Does FDI Regulatory Policies Influence FDI Inflows in Developing Countries? A Non Linear Analysis

Purpose: Foreign Direct Investment (FDI) inflow is regarded as highly important particularly for developing countries as it enhances economic activities and creates job opportunities. The main objective of the present study is to analyze the impact of two regulatory policies i.e. Regulatory Restrictiveness Index (RRI) and Ease of Doing Business (EDB) on FDI inflows in developing countries. Research Gap: Not many studies have discussed the role of more than one regulatory policy to examine their impact on FDI inflows. Therefore, the present study is an attempt to bridge this research gap as it uses two regulatory policies to examine this relationship. Design/Methodology/Approach: The study performs the non-linear analysis using two separate models to determine FDI inflows in 39 developing countries for the period 1997-2020.For this purpose FGLS econometric technique is utilized. The Main Findings: The linearized marginal effects of RRI show that all the countries are located on the left side of U shaped curve while linearized marginal effects of EDB show that some countries lie on the left side and others lie on the right side of U shaped curve. The higher value of the level coefficient than the value of the quadratic coefficient reveals the stronger influence of level coefficients in both models. Theoretical/Practical Implications of the Findings: The study concludes that developing countries need to reduce FDI restrictions to attract maximum FDI inflows. Furthermore, it is recommended that for improving the confidence of foreign investors, appropriate and consistent policies should be designed and implemented

Solar Resource Assessment in Jammu and Kashmir State

The state of Jammu and Kashmir has diverse agro-climatic zones. The present paper on solar resource assessment in the state of Jammu and Kashmir is based on ten years of average data taken from NREL and SRRA stations. The state is blessed with huge solar potential, both for thermal generation as well as photovoltaic. The same energy can be used for electricity and process heat generation to mitigate growing energy crisis particularly in winter. The data as obtained from NREL and C-WET through SRRA stations revealed that the state is receiving more than 5 kWh/m2/day of average DNI and GHI every month which in itself can be harnessed for solar thermal energy and photovoltaic power. The average DNI and GHI received from last ten years varied from (1 kWh/day/m2) to (8kWh/day/m2) per day

Conformal Ricci collineations of static spherically symmetric spacetimes

Conformal Ricci collineations of static spherically symmetric spacetimes are studied. The general form of the vector fields generating conformal Ricci collineations is found when the Ricci tensor is non-degenerate, in which case the number of independent conformal Ricci collineations is \emph{fifteen}; the maximum number for 4-dimensional manifolds. In the degenerate case it is found that the static spherically symmetric spacetimes always have an infinite number of conformal Ricci collineations. Some examples are provided which admit non-trivial conformal Ricci collineations, and perfect fluid source of the matter

Pattern of panic-buying and its psychosocial correlates among Pakistani adults during COVID-19 pandemic

Background: As the COVID-19 pandemic rages on, one bizarre yet ubiquitous human behavior has resurfaced. Globally, people have engaged in panic buying and hoarding (PBH). This irrational practice of panic buying is driven by deficient, manipulated news amid COVID-19 crisis.Methods: A cross-sectional study was conducted with Pakistani adults (≤18 years). Data was collected through an anonymous self-reported online survey from 17th April 2020 (0800 hours) through 20th April 2020 (2200 hours) via social media platforms. The survey consisted of sociodemographic characteristics, questions regarding food/essential supplies PBH and its psychosocial correlates- attitudes about COVID-19 severity (CA), values related to social responsibility (SR), social trust (ST), and self-interest (SI). Data was entered and analyzed using IBM Statistical package for social sciences (SPSS) version 20.Results: There were 786 participants in the survey; 59% were females. Mean age was 26.6±7.6 years. Mean PBH score was 2.31±0.85 (range: 1-5). Overall, 28.4% hoarded supplies a few times or more and 47% agreed to have bought more food/essential supplies due to COVID-19. Correlation analysis showed a 12.3% positive correlation of PBH with ST and 8.5% positive correlation with SI (p<0.05). In the multivariate regression model, PBH showed a statistically significant (p<0.05) positive impact on ST and SI.Conclusions: More than one-fourth of the individuals indulged in panic buying and hoarding during the COVID-19 in Pakistan. Fear of contracting the virus and uncertainty about the duration of lockdown was the common reasons behind PBH. Social trust and self-interest were significant psychosocial contributors to hoarding behavior.

Molecular basis of arsenite (As+3)-induced acute cytotoxicity in human cervical epithelial carcinoma cells

Background: Rapid industrialization is discharging toxic heavy metals into the environment, disturbing human health in many ways and causing various neurologic, cardiovascular, and dermatologic abnormalities and certain types of cancer. The presence of arsenic in drinking water from different urban and rural areas of the major cities of Pakistan, for example, Lahore, Faisalabad, and Kasur, was found to be beyond the permissible limit of 10 parts per billion set by the World Health Organization. Therefore the present study was initiated to examine the effects of arsenite (As+3) on DNA biosynthesis and cell death.Methods: After performing cytotoxic assays on a human epithelial carcinoma cell line, expression analysis was done by quantitative polymerase chain reaction, western blotting, and flow cytometry.Results: We show that As+3 ions have a dose- and time-dependent cytotoxic effect through the activation of the caspase-dependent apoptotic pathway. In contrast to previous research, the present study was designed to explore the early cytotoxic effects produced in human cells during exposure to heavy dosage of As+3 (7.5 μg/ml). Even treatment for 1 h significantly increased the mRNA levels of p21 and p27 and caspases 3, 7, and 9. It was interesting that there was no change in the expression levels of p53, which plays an important role in G2/M phase cell cycle arrest.Conclusion: Our results indicate that sudden exposure of cells to arsenite (As+3) resulted in cytotoxicity and mitochondrial-mediated apoptosis resulting from up-regulation of caspases.Keywords: apoptosis; epithelial carcinoma; cytotoxicity; arsenite; caspases; Pakistan Responsible Editor: Amin Bredan, VIB Inflammation Research Center &amp; Ghent University, Belgium

Categorisation of Mobile EEG : A Researcher’s Perspective

Researchers are increasingly attempting to undertake electroencephalography (EEG) recordings in novel environments and contexts outside of the traditional static laboratory setting. The term “mobile EEG,” although commonly used to describe many of these undertakings, is ambiguous, since it attempts to encompass a wide range of EEG device mobility, participant mobility, and system specifications used across investigations. To provide quantitative parameters for “mobile EEG,” we developed a Categorisation of Mobile EEG (CoME) scheme based upon scoring of device mobility (, from 0, off-body, to 5, head-mounted with no additional equipment), participant mobility (, from 0, static, to 5, unconstrained running), system specification (, from 4, lowest, to 20, highest), and number of channels () used. The CoME scheme was applied to twenty-nine published mobile EEG studies. Device mobility scores ranged from 0 to 4, participant mobility scores from 0 to 4, and system specification scores from 6 to 17. The format of the scores for the four parameters is given, for example, as (2, 4, 17, 32) and readily enables comparisons across studies. Our CoME scheme enables researchers to quantify the degree of device mobility, participant mobility, and system specification used in their “mobile EEG” investigations in a standardised way

Automated Quantification of Neuropad Improves Its Diagnostic Ability in Patients with Diabetic Neuropathy.

PublishedResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tNeuropad is currently a categorical visual screening test that identifies diabetic patients at risk of foot ulceration. The diagnostic performance of Neuropad was compared between the categorical and continuous (image-analysis (Sudometrics)) outputs to diagnose diabetic peripheral neuropathy (DPN). 110 subjects with type 1 and 2 diabetes underwent assessment with Neuropad, Neuropathy Disability Score (NDS), peroneal motor nerve conduction velocity (PMNCV), sural nerve action potential (SNAP), Deep Breathing-Heart Rate Variability (DB-HRV), intraepidermal nerve fibre density (IENFD), and corneal confocal microscopy (CCM). 46/110 patients had DPN according to the Toronto consensus. The continuous output displayed high sensitivity and specificity for DB-HRV (91%, 83%), CNFD (88%, 78%), and SNAP (88%, 83%), whereas the categorical output showed high sensitivity but low specificity. The optimal cut-off points were 90% for the detection of autonomic dysfunction (DB-HRV) and 80% for small fibre neuropathy (CNFD). The diagnostic efficacy of the continuous Neuropad output for abnormal DB-HRV (AUC: 91%, P = 0.0003) and CNFD (AUC: 82%, P = 0.01) was better than for PMNCV (AUC: 60%). The categorical output showed no significant difference in diagnostic efficacy for these same measures. An image analysis algorithm generating a continuous output (Sudometrics) improved the diagnostic ability of Neuropad, particularly in detecting autonomic and small fibre neuropathy.National Institute of Health (NIH)Juvenile Diabetes Research Foundation (JDRF

Small nerve fiber damage and Langerhans cells in type 1 and type 2 diabetes and LADA measured by corneal confocal microscopy

Purpose: Increased corneal and epidermal Langerhans cells (LCs) have been reported in patients with diabetic neuropathy. The aim of this study was to quantify the density of LCs in relation to corneal nerve morphology and the presence of diabetic neuropathy and to determine if this differed in patients with type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and latent autoimmune diabetes of adults (LADA). Methods: Patients with T1DM (n = 25), T2DM (n = 36), or LADA (n = 23) and control subjects (n = 23) underwent detailed assessment of peripheral neuropathy and corneal confocal microscopy. Corneal nerve fiber density (CNFD), branch density (CNBD), length (CNFL) and total, immature and mature LC densities were quantified. Results: Lower CNFD (P &lt; 0.001), CNBD (P &lt; 0.0001), and CNFL (P &lt; 0.0001) and higher LC density (P = 0.03) were detected in patients with T1DM, T2DM, and LADA compared to controls. CNBD was inversely correlated with mature (r = -0.5; P = 0.008), immature (r = -0.4; P = 0.02) and total (r = -0.5; P = 0.01) LC density, and CNFL was inversely correlated with immature LC density (r = -0.4; P = 0.03) in patients with T1DM but not in patients with T2DM and LADA. Conclusions: This study shows significant corneal nerve loss and an increase in LC density in patients with T1DM, T2DM, and LADA. Furthermore, increased LC density correlated with corneal nerve loss in patients with T1DM