Facile Protocol for Water-Tolerant “Frustrated Lewis Pair”-Catalyzed Hydrogenation

Despite rapid advances in the field of metal-free, “frustrated Lewis pair” (FLP)-catalyzed hydrogenation, the need for strictly anhydrous reaction conditions has hampered wide-scale uptake of this methodology. Herein, we report that, despite the generally perceived moisture sensitivity of FLPs, 1,4-dioxane solutions of B(C6F5)3 actually show appreciable moisture tolerance and can catalyze hydrogenation of a range of weakly basic substrates without the need for rigorously inert conditions. In particular, reactions can be performed directly in commercially available nonanhydrous solvents without subsequent drying or use of internal desiccants

Evaluating machine learning techniques for archaeological lithic sourcing: a case study of flint in Britain

The original version of this Article contained errors in the legends of Figure 8 and 9. The legend of Figure 8: “Learning curve shows F1 score for train and test data against number of observations in training data.” now reads: “Box Plot of F1 Scores for each model, showing good equality of variances.

Novel B(Ar')2(Ar'') hetero-tri(aryl)boranes: a systematic study of Lewis acidity

A series of homo- and hetero-tri(aryl)boranes incorporating pentafluorophenyl, 3,5-bis(trifluoromethyl)phenyl, and pentachlorophenyl groups, four of which are novel species, have been studied as the acidic component of frustrated Lewis pairs for the heterolytic cleavage of H2. Under mild conditions eight of these will cleave H2; the rate of cleavage depending on both the electrophilicity of the borane and the steric bulk around the boron atom. Electrochemical studies allow comparisons of the electrophilicity with spectroscopic measurements of Lewis acidity for different series of boranes. Discrepancies in the correlation between these two types of measurements, combined with structural characterisation of each borane, reveal that the twist of the aryl rings with respect to the boron-centred trigonal plane is significant from both a steric and electronic perspective, and is an important consideration in the design of tri(aryl)boranes as Lewis acids

The future of decisions from experience : connecting real-world decision problems to cognitive processes

In many important real-world decision domains, such as finance, the environment, and health, behavior is strongly influenced by experience. Renewed interest in studying this influence led to important advancements in the understanding of these decisions from experience (DfE) in the last 20 years. Building on this literature, we suggest ways the standard experimental design should be extended to better approach important real-world DfE. These extensions include, for example, introducing more complex choice situations, delaying feedback, and including social interactions. When acting upon experiences in these richer and more complicated environments, extensive cognitive processes go into making a decision. Therefore, we argue for integrating cognitive processes more explicitly into experimental research in DfE. These cognitive processes include attention to and perception of numeric and nonnumeric experiences, the influence of episodic and semantic memory, and the mental models involved in learning processes. Understanding these basic cognitive processes can advance the modeling, understanding and prediction of DfE in the laboratory and in the real world. We highlight the potential of experimental research in DfE for theory integration across the behavioral, decision, and cognitive sciences. Furthermore, this research could lead to new methodology that better informs decision-making and policy interventions

Distributed team health data science in risk of non-Vitamin K Oral Anticoagulant after Intracranial Haemorrhage

Introduction New non-vitamin K Target Specific Oral Anticoagulants (TSOACs) have a favourable risk-benefit profile and debatable cost effectiveness. Large numbers and data from multiple countries in a European study are required to investigate safety issue of TSOACs in subgroups, e.g. people with an intracranial haemorrhage. Objectives and Approach We developed an approach to rapidly replicate data and analyses to support cross-country distributed research within the UK/EU using Electronic Health Records (EHRs). This project was conceptualised and initialled by linking relevant datasets held in multiple data warehouses, in Scotland with the Scottish National Data Safe Haven, and in Wales through the Secure Anonymised Information Linkage (SAIL) databank. Analysts in Edinburgh and Swansea had remote access to each other’s datasets and worked collaboratively to harmonise variables and analysis scripts. . A common R code script has been produced to harmonise individual data as well as the outputs from the study. Results The study screened data on 8M people to develop a cohort that included pseudonymised information of 4,153 individuals in Scotland and 2,676 individuals in Wales, 6,829 individuals in total. Standardised risk analyses were completed in both settings with ongoing work in combining the analyses. In Wales, 39.5% of the patients in the cohort had been admitted to hospitals due to serious vascular events or died caused by these events, after intracranial haemorrhage. Incident rates for male and female are 0.63 and 0.7 respectively. Within the cohort, 0.5% were prescribed with TSOACs and 3% with Warfarin (included as reference). The project is also in the process of including other European jurisdictions. Conclusion/Implications The adopted approach was the simplest, yet most efficient and cost-effective method to ensure consistency in analysis and coherence with currently available governance systems of both safe havens. It can also be considered as an initialisation of developing infrastructure to support research using EHRs across the UK and EU

Application of an evidence-based, out-patient treatment strategy for COVID-19: Multidisciplinary medical practice principles to prevent severe disease☆

The COVID-19 pandemic has devastated individuals, families, and institutions throughout the world. Despite the breakneck speed of vaccine development, the human population remains at risk of further devastation. The decision to not become vaccinated, the protracted rollout of available vaccine, vaccine failure, mutational forms of the SARS virus, which may exhibit mounting resistance to our molecular strike at only one form of the viral family, and the rapid ability of the virus(es) to hitch a ride on our global transportation systems, means that we are will likely continue to confront an invisible, yet devastating foe. The enemy targets one of our human physiology’s most important and vulnerable life-preserving body tissues, our broncho-alveolar gas exchange apparatus. Notwithstanding the fear and the fury of this microbe\u27s potential to raise existential questions across the entire spectrum of human endeavor, the application of an early treatment intervention initiative may represent a crucial tool in our defensive strategy. This strategy is driven by evidence-based medical practice principles, those not likely to become antiquated, given the molecular diversity and mutational evolution of this very clever “world traveler