801 research outputs found
K2-137 b: an Earth-sized planet in a 4.3-hour orbit around an M-dwarf
We report the discovery from K2 of a transiting terrestrial planet in an
ultra-short-period orbit around an M3-dwarf. K2-137 b completes an orbit in
only 4.3 hours, the second-shortest orbital period of any known planet, just 4
minutes longer than that of KOI 1843.03, which also orbits an M-dwarf. Using a
combination of archival images, AO imaging, RV measurements, and light curve
modelling, we show that no plausible eclipsing binary scenario can explain the
K2 light curve, and thus confirm the planetary nature of the system. The
planet, whose radius we determine to be 0.89 +/- 0.09 Earth radii, and which
must have a iron mass fraction greater than 0.45, orbits a star of mass 0.463
+/- 0.052 Msol and radius 0.442 +/- 0.044 Rsol.Comment: 12 pages, 9 figures, accepted for publication in MNRA
Impact of Tumor LINE-1 Methylation Level and Neoadjuvant Treatment and Its Association with Colorectal Cancer Survival
Recent studies suggest that long-interspersed nucleotide element-1 (LINE-1) hypomethylation is commonly found in colorectal cancer (CRC), and is associated with worse prognosis. However, the utility of LINE-1 methylation on the prognosis of CRC is still controversial, and may be due to the fact that some clinical and pathological features may affect LINE-1 methylation. Thus, the aim of this study was to assess the prognostic value of tumor LINE-1 methylation in CRC, through their association with the CRC clinical and pathological characteristics. Survival of sixty-seven CRC patients was evaluated according to the median of tumor LINE-1 methylation, as well as pathological and oncological variables. We also studied the association between LINE-1 methylation and pathological features, and finally, we assessed the overall and disease-free survival of LINE1 methylation, stratified by neoadjuvant treatment and further checked by multivariate Cox regression to assess the statistical interactions. LINE-1 was hypomethylated in the CRC tumor with respect to the tumor adjacent-free area (p < 0.05), without association with any other clinical and oncological features, nor with overall and disease-free survival rates for CRC. Relevantly, in neoadjuvant treatment, LINE-1 methylation was associated with survival rates. Thus, disease-free and overall survival rates of treated CRC patients were worse in the hypomethylated LINE-1 tumors than those with normal LINE-1 methylation (p = 0.004 and 0.0049, respectively). Indeed, LINE-1 was hypermethylated more in the treated patients than in the non-treated patients (p < 0.05). The present study showed that tumor LINE-1 hypomethylation was associated with worse survival rates in only treated patients. Our data suggest an interactive effect of neoadjuvant treatment and tumor LINE-1 methylation, which could be a specific-tissue biomarker to predict survival of the treated patients, and help to personalize treatment in CRC
A strongly magnetized pulsar within grasp of the Milky Way's supermassive black hole
The center of our Galaxy hosts a supermassive black hole, Sagittarius (Sgr)
A*. Young, massive stars within 0.5 pc of SgrA* are evidence of an episode of
intense star formation near the black hole a few Myr ago, which might have left
behind a young neutron star traveling deep into SgrA*'s gravitational
potential. On 2013 April 25, a short X-ray burst was observed from the
direction of the Galactic center. Thanks to a series of observations with the
Chandra and the Swift satellites, we pinpoint the associated magnetar at an
angular distance of 2.4+/-0.3 arcsec from SgrA*, and refine the source spin
period and its derivative (P=3.7635537(2) s and \dot{P} = 6.61(4)x10^{-12}
s/s), confirmed by quasi simultaneous radio observations performed with the
Green Bank (GBT) and Parkes antennas, which also constrain a Dispersion Measure
of DM=1750+/-50 pc cm^{-3}, the highest ever observed for a radio pulsar. We
have found that this X-ray source is a young magnetar at ~0.07-2 pc from SgrA*.
Simulations of its possible motion around SgrA* show that it is likely (~90%
probability) in a bound orbit around the black hole. The radiation front
produced by the past activity from the magnetar passing through the molecular
clouds surrounding the Galactic center region, might be responsible for a large
fraction of the light echoes observed in the Fe fluorescence features.Comment: ApJ Letters in pres
Multicolour photometry for exoplanet candidate validation
Context. The TESS and PLATO missions are expected to find vast numbers of new
transiting planet candidates. However, only a fraction of these candidates will
be legitimate planets, and the candidate validation will require a significant
amount of follow-up resources. Radial velocity follow-up can be carried out
only for the most promising candidates around bright, slowly rotating, stars.
Thus, before devoting RV resources to candidates, they need to be vetted using
cheaper methods, and, in the cases for which an RV confirmation is not
feasible, the candidate's true nature needs to be determined based on these
alternative methods alone.
Aims. We study the applicability of multicolour transit photometry in the
validation of transiting planet candidates when the candidate signal arises
from a real astrophysical source. We seek to answer how securely can we
estimate the true uncontaminated star-planet radius ratio when the light curve
may contain contamination from unresolved light sources inside the photometry
aperture when combining multicolour transit observations with a physics-based
contamination model.
Methods. The study is based on simulations and ground-based transit
observations. The analyses are carried out with a contamination model
integrated into the PyTransit v2 transit modelling package, and the
observations are carried out with the MuSCAT2 multicolour imager installed in
the 1.5 m TCS in the Teide Observatory.
Results. We show that multicolour transit photometry can be used to estimate
the amount of flux contamination and the true radius ratio. Combining the true
radius ratio with an estimate for the stellar radius yields the true absolute
radius of the transiting object, which is a valuable quantity in statistical
candidate validation, and enough in itself to validate a candidate whose radius
falls below the theoretical lower limit for a brown dwarf.Comment: Accepted to A&
Entrepreneurial intention and obstacles of undergraduate students: the case of the universities of Andalusia
This paper studies entrepreneurial intentions in undergraduate students and the obstacles perceived by the students in the process of starting their own business. Using a sample of 1053 undergraduate students from Andalusia universities, this study explores attitudes, capacities and social environment to determine the profile of university’s entrepreneurs. The results of the structural model show that motivational factors determine entrepreneurship university students, while environmental or regional factors indirectly determine undergraduates’ choice of employment status. We also find that personal variables and attitudes related to the desire for self-realization have the greatest influence on the entrepreneurial intention university students. In addition, the findings from the regression analysis exhibit that financial obstacles, the lack of experience and training are the main barriers students perceive to starting their own business. The results contribute to theories of entrepreneurship education and intentions in the context of higher education. The authors discuss implications universities and policymakers
Electronic properties and Fermi surface of Ag(111) films deposited onto H-passivated Si(111)-(1x1) surfaces
Silver films were deposited at room temperature onto H-passivated Si(111)
surfaces. Their electronic properties have been analyzed by angle-resolved
photoelectron spectroscopy. Submonolayer films were semiconducting and the
onset of metallization was found at a Ag coverage of 0.6 monolayers. Two
surface states were observed at -point in the metallic films,
with binding energies of 0.1 and 0.35 eV. By measurements of photoelectron
angular distribution at the Fermi level in these films, a cross-sectional cut
of the Fermi surface was obtained. The Fermi vector determined along different
symmetry directions and the photoelectron lifetime of states at the Fermi level
are quite close to those expected for Ag single crystal. In spite of this
concordance, the Fermi surface reflects a sixfold symmetry rather than the
threefold symmetry of Ag single crystal. This behavior was attributed to the
fact that these Ag films are composed by two domains rotated 60.Comment: 9 pages, 8 figures, submitted to Physical Review
Quantification of inaccurate diagnosis of COPD in primary care medicine: An analysis of the COACH clinical audit
Background: Inaccurate diagnosis in COPD is a current problem with relevant consequences in terms of inefficient health care, which has not been thoroughly studied in primary care medicine. The aim of the present study was to evaluate the degree of inaccurate diagnosis in Primary Care in Spain and study the determinants associated with it. Methods: The Community Assessment of COPD Health Care (COACH) study is a national, observational, randomized, non-interventional, national clinical audit aimed at evaluating clinical practice for patients with COPD in primary care medicine in Spain. For the present analysis, a correct diagnosis was evaluated based on previous exposure and airway obstruction with and without the presence of symptoms. The association of patient-level and center-level variables with inaccurate diagnosis was studied using multivariate multilevel binomial logistic regression models. Results: During the study 4,307 cases from 63 centers were audited. The rate of inaccurate diagnosis was 82.4% (inter-regional range from 76.8% to 90.2%). Patient-related interventions associated with inaccurate diagnosis were related to active smoking, lung function evaluation, and specific therapeutic interventions. Center-level variables related to the availability of certain complementary tests and different aspects of the resources available were also associated with an inaccurate diagnosis. Conclusions: The prevalence data for the inaccurate diagnosis of COPD in primary care medicine in Spain establishes a point of reference in the clinical management of COPD. The descriptors of the variables associated with this inaccurate diagnosis can be used to identify cases and centers in which inaccurate diagnosis is occurring considerably, thus allowing for improvement
The effect of tourism education on students? entrepreneurial vocation
This paper aims to examine how higher education affects entrepreneurial vocation in a very specific segment, namely university education in tourism. We used a theoretical approach based on the psychological foundations of intentional theory to analyse a sample of 122 graduate and undergraduate university students in tourism from the perspective of higher education. The results show the differential effect of curricular and extracurricular activities on intentions, attitudes and behavioural control, while there is very little effect on the development of entrepreneurial competencies
Maintenance therapy of patients with recurrent epithelial ovarian carcinoma with the anti-tumor-associated-mucin-1 antibody gatipotuzumab: results from a double-blind, placebo-controlled, randomized, phase II study
BACKGROUND: Gatipotuzumab is a humanized monoclonal antibody recognizing the carbohydrate-induced epitope of the tumor-associated mucin-1 (TA-MUC1). This study aimed to evaluate the efficacy and safety of switch maintenance therapy with gatipotuzumab in patients with TA-MUC1-positive recurrent ovarian, fallopian tube, or primary high-grade serous peritoneal cancer. PATIENTS AND METHODS: In this double-blind, randomized, placebo-controlled, phase II trial, patients with at least stable disease (SD) following chemotherapy were randomized 2:1 to receive intravenous gatipotuzumab (500 mg followed by 1700 mg 1 week later) or placebo every 3 weeks until tumor progression or unacceptable toxicity occurred. Stratification factors were the number of prior chemotherapy lines (2 versus 3-5), response versus SD after the most recent chemotherapy, and progression-free survival (PFS) <6 versus 6-12 months following the prior therapy. Primary endpoint was PFS according to modified immune-related RECIST 1.1 response criteria. Secondary endpoints were PFS at 6 months, safety, overall response rate, CA-125 progression, overall survival, quality of life, and pharmacokinetics. RESULTS: Overall, 216 patients were randomized to gatipotuzumab (n = 151) or placebo (n = 65). Median PFS with gatipotuzumab was 3.5 months as compared with 3.5 months with placebo (hazard ratio 0.96, 95% confidence interval 0.69-1.33, P = 0.80). No advantage for gatipotuzumab over placebo was seen in the secondary efficacy endpoints or in any stratified subgroups. Gatipotuzumab was well tolerated, with mild to moderate infusion-related reactions being the most common adverse events. CONCLUSIONS: Gatipotuzumab switch maintenance therapy does not improve outcome in TA-MUC1-positive ovarian cancer patients. TRIAL REGISTRATION: ClinicalTrials.govNCT01899599; https://clinicaltrials.gov/ct2/show/NCT01899599
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