Origin of second-harmonic generation in the incommensurate phase of K2SeO4

We show that a ferroelectric phase transition takes place in the incommensurate phase of the K2SeO4 crystal. The ferroelectric character of the IC phase explains the second-harmonic generation observed in the corresponding temperature range.Comment: 5 pages, 1 figur

Electronic educational resources in learning and fixing practical skills histology in the study in medical university

This article analyzes the first Russian experience in the development and application in teaching medical students a multimedia electronic educational resources in the Department of Histology. It is shown the need to introduce into the educational process of students new learning opportunities that enable professionals to form a new type of thinking, and owns the modern information technologies.Статья посвящена анализу первого в России опыта разработки и применения в обучении студентов медицинских вузов мультимедийного электронного образовательного ресурса на кафедре гистологии. Показана необходимость внедрения в учебный процесс новых возможностей обучения студентов, позволяющих формировать специалистов с новым типом мышления и владеющего современными информационными технологиями

Usual and written law in the russian state of the early modern era: the problem of correlation

The article deals with the problems associated with the peculiarities of Russian state legal system development during the early modern era. The authors focused on the correlation of oral legal tradition, which forms the basis of customary law, and written, codified la

Comprehensive mapping of tissue cell architecture via integrated single cell and spatial transcriptomics

elocation-id: 2020.11.15.378125elocation-id: 2020.11.15.378125The spatial organization of cell types in tissues fundamentally shapes cellular interactions and function, but the high-throughput spatial mapping of complex tissues remains a challenge. We present сell2location, a principled and versatile Bayesian model that integrates single-cell and spatial transcriptomics to map cell types in situ in a comprehensive manner. We show that сell2location outperforms existing tools in accuracy and comprehensiveness and we demonstrate its utility by mapping two complex tissues. In the mouse brain, we use a new paired single nucleus and spatial RNA-sequencing dataset to map dozens of cell types and identify tissue regions in an automated manner. We discover novel regional astrocyte subtypes including fine subpopulations in the thalamus and hypothalamus. In the human lymph node, we resolve spatially interlaced immune cell states and identify co-located groups of cells underlying tissue organisation. We spatially map a rare pre-germinal centre B-cell population and predict putative cellular interactions relevant to the interferon response. Collectively our results demonstrate how сell2location can serve as a versatile first-line analysis tool to map tissue architectures in a high-throughput manner.Competing Interest StatementThe authors have declared no competing interest

Measurement of Dielectric Suppression of Bremsstrahlung

In 1953, Ter-Mikaelian predicted that the bremsstrahlung of low energy photons in a medium is suppressed because of interactions between the produced photon and the electrons in the medium. This suppression occurs because the emission takes place over on a long distance scale, allowing for destructive interference between different instantaneous photon emission amplitudes. We present here measurements of bremsstrahlung cross sections of 200 keV to 20 MeV photons produced by 8 and 25 GeV electrons in carbon and gold targets. Our data shows that dielectric suppression occurs at the predicted level, reducing the cross section up to 75 percent in our data.Comment: 11 pages, format is postscript file, gzip-ed, uuencode-e

ПОЛУЧЕНИЕ И СРАВНИТЕЛЬНАЯ ОЦЕНКА РЕГЕНЕРАНТНЫХ ЛИНИЙ ОГУРЦА

Application of such biotechnological method as a callus culture, allowed developing the somaclonal variants of cucumber, six of which were selected as a regenerated lines for the breeding program. New forms are characterized by early-ripeness, percent of parthenocarpy, good quality, yield and fruit weight. These lines can be used as an initial material for heterosis breeding and for improvement of donor cultivars of cucumber.Применение методов биотехнологии, в частности каллусной культуры, позволило за короткий срок получить сомаклональные варианты огурца, из которых было отобрано 6 перспективных регенерантных линий. Новые генотипы отличались раннеспелостью, процентом партенокарпии, массой и качеством плодов, урожайностью. Линии можно использовать в качестве исходного материала в гетерозисной селекции огурца, а также для улучшения донорных сортов

Comparison of the results of ⁸⁵Kr transport modeling with the ACURATE field experiment data

© 2017, Allerton Press, Inc.Currently the Nuclear Safety Institute of the Russian Academy of Sciences (NSI RAS) jointly with the Hydrometcenter of Russia is developing the system for forecasting the transfer of radio-active substances in the atmosphere in case of radiation accidents at Russian nuclear power plants. The operation of the system is based on the numerical hydrodynamic model which allows forecasting meteorological parameters and is coupled with the mesoscale dispersion model of the transfer ofradioactive substances in the atmosphere. The results are presented of 85Kr transport modeling under the conditions of the ACURATE experiment with three transport models: FLEXPART, HYSPLIT, and the model from the NOSTRADAMUS software package. It is demonstrated that all three Lagrangian models can give a qualitative description of concentration fields from the ACURATE experiment with the best value of the RANK metric (2.5) based on three statistics

APLIKASI MANAJEMEN KEGIATAN UNTUK ORGANISASI NON PROFIT BERBASIS WEBSITE

Suatu organisasi memiliki berbagai program kerja, yang di dalamnya ada kepanitian khusus. Biasanya manajemen kegiatan yang berisi pengelolaan keuangan pada masing-masing organisasi dan lembaga dikepalai oleh bendahara. Pengelolaan keuangan tersebut menjadi sebuah kebutuhan, karena bendahara tersebut wajib selalu melaporkan pencatatan keuangan. Tentu akan menjadi tidak efektif jika melakukan pencatatan keuangan harus melakukannya secara manual. Di samping susah, pencatatan secara manual sangat beresiko seperti rusak dan hilangnya buku pencatatan. Ada lagi pencatatan dengan cara lain yaitu menggunakan software yang sudah ada seperti Microsoft Excel, namun hal tersebut masih kurang efisien dan kurang efektif sehingga diperlukan tools pencatatan yang lebih baik agar mencapai tujuan dan sasaran yang diinginkan. Subjek penelitian yang dibahas pada penelitian ini adalah aplikasi pengelolaan keuangan untuk organisasi non profit berbasis website. Langkah pengembangan aplikasi yaitu menggunakan waterfall model. Dari penelitian yang dilakukan menghasilkan sebuah website tentang ”aplikasi manajemen kegiatan untuk organisasi non profit berbasis website” yang dapat digunakan untuk melakukan manajemen kegiatan bagi organisasi non profit sehingga pekerjaan seorang bendahara menjadi mudah dan efektif.Keywords: Manajemen Kegiatan, Nonprofit Online, Organisasi Non Profit

Bremsstrahlung Suppression due to the LPM and Dielectric Effects in a Variety of Materials

The cross section for bremsstrahlung from highly relativistic particles is suppressed due to interference caused by multiple scattering in dense media, and due to photon interactions with the electrons in all materials. We present here a detailed study of bremsstrahlung production of 200 keV to 500 MeV photons from 8 and 25 GeV electrons traversing a variety of target materials. For most targets, we observe the expected suppressions to a good accuracy. We observe that finite thickness effects are important for thin targets.Comment: 52 pages, 13 figures (incorporated in the revtex LaTeX file

The regulatory subunit of PKA-I remains partially structured and undergoes β-aggregation upon thermal denaturation

Background: The regulatory subunit (R) of cAMP-dependent protein kinase (PKA) is a modular flexible protein that responds with large conformational changes to the binding of the effector cAMP. Considering its highly dynamic nature, the protein is rather stable. We studied the thermal denaturation of full-length RIα and a truncated RIα(92-381) that contains the tandem cyclic nucleotide binding (CNB) domains A and B. Methodology/Principal Findings: As revealed by circular dichroism (CD) and differential scanning calorimetry, both RIα proteins contain significant residual structure in the heat-denatured state. As evidenced by CD, the predominantly α-helical spectrum at 25°C with double negative peaks at 209 and 222 nm changes to a spectrum with a single negative peak at 212-216 nm, characteristic of β-structure. A similar α→β transition occurs at higher temperature in the presence of cAMP. Thioflavin T fluorescence and atomic force microscopy studies support the notion that the structural transition is associated with cross-β-intermolecular aggregation and formation of non-fibrillar oligomers. Conclusions/Significance: Thermal denaturation of RIα leads to partial loss of native packing with exposure of aggregation-prone motifs, such as the B' helices in the phosphate-binding cassettes of both CNB domains. The topology of the β-sandwiches in these domains favors inter-molecular β-aggregation, which is suppressed in the ligand-bound states of RIα under physiological conditions. Moreover, our results reveal that the CNB domains persist as structural cores through heat-denaturation. © 2011 Dao et al