The radio source B 1834+620: A double-double radio galaxy with interesting properties

We present a study of the peculiar radio galaxy B 1834+620. It is characterised by the presence of a 420-kpc large edge-brightened radio source which is situated within, and well aligned with, a larger (1.66 Mpc) radio source. Both sources apparently originate in the same host galaxy, which has a R_s-magnitude of 19.7 and a redshift of 0.5194, as determined from the strong emission-lines in the spectrum. We have determined the rotation measures towards this source, as well as the radio spectral energy distribution of its components. The radio spectrum of the large outer source is steeper than that of the smaller inner source. The radio core has a spectrum that peaks at a frequency of a few GHz. The rotation measures towards the four main components are quite similar, within $\sim\!2$ rad m$^{-2}$ of 58 rad m$^{-2}$. They are probably largely galactic in origin. We have used the presence of a bright hotspot in the northern outer lobe to constrain the advance velocity of the inner radio lobes to the range between 0.19c and 0.29c, depending on the orientation of the source. This corresponds to an age of this structure in the range between 2.6 and 5.8 Myr. We estimate a density of the ambient medium of the inner lobes of \la 1.6 \times 10^{-30} gr\,cm$^{-3}$ (particle density \la 8 \times 10^{-7} cm$^{-3}$). A low ambient density is further supported by the discrepancy between the large optical emission-line luminosity of the host galaxy and the relatively low radio power of the inner lobes.Comment: Accepted for publication in MNRA

The effects of increased therapy time on cognition and mood in frail patients with a stroke who rehabilitate on rehabilitation units of nursing homes in the Netherlands: a protocol of a comparative study

BACKGROUND: Recovery after stroke is dependent on how much time can be spent on rehabilitation. Recently, we found that therapy time for older stroke patients on a rehabilitation unit of a nursing home could be increased significantly from 8.6 to at least 13 hours a week. This increase was attained by the implementation of interventions, focused on strength, mobility and balance. Nurses carried out these exercises with the patients during their daily activities. The aim of the present study is to investigate if increased therapy time has a positive effect on cognition, mood (depression and anxiety), and ADL in stroke patients. METHODS: A comparative single blind controlled study will be applied. Patients suffering from a stroke and staying on one of the rehabilitation units of the nursing homes are eligible for participation. Participants belong to the intervention group if they stay in two nursing homes where four interventions of the Clinical Nursing Rehabilitation Stroke Guideline were implemented. Participants who stay in two nursing homes where therapy is given according to the Dutch stroke Guideline, are included in the control group. Clinical neuropsychologists will assess patients’ cognitive functioning, level of depression (mood) and anxiety. Nurses will assess a Barthel Index score on a weekly basis (ADL). These variables are measured at baseline, after 8 weeks and at the moment when participants are discharged from the nursing home. DISCUSSION: The present study evaluates the effect of increased therapy time on cognition, mood (level of depression and anxiety), and ADL in stroke patients. When positive effects will be found this study can guide policy makers and practitioners on how to implement more therapy time on rehabilitation wards of nursing homes. TRIAL REGISTRATION: TNR Our study has been documented in the Dutch Trial Registration, TC = 3871

The carbon footprint of NL astronomy in 2019

Science Communication and Societ

Episodic Star Formation Coupled to Reignition of Radio Activity in 3C 236

We present Hubble Space Telescope UV and optical imaging of the radio galaxy 3C 236, whose relic 4 Mpc radio jet lobes and inner 2 kpc CSS radio source are evidence of multiple epochs of AGN activity. Our data confirm the presence of four bright knots of FUV emission in an arc along the edge of the inner circumnuclear dust disk in the galaxy's nucleus, as well as FUV emission cospatial with the nucleus itself. We interpret these to be sites of recent or ongoing star formation. We present photometry of these knots, as well as an estimate for the internal extinction in the source using the Balmer decrement from SDSS spectroscopy. We estimate the ages of the knots by comparing our extinction-corrected photometry with stellar population synthesis models. We find the four knots cospatial with the dusty disk to be young, of order 10^7 yr old. The FUV emission in the nucleus is likely due to an episode of star formation triggered ~10^9 yr ago. We argue that the young 10^7 yr old knots stem from an episode of star formation that was roughly coeval with the event resulting in reignition of radio activity, creating the CSS source. The 10^9 yr old stars in the nucleus may be associated with the previous epoch of activity that generated the 4 Mpc relic source, before it was cut off by exhaustion or interruption. The ages of the knots, considered in context with the disturbed morphology of the nuclear dust and the double-double morphology of the "old" and "young" radio sources, present evidence for an episodic AGN/starburst connection. We suggest that the AGN fuel supply was interrupted for ~10^7 yr due to a minor merger event and has now been restored, and the resultant non-steady flow of gas toward the nucleus is likely responsible for both the new episode of infall-induced star formation and also the multiple epochs of radio activity.Comment: 15 pages, 7 figures. Accepted for publication in ApJ

Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.

The occurrence of non-epileptic hyperkinetic movements in the context of developmental epileptic encephalopathies is an increasingly recognized phenomenon. Identification of causative mutations provides an important insight into common pathogenic mechanisms that cause both seizures and abnormal motor control. We report bi-allelic loss-of-function CACNA1B variants in six children from three unrelated families whose affected members present with a complex and progressive neurological syndrome. All affected individuals presented with epileptic encephalopathy, severe neurodevelopmental delay (often with regression), and a hyperkinetic movement disorder. Additional neurological features included postnatal microcephaly and hypotonia. Five children died in childhood or adolescence (mean age of death: 9 years), mainly as a result of secondary respiratory complications. CACNA1B encodes the pore-forming subunit of the pre-synaptic neuronal voltage-gated calcium channel Cav2.2/N-type, crucial for SNARE-mediated neurotransmission, particularly in the early postnatal period. Bi-allelic loss-of-function variants in CACNA1B are predicted to cause disruption of Ca2+ influx, leading to impaired synaptic neurotransmission. The resultant effect on neuronal function is likely to be important in the development of involuntary movements and epilepsy. Overall, our findings provide further evidence for the key role of Cav2.2 in normal human neurodevelopment.MAK is funded by an NIHR Research Professorship and receives funding from the Wellcome Trust, Great Ormond Street Children's Hospital Charity, and Rosetrees Trust. E.M. received funding from the Rosetrees Trust (CD-A53) and Great Ormond Street Hospital Children's Charity. K.G. received funding from Temple Street Foundation. A.M. is funded by Great Ormond Street Hospital, the National Institute for Health Research (NIHR), and Biomedical Research Centre. F.L.R. and D.G. are funded by Cambridge Biomedical Research Centre. K.C. and A.S.J. are funded by NIHR Bioresource for Rare Diseases. The DDD Study presents independent research commissioned by the Health Innovation Challenge Fund (grant number HICF-1009-003), a parallel funding partnership between the Wellcome Trust and the Department of Health, and the Wellcome Trust Sanger Institute (grant number WT098051). We acknowledge support from the UK Department of Health via the NIHR comprehensive Biomedical Research Centre award to Guy's and St. Thomas' National Health Service (NHS) Foundation Trust in partnership with King's College London. This research was also supported by the NIHR Great Ormond Street Hospital Biomedical Research Centre. J.H.C. is in receipt of an NIHR Senior Investigator Award. The research team acknowledges the support of the NIHR through the Comprehensive Clinical Research Network. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, Department of Health, or Wellcome Trust. E.R.M. acknowledges support from NIHR Cambridge Biomedical Research Centre, an NIHR Senior Investigator Award, and the University of Cambridge has received salary support in respect of E.R.M. from the NHS in the East of England through the Clinical Academic Reserve. I.E.S. is supported by the National Health and Medical Research Council of Australia (Program Grant and Practitioner Fellowship)

Radio galaxies with a 'double-double' morphology - II. The evolution of double-double radio galaxies and implications for the alignment effect in FRII sources

A double-double radio galaxy (DDRG) is defined as consisting of a pair of double radio sources with a common centre. In this paper we present an analytical model in which the peculiar radio structure of DDRGs is caused by an interruption of the jet flow in the central AGN. The new jets emerging from the restarted AGN give rise to an inner source structure within the region of the old, outer cocoon. Standard models of the evolution of FRII sources predict gas densities within the region of the old cocoon that are insufficient to explain the observed properties of the inner source structure. Therefore additional material must have passed from the environment of the source through the bow shock surrounding the outer source structure into the cocoon. We propose that this material is warm clouds (~104 K) of gas embedded in the hot IGM which are eventually dispersed over the cocoon volume by surface instabilities induced by the passage of cocoon material. The derived lower limits for the volume filling factors of these clouds are in good agreement with results obtained from optical observations. The long time-scales for the dispersion of the clouds (~107 yr) are consistent with the apparently exclusive occurrence of the DDRG phenomenon in large (≥700 kpc) radio sources, and with the observed correlation of the strength of the optical/UV alignment effect in z ~1 FRII sources with their linear size

Autonomous mesoscale positioning emerging from myelin filament self-organization and Marangoni flows

Contains fulltext : 225036.pdf (publisher's version ) (Open Access

Radio galaxies with a 'double-double morphology' - I. Analysis of the radio properties and evidence for interrupted activity in active galactic nuclei

We present four Mpc-sized radio galaxies which consist of a pair of double-lobed radio sources, aligned along the same axis, and with a coinciding radio core. We call these peculiar radio sources 'double-double' radio galaxies (DDRGs) and propose a general definition of such sources: a 'double-double' radio galaxy consists of a pair of double radio sources with a common centre. Furthermore, the two lobes of the inner radio source must have a clearly extended, edge-brightened radio morphology. Adopting this definition, we find several other candidate DDRGs in the literature. We find that in all sources the smaller (inner) pair of radio lobes is less luminous than the larger (outer) pair, and that the ratio of 1.4-GHz flux density of these two pairs appears to be anticorrelated with the projected linear size of the inner source. Also, the outer radio structures are large, exceeding 700kpc. We discuss possible formation scenarios of the DDRGs, and we conclude that an interruption of the jet-forming central activity is the most likely mechanism. For one of our sources (B1834+620) we have been able observationally to constrain the length of time of the interruption to a few Myr. We discuss several scenarios for the cause of the interruption, and suggest multiple encounters between interacting galaxies as a possibility. Finally, we discuss whether such interruptions help the formation of extremely large radio sources

Autonomous Mesoscale Positioning Emerging from Spatiotemporally Controlled Coupling Between Self-Assembly and Gradient-Driven Molecular Fluxes

Out-of-equilibrium molecular systems hold great promise as dynamic, reconfigurable matter that executes complex tasks autonomously. However, translating molecular scale dynamics into spatiotemporally controlled phenomena at mesoscopic length scales remains a challenge. In living cells, reliable positioning processes such as the centering of the centrosome involve forces that result from dissipative self-assembly. We demonstrate how spatiotemporal positioning emerges in synthetic systems where self-assembly is coupled to molecular fluxes originating from concentration gradients. At the core of our system are millimeter long self-assembled filaments and Marangoni flows induced by non-uniform amphiphile distributions. We demonstrate how repulsive and attractive forces that are generated as filaments organize between source and drain droplets sustain autonomous positioning of dynamic assemblies at the mesoscale. Our concepts provide a new paradigm for the development of non-equilibrium matter with spatiotemporal programmability. </p