A practical approach to navigating uncertainty within innovative markets for Carthago, a fire prevention and response startup concept: technology analysis & diffusion

Despite efforts to establish methods for innovation and market entry, the element of uncertainty makes it difficult for firms to ensure success when introducing a new product. Therefore, mitigation of uncertainty is paramount to cultivating innovation and growth. This paper provides a practical example of uncertainty reduction in the context of Carthago, a developing startup looking to provide technological solutions to the growing wildfire problems in Portugal and Europe. Structured around the Innovator’s Method, additional frameworks like the social business model canvas, strategic foresight and scenario planning will be used to advise Carthago’s approach to uncertainty mitigation and market entry

Calpain 3 and CaMKIIβ signaling are required to induce HSP70 necessary for adaptive muscle growth after atrophy.

Mutations in CAPN3 cause autosomal recessive limb girdle muscular dystrophy 2A. Calpain 3 (CAPN3) is a calcium dependent protease residing in the myofibrillar, cytosolic and triad fractions of skeletal muscle. At the triad, it colocalizes with calcium calmodulin kinase IIβ (CaMKIIβ). CAPN3 knock out mice (C3KO) show reduced triad integrity and blunted CaMKIIβ signaling, which correlates with impaired transcriptional activation of myofibrillar and oxidative metabolism genes in response to running exercise. These data suggest a role for CAPN3 and CaMKIIβ in gene regulation that takes place during adaptation to endurance exercise. To assess whether CAPN3- CaMKIIβ signaling influences skeletal muscle remodeling in other contexts, we subjected C3KO and wild type mice to hindlimb unloading and reloading and assessed CaMKIIβ signaling and gene expression by RNA-sequencing. After induced atrophy followed by 4 days of reloading, both CaMKIIβ activation and expression of inflammatory and cellular stress genes were increased. C3KO muscles failed to activate CaMKIIβ signaling, did not activate the same pattern of gene expression and demonstrated impaired growth at 4 days of reloading. Moreover, C3KO muscles failed to activate inducible HSP70, which was previously shown to be indispensible for the inflammatory response needed to promote muscle recovery. Likewise, C3KO showed diminished immune cell infiltration and decreased expression of pro-myogenic genes. These data support a role for CaMKIIβ signaling in induction of HSP70 and promotion of the inflammatory response during muscle growth and remodeling that occurs after atrophy, suggesting that CaMKIIβ regulates remodeling in multiple contexts: endurance exercise and growth after atrophy

Eficácia dos exercícios de Cawthorne e Cooksey na melhoria do equilíbrio e na prevenção de quedas em pessoas idosas: revisão da literatura

Projeto de Graduação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciado em FisioterapiaObjetivo: Analisar os resultados de ensaios clínicos sobre o protocolo de Cawthorne e Cooksey na melhoria do equilíbrio em indivíduos idosos. Metodologia: Pesquisa computorizada nas bases de dados: DOAJ (Directory of Open Access Journals); EBSCO; LILACS;PEDro; PubMed/Medline; SCIelo; ScienceDirect; ISI Web of Knowledge a fim de pesquisar estudos randomizados controlados. Foram selecionados artigos em língua inglesa e portuguesa. A análise dos estudos foi feita por meio de revisão crítica dos conteúdos. Resultado: foram incluídos 5 estudos randomizados controlados envolvendo 201 participantes. Conclusão: O protocolo de Cawthorne e Cooksey permite novos padrões de estimulação vestibular e esta intervenção seria capaz de promover melhoras nas reações de equilíbrio bem como na melhoria da autoconfiança e assim na prevenção de quedas.Objective: To analyze the results of different Clinical Trials concerning the efficacy of the Cawthorne and Cooksey exercise protocol in improving balance in elderly individuals. Methodology: A computerized search was conducted in the following databases: DOAJ (Directory of Open Access Journals); EBSCO; LILACS;PEDro; PubMed/Medline; SCIelo; ScienceDirect; ISI Web of Knowledge; with the intent of finding Randomized controlled trials. English and Portuguese written articles were selected. The analysis was made by critical revision of contents. Results: 5 randomized clinical trials were included, totaling 201 participants overall. Conclusion: The Cawthorne and Cooksey exercise protocol allows new patterns of vestibular stimulation, allowing this intervention to promote improvements in balance, as well as improvements in self-confidence and fall prevention.N/

Comparison between Two Implementations of iCub's Fingertip

n/

Eficácia dos exercícios de Cawthorne e Cooksey na melhoria do equilíbrio e na prevenção de quedas em pessoas idosas: revisão da literatura

Projeto de Graduação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciado em FisioterapiaObjetivo: Analisar os resultados de ensaios clínicos sobre o protocolo de Cawthorne e Cooksey na melhoria do equilíbrio em indivíduos idosos. Metodologia: Pesquisa computorizada nas bases de dados: DOAJ (Directory of Open Access Journals); EBSCO; LILACS;PEDro; PubMed/Medline; SCIelo; ScienceDirect; ISI Web of Knowledge a fim de pesquisar estudos randomizados controlados. Foram selecionados artigos em língua inglesa e portuguesa. A análise dos estudos foi feita por meio de revisão crítica dos conteúdos. Resultado: foram incluídos 5 estudos randomizados controlados envolvendo 201 participantes. Conclusão: O protocolo de Cawthorne e Cooksey permite novos padrões de estimulação vestibular e esta intervenção seria capaz de promover melhoras nas reações de equilíbrio bem como na melhoria da autoconfiança e assim na prevenção de quedas.Objective: To analyze the results of different Clinical Trials concerning the efficacy of the Cawthorne and Cooksey exercise protocol in improving balance in elderly individuals. Methodology: A computerized search was conducted in the following databases: DOAJ (Directory of Open Access Journals); EBSCO; LILACS;PEDro; PubMed/Medline; SCIelo; ScienceDirect; ISI Web of Knowledge; with the intent of finding Randomized controlled trials. English and Portuguese written articles were selected. The analysis was made by critical revision of contents. Results: 5 randomized clinical trials were included, totaling 201 participants overall. Conclusion: The Cawthorne and Cooksey exercise protocol allows new patterns of vestibular stimulation, allowing this intervention to promote improvements in balance, as well as improvements in self-confidence and fall prevention.N/

Chapter Large Scale Capacitive Skin for Robots

Communications engineering / telecommunication

Large Scale Capacitive Skin for Robots

Communications engineering / telecommunication

Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis.

Liver X receptors (LXRs) are transcriptional regulators of cellular and systemic cholesterol homeostasis. Under conditions of excess cholesterol, LXR activation induces the expression of several genes involved in cholesterol efflux, facilitates cholesterol esterification by promoting fatty acid synthesis, and inhibits cholesterol uptake by the low-density lipoprotein receptor. The fact that sterol content is maintained in a narrow range in most cell types and in the organism as a whole suggests that extensive crosstalk between regulatory pathways must exist. However, the molecular mechanisms that integrate LXRs with other lipid metabolic pathways are incompletely understood. Here we show that ligand activation of LXRs in mouse liver not only promotes cholesterol efflux, but also simultaneously inhibits cholesterol biosynthesis. We further identify the long non-coding RNA LeXis as a mediator of this effect. Hepatic LeXis expression is robustly induced in response to a Western diet (high in fat and cholesterol) or to pharmacological LXR activation. Raising or lowering LeXis levels in the liver affects the expression of genes involved in cholesterol biosynthesis and alters the cholesterol levels in the liver and plasma. LeXis interacts with and affects the DNA interactions of RALY, a heterogeneous ribonucleoprotein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the mouse liver. These findings outline a regulatory role for a non-coding RNA in lipid metabolism and advance our understanding of the mechanisms that coordinate sterol homeostasis