Elimination of Clock Jitter Noise in Spaceborn Laser Interferometers

Space gravitational wave detectors employing laser interferometry between free-flying spacecraft differ in many ways from their laboratory counterparts. Among these differences is the fact that, in space, the end-masses will be moving relative to each other. This creates a problem by inducing a Doppler shift between the incoming and outgoing frequencies. The resulting beat frequency is so high that its phase cannot be read to sufficient accuracy when referenced to state-of-the-art space-qualified clocks. This is the problem that is addressed in this paper. We introduce a set of time-domain algorithms in which the effects of clock jitter are exactly canceled. The method employs the two-color laser approach that has been previously proposed, but avoids the singularities that arise in the previous frequency-domain algorithms. In addition, several practical aspects of the laser and clock noise cancellation schemes are addressed.Comment: 20 pages, 5 figure

Crystal Indentation Hardness

There is expanded interest in the long-standing subject of the hardness properties of materials. A major part of such interest is due to the advent of nanoindentation hardness testing systems which have made available orders of magnitude increases in load and displacement measuring capabilities achieved in a continuously recorded test procedure. The new results have been smoothly merged with other advances in conventional hardness testing and with parallel developments in improved model descriptions of both elastic contact mechanics and dislocation mechanisms operative in the understanding of crystal plasticity and fracturing behaviors. No crystal is either too soft or too hard to prevent the determination of its elastic, plastic and cracking properties under a suitable probing indenter. A sampling of the wealth of measurements and reported analyses associated with the topic on a wide variety of materials are presented in the current Special Issue

NYMPH: A multiprocessor for manipulation applications

The robotics group of the Stanford Artificial Intelligence Laboratory is currently developing a new computational system for robotics applications. Stanford's NYMPH system uses multiple NSC 32016 processors and one MC68010 based processor, sharing a common Intel Multibus. The 32K processors provide the raw computational power needed for advanced robotics applications, and the 68K provides a pleasant interface with the rest of the world. Software has been developed to provide useful communications and synchronization primitives, without consuming excessive processor resources or bus bandwidth. NYMPH provides both large amounts of computing power and a good programming environment, making it an effective research tool

Approaches for scalable modeling and emulation of cyber systems : LDRD final report.

The goal of this research was to combine theoretical and computational approaches to better understand the potential emergent behaviors of large-scale cyber systems, such as networks of {approx} 10{sup 6} computers. The scale and sophistication of modern computer software, hardware, and deployed networked systems have significantly exceeded the computational research community's ability to understand, model, and predict current and future behaviors. This predictive understanding, however, is critical to the development of new approaches for proactively designing new systems or enhancing existing systems with robustness to current and future cyber threats, including distributed malware such as botnets. We have developed preliminary theoretical and modeling capabilities that can ultimately answer questions such as: How would we reboot the Internet if it were taken down? Can we change network protocols to make them more secure without disrupting existing Internet connectivity and traffic flow? We have begun to address these issues by developing new capabilities for understanding and modeling Internet systems at scale. Specifically, we have addressed the need for scalable network simulation by carrying out emulations of a network with {approx} 10{sup 6} virtualized operating system instances on a high-performance computing cluster - a 'virtual Internet'. We have also explored mappings between previously studied emergent behaviors of complex systems and their potential cyber counterparts. Our results provide foundational capabilities for further research toward understanding the effects of complexity in cyber systems, to allow anticipating and thwarting hackers

The Ursinus Weekly, March 1, 1954

Helfferich tells causes of delay in Union work • U.C. Supply Store resumes full operation today • Ruby show to be presented • Band starts practice for Spring concert • Composition and technique discussed by Walter Hansen • Summer School to feature single session • U. of Penn band to present concert here • Dorthee von Miller to speak at AAUW program Wed. • Spring play cast revealed; Wright, Rack in lead roles • WSGA group holds meeting • John Canady to speak at seminar sessions • WAA will present variety show Mar. 11 • Dr. Allan Rice to present Scandinavian readings • Editorials: Support the Supply; Chinese controversy • Unusual campus rules • She felt like a young colt; But looked like an old .45 • Al Sare tells of Navy life • Reporter misses big scoop; Must turn in notebook • Just plain Bill reports Belles vs. Albright game • Little Belles top Bryn Mawr • Muhlenberg decisions Bears in heartbreaker • Shreiner, Hobson, South, Rimby\u27s, Maples win • Cagemen top Fords in two overtimes • Belles down C. Hill, 57-13 • Bears top Drexel, 24-8 prior to M.A.C. wrestling • Chestnut Hill topples U.C. mermaids, 37-19 • PMC squeezes netmen to win • Snell\u27s Belles win again; Hand Wagner 55-20 losshttps://digitalcommons.ursinus.edu/weekly/1490/thumbnail.jp

The Ursinus Weekly, March 1, 1954

Helfferich tells causes of delay in Union work • U.C. Supply Store resumes full operation today • Ruby show to be presented • Band starts practice for Spring concert • Composition and technique discussed by Walter Hansen • Summer School to feature single session • U. of Penn band to present concert here • Dorthee von Miller to speak at AAUW program Wed. • Spring play cast revealed; Wright, Rack in lead roles • WSGA group holds meeting • John Canady to speak at seminar sessions • WAA will present variety show Mar. 11 • Dr. Allan Rice to present Scandinavian readings • Editorials: Support the Supply; Chinese controversy • Unusual campus rules • She felt like a young colt; But looked like an old .45 • Al Sare tells of Navy life • Reporter misses big scoop; Must turn in notebook • Just plain Bill reports Belles vs. Albright game • Little Belles top Bryn Mawr • Muhlenberg decisions Bears in heartbreaker • Shreiner, Hobson, South, Rimby\u27s, Maples win • Cagemen top Fords in two overtimes • Belles down C. Hill, 57-13 • Bears top Drexel, 24-8 prior to M.A.C. wrestling • Chestnut Hill topples U.C. mermaids, 37-19 • PMC squeezes netmen to win • Snell\u27s Belles win again; Hand Wagner 55-20 losshttps://digitalcommons.ursinus.edu/weekly/1490/thumbnail.jp

Real-world outcomes of sipuleucel-T treatment in PROCEED, a prospective registry of men with metastatic castration-resistant prostate cancer.

BackgroundThe large registry, PROVENGE Registry for the Observation, Collection, and Evaluation of Experience Data (PROCEED)(NCT01306890), evaluated sipuleucel-T immunotherapy for asymptomatic/minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC).MethodsPROCEED enrolled patients with mCRPC receiving 3 biweekly sipuleucel-T infusions. Assessments included overall survival (OS), serious adverse events (SAEs), cerebrovascular events (CVEs), and anticancer interventions (ACIs). Follow-up was for ≥3 years or until death or study withdrawal.ResultsIn 2011-2017, 1976 patients were followed for 46.6 months (median). The median age was 72 years, and the baseline median prostate-specific antigen level was 15.0 ng/mL; 86.7% were white, and 11.6% were African American. Among the patients, 1902 had 1 or more sipuleucel-T infusions. The median OS was 30.7 months (95% confidence interval [CI], 28.6-32.2 months). Known prognostic factors were independently associated with OS in a multivariable analysis. Among the 1255 patients who died, 964 (76.8%) died of prostate cancer (PC) progression. The median time from the first infusion to PC death was 42.7 months (95% CI, 39.4-46.2 months). The incidence of sipuleucel-T-related SAEs was 3.9%. The incidence of CVEs was 2.8%, and the rate per 100 person-years was 1.2 (95% CI, 0.9-1.6). The CVE incidence among 11,972 patients with mCRPC from the Surveillance, Epidemiology, and End Results-Medicare database was 2.8%; the rate per 100 person-years was 1.5 (95% CI, 1.4-1.7). One or more ACIs (abiraterone, enzalutamide, docetaxel, cabazitaxel, or radium 223) were received by 77.1% of the patients after sipuleucel-T; 32.5% and 17.4% of the patients experienced 1- and 2-year treatment-free intervals, respectively.ConclusionsPROCEED provides contemporary survival data for sipuleucel-T-treated men in a real-world setting of new life-prolonging agents, which will be useful in discussing treatment options with patients and in powering future trials with sipuleucel-T. The safety and tolerability of sipuleucel-T in PROCEED were consistent with previous findings

Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate

Contains fulltext : 34911.pdf (publisher's version ) (Open Access)BACKGROUND: The common marmoset monkey (Callithrix jacchus), a small non-endangered New World primate native to eastern Brazil, is becoming increasingly used as a non-human primate model in biomedical research, drug development and safety assessment. In contrast to the growing interest for the marmoset as an animal model, the molecular tools for genetic analysis are extremely limited. RESULTS: Here we report the development of the first marmoset-specific oligonucleotide microarray (EUMAMA) containing probe sets targeting 1541 different marmoset transcripts expressed in hippocampus. These 1541 transcripts represent a wide variety of different functional gene classes. Hybridisation of the marmoset microarray with labelled RNA from hippocampus, cortex and a panel of 7 different peripheral tissues resulted in high detection rates of 85% in the neuronal tissues and on average 70% in the non-neuronal tissues. The expression profiles of the 2 neuronal tissues, hippocampus and cortex, were highly similar, as indicated by a correlation coefficient of 0.96. Several transcripts with a tissue-specific pattern of expression were identified. Besides the marmoset microarray we have generated 3215 ESTs derived from marmoset hippocampus, which have been annotated and submitted to GenBank [GenBank: EF214838-EF215447, EH380242-EH382846]. CONCLUSION: We have generated the first marmoset-specific DNA microarray and demonstrated its use to characterise large-scale gene expression profiles of hippocampus but also of other neuronal and non-neuronal tissues. In addition, we have generated a large collection of ESTs of marmoset origin, which are now available in the public domain. These new tools will facilitate molecular genetic research into this non-human primate animal model

Financing water resource infrastructure, 1987 September 1

The contents of this paper were drafted from a workgroup report to an Engineering Foundation Conference entitled Financing and Amortizing Water Resources Infrastructure held at Palm Coast, Florida, March 29-April 3, 1987. A slightly different version of this paper appeared in the conference proceedings