The Impact of a Campus-Based 4-H Summer Conference Program on Youth Thriving

In 2014 the Oregon 4-H program adopted a new program model to describe and evaluate the impact of 4-H on youths. The model is based on promoting thriving in young people, with an emphasis on high program quality. This article discusses the impact on thriving in 378 youth participants of the 4-H Summer Conference (4-HSC) program. The results of the study conducted provide preliminary support for the validity of the program model as well as the impact of the 4-HSC program on participants. Additionally, the study has implications for the use of program models in translating research into practice across Extension programs

From 4-H International Youth Exchange to Global Citizen: Common Pathways of Ten Past Program Participants

This qualitative study examined the life course of ten adults who participated as youth in the 4-H International Exchange program. The purpose of this research was to explore the pathways that led each participant to their exchange experience as a youth and how that experience set the stage for further development into an adulthood marked by cultural interest, awareness, competence and global citizenship. Using a grounded theory approach the data were analyzed through selective, open, and axial codings that elucidated a series of key events, opportunities, and qualities that form a common pathway among all participants. The results of this research contribute to the articulation of a theory of change upon which international youth exchange programs can be effectively developed and enhanced. Specific recommendations for international youth exchange programs are presented

Biochemical and genetic analysis of the role of the viral polymerase in enterovirus recombination

Funding: Biotechnology and Biological Sciences Research Council [BB/M009343/1] and PhD. studentship funding for AW (to D.J.E.); NIH [R01 AI045818 from NIAID to C.E.C.). Funding for open access charge: Biotechnology and Biological Sciences Research Council and University of St. Andrews.Genetic recombination in single-strand, positive-sense RNA viruses is a poorly understand mechanism responsible for generating extensive genetic change and novel phenotypes. By moving a critical cis-acting replication element (CRE) from the polyprotein coding region to the 3’ non-coding region we have further developed a cell-based assay (the 3’CRE-REP assay) to yield recombinants throughout the non-structural coding region of poliovirus from dually transfected cells. We have additionally developed a defined biochemical assay in which the only protein present is the poliovirus RNA dependent RNA polymerase (RdRp), which recapitulates the strand transfer events of the recombination process. We have used both assays to investigate the role of the polymerase fidelity and nucleotide turnover rates in recombination. Our results, of both poliovirus intertypic and intratypic recombination in the CRE-REP assay and using a range of polymerase variants in the biochemical assay, demonstrate that RdRp fidelity is a fundamental determinant of recombination frequency. High fidelity polymerases exhibit reduced recombination and low fidelity polymerases exhibit increased recombination in both assays. These studies provide the basis for the analysis of poliovirus recombination throughout the non-structural region of the virus genome and provide a defined biochemical assay to further dissect this important evolutionary process.Publisher PDFPeer reviewe

Conformational and Phase Transitions of Brush-like Macromolecules at Interfaces

Flexible molecular brushes have exhibited extraordinary conformational and phase behavior that is largely a result of their brush-like architecture. The interaction between the densely grafted side chains controls both the conformation of the flexible backbone (hence molecular shape) and the intramolecular interactions (hence ordering and mixing). The unusual behavior of molecular brushes was especially evident when studying either single adsorbed molecules or dense monolayers on substrates. Molecular imaging by atomic force microscopy in combination with Langmuir-Blodgett monolayer characterization and replication via a PFPE-based soft-lithography technique proved to be an invaluable tool to characterize molecular weight distributions, individual branch size distributions, and conformational transitions of individual brush-like macromolecules. These molecules were observed to undergo discrete conformational transitions in response to changes of substrate area and substrate chemical composition. The transitions depended on the details of the molecular branching architecture as well as the molecular chemical composition. In addition to the molecular properties, the brush architecture stabilized the ordering of disk-like macromolecules and enhanced the mixing of two otherwise immiscible polymers. Not only did they mix, but they also exhibited an ordered structure of alternating hydrophilic and hydrophobic molecules

An exploration of the organisational stressors encountered by international disability footballers

Presently, disability athletes remain under-represented in organisational stressor research. Our study sought to bring novel insights to this area by determining the organisational stressors experienced by international disability footballers. Twelve current international disability footballers (10 male, 2 female) from a range of UK impairment squads took part in the study. Semi-structured interviews were completed with each participant, and data were analysed by content analysis procedures. Organisational stressors data were abstracted into Arnold, Wagstaff, Steadman, and Pratt’s (2017) concepts, and Arnold and Fletcher’s (2012) four general dimensions: leadership and personnel issues, cultural and team issues, logistical and environmental issues, and performance and personal issues, revealing a series of football specific nuances. Our study is the first exploration of the prevalence of organisational stressors within international disability football. Our study also provides practitioners with an understanding of the common and unique organisational stressors faced by international disability footballers. Finally, we suggest a series of practical recommendations for policy development within disability football organisations to aid athletes to effective manage organisational stressors.</div

Thermal and Photochemical Reduction and Functionalization Chemistry of the Uranyl Dication, [U VI O2] 2+

The uranyl ion, [UVIO2]2+, possesses rigorously trans, strongly covalent, and chemically robust U-oxo groups. However, through the use of anaerobic reaction techniques, both one- and two-electron reductive functionalization of the uranyl oxo groups has been discovered and developed. Prior to 2010, this unusual reactivity centered around the reductive silylation of the uranyl ion which entailed conversion of the oxo ligands into siloxy ligands and reductive metalation of the uranyl oxo with Group 1 and f-block metals. This review surveys the large number of new examples of reductive functionalization of the uranyl ion that have been reported since 2010, including reductive borylation and alumination, metalation with d- or f-block metals, and new examples of reductive silylation. Other examples of oxo-group functionalization of [UVIO2]2+ that do not involve reduction, mainly with Group 1 cations, are also covered, along with new advances in the photochemistry of the uranyl(VI) ion that involve the transient formation of formally uranyl(V) [UVO2]+ ion

Employee engagement, human resource management practices and competitive advantage

AbstractPurpose - The purpose of this paper is to argue in support of a model that shows how four key HRM practices focused on engagement influence organizational climate, job demands and job resources, the psychological experiences of safety, meaningfulness and availability at work, employee engagement, and individual, group and organizational performance and competitive advantage.Design/methodology/approach - This conceptual review focuses on the research evidence showing interrelationships between organizational context factors, job factors, individual employee psychological and motivational factors, employee outcomes, organizational outcomes and competitive advantage. The proposed model integrates frameworks that have previously run independently in the HR and engagement literatures.Findings - The authors conclude that HRM practitioners need to move beyond the routine administration of annual engagement surveys and need to embed engagement in HRM policies and practices such personnel selection, socialization, performance management, and training and development.Practical implications - The authors offer organizations clear guidelines for how HR practices (i.e. selection, socialization, performance management, training) can be used to facilitate and improve employee engagement and result in positive outcomes that will help organizations achieve a competitive advantage.Originality/value - The authors provide useful new insights for researchers and management professionals wishing to embed engagement within the fabric of HRM policies and practices and employee behaviour, and organizational outcomes.<br /

From 4-H International Youth Exchange to Global Citizen: Common Pathways of Ten Past Program Participants

This qualitative study examined the life course of ten adults who participated as youth in the 4-H International Exchange program. The purpose of this research was to explore the pathways that led each participant to their exchange experience as a youth and how that experience set the stage for further development into an adulthood marked by cultural interest, awareness, competence and global citizenship. Using a grounded theory approach the data were analyzed through selective, open, and axial codings that elucidated a series of key events, opportunities, and qualities that form a common pathway among all participants. The results of this research contribute to the articulation of a theory of change upon which international youth exchange programs can be effectively developed and enhanced. Specific recommendations for international youth exchange programs are presented

Investcorp

Investcorp is a publicly traded global alternative asset management company headquartered in Manama, Bahrain. It manages a huge hedge fund, along with other assets. The case describes Investcorp’s history, investment strategies, and major competitors. The company has a highly aggressive growth strategy, but it is also facing the retirement of its CEO