1,294 research outputs found
O tratamento e a sobrevida no mieloma múltiplo
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina. Departamento de Clinica Medica
Scaling laws for soliton pulse compression by cascaded quadratic nonlinearities
We present a detailed study of soliton compression of ultra-short pulses
based on phase-mismatched second-harmonic generation (\textit{i.e.}, the
cascaded quadratic nonlinearity) in bulk quadratic nonlinear media. The
single-cycle propagation equations in the temporal domain including
higher-order nonlinear terms are presented. The balance between the quadratic
(SHG) and the cubic (Kerr) nonlinearity plays a crucial role: we define an
effective soliton number -- related to the difference between the SHG and the
Kerr soliton numbers -- and show that it has to be larger than unity for
successful pulse compression to take place. This requires that the phase
mismatch be below a critical level, which is high in a material where the
quadratic nonlinearity dominates over the cubic Kerr nonlinearity. Through
extensive numerical simulations we find dimensionless scaling laws, expressed
through the effective soliton number, which control the behaviour of the
compressed pulses. These laws hold in the stationary regime, in which
group-velocity mismatch effects are small, and they are similar to the ones
observed for fiber soliton compressors. The numerical simulations indicate that
clean compressed pulses below two optical cycles can be achieved in a
-barium borate crystal at appropriate wavelengths, even for picosecond
input pulses.Comment: 11 pages, 8 figures, resubmitted version, to appear in October issue
of J. Opt. Soc. Am. B. Substantially revised, updated mode
Espresso coffees, caffeine and chlorogenic acid intake: potential health implications
HPLC analysis of 20 commercial espresso coffees revealed 6-fold differences in caffeine levels, a 17-fold range of caffeoylquinic acid contents, and 4-fold differences in the caffeoylquinic acid:caffeine ratio. These variations reflect differences in batch-to-batch bean composition, possible blending of arabica with robusta beans, as well as roasting and grinding procedures, but the predominant factor is likely to be the amount of beans used in the coffee-making/barista processes. The most caffeine in a single espresso was 322 mg and a further three contained >200 mg, exceeding the 200 mg day−1 upper limit recommended during pregnancy by the UK Food Standards Agency. This snap-shot of high-street expresso coffees suggests the published assumption that a cup of strong coffee contains 50 mg caffeine may be misleading. Consumers at risk of toxicity, including pregnant women, children and those with liver disease, may unknowingly ingest excessive caffeine from a single cup of espresso coffee. As many coffee houses prepare larger volume coffees, such as Latte and Cappuccino, by dilution of a single or double shot of expresso, further study on these products is warranted. New data are needed to provide informative labelling, with attention to bean variety, preparation, and barista methods
RNA interference against polo-like kinase-1 in advanced non-small cell lung cancers
Worldwide, approximately one and a half million new cases of lung cancer are diagnosed each year, and about 85% of lung cancer are non-small cell lung cancer (NSCLC). As the molecular pathogenesis underlying NSCLC is understood, new molecular targeting agents can be developed. However, current therapies are not sufficient to cure or manage the patients with distant metastasis, and novel strategies are necessary to be developed to cure the patients with advanced NSCLC
Sterilizing Activity of Second-Line Regimens Containing TMC207 in a Murine Model of Tuberculosis
RATIONALE: The sterilizing activity of the regimen used to treat multidrug resistant tuberculosis (MDR TB) has not been studied in a mouse model. OBJECTIVE AND METHODS: Swiss mice were intravenously inoculated with 6 log10 of Mycobacterium tuberculosis (TB) strain H37Rv, treated with second-line drug combinations with or without the diarylquinoline TMC207, and then followed without treatment for 3 more months to determine relapse rates (modified Cornell model). MEASUREMENTS: Bactericidal efficacy was assessed by quantitative lung colony-forming unit (CFU) counts. Sterilizing efficacy was assessed by measuring bacteriological relapse rates 3 months after the end of treatment. MAIN RESULTS: The relapse rate observed after 12 months treatment with the WHO recommended MDR TB regimen (amikacin, ethionamide, pyrazinamide and moxifloxacin) was equivalent to the relapse rate observed after 6 months treatment with the recommended drug susceptible TB regimen (rifampin, isoniazid and pyrazinamide). When TMC207 was added to this MDR TB regimen, the treatment duration needed to reach the same relapse rate dropped to 6 months. A similar relapse rate was also obtained with a 6-month completely oral regimen including TMC207, moxifloxacin and pyrazinamide but excluding both amikacin and ethionamide. CONCLUSIONS: In this murine model the duration of the WHO MDR TB treatment could be reduced to 12 months instead of the recommended 18-24 months. The inclusion of TMC207 in the WHO MDR TB treatment regimen has the potential to further shorten the treatment duration and at the same time to simplify treatment by eliminating the need to include an injectable aminoglycoside
同型な基本カンドルをもつリボン2 次元結び目とリボントーラス結び目の基本バイカンドル
広島大学(Hiroshima University)博士(理学)Sciencedoctora
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