22 research outputs found
International Virtual Research Organization Network Evolution
International Virtual Research Organizations (IVROs) are organizations established to foster collaboration between international groups using cyberinfrastructure, which provides mechanisms for organizing, planning, and executing scientific research. This study traces the evolution of the organizational network of a large multi-disciplinary IVRO over the course of nine years. Results show significant deviations in participation during certain years that may indicate organizational turbulenc
A Typology of Virtual Research Environments
Virtual Research Environments (VREs) are online spaces that support communication and collaboration among scientists. Hundreds of VREs have been constructed using various configurations of research tools and information and communication technologies (ICTs) to serve many disciplines and interdisciplinary inquiry. This study characterizes a large sample of VREs in terms of the research and ICT resources they incorporate and derives a typology of VREs based on their particular ICT configurations. The four types are correlated with previous VRE typologies and disciplinary domains. Results indicate that there are correspondences, but that types of ICT configurations also exhibit complex relationships with function and discipline
Lake depth alters the trajectory of ontogenetic niche shifts in Eurasian perch (Perca fluviatilis) in small lakes
The trophic niche of aquatic generalist predators is influenced by ontogeny, habitat characteristics, availability and type of prey, and competitive interactions. Many interrelated lake characteristics influence the availability of prey and may thereby impact foraging niches and the trajectory of ontogenetic niche shifts. Our work uses Eurasian perch (Perca fluviatilis) as a model species to examine the correlation of multiple lake and fish community characteristics with the size-dependency of perch populations' realised trophic niche. We used carbon and nitrogen stable isotopes to correlate the changes in perch trophic position across a gradient of total lengths in seven gravel pit lakes that differed in lake morphology, habitat heterogeneity, productivity, structural complexity, and fish community composition. Perch populations in lakes with more shallow-water habitat reached a higher trophic position at smaller sizes than perch in deeper lakes. However, the changes in trophic position with increasing size were less pronounced compared to perch from deeper lakes. Large individuals from the latter perch populations ultimately achieved higher mean trophic positions compared to fish from shallow lakes. Perch in lakes with more shallow-water habitat may, therefore, achieve lower rates of piscivory because of higher relative availability of macroinvertebrates or greater competition with zooplanktivores. Our results suggest that large, piscivorous perch are more likely to develop in deeper lakes, and that these changes in perch trophic position across ontogeny are more strongly related to the depth of lakes than to the type of structured habitat in the littoral zone.Peer Reviewe
Environmental determinants of perch (Perca fluviatilis) growth in gravel pit lakes and the relative performance of simple versus complex ecological predictors
Growth of fish is an important contributor to individual fitness as well as fish production. Explaining and predicting growth variation across populations is thus important from fundamental and applied perspectives, which requires knowledge about the ecological factors involved in shaping growth. To that end, we estimated environment-dependent von Bertalanffy growth models for 13 gravel pit lake populations of Eurasian perch (Perca fluviatilis) from north-western Germany. To identify the main drivers of perch growth, we evaluated the performance of 16 different biotic or abiotic lake variables in explaining growth variation among lakes. In addition, we compared growth predictions from the best-performing model incorporating âcomplexâ variables that require intensive sampling effort, with a model using only âsimpleâ, easily measurable lake variables (e.g. shoreline development factor). The derivation of a simple model aimed at future applications in typically data-poor inland fisheries, predicting expected growth potential from easily measurable lake variables. A model combining metabolic biomass of predators, maximum depth and shoreline development factor performed best in predicting perch growth variation across gravel pits. All three parameters in this model were positively related to perch growth. The best-performing simple model consisted only of the shoreline development factor. Length-at-age predictions from both models were largely identical, highlighting the utility of shoreline development factor in approximating growth potential of perch in gravel pits similar to our study lakes. Our results can be used to inform fisheries management and restoration efforts at existing or newly excavated gravel pit lakes.Bundesamt fĂŒr Naturschutz
http://dx.doi.org/10.13039/501100010415Bundesministerium fĂŒr Bildung und Forschung
http://dx.doi.org/10.13039/501100002347Spanish Ministry of Economy, Industry and Competitiveness
http://dx.doi.org/10.13039/501100010198Peer Reviewe
Localization and functional consequences of a direct interaction between TRIOBP-1 and hERG/KCNH2 proteins in the heart
Reduced levels of hERG protein and the corresponding repolarizing current IKr can cause arrhythmia and sudden cardiac death, but the underlying cellular mechanisms controlling hERG surface expression are not well understood. We identified TRIOBP-1, an F-actin binding protein previously associated with actin polymerization, as a putative hERG-interacting protein in a yeast-two hybrid screen of a cardiac library. We corroborated this interaction using Forster resonance energy transfer (FRET) in HEK293 cells and co-immunoprecipitation in HEK293 cells and native cardiac tissue. TRIOBP-1 overexpression reduced hERG surface expression and current density, whereas reducing TRIOBP-1 expression via shRNA knockdown resulted in increased hERG protein levels. Immunolabeling in rat cardiomyocytes showed that native TRIOBP-1 overlapped predominantly with myosin binding protein C and secondarily with rat ERG. In human stem cell-derived cardiomyocytes, TRIOBP-1 overexpression caused intracellular co-sequestration of hERG signal, reduced native IKr, and disrupted action potential repolarization. Calcium currents were also reduced to a lesser degree and cell capacitance was increased. These findings establish that TRIOBP-1 interacts directly with hERG and can affect protein levels, IKr magnitude, and cardiac membrane excitability
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Tracing the Evolution of Collaborative Virtual Research Environments: A Critical Events-Based Perspective
A significant number of scientific projects pursuing large scale, complex investigations involve dispersed research teams, which conduct a large part or their work virtually. Virtual Research Environments (VREs), cyberinfrastructure that facilitates coordinated activities amongst dispersed scientists, thus provide a rich context to study organizational evolution. Due to the constantly evolving nature of technologies, it is important to understand how teams of scientists, system developers, and managers respond to critical incidents. Critical events are organizational situations that trigger strategic decision making to adjust structure or redirect processes in order to maintain balance or improve an already functioning system. This study examines two prominent VREs: The United States Virtual Astronomical Observatory (US-VAO) and the HathiTrust Research Center (HTRC) in order to understand how these environments evolve through critical events and strategic choices. Communication perspectives lend themselves well to a study of VRE development and evolution because of the central role occupied by communication technologies in both the functionality and management of VREs. Using the grounded theory approach, this study uses organizational reports to trace how critical events and their resulting strategic choices shape these organizations over time. The study also explores how disciplinary demands influence critical events
A SocialâEcological Odyssey in Fisheries and Wildlife Management
Aldo Leopold, famous ecologist and âfatherâ of North American wildlife management, once said, âThese are two things that interest me: the relation of people to each other, and the relation of people to landâ (Leopold 1947). Ever prescient, Leopold recognized that natural resource management is fundamentally about humans and their relationship with nature well before conservation became an established way of thinking, much less the bedrock of entire professions. Similarly, amid the Green Revolution to increase agricultural production, in part, through widespread use of pesticides, renowned environmentalist and journalist Rachel Carson noted that we are all âa part of nature, and [our] war against nature is inevitably a war against [ourselves]â (Carson 1962). Leopoldâs and Carsonâs words spoke volumes about pressing problems facing humanity and ecosystems at a time when innovative socialâecological thinking in mainstream spheres was direly needed.
Throughout their lives, Leopold and Carson illustrated, in word and deed, how people and the environment are intertwined in ways that affect the productivity and sustainability of human and natural systems. Today, these humanâ environmental connections are well known by some groups of peopleâthanks to dedicated natural resource scientists, managers, and communicators, not to mention millennia-old connections to and understandings of the land by Indigenous peoplesâbut are too often unrecognized or taken for granted in broader society. The consequence of such socialâecological silence is a modern natural resource policy management environment that tends to approach conservation in fragments as opposed to holistically across human/social systems (e.g., socioeconomic, political, cultural) and natural/ecological systems (e.g., biological, geological, climatological). Although such fragmentation results from the historical independence of social and natural sciences, as well as the difficulty of integrating them (Liu et al. 2007a, 2007b; Ostrom 2009), we now have the knowledge and tools to write a new socialâecological chapter in conservation history. This is a crucial task because many of the worldâs most pressing environmental challengesâ those that threaten ecosystems and human systems alike (e.g., climate change, biodiversity loss, air and water pollution, food and nutrition insecurity, water scarcity)âare socialâecological by origin and structure, demanding integrative solutions rooted in humanâenvironmental inquiry. Fortunately, the interconnectedness of humans and nature that so fascinated Leopold, Carson, and countless others represents an expanding research areaâcoupled human and natural systems (CHANS)âwith promising potential to improve ecosystem integrity and human health and wellbeing (Hulina et al. 2017; LĂłpez-Hoffman et al. 2017a; Kaemingk et al. 2020)