1,065 research outputs found

    NE3 THE IMPORTANCE OF MODIFYING THE COURSE OF ALZHEIMER'S DISEASE: OLDER AMERICANS' RISK-BENEFIT PREFERENCES FOR NEW TREATMENTS

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    Delegating Quantum Computation in the Quantum Random Oracle Model

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    A delegation scheme allows a computationally weak client to use a server's resources to help it evaluate a complex circuit without leaking any information about the input (other than its length) to the server. In this paper, we consider delegation schemes for quantum circuits, where we try to minimize the quantum operations needed by the client. We construct a new scheme for delegating a large circuit family, which we call "C+P circuits". "C+P" circuits are the circuits composed of Toffoli gates and diagonal gates. Our scheme is non-interactive, requires very little quantum computation from the client (proportional to input length but independent of the circuit size), and can be proved secure in the quantum random oracle model, without relying on additional assumptions, such as the existence of fully homomorphic encryption. In practice the random oracle can be replaced by an appropriate hash function or block cipher, for example, SHA-3, AES. This protocol allows a client to delegate the most expensive part of some quantum algorithms, for example, Shor's algorithm. The previous protocols that are powerful enough to delegate Shor's algorithm require either many rounds of interactions or the existence of FHE. The protocol requires asymptotically fewer quantum gates on the client side compared to running Shor's algorithm locally. To hide the inputs, our scheme uses an encoding that maps one input qubit to multiple qubits. We then provide a novel generalization of classical garbled circuits ("reversible garbled circuits") to allow the computation of Toffoli circuits on this encoding. We also give a technique that can support the computation of phase gates on this encoding. To prove the security of this protocol, we study key dependent message(KDM) security in the quantum random oracle model. KDM security was not previously studied in quantum settings.Comment: 41 pages, 1 figures. Update to be consistent with the proceeding versio

    DC-SIGN–mediated Infectious Synapse Formation Enhances X4 HIV-1 Transmission from Dendritic Cells to T Cells

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    Dendritic cells (DCs) are essential for the early events of human immunodeficiency virus (HIV) infection. Model systems of HIV sexual transmission have shown that DCs expressing the DC-specific C-type lectin DC-SIGN capture and internalize HIV at mucosal surfaces and efficiently transfer HIV to CD4+ T cells in lymph nodes, where viral replication occurs. Upon DC–T cell clustering, internalized HIV accumulates on the DC side at the contact zone (infectious synapse), between DCs and T cells, whereas HIV receptors and coreceptors are enriched on the T cell side. Viral concentration at the infectious synapse may explain, at least in part, why DC transmission of HIV to T cells is so efficient

    Strongly anisotropic spin relaxation in graphene/transition metal dichalcogenide heterostructures at room temperature

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    Graphene has emerged as the foremost material for future two-dimensional spintronics due to its tuneable electronic properties. In graphene, spin information can be transported over long distances and, in principle, be manipulated by using magnetic correlations or large spin-orbit coupling (SOC) induced by proximity effects. In particular, a dramatic SOC enhancement has been predicted when interfacing graphene with a semiconducting transition metal dechalcogenide, such as tungsten disulphide (WS2_2). Signatures of such an enhancement have recently been reported but the nature of the spin relaxation in these systems remains unknown. Here, we unambiguously demonstrate anisotropic spin dynamics in bilayer heterostructures comprising graphene and WS2_2. By using out-of-plane spin precession, we show that the spin lifetime is largest when the spins point out of the graphene plane. Moreover, we observe that the spin lifetime varies over one order of magnitude depending on the spin orientation, indicating that the strong spin-valley coupling in WS2_2 is imprinted in the bilayer and felt by the propagating spins. These findings provide a rich platform to explore coupled spin-valley phenomena and offer novel spin manipulation strategies based on spin relaxation anisotropy in two-dimensional materials

    A novel role for the root cap in phosphate uptake and homeostasis

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    The root cap has a fundamental role in sensing environmental cues as well as regulating root growth via altered meristem activity. Despite this well-established role in the control of developmental processes in roots, the root cap's function in nutrition remains obscure. Here, we uncover its role in phosphate nutrition by targeted cellular inactivation or phosphate transport complementation in Arabidopsis, using a transactivation strategy with an innovative high-resolution real-time P-33 imaging technique. Remarkably, the diminutive size of the root cap cells at the root-to-soil exchange surface accounts for a significant amount of the total seedling phosphate uptake (approximately 20%). This level of Pi absorption is sufficient for shoot biomass production (up to a 180% gain in soil), as well as repression of Pi starvation-induced genes. These results extend our understanding of this important tissue from its previously described roles in environmental perception to novel functions in mineral nutrition and homeostasis control

    Geographical interdependence, international trade and economic dynamics: the Chinese and German solar energy industries

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    The trajectories of the German and Chinese photovoltaic industries differ significantly yet are strongly interdependent. Germany has seen a rapid growth in market demand and a strong increase in production, especially in the less developed eastern half of the country. Chinese growth has been export driven. These contrasting trajectories reflect the roles of market creation, investment and credit and the drivers of innovation and competitiveness. Consequent differences in competiveness have generated major trade disputes
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