Historical review of fire safety at NPP and application of fire PSA to Westinghouse PWR NPP in the frame of risk-informed decision making by

The importance of fire as a potential initiator of multiple-system failures took on a new perspective after the cable-tray fire at Browns Ferry in 1975 The review have shown that the first generation Nuclear Power Plant (NPP) fire safety was not factored as high risk area that needed to be effectively assessed and quantified. This resulted in development of peculiar fire safety regulations, standards and expensive backfits. Lack of appropriate regulations and effective methods of fire risk assessment, prescriptive, difficult and expensive retrofit regulations were instituted in USA. The alternative risk-informed performance based regulation was established in USA to resolve the challenges of the prescriptive rules. The review have revealed that both the prescriptive and risk-informed performance based approaches will not represent adequate design basis for new Nuclear Power Plants. The Japanese were pulled in the path of renew fire safety regulations and risk quantification after the Fukushima accident. It has been recognized that effective fire safety assessment, and culture, in concert with countermeasures to prevent, detect, suppress, and mitigate the effect of fires if they occur, will minimized NPP fire risk. Among the numerous recommendation the fire safety at NPP must be planned and engineered before construction begin using the state-of-the-arts technology. Also, the methods of fire risk assessment must integrate the state-of-the-arts deterministic and probabilistic approaches. Two methods are presented which serve to incorporate the fire-related risk into the current practices in nuclear power plants with respect to the assessment of configurations. The first method is a fire protection systems and key safety functions Unavailability Matrix (UM) which is developed to identify structures, systems, and components significant for fire-related risk. The second method is a fire zones and key safety functions (KSFs) fire risk matrix which is useful to identify fire zones which are candidates for risk management actions. The UM is an innovative tool to communicate fire risk. The Monte Carlo method has been used to assess the uncertainty of the UM. The analysis shows that the uncertainty is sufficiently bounded. The significant fire-related risk is localized in six KSF representative components and one fire protection system which should be included in the maintenance rule. The unavailability of fire protection systems does not significantly affect the risk. The fire risk matrix identifies the fire zones that contribute the most to the fire-related risk. These zones belong to the control building and electric penetrations building. The aggregation of Internal Events PSA model and Fire PSA model have shown that the Fire PSA contributes 38.4% to the Risk increase. The feasibility of developing Fire-related Risk Monitor from the FIRE PSA for the Spanish NPP was carried out. One of the main challenges is that RiskSpectrum® fire PSA has 384 fire cases and 384 CDF but in Risk Monitor one CDF is required. However, CAFTA is unable to convert a Sequential Fault Tree structure of the internal Event tree in the Fire PSA. The conversion fails to implement neither all of the sequences leading to core damage nor the Fault Tree selection of the frequency of fire. The proposal is to suppress exchange events and introduce the alignment of the consequences so that a unique result of core damage can be quantified. The detection and fire suppression Event Trees in the reference model were replaced by detection and fire extinction Fault trees. The frequency of each Fire Case of the conversion model and the reference model are quantified and the frequencies compared. The results shows that 90% of the cases are valid, however, the rest have challenges with MCS. A unique CDF of 7.65x10-7 is quantified compared with 9.83×10-6 of the reference. The conversion of the new model in CAFTA was not successful due to software incompatibility.La importància del incendi com un potencial iniciador de sistema múltiples fallides van agafar una nova perspectiva després del incendi al cable-safata de Browns Ferry el 1975. La revisió ha mostrat que la primera generació de seguretat contra incendis de centrals d'Energia Nuclear (NPP) no va ser àrea de alt risc, àrea que necessitava ser efectivament avaluada i quantificada. Això va resultar en el desenvolupament de normes de seguretat de incendi peculiar, estàndards i cares revisions. La manca d'una reglamentació adequada i mètodes eficaços d'avaluació de risc d'incendi, va fer que als USA foren instituïts mètodes d'adaptació de normativa preceptius, difícils i costós. L'alternativa de regulació informada per el risc es va establir als USA per resoldre els reptes de la regulació preceptiva. La revisió ha mostrat que tant als enfocaments de normativa preceptiva i regulació informada per el risc no representen bases de disseny adequades per a noves NPP. Ha estat reconeguda que la efectiva avaluació de seguretat al incendi i la cultura en concert amb mesures per prevenir, detectar, suprimir i mitigar l'efecte d'incendis, si es produeixen, minimitzarà el risc d'incendi en una NPP. Entre les nombroses recomanacions la seguretat contra incendis a una NPP s'hauran previst i dissenyat abans de començar la construcció i utilitzant estat del art de la tecnologia. També, els mètodes d'avaluació del risc d'incendi tindran que integrar el estat del art en els enfocaments de determinista i probabilístics. Dos mètodes són presentats que serveixen per incorporar el risc relacionats amb el foc a les pràctiques actuals en centrals nuclears en respecte a l'avaluació de configuracions. El primer mètode és un sistema de protecció contra incendis i una matriu de indisponiblitats de les funcions clau de seguretat (MU) que es desenvolupa per a identificar estructures, sistemes i components significatius per riscos relacionats amb els incendis. El segon mètode és zones de focs i matriu de risc d'incendi i funcions (KSFs) clau de seguretat que és útil identificar les zones de foc que són candidats per a les accions de gestió de risc. La MU és una eina innovadora per comunicar el risc d'incendi. El risc significatiu relacionats amb el incendi està localitzat en sis components representatius KSF i un sistema de protecció de foc que cal que figuri en la regla de manteniment. La manca de sistemes de protecció contra incendis no afecta significativament al risc. La matriu de risc d'incendi identifica les zones de foc que mes contribueixen al risc relacionats amb el incendi. Aquestes zones pertanyen a l'edifici de control i edifici de penetracions elèctriques. L'agregació del model de PSA de esdeveniments interns i model de incendis PSA han demostrat que el PSA de incendis aporta 38.4% a l'augment de risc. S'ha desenvolupat la viabilitat del Monitor de risc de incendis a partir del PSA de incendis per a una central nuclear espanyola. Un dels reptes principals és que RiskSpectrum® incendis PSA te 384 casos de incendis i te 384 CDF però en risc Monitor és necessària una CDF. Tanmateix, el CAFTA és incapaç de convertir una estructura seqüencial de arbre de fallida de l'arbre esdeveniment interna en el PSA de incendis. La conversió fracassa al posar en pràctica totes les seqüències de danys al nucli i la selecció de l'arbre de fallida de la freqüència de incendi. La descoberta i supressió de arbres de l'esdeveniment de incendi en el model de referència es van substituir per detecció i els arbres de fallades d'extinció d'incendi. La freqüència de cada cas de incendi del model de conversió i el model de referència son quantificades i les freqüències son comparades. Els resultats demostra que el 90% dels casos són vàlid, no obstant això, la resta té reptes amb MCS. Un únic CDF de 7.65x10-7 s'ha quantificat en comparació amb 9.83 × 10-6 de la referència. La conversió del nou model a CAFTA no va tenir èxit a causa de la incompatibilitat del programari

Historical review of fire safety at NPP and application of fire PSA to Westinghouse PWR NPP in the frame of risk-informed decision making by

The importance of fire as a potential initiator of multiple-system failures took on a new perspective after the cable-tray fire at Browns Ferry in 1975 The review have shown that the first generation Nuclear Power Plant (NPP) fire safety was not factored as high risk area that needed to be effectively assessed and quantified. This resulted in development of peculiar fire safety regulations, standards and expensive backfits. Lack of appropriate regulations and effective methods of fire risk assessment, prescriptive, difficult and expensive retrofit regulations were instituted in USA. The alternative risk-informed performance based regulation was established in USA to resolve the challenges of the prescriptive rules. The review have revealed that both the prescriptive and risk-informed performance based approaches will not represent adequate design basis for new Nuclear Power Plants. The Japanese were pulled in the path of renew fire safety regulations and risk quantification after the Fukushima accident. It has been recognized that effective fire safety assessment, and culture, in concert with countermeasures to prevent, detect, suppress, and mitigate the effect of fires if they occur, will minimized NPP fire risk. Among the numerous recommendation the fire safety at NPP must be planned and engineered before construction begin using the state-of-the-arts technology. Also, the methods of fire risk assessment must integrate the state-of-the-arts deterministic and probabilistic approaches. Two methods are presented which serve to incorporate the fire-related risk into the current practices in nuclear power plants with respect to the assessment of configurations. The first method is a fire protection systems and key safety functions Unavailability Matrix (UM) which is developed to identify structures, systems, and components significant for fire-related risk. The second method is a fire zones and key safety functions (KSFs) fire risk matrix which is useful to identify fire zones which are candidates for risk management actions. The UM is an innovative tool to communicate fire risk. The Monte Carlo method has been used to assess the uncertainty of the UM. The analysis shows that the uncertainty is sufficiently bounded. The significant fire-related risk is localized in six KSF representative components and one fire protection system which should be included in the maintenance rule. The unavailability of fire protection systems does not significantly affect the risk. The fire risk matrix identifies the fire zones that contribute the most to the fire-related risk. These zones belong to the control building and electric penetrations building. The aggregation of Internal Events PSA model and Fire PSA model have shown that the Fire PSA contributes 38.4% to the Risk increase. The feasibility of developing Fire-related Risk Monitor from the FIRE PSA for the Spanish NPP was carried out. One of the main challenges is that RiskSpectrum® fire PSA has 384 fire cases and 384 CDF but in Risk Monitor one CDF is required. However, CAFTA is unable to convert a Sequential Fault Tree structure of the internal Event tree in the Fire PSA. The conversion fails to implement neither all of the sequences leading to core damage nor the Fault Tree selection of the frequency of fire. The proposal is to suppress exchange events and introduce the alignment of the consequences so that a unique result of core damage can be quantified. The detection and fire suppression Event Trees in the reference model were replaced by detection and fire extinction Fault trees. The frequency of each Fire Case of the conversion model and the reference model are quantified and the frequencies compared. The results shows that 90% of the cases are valid, however, the rest have challenges with MCS. A unique CDF of 7.65x10-7 is quantified compared with 9.83×10-6 of the reference. The conversion of the new model in CAFTA was not successful due to software incompatibility.La importància del incendi com un potencial iniciador de sistema múltiples fallides van agafar una nova perspectiva després del incendi al cable-safata de Browns Ferry el 1975. La revisió ha mostrat que la primera generació de seguretat contra incendis de centrals d'Energia Nuclear (NPP) no va ser àrea de alt risc, àrea que necessitava ser efectivament avaluada i quantificada. Això va resultar en el desenvolupament de normes de seguretat de incendi peculiar, estàndards i cares revisions. La manca d'una reglamentació adequada i mètodes eficaços d'avaluació de risc d'incendi, va fer que als USA foren instituïts mètodes d'adaptació de normativa preceptius, difícils i costós. L'alternativa de regulació informada per el risc es va establir als USA per resoldre els reptes de la regulació preceptiva. La revisió ha mostrat que tant als enfocaments de normativa preceptiva i regulació informada per el risc no representen bases de disseny adequades per a noves NPP. Ha estat reconeguda que la efectiva avaluació de seguretat al incendi i la cultura en concert amb mesures per prevenir, detectar, suprimir i mitigar l'efecte d'incendis, si es produeixen, minimitzarà el risc d'incendi en una NPP. Entre les nombroses recomanacions la seguretat contra incendis a una NPP s'hauran previst i dissenyat abans de començar la construcció i utilitzant estat del art de la tecnologia. També, els mètodes d'avaluació del risc d'incendi tindran que integrar el estat del art en els enfocaments de determinista i probabilístics. Dos mètodes són presentats que serveixen per incorporar el risc relacionats amb el foc a les pràctiques actuals en centrals nuclears en respecte a l'avaluació de configuracions. El primer mètode és un sistema de protecció contra incendis i una matriu de indisponiblitats de les funcions clau de seguretat (MU) que es desenvolupa per a identificar estructures, sistemes i components significatius per riscos relacionats amb els incendis. El segon mètode és zones de focs i matriu de risc d'incendi i funcions (KSFs) clau de seguretat que és útil identificar les zones de foc que són candidats per a les accions de gestió de risc. La MU és una eina innovadora per comunicar el risc d'incendi. El risc significatiu relacionats amb el incendi està localitzat en sis components representatius KSF i un sistema de protecció de foc que cal que figuri en la regla de manteniment. La manca de sistemes de protecció contra incendis no afecta significativament al risc. La matriu de risc d'incendi identifica les zones de foc que mes contribueixen al risc relacionats amb el incendi. Aquestes zones pertanyen a l'edifici de control i edifici de penetracions elèctriques. L'agregació del model de PSA de esdeveniments interns i model de incendis PSA han demostrat que el PSA de incendis aporta 38.4% a l'augment de risc. S'ha desenvolupat la viabilitat del Monitor de risc de incendis a partir del PSA de incendis per a una central nuclear espanyola. Un dels reptes principals és que RiskSpectrum® incendis PSA te 384 casos de incendis i te 384 CDF però en risc Monitor és necessària una CDF. Tanmateix, el CAFTA és incapaç de convertir una estructura seqüencial de arbre de fallida de l'arbre esdeveniment interna en el PSA de incendis. La conversió fracassa al posar en pràctica totes les seqüències de danys al nucli i la selecció de l'arbre de fallida de la freqüència de incendi. La descoberta i supressió de arbres de l'esdeveniment de incendi en el model de referència es van substituir per detecció i els arbres de fallades d'extinció d'incendi. La freqüència de cada cas de incendi del model de conversió i el model de referència son quantificades i les freqüències son comparades. Els resultats demostra que el 90% dels casos són vàlid, no obstant això, la resta té reptes amb MCS. Un únic CDF de 7.65x10-7 s'ha quantificat en comparació amb 9.83 × 10-6 de la referència. La conversió del nou model a CAFTA no va tenir èxit a causa de la incompatibilitat del programari.Postprint (published version

Development and assessment of fire-related risk unavailability matrices to support the application of the maintenance rule in a PWR nuclear power plant

Two methods are presented which serve to incorporate the fire-related risk into the current practices in nuclear power plants with respect to the assessment of configurations. The development of these methods is restricted to the compulsory use of fire probabilistic safety assessment (PSA) models. The first method is a fire protection systems and key safety functions unavailability matrix which is developed to identify structures, systems, and components significant for fire-related risk. The second method is a fire zones and key safety functions (KSFs) fire risk matrix which is useful to identify fire zones which are candidates for risk management actions. Specific selection and quantification methodologies have been developed to obtain the matrices. The Monte Carlo method has been used to assess the uncertainty of the unavailability matrix. The analysis shows that the uncertainty is sufficiently bounded. The significant fire-related risk is localized in six KSF representative components and one fire protection system which should be included in the maintenance rule. The unavailability of fire protection systems does not significantly affect the risk. The fire risk matrix identifies the fire zones that contribute the most to the fire-related risk. These zones belong to the control building and electric penetrations building.Peer ReviewedPostprint (published version

Renal abnormalities among children with sickle cell conditions in highly resource-limited setting in Ghana

Sickle cell disease (SCD) is associated with progressive multi-organ failure especially, the brain and kidney and leads to high morbidity and mortality rate. The aim of this study was to determine the prevalence of renal abnormalities among children with SCD. This cross-sectional study recruited 212 sickling positive patients comprising of 96 Hb AS, 48 Hb SC, and 68 Hb SS phenotypes from the Pediatric Unit of Wassa Akropong Government Hospital, Wassa Akropong, Ghana. Early morning urine and venous blood samples were collected from each participant. Urinalysis was conducted and serum urea and creatinine levels were estimated. Estimate glomerular filtration rate (eGFR) was calculated using the Swartz equation. Classification of chronic kidney disease (CKD) was based on ‘The Kidney Disease: Improving Global Outcomes (KIDIGO)’ criteria. The mean age of the children were 7.90 years. Serum creatinine (p = 0.0310) and urea (p\u3c0.0001) levels were significantly higher among Hb AS participants compared with Hb SS phenotype. The prevalent indicators of renal abnormalities were proteinuria (26.4%), urine granular cast (5.6%) and CKD (39.6%). Proteinuria, urine granular cast and CKD were most prevalent among Hb SS (47.1%, 11.8% and 73.5% respectively) compared with Hb SC (41.7%, 8.3%, and 45.8% respectively) and Hb AS (4.2%, 0.0%, and 14.5%) phenotypes, respectively. Sickle cell conditions were significantly associated with proteinuria (p\u3c0.0001) and CKD (p = 0.0378). Children with Hb SS [aOR = 5.04, 95% CI (2.47–10.3); p\u3c0.0001] and Hb SC [aOR = 3.14 95% CI (1.39–7.01); p = 0.0174] were at increased odds of developing CKD after adjusting for age, BMI and gender. Proteinuria and CKD are associated with sickle cell disease (Hb SC and Hb SS). Renal function should be routinely monitored for children with SCD

Cystic Fibrosis in two Ghanaian Children

Cystic fibrosis (CF) is a severe life-limiting genetic disorder resulting from mutations in the cystic fibrosis transmembrane regulator gene and is reported to be more prevalent among Caucasians than people of African descent. The past three decades have seen a gradual increase in the reporting of CF in non-European populations with CF in all regions including Africa. We report on the first two known Ghanaian children diagnosed with CF presenting early in infancy. The first patient presented with severe acute malnutrition and persistent diarrhea resulting from severe exocrine pancreatic insufficiency. In the second patient, there were recurrent wheeze and recurrent pneumonia, severe dehydration with metabolic alkalosis. Diagnosis of CF in Ghana is challenging due to the absence of diagnostic tools such as sweat testing equipment. In the first patient, sweat testing and genetic testing were done in South Africa. In the second patient, sweat testing was not done but diagnosis was confirmed by genetic testing. Both patients presented with classical CF symptoms including Pseudomonas aeruginosa airway infection before age 6 months. Both children are currently alive and healthy on appropriate treatment. These case reports highlight the growing evidence of CF occurring in people of African descent and the diagnostic challenges faced in Africa

Effect of Left Atrial Function Index on Late Atrial Fibrillation Recurrence after Pulmonary Vein Isolation

Background: Although the rates of catheter ablation (CA) for atrial fibrillation (AF) are rapidly increasing, there are few predictors of outcome to help inform appropriate patient selection for this procedure. Traditional echocardiographic measures of atrial structure do not significantly reclassify risk of AF recurrence over and above the clinical risk factors. Left Atrial Function Index (LAFI) is a rhythm-independent measure of atrial function. We hypothesized that baseline LAFI would relate to AF recurrence after CA. Methods: Pre-procedural echocardiograms from 170 participants, who underwent CA for AF and were enrolled in the UMMC AF Treatment Registry, were analyzed. LAFI was calculated by a previously validated formula. Primary outcome was late or clinically significant AF recurrence 3-12 months after CA. Baseline clinical, laboratory and echocardiographic variables were compared between the recurrence and non-recurrence groups. Results: Study participants were middle aged (60+/10 years) and had a moderate-to-severe burden of cardiovascular comorbidities. 78 participants (46%) experienced late AF recurrence. Mean LAFI was 0.26+/-0.18. In multivariate analysis, lower LAFI was independently associated with the risk of recurrence (0.23 in recurrence group vs 0.29 in non-recurrence group, p \u3c 0.01). Predictive value of LAFI for AF recurrence was similar to CHADS2 score (c-statistic 0.60 vs 0.58, p 0.76). In subgroup of patients with persistent AF, LAFI predicted AF recurrence more strongly than CHADS2 score (c-statistic: 0.79 vs 0.58, p 0.02). Conclusions: In our cohort of 170 participants with AF undergoing index CA ablation, we observed that LAFI related to late AF recurrence after CA, independent of the traditional risk factors. Since LAFI can be calculated from almost any traditional echocardiographic recording, our findings suggest that LAFI may help guide therapeutic decision-making regarding application of CA, particularly among challenging patients with symptomatic persistent AF

Scenario Planning for Restorative Justice in Lakeland

Final project for URSP708: Community Planning Studio (Fall 2022). University of Maryland, College Park.This report begins with a discussion of the concept of restorative justice and the three themes that guided and organized our work — community infrastructure, housing and land use, and climate change adaptation and mitigation. Following this introduction of the three guiding themes, the report contains a summary of our analysis of existing conditions, including a review of different planning sectors, a brief history of Lakeland, and a summary of plans and policies that have influenced the course of Lakeland. The next section of the report is a summary of the findings of our various community engagement approaches, including recommendations for future best practices for the city and the Restorative Justice Commission as they continue this work. Finally, we present the three planning scenarios — Status Quo, Reform, and Revolutionary — that envision various alternative futures for Lakeland.City of College Par

Non-Native R1 Substitution in the S4 Domain Uniquely Alters Kv4.3 Channel Gating

The S4 transmembrane domain in Shaker (Kv1) voltage-sensitive potassium channels has four basic residues (R1–R4) that are responsible for carrying the majority of gating charge. In Kv4 channels, however, R1 is replaced by a neutral valine at position 287. Among other differences, Kv4 channels display prominent closed state inactivation, a mechanism which is minimal in Shaker. To determine if the absence of R1 is responsible for important variation in gating characteristics between the two channel types, we introduced the V287R mutant into Kv4.3 and analyzed its effects on several voltage sensitive gating transitions. We found that the mutant increased the voltage sensitivity of steady-state activation and altered the kinetics of activation and deactivation processes. Although the kinetics of macroscopic inactivation were minimally affected, the characteristics of closed-state inactivation and recovery from open and closed inactivated states were significantly altered. The absence of R1 can only partially account for differences in the effective voltage sensitivity of gating between Shaker and Kv4.3. These results suggest that the S4 domain serves an important functional role in Kv4 channel activation and deactivation processes, and also those of closed-state inactivation and recovery

Role of CCL3L1-CCR5 Genotypes in the Epidemic Spread of HIV-1 and Evaluation of Vaccine Efficacy

Polymorphisms in CCR5, the major coreceptor for HIV, and CCL3L1, a potent CCR5 ligand and HIV-suppressive chemokine, are determinants of HIV-AIDS susceptibility. Here, we mathematically modeled the potential impact of these genetic factors on the epidemic spread of HIV, as well as on its prevention.Ro, the basic reproductive number, is a fundamental concept in explaining the emergence and persistence of epidemics. By modeling sexual transmission among HIV+/HIV- partner pairs, we find that Ro estimates, and concordantly, the temporal and spatial patterns of HIV outgrowth are highly dependent on the infecting partners' CCL3L1-CCR5 genotype. Ro was least and highest when the infected partner possessed protective and detrimental CCL3L1-CCR5 genotypes, respectively. The modeling data indicate that in populations such as Pygmies with a high CCL3L1 gene dose and protective CCR5 genotypes, the spread of HIV might be minimal. Additionally, Pc, the critical vaccination proportion, an estimate of the fraction of the population that must be vaccinated successfully to eradicate an epidemic was <1 only when the infected partner had a protective CCL3L1-CCR5 genotype. Since in practice Pc cannot be >1, to prevent epidemic spread, population groups defined by specific CCL3L1-CCR5 genotypes might require repeated vaccination, or as our models suggest, a vaccine with an efficacy of >70%. Further, failure to account for CCL3L1-CCR5-based genetic risk might confound estimates of vaccine efficacy. For example, in a modeled trial of 500 subjects, misallocation of CCL3L1-CCR5 genotype of only 25 (5%) subjects between placebo and vaccine arms results in a relative error of approximately 12% from the true vaccine efficacy.CCL3L1-CCR5 genotypes may impact on the dynamics of the HIV epidemic and, consequently, the observed heterogeneous global distribution of HIV infection. As Ro is lowest when the infecting partner has beneficial CCL3L1-CCR5 genotypes, we infer that therapeutic vaccines directed towards reducing the infectivity of the host may play a role in halting epidemic spread. Further, CCL3L1-CCR5 genotype may provide critical guidance for optimizing the design and evaluation of HIV-1 vaccine trials and prevention programs

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century