An amplifier-less acquisition chain for power measurements in series resonant inverters

Successive approximation register (SAR) analog-to-digital converter (ADC) manufacturers recommend the use of a driver amplifier to achieve the best performance. When a driver amplifier is not used, the conversion speed is severely penalized because of the need to meet the settling time constraint. This paper proposes a simple digital correction method to raise the performance (conversion speed and/or accuracy) when the acquisition chain lacks a driver amplifier. It is intended to reduce the cost, size and power consumption of the conditioning circuit while maintaining acceptable performance. The method is applied to the measurement of the output power delivered by a series resonant inverter for domestic induction heating

La huella de las oscilaciones globales del nivel del mar durante los últimos 530000 años en el Golfo de León y su variabilidad durante el estadio isotópico marino 3

El sondeo PRGL1-4, recuperado en el talud superior, ha proporcionado un registro único, continuo y de larga duración para la investigación del impacto de las oscilaciones del nivel del mar de escala glacial/interglacial durante el Pleistoceno Superior en la construcción del margen continental del Golfo de León, dominado por aportaciones sedimentarias de origen fluvial. El estudio en detalle de los cambios del tamaño de grano y la composición elemental del sedimento, junto con una robusta cronoestratigrafía basada en el registro de isótopos de oxígeno en foraminíferos planctónicos, ha permitido reinterpretar la sismoestratigrafia del margen para los últimos 530 ka. El sondeo PRGL1-4 comprende el apilamiento formado por cinco unidades depositadas durante las bajadas del nivel del mar de los últimos cinco ciclos glacial/interglacial de 100 ka. La extensa plataforma del Golfo de León ha jugado un papel determinante en el desarrollo del margen profundo puesto que las oscilaciones del nivel del mar, además de modificar el espacio de acomodación, influyeron directamente en cambios cíclicos del modelo deposicional a través de la activación y desactivación de procesos con gran capacidad erosiva y de transporte de sedimento más allá de la plataforma. El registro del sondeo PRGL1-4 también muestra el impacto de las oscilaciones del nivel del mar a escala milenaria durante el MIS 3, con evidencias claras de la ocurrencia de niveles del mar altos durante la fase inicial de todos y cada uno de los interestadios cálidos de los ciclos de Dansgaard-Oeschger. El registro PRGL1-4 supone, por tanto, la primera evidencia de un acoplamiento consistente entre las oscilaciones del nivel del mar y la variabilidad climática rápida de escala milenaria asociada a los ciclos de Dansgaard-Oeschger

Impact of iceberg melting on Mediterranean thermohaline circulation during Heinrich events

Down-core samples of planktonic and benthic foraminifera were analyzed for oxygen and carbon isotopes in International Marine Past Global Changes Study (IMAGES) core MD99-2343 in order to study the interactions between climate change in the Northern Hemisphere and the western Mediterranean thermohaline circulation at times of Heinrich events (HE). Our results confirm the antiphase correlation between enhanced North Atlantic Deep Water formation and low ventilation in the Mediterranean. However, this study reveals that this antiphase relationship in deepwater formation between the North Atlantic and Mediterranean was interrupted during times of HE when the injection of large volumes of water from melting icebergs reached the entrance to the Mediterranean. These events, which lasted less than 1000 years, are represented by pronounced decreases in both planktonic d18O and benthic d13C signals. Lower salinities of Mediterranean surface water resulted in a slowdown of western Mediterranean deepwater overturn even though cold sea surface temperatures and drier climate should have resulted in enhanced deepwater formation

Holocene climate variability in the Western Mediterranean region from a deep water sediment record

The detailed analysis of the International Marine Past Global Changes Study core MD99-2343 recovered from a sediment drift at 2391 m water depth north of the island of Minorca illustrates the effects of climate variability on thermohaline circulation in the western Mediterranean during the last 12 kyr. Geochemical ratios associated with terrigenous input resulted in the identification of four phases representing different climatic and deepwater overturning conditions in the Western Mediterranean Basin during the Holocene. Superimposed on the general trend, eight centennial- to millennial-scale abrupt events appear consistently in both grain size and geochemical records, which supports the occurrence of episodes of deepwater overturning reinforcement in the Western Mediterranean Basin. The observed periodicity for these abrupt events is in agreement with the previously defined Holocene cooling events of the North Atlantic region, thus supporting a strong Atlantic-Mediterranean climatic link at high-frequency time intervals during the last 12 kyr. The rapid response of the Mediterranean thermohaline circulation to climate change in the North Atlantic stresses the importance of atmospheric teleconnections in transferring climate variability from high latitudes to midlatitudes

Characterisation of Extreme Precipitation Events in the Pyrenees: From the Local to the Synoptic Scale

Mountain systems within the Mediterranean region, e.g., the Pyrenees, are very sensitive to climate change. In the present study, we quantified the magnitude of extreme precipitation events and the number of days with torrential precipitation (daily precipitation ≥ 100 mm) in all the rain gauges available in the Pyrenees for the 1981-2015 period, analyzing the contribution of the synoptic scale in this type of event. The easternmost (under Mediterranean influence) and north-westernmost (under Atlantic influence) areas of the Pyrenees registered the highest number of torrential events. The heaviest events are expected in the eastern part, i.e., 400 mm day−1 for a return period of 200 years. Northerly advections over the Iberian Peninsula, which present a low zonal index, i.e., implying a stronger meridional component, give rise to torrential events over the western Pyrenees; and easterly advections favour extreme precipitation over the eastern Pyrenees. The air mass travels a long way, from the east coast of North America, bringing heavy rainfall to the western Pyrenees. In the case of the torrential events over the eastern Pyrenees, the trajectory of the air mass causing the events in these areas is very short and originates in the Mediterranean Basin. The North Atlantic Oscillation (NAO) index has no influence upon the occurrence of torrential events in the Pyrenees, but these events are closely related to certain Mediterranean teleconnections such as the Western Mediterranean Oscillation (WeMO)

M2 Cortex-Dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington's Disease

Huntington's disease (HD) is a neurological disorder characterized by motor disturbances. HD pathology is most prominent in the striatum, the central hub of the basal ganglia. The cerebral cortex is the main striatal afferent, and progressive cortico-striatal disconnection characterizes HD. We mapped striatal network dysfunction in HD mice to ultimately modulate the activity of a specific cortico-striatal circuit to ameliorate motor symptoms and recover synaptic plasticity. Multimodal MRI in vivo indicates cortico-striatal and thalamo-striatal functional network deficits and reduced glutamate/glutamine ratio in the striatum of HD mice. Moreover, optogenetically-induced glutamate release from M2 cortex terminals in the dorsolateral striatum (DLS) was undetectable in HD mice and striatal neurons show blunted electrophysiological responses. Remarkably, repeated M2-DLS optogenetic stimulation normalized motor behavior in HD mice and evoked a sustained increase of synaptic plasticity. Overall, these results reveal that selective stimulation of the M2-DLS pathway can become an effective therapeutic strategy in HD

Fixed and Drifting Buoys around the National Spanish Waters

Improving the knowledge of the seas surrounding the Iberian Peninsula, Balearic and Canary islands is one of the objectives for the Spanish oceanographic community. For that purpose, a number of fixed and drifting buoys have been deployed in the last 25 years. Parameters measured included sea surface temperature and salinity, ocean current velocity, air temperature, humidity, wave characteristic and wind velocity. The national aim is to increase the quantity, quality, coverage and timeliness of atmospheric and oceanographic data. These observations are used immediately to improve forecast and therefore increase marine safety

Jardins per a la salut

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia. Assignatura: Botànica farmacèutica. Curs: 2014-2015. Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són el recull de les fitxes botàniques de 128 espècies presents en el Jardí Ferran Soldevila de l’Edifici Històric de la UB. Els treballs han estat realitzats manera individual per part dels estudiants dels grups M-3 i T-1 de l’assignatura Botànica Farmacèutica durant els mesos de febrer a maig del curs 2014-15 com a resultat final del Projecte d’Innovació Docent «Jardins per a la salut: aprenentatge servei a Botànica farmacèutica» (codi 2014PID-UB/054). Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pels professors de l’assignatura. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica. També s’ha pretès motivar els estudiants a través del retorn de part del seu esforç a la societat a través d’una experiència d’Aprenentatge-Servei, deixant disponible finalment el treball dels estudiants per a poder ser consultable a través d’una Web pública amb la possibilitat de poder-ho fer in-situ en el propi jardí mitjançant codis QR amb un smartphone

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe