Multivalent 1,2,3‐Triazole‐Linked Carbohydrate Mimetics by Huisgen–Meldal‐Sharpless Cycloadditions of an Azidopyran

Starting from an enantiopure 3‐azido‐substituted pyran derivative and various oligo‐alkynes a series of multivalent 1,2,3‐triazole‐linked carbohydrate mimetics was synthesized. The copper‐catalyzed Huisgen–Meldal‐Sharpless cycloaddition (CuAAC) served as key coupling reaction. Cu/C in the presence of triethylamine proved to be a good catalytic system in most cases. Tri‐, tetra‐, hexa‐, and octavalent compounds with typical rigid or flexible core units were prepared. The most complex compound contains a C60‐fullerene center leading to a dodecavalent carbohydrate mimetic. Only a few of the multivalent target compounds could be converted into pure O‐sulfated derivatives that are required for their evaluation as L‐ and P‐selectin ligands. Nevertheless, preliminary experiments suggest that the dodecavalent C60‐derived compound may be a promising ligand of these biologically important proteins with IC50 values in the low nanomolar range

Cosmology and Cosmogony in a Cyclic Universe

In this paper we discuss the properties of the quasi-steady state cosmological model (QSSC) developed in 1993 in its role as a cyclic model of the universe driven by a negative energy scalar field. We discuss the origin of such a scalar field in the primary creation process first described by F. Hoyle and J. V. Narlikar forty years ago. It is shown that the creation processes which takes place in the nuclei of galaxies are closely linked to the high energy and explosive phenomena, which are commonly observed in galaxies at all redshifts. The cyclic nature of the universe provides a natural link between the places of origin of the microwave background radiation (arising in hydrogen burning in stars), and the origin of the lightest nuclei (H, D, He$^3$ and He$^4$). It also allows us to relate the large scale cyclic properties of the universe to events taking place in the nuclei of galaxies. Observational evidence shows that ejection of matter and energy from these centers in the form of compact objects, gas and relativistic particles is responsible for the population of quasi-stellar objects (QSOs) and gamma-ray burst sources in the universe. In the later parts of the paper we briefly discuss the major unsolved problems of this integrated cosmological and cosmogonical scheme. These are the understanding of the origin of the intrinsic redshifts, and the periodicities in the redshift distribution of the QSOs.Comment: 51 pages including 1 figur

Dwarf Elliptical Galaxies

Dwarf elliptical (dE) galaxies, with blue absolute magnitudes typically fainter than $M_B = -16$, are the most numerous type of galaxy in the nearby universe. Tremendous advances have been made over the past several years in delineating the properties of both Local Group satellite dE's and the large dE populations of nearby clusters. We review some of these advances, with particular attention to how well currently available data can constrain 1) models for the formation of dE's, 2) the physical and evolutionary connections between different types of galaxies (nucleated and nonnucleated dE's, compact E's, irregulars, and blue compact dwarfs) that overlap in the same portion of the mass-spectrum of galaxies, 3) the contribution of dE's to the galaxy luminosity functions in clusters and the field, 4) the star-forming histories of dE's and their possible contribution to faint galaxy counts, and 5) the clustering properties of dE's. In addressing these issues, we highlight the extent to which selection effects temper these constraints, and outline areas where new data would be particularly valuable.Comment: 63p, uuencoded compressed postscript, 2/8 figs included, A&A Review in press, request paper copies from [email protected], STScI 86

Iterations chaotiques discretes

SIGLEAvailable at INIST (FR), Document Supply Service, under shelf-number : 17660 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc