Substance Use and Depression Symptomatology: Measurement Invariance of the Beck Depression Inventory (BDI-II) among Non-Users and Frequent-Users of Alcohol, Nicotine and Cannabis

Depression is a highly heterogeneous condition, and identifying how symptoms present in various groups may greatly increase our understanding of its etiology. Importantly, Major Depressive Disorder is strongly linked with Substance Use Disorders, which may ameliorate or exacerbate specific depression symptoms. It is therefore quite plausible that depression may present with different symptom profiles depending on an individual’s substance use status. Given these observations, it is important to examine the underlying construct of depression in groups of substance users compared to non-users. In this study we use a non-clinical sample to examine the measurement structure of the Beck Depression Inventory (BDI-II) in non-users and frequent-users of various substances. Specifically, measurement invariance was examined across those who do vs. do not use alcohol, nicotine, and cannabis. Results indicate strict factorial invariance across non-users and frequent-users of alcohol and cannabis, and metric invariance across non-users and frequent-users of nicotine. This implies that the factor structure of the BDI-II is similar across all substance use groups

UK College of Medicine African-American Medical Students\u27 Experience with Faculty Mentoring

This research study explored the faculty mentoring experiences of African-American medical students at the University of Kentucky College of Medicine (UK COM). The purpose of the research is to determine benefits and challenges expressed by the African-American students so that UK COM can use the student voices to improve faculty mentoring for this student population. The following broad questions guided the research: 1) What are UK College of Medicine African-American medical students’ experiences with faculty mentoring? 2) What are UK College of Medicine African-American medical students’ experience with faculty mentoring on a satellite regional campus? Specifically, the investigation seeks to provide further detail regarding positive aspects of African-American medical students’ experiences with mentoring as well as information about the challenges these students face—to inform future medical student mentoring programs for this under-represented population of students. The study revealed that students perceived faculty mentoring to be beneficial to their personal and professional development; beneficial for learning about leadership, research, scholarship, and conference opportunities; and beneficial for networking and having a role model. However, this study found that African-American students desire more faculty of color, more programming and resources related to mentoring, and better availability of mentors. The study also found a need for more mentoring opportunities and better communication about mentoring for students on satellite regional campuses

Angry White Men on Campus: Theoretical Perspectives and Recommended Responses

In this article, the authors explore a rise in violent protest among white college men, theoretical interpretations of this trend, and recommendations that student affairs educators can implement to address the harmful acts of white male on campus. By examining hegemonic masculinity, the theory of dispossession, anomic protest masculinity, and white men’s disengagement in college, student affairs professionals can begin to understand the larger contemporary trend of student activism among white college men. Moreover, evaluating common strategies for engaging college men, including behavior-only approaches, bad-dogging accountability practices, and white privilege pedagogy, educators can gain perspective on how current responses in the field of student affairs may be counterproductive to solving the problem of protest masculinities on campus. Finally, through a critical analysis of patriarchy and white supremacy as systems of oppression in graduate preparation, professional development, and individual self-reflection, educators can begin to effectively engage angry white men in college

Exploring Alternatives to Out-of-School Suspension in Kentucky: A quasi-experimental study examining the effectiveness of Community service work

This paper addresses the ineffective and often negative impacts that various forms of disciplinary measures have on students (e.g. out-of-school suspension, in-school suspension, and placement in alternative schools) then discusses community service as a viable alternative to these programs. Data from 17 middle and high schools in Kentucky that implemented community service in lieu of suspension are compared to data from 17 control schools to explore whether or not community service programs are effective in reducing school suspensions. The findings illustrate that community service programs are effective in reducing the amount of out-of-school suspensions in those schools that use community service programs. Therefore, the authors suggest that implementing community service works as a viable alternative to in-school or out-of-school suspensions has the potential to improve academic performance and conduct within public school settings

Multi-criteria analysis of landslide susceptibility, Afghanistan

This presentation was given as part of the GIS Day@KU symposium on November 16, 2016. For more information about GIS Day@KU activities, please see http://gis.ku.edu/gisday/2016/.Landslides are among the most destructive forces of nature. Estimating susceptibility through modeling is an essential tool for planning and mitigation efforts. Some regions, however, are too dangerous or lack the capacity to develop extensive inventories for rigorous analyses. Remote sensing and GIS allow for initial risk assessment and hazard planning. Data derived primarily from remote sensing, or developed before and during war efforts of the last few decades were used for this study of landslide susceptibility in Afghanistan.Platinum Sponsors: KU Department of Geography and Atmospheric Science. Gold Sponsors: Enertech, KU Environmental Studies Program, KU Libraries. Silver Sponsors: Douglas County, Kansas, KansasView, State of Kansas Data Access & Support Center (DASC) and the KU Center for Global and International Studies

Low-Frequency Radio Transients in the Galactic Center

We report the detection of a new radio transient source, GCRT J1746-2757, located only 1.1 degrees north of the Galactic center. Consistent with other radio transients toward the Galactic center, this source brightened and faded on a time scale of a few months. No X-ray counterpart was detected. We also report new 0.33 GHz measurements of the radio counterpart to the X-ray transient source, XTE J1748-288, previously detected and monitored at higher radio frequencies. We show that the spectrum of XTE J1748-288 steepened considerably during a period of a few months after its peak. We also discuss the need for a more efficient means of finding additional radio transients

Bifurcation study of blood flow control in the kidney.

Renal blood flow is maintained within a narrow window by a set of intrinsic autoregulatory mechanisms. Here, a mathematical model of renal hemodynamics control in the rat kidney is used to understand the interactions between two major renal autoregulatory mechanisms: the myogenic response and tubuloglomerular feedback. A bifurcation analysis of the model equations is performed to assess the effects of the delay and sensitivity of the feedback system and the time constants governing the response of vessel diameter and smooth muscle tone. The results of the bifurcation analysis are verified using numerical simulations of the full nonlinear model. Both the analytical and numerical results predict the generation of limit cycle oscillations under certain physiologically relevant conditions, as observed in vivo

Short Duration Waveforms Recorded Extracellularly from Freely Moving Rats are Representative of Axonal Activity

While extracellular somatic action potentials from freely moving rats have been well characterized, axonal activity has not. We report direct extracellular tetrode recordings of putative axons whose principal feature is a short duration waveform (SDW) with an average peak-trough length less than 179 μs. While SDW recordings using tetrodes have previously been treated as questionable or classified as cells, we hypothesize that they are representative of axonal activity. These waveforms have significantly shorter duration than somatic action potentials, are triphasic and are therefore similar to classic descriptions of microelectrode recordings in white matter and of in vitro action potential propagation along axons. We describe SDWs recorded from pure white-matter tracts including the alveus and corpus callosum. Recordings of several SDWs in the alveus exhibit grid-like firing patterns suggesting these axons carry spatial information from entorhinal cortical neurons. Finally, we locally injected the GABAA agonist Muscimol into layer CA1 of the hippocampus while simultaneously recording somatic activity and SDWs on the same tetrodes. The persistent activity of SDWs during Muscimol inactivation of somatic action potentials indicates that SDWs are representative of action potential propagation along axons projecting from more distal somata. This characterization is important as it illustrates the dangers of exclusively using spike duration as the sole determinant of unit type, particularly in the case of interneurons whose peak-trough times overlap with SDWs. It may also allow future studies to explore how axonal projections from disparate brain regions integrate spatial information in the hippocampus, and provide a basis for studying the effects of pharmaceutical agents on signal transmission in axons, and ultimately to aid in defining the potential role of axons in cognition

Relating the metatranscriptome and metagenome of the human gut

Although the composition of the human microbiome is now wellstudied, the microbiota’s \u3e8 million genes and their regulation remain largely uncharacterized. This knowledge gap is in part because of the difficulty of acquiring large numbers of samples amenable to functional studies of the microbiota. We conducted what is, to our knowledge, one of the first human microbiome studies in a well-phenotyped prospective cohort incorporating taxonomic, metagenomic, and metatranscriptomic profiling at multiple body sites using self-collected samples. Stool and saliva were provided by eight healthy subjects, with the former preserved by three different methods (freezing, ethanol, and RNAlater) to validate self-collection. Within-subject microbial species, gene, and transcript abundances were highly concordant across sampling methods, with only a small fraction of transcripts (\u3c5%) displaying between-method variation. Next, we investigated relationships between the oral and gut microbial communities, identifying a subset of abundant oral microbes that routinely survive transit to the gut, but with minimal transcriptional activity there. Finally, systematic comparison of the gut metagenome and metatranscriptome revealed that a substantial fraction (41%) of microbial transcripts were not differentially regulated relative to their genomic abundances. Of the remainder, consistently underexpressed pathways included sporulation and amino acid biosynthesis, whereas up-regulated pathways included ribosome biogenesis and methanogenesis. Across subjects, metatranscriptional profiles were significantly more individualized than DNA-level functional profiles, but less variable than microbial composition, indicative of subject-specific whole-community regulation. The results thus detail relationships between community genomic potential and gene expression in the gut, and establish the feasibility of metatranscriptomic investigations in subject-collected and shipped samples