMCH, sam ili u kombinaciji sa XG, izvrstan materijal za sustave za specifičnu isporuku CP iz hidrodinamički balansiranih kapsula

Study of Vagendriya with its Related Structures - A Review

According to Ayurveda classic texts Indriyas are the apparatus to attain knowledge for Atma. Acharya Charaka described Indriya as basic instrument in differentiating the living and non-living matters. Whereas in contemporary science Indriyas are dealt only with structure i.e. sense organ where the actual transduction process takes place. Indriyas are composed of five elements still specific Mahabhuta dominates precise Indriya. This is the reason behind reception of specific sensation by its respective Indriya. Many sensory and motor functions are performed by Indriyas. Indriyas of human body plays a very vital role in carrying out day to day activites of human body. Modern science also accepts the same concept in the form of sensation and perception that allows the human to detect and understand the various stimuli and collect information from internal or external environment of an organism and send them to CNS. All Indriyas work will be meaningless if Vayu will not work hand to hand with these Indriyas. Vagendriya a motor organ which act as a passive partner on receiving command from its higher centre located in Shira, which is ultimately a site for location of control center of all motor as well as sense organs and thus it is said to be ‘Uttamaang.’ Ayurvedic approach towards speech production is reflected as Vak Pravrutti. Speech is multiphase unique phenomenon and is believed to be outcome of combined effort of Acoustic signals, Articulatory signals and Muscle coordination along with Nervous assistance viz. Wernicke’s area and Broca’s area

Application of Artificial Neural Network for Analysis of Self-Excited Induction Generator

It is observed that conventional techniques to analyse the steady state analysis of Self-Excited Induction Generator (SEIG) involve cumbersome mathematical procedures. In this paper an Artificial Intelligence (AI) technique has been used to analyse the behaviour of Self-Excited Induction Generator, which does not require rigorous modelling as required in conventional techniques. Proposed Artificial Neural Network (ANN) model has been implemented to predict the effect of speed, capacitance and load on generated voltage and frequency of SEIG. Experimental data is used for the training of ANN. Results obtained from the trained ANN are found to be in close agreement with the experimental results.Facultad de Informátic

Preparation and characterization of gellan-chitosan polyelectrolyte complex beads

The purpose of the present investigation was to prepare gellan-chitosan polyelectrolyte complex beads in one step and to explore the potential of the prepared beads in the oral delivery of metronidazole (log P = 0.0) and metronidazole benzoate (log P = 2.19). Beads were prepared by extruding aqueous solution of gellan gum (with or without drugs) into chitosan solution in acetic acid pH adjusted to 3.5. Prepared beads exhibited poor encapsulation and burst release for metronidazole, while very high encapsulation and extended release was observed for metronidazole benzoate in simulated gastric fluid (SGF, pH 1.2). Incorporation of type A & B gelatin significantly improved the metronidazole encapsulation in the beads but the release pattern remained the same. Overall, gellan-chitosan beads showed poor retardant capacity of drug release for metronidazole whereas good retardant capacity was observed for metronidazole benzoate.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Application of Artificial Neural Network for Analysis of Self-Excited Induction Generator

It is observed that conventional techniques to analyse the steady state analysis of Self-Excited Induction Generator (SEIG) involve cumbersome mathematical procedures. In this paper an Artificial Intelligence (AI) technique has been used to analyse the behaviour of Self-Excited Induction Generator, which does not require rigorous modelling as required in conventional techniques. Proposed Artificial Neural Network (ANN) model has been implemented to predict the effect of speed, capacitance and load on generated voltage and frequency of SEIG. Experimental data is used for the training of ANN. Results obtained from the trained ANN are found to be in close agreement with the experimental results.Facultad de Informátic

Exponential decontamination models for count data

Several models are developed for the estimation of the rate of exponential die-off from decontamination data. Calculations with illustrative data are reported which indicate that the estimation of this rate and its variance are sensitive to changes in modelling assumptions. Since extrapolation using this estimated rate is used in the specification of planetary quarantine standards, special care should be taken in the selection of an appropriate model and corresponding estimation procedure for the analysis of each set of decontamination data to be used for this purpose.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43352/1/11084_2004_Article_BF00924214.pd

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum