Trends in the design and use of elastin-like recombinamers as biomaterials

Producción CientíficaElastin-like recombinamers (ELRs), which derive from one of the repetitive domains found in natural elastin, have been intensively studied in the last few years from several points of view. In this mini review, we discuss all the recent works related to the investigation of ELRs, starting with those that define these polypeptides as model intrinsically disordered proteins or regions (IDPs or IDRs) and its relevance for some biomedical applications. Furthermore, we summarize the current knowledge on the development of drug, vaccine and gene delivery systems based on ELRs, while also emphasizing the use of ELR-based hydrogels in tissue engineering and regenerative medicine (TERM). Finally, we show different studies that explore applications in other fields, and several examples that describe biomaterial blends in which ELRs have a key role. This review aims to give an overview of the recent advances regarding ELRs and to encourage further investigation of their properties and applications.Comisión Europea (project NMP-2014-646075)Ministerio de Economía, Industria y Competitividad (projects PCIN-2015-010 / MAT2016-78903-R / BES-2014-069763)Junta de Castilla y León (project VA317P18

Using social cues to estimate possible destinations when driving a robotic wheelchair

International audienceApproaching a group of humans is an important navigation task. Although many methods have been proposed to avoid interrupting groups of people engaged in a conversation, just a few works have considered the proper way of joining those groups. Research in the field of social sciences have proposed geometric models to compute the best points to join a group. In this article we propose a method to use those points as possible destinations when driving a robotic wheelchair. Those points are considered together with other possible destinations in the environment such as points of interest or typical static destinations defined by the user's habits. The intended destination is inferred using a Dynamic Bayesian Network that takes into account the contextual information of the environment and user's orders to compute the probability for each destination

Enseñanza tradicional y competencias de investigación científica en estudiantes de un instituto superior tecnológico público, Piura, 2023

Este estudio investigó la relación entre la enseñanza tradicional y las competencias de investigación científica en estudiantes de un instituto superior tecnológico público en Piura. Se utilizó un enfoque cuantitativo y un diseño no experimental correlacional, los datos se recolectaron mediante encuestas a una muestra de 169 estudiantes, los resultados mostraron una relación débil y negativa entre la enseñanza tradicional y las competencias de investigación científica, no se encontró una relación significativa entre la enseñanza tradicional y las habilidades cognitivas o tecnológicas, pero se encontró una relación significativa y negativa con las habilidades metodológicas, estos resultados demuestran que la enseñanza tradicional no es efectiva para promover el desarrollo de competencias de investigación científica en este contexto

El atomismo en la concepción epistémica de Galileo

 Democritus of Abdera (about 460-350 ANC), a contemporary of Socrates, disciple of Leucippus, and scientific research -naturalista acknowledged even by his opponents as Aristotle, began to explain the nature of all things and for him this was materials consisting of tiny particles, "rough" or "smooth", unchanging and indivisible, homogeneous and actual calls atoms, that by virtue of its existence and knowability are the different types and textures of matter that exists. The phenomena of atoms are formed. The turning point in the development of science that Galileo began in the seventeenth century, was based on the atomism of Democritus. Galileo's philosophy stands out for having prioritized the quantitative over the qualitative, being the first and the main seal research of modern natural science. The atomistic philosophy of Democritus was projected to the physics of Newton, whose contribution revolutionized human knowledge and our vision of the universe.Demócrito de Abdera (aproximadamente 460-350 a.n.C.), contemporáneo de Sócrates, discípulo de Leucipo, y por su investigación científica -naturalista reconocido incluso por sus adversarios como Aristóteles-, se dedicó a explicar la naturaleza de todas las cosas y para él esta estaba constituida por unas partículas materiales diminutas, “rugosas” o “lisas”, inalterables e indivisibles, homogéneas y reales llamadas átomos, esto en virtud de su existencia y cognoscibilidad forman las distintas clases y texturas de materia que existe. Los fenómenos se forman de átomos. La inflexión en el desarrollo de la ciencia que Galileo inició en el siglo XVII, se basó en el atomismo de Demócrito. La filosofía de Galileo se distingue por haber priorizado lo cuantitativo sobre lo cualitativo, quedando el primero como el sello principal de la investigación de la ciencia natural moderna. La filosofía atomista de Demócrito se proyectó hasta la física de Newton, cuyo aporte revolucionó el conocimiento humano y nuestra visión del universo