Niizhaaweynima-nimama (Mother Earth Song)

This study investigates factors that have contributed to other Indigenous Peoples’ successes at the post-secondary level in graduate studies by interviewing Indigenous People that have gone through the system and have graduated. The study examines how Indigenous ways of knowing, seeing, doing and being contribute to an Indigenous scholar’s success while in a Eurocentric educational setting. By exploring how Indigenous ways of knowing, seeing, doing and being have contributed to the success of Indigenous People at the post-secondary and graduate level, this may provide insight into helping future generations of Indigenous scholars understand how Indigenous traditions assist them in fulfilling their responsibilities to family, community, and scholarship. What was found was the importance of relationships and how these relationships are woven into each scholars’ work through an Indigenous way of knowing, seeing doing and being. The study is framed from the unique perspective of a traditional Indigenous male, who is a single parent

Theoretical Limb Darkening for Classical Cepheids: II. Corrections for the Geometric Baade-Wesselink Method

The geometric Baade-Wesselink method is one of the most promising techniques for obtaining a better calibration of the Cepheid period-luminosity relation by means of interferometric measurements of accurate diameters. In this paper we present new wavelength- and phase-dependent limb darkening corrections based on our time-dependent hydrodynamic models of the classical Cepheid zeta Gem. We show that a model simulation of a Cepheid atmosphere, taking into account the hydrodynamic effects associated with the pulsation, shows strong departures from the limb darkening otherwise predicted by a static model. For most of its pulsational cycle the hydrodynamic model predicts a larger limb darkening then the equivalent static model. The hydrodynamics affects the limb darkening mainly at UV and optical wavelengths. Most of these effects evolve slowly as the star pulsates, but there are phases, associated with shocks propagating into the photosphere, in which significant changes in the limb darkening take place on time-scales of the order of less than a day. We assess the implication of our model LD corrections fitting the geometric Baade-Wesselink distance of zeta Gem for the available near-IR PTI data. We discuss the effects of our model limb darkening on the best fit result, and analyze the requirements needed to test the time-dependence of the limb darkening with future interferometric measurements.Comment: 22 pages, 5 figures, to be published on the Astrophysical Journal, June 1 2003 issu

Improved spacecraft radio science using an on-board atomic clock: application to gravitational wave searches

Recent advances in space-qualified atomic clocks (low-mass, low power-consumption, frequency stability comparable to that of ground-based clocks) can enable interplanetary spacecraft radio science experiments at unprecedented Doppler sensitivities. The addition of an on-board digital receiver would allow the up- and down-link Doppler frequencies to be measured separately. Such separate, high-quality measurements allow optimal data combinations that suppress the currently-leading noise sources: phase scintillation noise from the Earth's atmosphere and Doppler noise caused by mechanical vibrations of the ground antenna. Here we provide a general expression for the optimal combination of ground and on-board Doppler data and compute the sensitivity such a system would have to low-frequency gravitational waves (GWs). Assuming a plasma scintillation noise calibration comparable to that already demonstrated with the multi-link CASSINI radio system, the space-clock/digital-receiver instrumentation enhancements would give GW strain sensitivity of $2.0 \times 10^{-17}$ for randomly polarized, monochromatic GW signals over a two-decade ($\sim0.0001-0.01$ Hz) region of the low-frequency band. This is about an order of magnitude better than currently achieved with traditional two-way coherent Doppler experiments. The utility of optimally combining simultaneous up- and down-link observations is not limited to GW searches. The Doppler tracking technique discussed here could be performed at minimal incremental cost to also improve other radio science experiments (i.e. tests of relativistic gravity, planetary and satellite gravity field measurements, atmospheric and ring occultations) on future interplanetary missions.Comment: 21 pages, 5 figures. Submitted to Phys. Rev.

Mesoproterozoic surface oxygenation accompanied major sedimentary manganese deposition at 1.4 and 1.1 Ga

This research was funded by the Australian Science and Industry Endowment Fund (SIEF) as part of The Distal Footprints of Giant Ore Systems: UNCOVER Australia Project (RP04-063)—Capricorn Distal Footprints. EAS also thanks the donors of The American Chemical Society Petroleum Research Fund for partial support of this research (61017-ND2).Peer reviewedPublisher PD

The influence of increased passive stiffness of the trunk and hips on balance control during reactive stepping

The final publication is available at Elsevier via https://doi.org/10.1016/j.gaitpost.2019.05.018. © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/Background Age-related changes, which include increased trunk and hip stiffness, negatively influence postural balance. While previous studies suggest no net-effect of trunk and hip stiffness on initial trip-recovery responses, no study to date has examined potential effects during the dynamic restabilisation phase following foot contact. Research question Does increased trunk and hip stiffness, in isolation from other ageing effects, negatively influence balance during the restabilisation phase of reactive stepping. Methods Balance perturbations were applied using a tether-release paradigm, which required participants to react with a single-forward step. Sixteen young adults completed two blocks of testing: a baseline and an increased stiffness (corset) condition. Whole-body kinematics were utilized to estimate spatial step parameters, center of mass (COM), COM incongruity (peak - final position) and time to restabilisation, in anteroposterior (AP) and mediolateral (ML) directions. Results In the corset condition, peak COM displacement was increased in both directions (p  0.233). Increased passive stiffness also increased the magnitude and variability of peak shear ground reaction force, COM incongruity, and time to restabilisation in the ML (but not AP) direction (p < 0.027). Significance In contrast to previous literature, increased stiffness resulted in greater peak COM displacement in both directions. Our results suggest increased trunk and hip stiffness have detrimental effects on dynamic stability following a reactive step, particularly in the ML direction. Observed increases in magnitude and variability of COM incongruity suggest the likelihood of a sufficiently large loss of ML stability - requiring additional steps - was increased by stiffening of the hips and trunk. The current findings suggest interventions aiming to mobilize the trunk and hips, in conjunction with strengthening, could improve balance and reduce the risk of falls.This research was funded in part by grants from the Natural Sciences and Engineering Research Council of Canada (RGPIN-2015-03636), the Canadian Foundation for Innovation (Grant #25351) and the Ontario Ministry of Research and Innovation (Grant #25351 and ER14-10-236)

Structures of Phytophthora RXLR Effector Proteins: a conserved but adaptable fold underpins functional diversity

Phytopathogens deliver effector proteins inside host plant cells to promote infection. These proteins can also be sensed by the plant immune system, leading to restriction of pathogen growth. Effector genes can display signatures of positive selection and rapid evolution, presumably a consequence of their co-evolutionary arms race with plants. The molecular mechanisms underlying how effectors evolve to gain new virulence functions and/or evade the plant immune system are poorly understood. Here, we report the crystal structures of the effector domains from two oomycete RXLR proteins, Phytophthora capsici AVR3a11 and Phytophthora infestans PexRD2. Despite sharin

Real-world outcomes of sipuleucel-T treatment in PROCEED, a prospective registry of men with metastatic castration-resistant prostate cancer.

BackgroundThe large registry, PROVENGE Registry for the Observation, Collection, and Evaluation of Experience Data (PROCEED)(NCT01306890), evaluated sipuleucel-T immunotherapy for asymptomatic/minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC).MethodsPROCEED enrolled patients with mCRPC receiving 3 biweekly sipuleucel-T infusions. Assessments included overall survival (OS), serious adverse events (SAEs), cerebrovascular events (CVEs), and anticancer interventions (ACIs). Follow-up was for ≥3&nbsp;years or until death or study withdrawal.ResultsIn 2011-2017, 1976 patients were followed for 46.6&nbsp;months (median). The median age was 72&nbsp;years, and the baseline median prostate-specific antigen level was 15.0&nbsp;ng/mL; 86.7% were white, and 11.6% were African American. Among the patients, 1902 had 1 or more sipuleucel-T infusions. The median OS was 30.7&nbsp;months (95% confidence interval [CI], 28.6-32.2&nbsp;months). Known prognostic factors were independently associated with OS in a multivariable analysis. Among the 1255 patients who died, 964 (76.8%) died of prostate cancer (PC) progression. The median time from the first infusion to PC death was 42.7&nbsp;months (95% CI, 39.4-46.2&nbsp;months). The incidence of sipuleucel-T-related SAEs was 3.9%. The incidence of CVEs was 2.8%, and the rate per 100 person-years was 1.2 (95% CI, 0.9-1.6). The CVE incidence among 11,972 patients with mCRPC from the Surveillance, Epidemiology, and End Results-Medicare database was 2.8%; the rate per 100 person-years was 1.5 (95% CI, 1.4-1.7). One or more ACIs (abiraterone, enzalutamide, docetaxel, cabazitaxel, or radium 223) were received by 77.1% of the patients after sipuleucel-T; 32.5% and 17.4% of the patients experienced 1- and 2-year treatment-free intervals, respectively.ConclusionsPROCEED provides contemporary survival data for sipuleucel-T-treated men in a real-world setting of new life-prolonging agents, which will be useful in discussing treatment options with patients and in powering future trials with sipuleucel-T. The safety and tolerability of sipuleucel-T in PROCEED were consistent with previous findings