Anomalous magnetic and weak magnetic dipole moments of the τ\tau lepton in the simplest little Higgs model

We obtain analytical expressions, both in terms of parametric integrals and Passarino-Veltman scalar functions, for the one-loop contributions to the anomalous weak magnetic dipole moment (AWMDM) of a charged lepton in the framework of the simplest little Higgs model (SLHM). Our results are general and can be useful to compute the weak properties of a charged lepton in other extensions of the standard model (SM). As a by-product we obtain generic contributions to the anomalous magnetic dipole moment (AMDM), which agree with previous results. We then study numerically the potential contributions from this model to the $\tau$ lepton AMDM and AWMDM for values of the parameter space consistent with current experimental data. It is found that they depend mainly on the energy scale $f$ at which the global symmetry is broken and the $t_\beta$ parameter, whereas there is little sensitivity to a mild change in the values of other parameters of the model. While the $\tau$ AMDM is of the order of $10^{-9}$, the real (imaginary) part of its AWMDM is of the order of $10^{-9}$ ($10^{-10}$). These values seem to be out of the reach of the expected experimental sensitivity of future experiments.Comment: 23 pages, 11 figures, new analysis and References adde

Corso, un buldog con ansiedad por separación

Se describe un caso de ansiedad por separación en un Buldog Francés macho de 1,7 años de edad. Sus dueños acuden a la consulta, ya que Corso destroza todo cuando se queda solo en casa. En un primer momento fue el salón, en donde fue necesario realizar obras de reparación de los destrozos provocados por el paciente. En la actualidad es un pasillo, su nueva ubicación cuando está solo. El tratamiento se compuso de tres partes: terapia farmacológica consistente en Trankimazin 1mg 1/24h y Fluoxetina 20mg 1/24h, la modificación de su entorno y una modificación de conducta, facilitada por el propio tratamiento farmacológico. Siete meses después, tras varios seguimientos, Corso es dado el alta, prolongándole el tratamiento farmacológico de Fluoxetina, media dosis durante un mes más.Privateering is described to a case of separation anxiety in a French Bulldog of 1,7 years, called Corso. The owners go to the clinic because Corso destroys everything when left alone at home. Initially was the living room where they had to make repairs of damage caused by Corso. Currently is a corridor, its new location when left alone. Treatment consisted of three parts: first the pharmacological treatment Trankimazin 1mg 1/24h and Fluoxetina 20mg 1/24h, then changing his environment and also a behavior modification helped by the pharmalogical treatment. Seven months later, and after several follow-ups, Corso was medical discharged but the pharmacological treatment was maintained for a month with half dose of Fluoxetina

Assessment of natural ventilation strategy to decrease the risk of COVID 19 infection at a rural elementary school

Natural ventilation in low-budget elementary schools is the main focus to ensure the health and comfort of its occupants, specifically when looking at the global pandemic related to SARS-COV-2. This paper presents an experimental and novel study of natural ventilation in a public elementary school (Los Zumacales), with a particularly low economic budget. The study was carried out during the winter months of the Covid 19 pandemic. The school is located in the rural area of Castilla y León (North-Western Spain) far from high traffic roads. In this study, a methodology of measuring CO2 concentration was applied in nine classrooms in a school. The experimental study shows the level of natural ventilation in each classroom, expressed in Air Changes per Hour (ACH), using the Decay CO2 concentration method. The method is proven by comparing the experimental values of the obtained ACH with those determined by the most powerful methods to achieve appropriate ventilation levels. Thus, ensuring health protection protocol in rural schools, against the COVID 19 pandemic. Harvard guide and Spanish regulations (RITE), two widely recognized methods have been used together with the experimentally obtained standard by Rey et al. Only one classroom showed a value lower than 3 indicating poor ventilation. In this study, the degree of thermal comfort in the nine classrooms were also analyzed according to the EN15251 standard. An average indoor temperature of approximately 19 °C was obtained, and the relative humidity was stable and correct according to Spanish regulations. In addition, the risk of infection in each classroom was estimated following the international method recommended by the federation of European Heating, Ventilation, and Air Conditioning Associations (REHVA). The probability of infection in all the cases studied was less than 14%.Funding for open access charge: Universidad de Málaga/CBU

Chaos and stability in a two-parameter family of convex billiard tables

We study, by numerical simulations and semi-rigorous arguments, a two-parameter family of convex, two-dimensional billiard tables, generalizing the one-parameter class of oval billiards of Benettin--Strelcyn [Phys. Rev. A 17, 773 (1978)]. We observe interesting dynamical phenomena when the billiard tables are continuously deformed from the integrable circular billiard to different versions of completely-chaotic stadia. In particular, we conjecture that a new class of ergodic billiard tables is obtained in certain regions of the two-dimensional parameter space, when the billiards are close to skewed stadia. We provide heuristic arguments supporting this conjecture, and give numerical confirmation using the powerful method of Lyapunov-weighted dynamics.Comment: 19 pages, 13 figures. Submitted for publication. Supplementary video available at http://sistemas.fciencias.unam.mx/~dsanders

Spider silk gut: Development and characterization of a novel strong spider silk fiber

Spider silk fibers were produced through an alternative processing route that differs widely from natural spinning. The process follows a procedure traditionally used to obtain fibers directly from the glands of silkworms and requires exposure to an acid environment and subsequent stretching. The microstructure and mechanical behavior of the so-called spider silk gut fibers can be tailored to concur with those observed in naturally spun spider silk, except for effects related with the much larger cross-sectional area of the former. In particular spider silk gut has a proper ground state to which the material can revert independently from its previous loading history by supercontraction. A larger cross-sectional area implies that spider silk gut outperforms the natural material in terms of the loads that the fiber can sustain. This property suggests that it could substitute conventional spider silk fibers in some intended uses, such as sutures and scaffolds in tissue engineering.Ministerio de Economía y Competitividad (España) MAT2012-38412-C02-01Fondo Nacional de Ciencias Naturales de China 31160420, 31060282, 30760041Programa de Formación de Jóvenes Científicos (JingGang Star) 20133BCB2302

Estudio del mecanismo de eliminación demagnesio de aleaciones Al-Si en estado líquido mediante inyección de minerales base sílice

RESUMEN Se empleó el método de inyección sumergida de polvos por medio de un gas de arrastre inerte (Ar) con el fin de eliminar el magnesio de la aleación Al-Si A380 a 750 °C. Los polvos inyectados al baño de metal fundido fueron zeolita mineral, arena sílice y mezclas de ambas. Las variables de respuesta medidas fueron el contenido de magnesio en el baño metálico respecto al tiempo de inyección y las mermas de metal al final de cada experimento. En el análisis de resultados, la mezcla sílice:zeolita 66:34 % e.p. obtuvo la mayor eficiencia, lográndose una disminución en el contenido de magnesio en el baño metálico de 1 a 0.0066 % e.p. Los productos de reacción se analizaron por difracción de rayos-X, microscopía electrónica de barrido y de transmisión. Los resultados de estos análisis y el empleo del paquete termodinámico FactSage, versión 6, permitieron justificar el mecanismo de reacción entre los minerales y el aluminio líquido. ABSTRAC In order to eliminate magnesium from an A 380 Al-Si alloy at 750°C, the submerged powder injection method, using an inert carrier gas (Ar), was applied. The injected powders in the liquid aluminum bath were zeolite, silica and mixtures of zeolite-silica minerals. For each experiment the response variables were: eliminated magnesium versus injection time and quantity of drosses produced. Chemical analysis by atomic absorption spectrometry showed that mixtures of silica-zeolite 66:34 wt% have the best results with regarding to the removal magnesium from 1 to 0.0066 wt%. During the elimination of magnesium complex stoichiometry compounds were formed due to the reactions among zeolite, water steam and liquid aluminum. These compounds were analyzed by XRD, SEM and TEM. The results obtained, along with using the FactSage 6 thermodynamic software, allowed to elucidate the reaction mechanism between the minerals used and liquid aluminum

Characterization of the platelet phenotype caused by a germline RUNX1 Variant in a CRISPR/Cas9-generated murine model

RUNX1-related disorder (RUNX1-RD) is caused by germline variants affecting the RUNX1 gene. This rare, heterogeneous disorder has no specific clinical or laboratory phenotype, making genetic diagnosis necessary. Although international recommendations have been established to classify the pathogenicity of variants, identifying the causative alteration remains a challenge in RUNX1-RD. Murine models may be useful not only for definitively settling the controversy about the pathogenicity of certain RUNX1 variants, but also for elucidating the mechanisms of molecular pathogenesis. Therefore, we developed a knock-in murine model, using the CRISPR/Cas9 system, carrying the RUNX1 p.Leu43Ser variant (mimicking human p.Leu56Ser) to study its pathogenic potential and mechanisms of platelet dysfunction. A total number of 75 mice were generated; 25 per genotype (RUNX1WT/WT, RUNX1WT/L43S, and RUNX1L43S/L43S). Platelet phenotype was assessed by flow cytometry and confocal microscopy. On average, RUNX1L43S/L43S and RUNX1WT/L43S mice had a significantly longer tail-bleeding time than RUNX1WT/WT mice, indicating the variant's involvement in hemostasis. However, only homozygous mice displayed mild thrombocytopenia. RUNX1L43S/L43S and RUNX1WT/L43S displayed impaired agonist-induced spreading and α-granule release, with no differences in δ-granule secretion. Levels of integrin αIIbβ3 activation, fibrinogen binding, and aggregation were significantly lower in platelets from RUNX1L43S/L43S and RUNX1WT/L43S using phorbol 12-myristate 13-acetate (PMA), adenosine diphosphate (ADP), and high thrombin doses. Lower levels of PKC phosphorylation in RUNX1L43S/L43S and RUNX1WT/L43S suggested that the PKC-signaling pathway was impaired. Overall, we demonstrated the deleterious effect of the RUNX1 p.Leu56Ser variant in mice via the impairment of integrin αIIbβ3 activation, aggregation, α-granule secretion, and platelet spreading, mimicking the phenotype associated with RUNX1 variants in the clinical setting.This work was partially supported by grants from Instituto de Salud Carlos III (ISCIII) and Feder (PI17/01311, PI17/01966, and CB15/00055), Fundación Séneca (19873/GERM/15), Gerencia Regional de Salud (GRS 2061A/19 and 1647/A/17), Fundación Mutua Madrileña (FMM, AP172142019), and Sociedad Española de Trombosis y Hemostasia (SETH-FETH; Premio López Borrasca 2019 and Ayuda a Grupos de Trabajo en Patología Hemorrágica 2019). The authors' research on IPDs is conducted in accordance with the aims of the Functional and Molecular Characterization of Patients with Inherited Platelet Disorders Project, which is supported by the Hemorrhagic Diathesis Working Group of the Spanish Society of Thrombosis and Haemostasis. A.M.-Q., C.F.-I., and L.H.-C. were supported by predoctoral grants from the Junta de Castilla y León, Spain. E.V. was supported by the predoctoral grant from the University of Salamanca, Spain. IG-T and RB were supported by "Contratos postdoctorales Programa II) from the University of Salamanca, Spain