Effects of a Supermassive Black Hole Binary on a Nuclear Gas Disk

We study influence of a galactic central supermassive black hole (SMBH) binary on gas dynamics and star formation activity in a nuclear gas disk by making three-dimensional Tree+SPH simulations. Due to orbital motions of SMBHs, there are various resonances between gas motion and the SMBH binary motion. We have shown that these resonances create some characteristic structures of gas in the nuclear gas disk, for examples, gas elongated or filament structures, formation of gaseous spiral arms, and small gas disks around SMBHs. In these gaseous dense regions, active star formations are induced. As the result, many star burst regions are formed in the nuclear region.Comment: 19 pages, 11 figures, accepted for publication in Ap

Tidal disruption of dark matter halos around proto-globular clusters

Tidal disruption of dark matter halos around proto-globular clusters in a halo of a small galaxy is studied in the context of the hierarchical clustering scenario by using semi-cosmological N-body/SPH simulations assuming the standard cold dark matter model ($\Omega_0 = 1$). Our analysis on formation and evolution of the galaxy and its substructures archives until $z = 2.0$. In such a high-redshift universe, the Einstein-de Sitter universe is still a good approximation for a recently favored $\Lambda$-dominated universe, and then our results does not depend on the choice of cosmology. In order to resolve small gravitationally-bound clumps around galaxies and consider radiative cooling below $T = 10^4 K$, we adopt a fine mass resolution (m_{\rm SPH} = 1.12 \times 10^3 \Msun). Because of the cooling, each clump immediately forms a `core-halo' structure which consists of a baryonic core and a dark matter halo. The tidal force from the host galaxy mainly strips the dark matter halo from clumps and, as a result, theses clumps get dominated by baryons. Once a clump is captured by the host halo, its mass drastically decreases each pericenter passage. At $z = 2$, more than half of the clumps become baryon dominated systems (baryon mass/total mass $> 0.5$). Our results support the tidal evolution scenario of the formation of globular clusters and baryon dominated dwarf galaxies in the context of the cold dark matter universe.Comment: 9page, 13 figures. Accepted for publication in ApJ. A high-resolution PDF of the paper can be obtained from http://th.nao.ac.jp/~takayuki/ApJ05

Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo

AbstractSpecific inhibitors for cathepsin L and cathepsin S have been developed with the help of computer-graphic modeling based on the stereo-structure. The common fragment, N-(L-trans-carbamoyloxyrane-2-carbonyl)-phenylalanine-dimethylamide, is required for specific inhibition of cathepsin L. Seven novel inhibitors of the cathepsin L inhibitor Katunuma (CLIK) specifically inhibited cathepsin L at a concentration of 10−7 M in vitro, while almost no inhibition of cathepsins B, C, S and K was observed. Four of the CLIKs are stable, and showed highly selective inhibition for hepatic cathepsin L in vivo. One of the CLIK inhibitors contains an aldehyde group, and specifically inhibits cathepsin S at 10−7 M in vitro

Whole-genome sequencing of Theileria parva strains provides insight into parasite migration and diversification in the african continent

The disease caused by the apicomplexan protozoan parasite Theileria parva, known as East Coast fever or Corridor disease, is one of the most serious cattle diseases in Eastern, Central, and Southern Africa. We performed whole-genome sequencing of nine T. parva strains, including one of the vaccine strains (Kiambu 5), field isolates from Zambia, Uganda, Tanzania, or Rwanda, and two buffalo-derived strains. Comparison with the reference Muguga genome sequence revealed 34 814–121 545 single nucleotide polymorphisms (SNPs) that were more abundant in buffalo-derived strains. High-resolution phylogenetic trees were constructed with selected informative SNPs that allowed the investigation of possible complex recombination events among ancestors of the extant strains. We further analysed the dN/dS ratio (non-synonymous substitutions per non-synonymous site divided by synonymous substitutions per synonymous site) for 4011 coding genes to estimate potential selective pressure. Genes under possible positive selection were identified that may, in turn, assist in the identification of immunogenic proteins or vaccine candidates. This study elucidated the phylogeny of T. parva strains based on genome-wide SNPs analysis with prediction of possible past recombination events, providing insight into the migration, diversification, and evolution of this parasite species in the African continent

Tunneling Desorption of Single Hydrogen on the Surface of Titanium Dioxide

We investigated the reaction mechanism of the desorption of single hydrogen from a titanium dioxide surface excited by the tip of a scanning tunneling microscope (STM). Analysis of the desorption yield, in combination with theoretical calculations, indicates the crucial role played by the applied electric field. Instead of facilitating desorption by reducing the barrier height, the applied electric field causes a reduction in the barrier width, which, when coupled with the electron excitation induced by the STM tip, leads to the tunneling desorption of the hydrogen. A significant reduction in the desorption yield was observed when deuterium was used instead of hydrogen, providing further support for the tunneling-desorption mechanism

Catechol-TiO₂ hybrids for photocatalytic H₂ production and photocathode assembly

Visible-light driven H₂ evolution in water is achieved using catechol-photosensitised TiO₂ nanoparticles with a molecular nickel catalyst. Layer-by-layer immobilisation of catechol-TiO₂ onto tin-doped indium oxide electrodes generates photocathodic currents in the presence of an electron acceptor. This approach represents a new strategy for controlling photocurrent direction in dye-sensitised photoelectrochemical applications.We gratefully acknowledge financial support by the EPSRC and World Premier International Research Center Initiative, MEXT, Japan

Clinical efficacy and safety of monthly oral ibandronate 100 mg versus monthly intravenous ibandronate 1 mg in Japanese patients with primary osteoporosis

Summary: The MOVEST study evaluated the efficacy and safety of monthly oral ibandronate versus licensed monthly IV ibandronate in Japanese osteoporotic patients. Relative BMD gains after 12 months were 5.22 % oral and 5.34 % IV, showing non-inferiority of oral to IV ibandronate (primary endpoint). No new safety concerns were identified. Introduction: The randomized, phase 3, double-blind MOVEST (Monthly Oral VErsus intravenouS ibandronaTe) study evaluated the efficacy and safety of monthly oral ibandronate versus the licensed monthly intravenous (IV) ibandronate regimen in Japanese patients with osteoporosis. Methods: Ambulatory patients aged ?55 years with primary osteoporosis were randomized to receive oral ibandronate 100 mg/month plus monthly IV placebo, or IV ibandronate 1 mg/month plus monthly oral placebo. The primary endpoint was non-inferiority of oral versus IV ibandronate with respect to bone mineral density (BMD) gains at the lumbar spine after 12 months of treatment. Results: Four hundred twenty-two patients were enrolled with 372 patients in the per-protocol set (183 and 189 in the oral and IV ibandronate groups, respectively). The relative change from baseline in lumbar spine BMD values for the oral and IV ibandronate groups, respectively, was 5.22 % (95 % confidence interval [CI] 4.65, 5.80) and 5.34 % (95 % CI 4.78, 5.90). The least squares mean difference between the two groups was ?0.23 % (95 % CI ?0.97, 0.51), showing non-inferiority of oral ibandronate to IV ibandronate (non-inferiority limit = ?1.60). Changes in BMD values at other sites, and bone turnover marker levels in the oral ibandronate group, were comparable with those of the IV group. The safety profile was similar to that previously demonstrated; no new safety concerns were identified. Conclusions: This study demonstrated the non-inferiority of oral ibandronate 100 mg/month to IV ibandronate 1 mg/month (licensed dose in Japan) in increasing lumbar spine BMD in Japanese patients with primary osteoporosis