“I’m Just a Middleman : A Phenomenological Study of Specialized Literacy Professionals\u27 Experiences During the COVID-19 Pandemic

Specialized literacy professionals (SLPs) are an integral part of schools, serving as interventionists, coaches, coordinators, and more. They are called on to guide reading and writing in their schools, helping to build academic success for students. However, these individuals are asked to do so much in schools that they have difficulty meeting the expectations set for them. The International Literacy Association has spent decades creating and revising standards for literacy professionals helping to delineate roles for SLPs so that they have set responsibilities that they can focus on. Despite these efforts, SLPs continue to serve a multiplicity of roles. During the COVID-19 pandemic this was exacerbated as SLPs took on more roles and responsibilities than they have in the past. Further, research has failed to dig deeply into how SLPs perceive their role and their identity in schools. To help move SLPs toward the standards set forth by the International Literacy Association, we must first work to understand their current experiences. This phenomenology investigated the lived experiences of SLPs working in elementary school settings during the COVID-19 pandemic using dialogical self theory. Dialogical self theory acknowledges that individuals take on multiple positions in their lives and seeks to understand how those positions are negotiated within the self. Nine SLPs working throughout the United States participated in this study. Each participant completed an entry survey, two individual interviews, and six participants participated in focus group interviews. Data were analyzed using the guidelines set forth by Moustakas (1994). Results revealed that all participants had a professional and personal identity that they attempted to separate; they also used coping strategies to navigate their positions within their identities. All participants’ experiences were influenced by the COVID-19 pandemic because of the changes it created in their personal and professional identities and the positions within them. Some participants also experienced power differences and were influenced by the reading wars. A few participants’ experiences were influenced by taking on a new role during a pandemic. Findings from this study can be used to inform practice in elementary schools and SLP preparation programs in institutions of higher education

No patient left behind : The promise of immune priming with epigenetic agents

Checkpoint inhibitors, monoclonal antibodies that inhibit PD-1 or CTLA-4, have revolutionized the treatment of multiple cancers. Despite the enthusiasm for the clinical successes of checkpoint inhibitors, and immunotherapy, in general, only a minority of patients with specific tumor types actually benefit from treatment. Emerging evidence implicates epigenetic alterations as a mechanism of clinical resistance to immunotherapy. This review presents evidence for that association, summarizes the epi-based mechanisms by which tumors evade immunogenic cell death, discusses epigenetic modulation as a component of an integrated strategy to boost anticancer T cell effector function in relation to a tumor immunosuppression cycle and, finally, makes the case that the success of this no-patient-left-behind strategy critically depends on the toxicity profile of the epigenetic agent(s).Peer reviewe

RRx-001 in Refractory Small-Cell Lung Carcinoma: A Case Report of a Partial Response after a Third Reintroduction of Platinum Doublets.

RRx-001 is a pan-active, systemically nontoxic epigenetic inhibitor under investigation in advanced non-small cell lung cancer, small-cell lung cancer and high-grade neuroendocrine tumors in a Phase II clinical trial entitled TRIPLE THREAT (NCT02489903), which reexposes patients to previously effective but refractory platinum doublets after treatment with RRx-001. The purpose of this case study is first to report a partial response to carboplatin and etoposide in a patient with small-cell lung cancer pretreated with RRx-001, indicating episensitization or resensitization by epigenetic mechanisms, and second to discuss the literature related to small-cell lung cancer and episensitization

CF3 Rotation in 3-(Trifluoromethyl)phenanthrene. X-ray Diffraction and ab Initio Electronic Structure Calculations

The molecular and crystal structure of 3-(trifluoromethyl)phenanthrene has been determined by X-ray diffraction. The structure of the isolated molecule has been calculated using electronic structure methods at the HF/3-21G, HF/6-31G*, MP2/6-31G* and B3LYP/6-31G* levels. The potential energy surfaces for the rotation of the CF3 group in both the isolated molecule and cluster models for the crystal were computed using electronic structure methods. The barrier height for CF3 rotation in the isolated molecule was calculated to be 0.40 kcal mol-1 at B3LYP/6-311+G**//B3LYP/6-311+G**. The B3LYP/6-31G* calculated CF3 rotational barrier in a 13-molecule cluster based on the X-ray data was found to be 2.6 kcal mol-1. The latter is in excellent agreement with experimental results from the NMR relaxation experiments reported in the companion paper (Beckmann, P. A.; Rosenberg, J.; Nordstrom, K.; Mallory, C. W.; Mallory, F. B. J. Phys. Chem. A 2006, 110, 3947). The computational results on the models for the solid state suggest that the intermolecular interaction between nearest neighbor pairs of CF3 groups in the crystal accounts for roughly 75% of the barrier to rotation in the solid state. This pair is found to undergo cooperative reorientation. We attribute the CF3 reorientational disorder in the crystal as observed by X-ray diffraction to the presence of a pair of minima on the potential energy surface and the effects of librational motion

Comparisons of the M1 genome segments and encoded μ2 proteins of different reovirus isolates

BACKGROUND: The reovirus M1 genome segment encodes the μ2 protein, a structurally minor component of the viral core, which has been identified as a transcriptase cofactor, nucleoside and RNA triphosphatase, and microtubule-binding protein. The μ2 protein is the most poorly understood of the reovirus structural proteins. Genome segment sequences have been reported for 9 of the 10 genome segments for the 3 prototypic reoviruses type 1 Lang (T1L), type 2 Jones (T2J), and type 3 Dearing (T3D), but the M1 genome segment sequences for only T1L and T3D have been previously reported. For this study, we determined the M1 nucleotide and deduced μ2 amino acid sequences for T2J, nine other reovirus field isolates, and various T3D plaque-isolated clones from different laboratories. RESULTS: Determination of the T2J M1 sequence completes the analysis of all ten genome segments of that prototype. The T2J M1 sequence contained a 1 base pair deletion in the 3' non-translated region, compared to the T1L and T3D M1 sequences. The T2J M1 gene showed ~80% nucleotide homology, and the encoded μ2 protein showed ~71% amino acid identity, with the T1L and T3D M1 and μ2 sequences, respectively, making the T2J M1 gene and μ2 proteins amongst the most divergent of all reovirus genes and proteins. Comparisons of these newly determined M1 and μ2 sequences with newly determined M1 and μ2 sequences from nine additional field isolates and a variety of laboratory T3D clones identified conserved features and/or regions that provide clues about μ2 structure and function. CONCLUSIONS: The findings suggest a model for the domain organization of μ2 and provide further evidence for a role of μ2 in viral RNA synthesis. The new sequences were also used to explore the basis for M1/μ2-determined differences in the morphology of viral factories in infected cells. The findings confirm the key role of Ser/Pro208 as a prevalent determinant of differences in factory morphology among reovirus isolates and trace the divergence of this residue and its associated phenotype among the different laboratory-specific clones of type 3 Dearing

A Transdisciplinary Collaboration and Innovation Education Model and Experience

As the interconnectedness of the world grows, the need to prepare college students capable of addressing complexity likewise grows. In this context, the University of Dayton has developed and tested a transdisciplinary model for education. This model links multiple classes from different disciplines via a common theme and within a common space. It also employs an educational model premised on the following trajectory: disciplinary content development / transdisciplinary observation (empathy); transdisciplinary disruption leading to “A-Ha” observations which transform the disciplinary directions; and lastly transdisciplinary informed design and research. Central to this model is a 3,500 square foot common space used only by the classes participating in the experience. In this space classes share their reflections and content with other classes via both personal linkages and analog communications. The other classes respond to these from their disciplinary and personal perspectives. Thirteen classes, fourteen faculty, and over three-hundred students participated in a themed experience centered on the addiction crisis in Dayton, Ohio. Participants included faculty in applied creativity, engineering, health and sport science, education, theater, and religious studies. Also serving as co-teacher were community stakeholders. Assessment of the experience revealed variable student takeaways. Most prominent among these was student recognition that the experience had expanded their perspectives of the other disciplines. Most suggested that it had improved their ability to collaborate in a transdisciplinary environment and that it had significantly impacted their career aspirations. Fewer acknowledged the experience had improved their ability to create

The Year One Book: GEMnasium (A Transdisciplinary Test Lab for Social Change)

Through an experimental process that is mutually beneficial to community partners, more opportunities for undergraduate research and experiential learning are cultivated. The GEMnasium accomplished this through active efforts of teaching, researching and partnering with the core ethos of the University in mind: Learn: Teaching - Prepare servant-leaders through comprehensive academic and residential curricula and extraordinary experiential learning opportunities. Lead: Researching - Perform research that leads to deeper understanding, addresses critical issues, and supports economic growth. Serve: Partnering - Engage in mutually beneficial partnerships to strengthen our communities in Dayton and around the world. In doing so, faculty and staff prototyped a social innovation approach and curriculum through a radical new integrated student experience while developing shared scholarship of research “stacks” across the University of Dayton and inter-institutional partners for greater humanity impact. This integrated learning community was driven by cross-university “transdisciplinary faculties” that encouraged a fail fast, fail forward mindset surrounding humanity-centered growth. The participating educators and students focused on a unified grand challenge, contributing their own knowledge and expertise toward a collective effort

Health related quality of life outcomes following surgery and/or radiation for patients with potentially unstable spinal metastases.

Currently there is no prospective pain and health related quality of life (HRQOL) data of patients with potentially unstable spinal metastases who were treated with surgery ± radiation or radiation alone.An international prospective cohort multicenter study of patients with potentially unstable spinal metastases, defined by a SINS score 7 to 12, treated with surgery ± radiation or radiotherapy alone was conducted. HRQOL was evaluated with the numeric rating scale (NRS) pain score, the SOSGOQ2.0, the SF-36, and the EQ-5D at baseline and 6, 12, 26, and 52 weeks after treatment.A total of 136 patients were treated with surgery ± radiotherapy and 84 with radiotherapy alone. At baseline, surgically treated patients were more likely to have mechanical pain, a lytic lesion, a greater median Spinal Instability Neoplastic score, vertebral compression fracture, lower performance status, HRQOL, and pain scores. From baseline to 12 weeks post-treatment, surgically treated patients experienced a 3.0-point decrease in NRS pain score (95% CI -4.1 to -1.9, p.001), and a 12.7-point increase in SOSGOQ2.0 score (95% CI 6.3-19.1, p.001). Patients treated with radiotherapy alone experienced a 1.4-point decrease in the NRS pain score (95% CI -2.9 to 0.0, p=.046) and a 6.2-point increase in SOSGOQ2.0 score (95% CI -2.0 to 14.5, p=.331). Beyond 12 weeks, significant improvements in pain and HRQOL metrics were maintained up to 52-weeks follow-up in the surgical cohort, as compared with no significant changes in the radiotherapy alone cohort.Patients treated with surgery demonstrated clinically and statistically significant improvements in pain and HRQOL up to 1-year postsurgery. Treatment with radiotherapy alone resulted in improved pain scores, but these were not sustained beyond 3 months and HRQOL outcomes demonstrated nonsignificant changes over time. Within the SINS potentially unstable group, distinct clinical profiles were observed in patients treated with surgery or radiotherapy alone

C5 Palsy After Cervical Spine Surgery: A Multicenter Retrospective Review of 59 Cases.

STUDY DESIGN: A multicenter, retrospective review of C5 palsy after cervical spine surgery. OBJECTIVE: Postoperative C5 palsy is a known complication of cervical decompressive spinal surgery. The goal of this study was to review the incidence, patient characteristics, and outcome of C5 palsy in patients undergoing cervical spine surgery. METHODS: We conducted a multicenter, retrospective review of 13 946 patients across 21 centers who received cervical spine surgery (levels C2 to C7) between January 1, 2005, and December 31, 2011, inclusive. P values were calculated using 2-sample t test for continuous variables and χ(2) tests or Fisher exact tests for categorical variables. RESULTS: Of the 13 946 cases reviewed, 59 patients experienced a postoperative C5 palsy. The incidence rate across the 21 sites ranged from 0% to 2.5%. At most recent follow-up, 32 patients reported complete resolution of symptoms (54.2%), 15 had symptoms resolve with residual effects (25.4%), 10 patients did not recover (17.0%), and 2 were lost to follow-up (3.4%). CONCLUSION: C5 palsy occurred in all surgical approaches and across a variety of diagnoses. The majority of patients had full recovery or recovery with residual effects. This study represents the largest series of North American patients reviewed to date