Challenges in Exposure Modeling of Nanoparticles in Aquatic Environments

Managing the potential environmental risks of nanoparticles requires methods to link nanoparticle properties with macro-scale risks. This study outlines challenges in exposure modeling of nanoparticles in aquatic environments, such as the role of natural organic matter, natural colloids, fractal dimensions of agglomerates, coatings and doping of particles, and uncertainties regarding nanoparticle emissions to aquatic environments. The pros and cons of the exposure indicators mass concentration, particle number concentration, and surface area are discussed. By applying colloid chemistry kinetic equations describing particle agglomeration and sedimentation for the case of titanium dioxide nanoparticles, a limited exposure assessment including some of the factors mentioned is conducted with particle number concentration as the exposure indicator. The results of the modeling indicate that sedimentation, shear flows, and settling are of less importance with regard to particle number based predicted environmental concentrations. The inflow of nanoparticles to the water compartment had a significant impact in the model, and the collision efficiency (which is affected by natural organic matter) was shown to greatly affect model output. Implications for exposure modeling, regulation and science are discussed. A broad spectrum of scientific disciplines must be engaged in the development of exposure models where nano-level properties are linked to macro-scale risk

The value of eye-tracking technology in the analysis and interpretations of skeletal remains: A pilot study

This initial study is the first to use eye-trackers as a tool in order to study gaze pattern strategies and decision making processes involved in the assessment of skeletal remains. Three experienced participants were asked to wear eye-tracking glasses (Tobii Pro Glasses 2) when estimating sex and age-at-death of one set of skeletal remains from a known archeological sample. The study assessed participants' fixation points (the features of the skeleton focused on), fixation duration (the total time spent on each assessment and feature) as well as visit count and duration (the total number of visits and the duration of visits to particular areas). The preliminary results of this study identified differences in gaze “strategies” with regards to fixation points, visit duration, and visit counts between the participants. The data generated provide a starting point for assessing how such technologies could be used in order to more fully understand the decision making processes involved in forensic anthropological interpretations and their role in forensic reconstructions

Drone navigation and license place detection for vehicle location in indoor spaces

Millions of vehicles are transported every year, tightly parked in vessels or boats. To reduce the risks of associated safety issues like fires, knowing the location of vehicles is essential, since different vehicles may need different mitigation measures, e.g. electric cars. This work is aimed at creating a solution based on a nano-drone that navigates across rows of parked vehicles and detects their license plates. We do so via a wall-following algorithm, and a CNN trained to detect license plates. All computations are done in real-time on the drone, which just sends position and detected images that allow the creation of a 2D map with the position of the plates. Our solution is capable of reading all plates across eight test cases (with several rows of plates, different drone speeds, or low light) by aggregation of measurements across several drone journeys.Comment: Published at VIII International Workshop on Artificial Intelligence and Pattern Recognition, IWAIPR 202

Generation Y- en hållbar generation?

Corporate Social Responsibility (CSR) har under senare år fått stor uppmärksamhet i media och i företags strategier. Detta faktum innebär att kunder i olika grad allt mer kommer i kontakt med företags samhällsengagemang, inte minst inom resebranschen. Vilken betydelse har då denna kontakt för kundernas val av olika produkter och tjänster under konsumtionsprocessen? Ser kunderna en researrangörs CSR relaterade arbete som en kvalitetsskapande faktor eller väcker engagemanget istället misstankar om manipulation? Tidigare forskning behandlar faktorer som inverkar på kunders upplevda kvalité, dock saknas forskning på hur ett företags CSR arbete kan integreras bland de övriga varumärkesvärderingarna i den kvalitetsskapande processen för en specifik målgrupp. Intressant målgrupp för denna undersökning är den i teorin benämnda Generation Y, då denna generation anses komma ha en stor påverkan på resebranschen i framtiden

Feeling Small: Exploring the Tactile Perception Limits

The human finger is exquisitely sensitive in perceiving different materials, but the question remains as to what length scales are capable of being distinguished in active touch. We combine material science with psychophysics to manufacture and haptically explore a series of topographically patterned surfaces of controlled wavelength, but identical chemistry. Strain-induced surface wrinkling and subsequent templating produced 16 surfaces with wrinkle wavelengths ranging from 300 nm to 90 μm and amplitudes between 7 nm and 4.5 μm. Perceived similarities of these surfaces (and two blanks) were pairwise scaled by participants, and interdistances among all stimuli were determined by individual differences scaling (INDSCAL). The tactile space thus generated and its two perceptual dimensions were directly linked to surface physical properties – the finger friction coefficient and the wrinkle wavelength. Finally, the lowest amplitude of the wrinkles so distinguished was approximately 10 nm, demonstrating that human tactile discrimination extends to the nanoscale

SMAD4 haploinsufficiency in small intestinal neuroendocrine tumors

Background: Patients with small intestinal neuroendocrine tumors (SINETs) frequently present with lymph node and liver metastases at the time of diagnosis, but the molecular changes that lead to the progression of these tumors are largely unknown. Sequencing studies have only identified recurrent point mutations at low frequencies with CDKN1B being the most common harboring heterozygous mutations in less than 10% of all tumors. Although SINETs are genetically stable tumors with a low frequency of point mutations and indels, they often harbor recurrent hemizygous copy number alterations (CNAs) yet the functional implications of these CNA are unclear. Methods: Utilizing comparative genomic hybridization (CGH) arrays we analyzed the CNA profile of 131 SINETs from 117 patients. Two tumor suppressor genes and corresponding proteins i.e. SMAD4, and CDKN1B, were further characterized using a tissue microarray (TMA) with 846 SINETs. Immunohistochemistry (IHC) was used to quantify protein expression in TMA samples and this was correlated with chromosome number evaluated with fluorescent in-situ hybridization (FISH). Intestinal tissue from a Smad4+/− mouse model was used to detect entero-endocrine cell hyperplasia with IHC. Results: Analyzing the CGH arrays we found loss of chromosome 18q and SMAD4 in 71% of SINETs and that focal loss of chromosome 12 affecting the CDKN1B was present in 9.4% of SINETs. No homozygous loss of chromosome 18 was detected. Hemizygous loss of SMAD4, but not CDKN1B, significantly correlated with reduced protein levels but hemizygous loss of SMAD4 did not induce entero-endocrine cell hyperplasia in the Smad4+/− mouse model. In addition, patients with low SMAD4 protein expression in primary tumors more often presented with metastatic disease. Conclusions: Hemizygous loss of chromosome 18q and the SMAD4 gene is the most common genetic event in SINETs and our results suggests that this could influence SMAD4 protein expression and spread of metastases. Although SMAD4 haploinsufficiency alone did not induce tumor initiation, loss of chromosome 18 could represent an evolutionary advantage in SINETs explaining the high prevalence of this aberration. Functional consequences of reduced SMAD4 protein levels could hypothetically be a potential mechanism as to why loss of chromosome 18 appears to be clonally selected in SINETs

Infrared spectroscopy of intermediate mass young stellar objects

In this paper we present Spitzer Infrared Spectrograph spectroscopy for 14 intermediate-mass young stellar objects. We use Spitzer spectroscopy to investigate the physical properties of these sources and their environments. Our sample can be divided into two types of objects: young isolated, embedded objects with spectra that are dominated by ice and silicate absorption bands, and more evolved objects that are dominated by extended emission from polycyclic aromatic hydrocarbons (PAHs) and pure H2 rotational lines. We are able to constrain the illuminating FUV fields by classifying the PAH bands below 9micron. For most of the sources we are able to detect several atomic fine structure lines. In particular, the [NeII] line appearing in two regions could originate from unresolved photodissociation regions (PDRs) or J-shocks. We relate the identified spectral features to observations obtained from NIR through submillimeter imaging. The spatial extent of several H2 and PAH bands is matched with morphologies identified in previous Spitzer/IRAC observations. This also allows us to distinguish between the different H2 excitation mechanisms. In addition, we calculate the optical extinction from the silicate bands and use this to constrain the spectral energy distribution fit, allowing us to estimate the masses of these YSOs.Comment: 21 pages, 26 figures, accepted to Ap

Continuous hydrothermal flow synthesis of graphene quantum dots

Green fluorescent graphene quantum dots (GQD) have been synthesized via hydrothermal fragmentation using a continuous hydrothermal flow synthesis (CHFS) process as a single, rapid and environmentally benign method. This is in the presence of p-phosphonic acid calix[4]arene which enhances the optical properties of the graphene quantum dots through surface functionalization, with photoluminescence quantum yields of up to 4.5%. Potential environmental impact of a lab-scale supercritical CHFS process compared with that of conventional batch processing of GQDs has been assessed using the method of the International Reference Life Cycle Data System (ILCD)

Exploring the planetary boundary for chemical pollution

Rockström et al. (2009a, 2009b) have warned that humanity must reduce anthropogenic impacts defined by nine planetary boundaries if “unacceptable global change” is to be avoided. Chemical pollution was identified as one of those boundaries for which continued impacts could erode the resilience of ecosystems and humanity. The central concept of the planetary boundary (or boundaries) for chemical pollution (PBCP or PBCPs) is that the Earth has a finite assimilative capacity for chemical pollution, which includes persistent, as well as readily degradable chemicals released at local to regional scales, which in aggregate threaten ecosystem and human viability. The PBCP allows humanity to explicitly address the increasingly global aspects of chemical pollution throughout a chemical's life cycle and the need for a global response of internationally coordinated control measures. We submit that sufficient evidence shows stresses on ecosystem and human health at local to global scales, suggesting that conditions are transgressing the safe operating space delimited by a PBCP. As such, current local to global pollution control measures are insufficient. However, while the PBCP is an important conceptual step forward, at this point single or multiple PBCPs are challenging to operationalize due to the extremely large number of commercial chemicals or mixtures of chemicals that cause myriad adverse effects to innumerable species and ecosystems, and the complex linkages between emissions, environmental concentrations, exposures and adverse effects. As well, the normative nature of a PBCP presents challenges of negotiating pollution limits amongst societal groups with differing viewpoints. Thus, a combination of approaches is recommended as follows: develop indicators of chemical pollution, for both control and response variables, that will aid in quantifying a PBCP(s) and gauging progress towards reducing chemical pollution; develop new technologies and technical and social approaches to mitigate global chemical pollution that emphasize a preventative approach; coordinate pollution control and sustainability efforts; and facilitate implementation of multiple (and potentially decentralized) control efforts involving scientists, civil society, government, non-governmental organizations and international bodies