Aeroelastic control and estimation with a minimal nonlinear modal description

Modal-based, nonlinear Moving Horizon Estimation (MHE) and Model Predictive Control(MPC) strategies for very flexible aeroelastic systems are presented. They are underpinned by an aeroelastic model built from a 1D intrinsic (based on strains and velocities) description of geometrically-nonlinear beams and an unsteady Vortex Lattice aerodynamic model. Construction of a nonlinear, modal-based, reduced order model of the aeroelastic system, employing a state-space realisation of the linearised aerodynamics around an arbitrary reference point, allows us to capture the main nonlinear geometrical couplings at a very low computational cost. Embedding this model in both MHE and MPC strategies, which solve the system continuous-time adjoints efficiently to compute sensitivities, lays the foundations for real-time estimation and control of highly flexible aeroelastic systems. Finally, the performance and versatility of the framework operating in the nonlinear regime is demonstrated on two very flexible wing models, with notably different dynamics, and on two different control setups: a gust-load alleviation problem on a very high aspect ratio wing with slower dynamics, which involves substantial deflections; and flutter suppression on a flexible wing with significantly faster dynamics, where an unconventional nonlinear stabilisation mechanism is unveiled

Analysis of the intraspinal calcium dynamics and its implications on the plasticity of spiking neurons

The influx of calcium ions into the dendritic spines through the N-metyl-D-aspartate (NMDA) channels is believed to be the primary trigger for various forms of synaptic plasticity. In this paper, the authors calculate analytically the mean values of the calcium transients elicited by a spiking neuron undergoing a simple model of ionic currents and back-propagating action potentials. The relative variability of these transients, due to the stochastic nature of synaptic transmission, is further considered using a simple Markov model of NMDA receptos. One finds that both the mean value and the variability depend on the timing between pre- and postsynaptic action-potentials. These results could have implications on the expected form of synaptic-plasticity curve and can form a basis for a unified theory of spike time-dependent, and rate based plasticity.Comment: 14 pages, 10 figures. A few changes in section IV and addition of a new figur

Plan de negocio para determinar la viabilidad econ?mica y financiera de una nueva unidad de negocio de jugos naturales envasados, para la empresa Agrovado

El presente plan de negocios evaluar? la viabilidad econ?mica y financiera de una nueva unidad de negocio de jugos naturales envasados, compuesto por un mix de frutas y verduras, para la empresa Agrovado. Asimismo, desarrollar? el plan de marketing, plan de operaciones, recursos humanos, plan de evaluaci?n econ?mica y financiera para la implementaci?n exitosa del negocio

Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report.

We identified a PSEN1 (presenilin 1) mutation carrier from the world's largest autosomal dominant Alzheimer's disease kindred, who did not develop mild cognitive impairment until her seventies, three decades after the expected age of clinical onset. The individual had two copies of the APOE3 Christchurch (R136S) mutation, unusually high brain amyloid levels and limited tau and neurodegenerative measurements. Our findings have implications for the role of APOE in the pathogenesis, treatment and prevention of Alzheimer's disease