Recent Progress Made in the Development of High-Energy UV Transmitter

In this paper, the status of an all-solid-state UV converter development for ozone sensing applications is discussed. A high energy Nd:YAG laser for pumping the UV converter arrangement was recently reported. The pump is an all-solid-state, single longitudinal mode, and conductively cooled Nd:YAG laser operating at 1064 nm wavelength. Currently, this pump laser provides an output pulse energy of greater than 1J/pulse at 50 Hz PRF and a pulsewidth of 22 ns with an electrical-to-optical system efficiency of greater than 7% and a M(sup 2) value of approx. 2. The spatial profile of the output beam is a rectangular super Gaussian. This Nd:YAG pump laser has been developed to pump the nonlinear optics based UV converter arrangement to generate 320 nm and 308 nm wavelengths by means of 532 nm wavelength. Previously, this UV converter arrangement has demonstrated IR-to-UV conversion efficiency of 24% using a flash lamp pumped laser providing a round, flat top spatial profile. Recently, the UV converter was assembled and tested at NASA LaRC for pumping with the diode pumped Nd:YAG laser. With current spatial profile, the UV converter was made operational. Current efforts to maximize the nonlinear conversion efficiency by refining its spatial profile to match RISTRA OPO requirements are progressing

Single-mode, All-Solid-State Nd:YAG Laser Pumped UV Converter

In this paper, the status of a high-energy, all solid-state Nd:YAG laser pumped nonlinear optics based UV converter development is discussed. The high-energy UV transmitter technology is being developed for ozone sensing applications from space based platforms using differential lidar technique. The goal is to generate greater than 200 mJ/pulse with 10-50 Hz PRF at wavelengths of 308 nm and 320 nm. A diode-pumped, all-solid-state and single longitudinal mode Nd:YAG laser designed to provide conductively cooled operation at 1064 nm has been built and tested. Currently, this pump laser provides an output pulse energy of >1 J/pulse at 50 Hz PRF and a pulsewidth of 22 ns with an electrical-to-optical system efficiency of greater than 7% and a M(sup 2) value of <2. The single frequency UV converter arrangement basically consists of an IR Optical Parametric Oscillator (OPO) and a Sum Frequency Generator (SFG) setups that are pumped by 532 nm wavelength obtained via Second Harmonic Generation (SHG). In this paper, the operation of an inter cavity SFG with CW laser seeding scheme generating 320 nm wavelength is presented. Efforts are underway to improve conversion efficiency of this mJ class UV converter by modifying the spatial beam profile of the pump laser

Resolvin E1 Derived from Eicosapentaenoic Acid Prevents Hyperinsulinemia and Hyperglycemia in a Host Genetic Manner

The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology Eicosapentaenoic acid (EPA) has garnered attention after the success of the REDUCE-IT trial, which contradicted previous conclusions on EPA for cardiovascular disease risk. Here we first investigated EPA\u27s preventative role on hyperglycemia and hyperinsulinemia. EPA ethyl esters prevented obesity-induced glucose intolerance, hyperinsulinemia, and hyperglycemia in C57BL/6J mice. Supporting NHANES analyses showed that fasting glucose levels of obese adults were inversely related to EPA intake. We next investigated how EPA improved murine hyperinsulinemia and hyperglycemia. EPA overturned the obesity-driven decrement in the concentration of 18-hydroxyeicosapentaenoic acid (18-HEPE) in white adipose tissue and liver. Treatment of obese inbred mice with RvE1, the downstream immunoresolvant metabolite of 18-HEPE, but not 18-HEPE itself, reversed hyperinsulinemia and hyperglycemia through the G-protein coupled receptor ERV1/ChemR23. To translate the findings, we determined if the effects of RvE1 were dependent on host genetics. RvE1\u27s effects on hyperinsulinemia and hyperglycemia were divergent in diversity outbred mice that model human genetic variation. Secondary SNP analyses further confirmed extensive genetic variation in human RvE1/EPA-metabolizing genes. Collectively, the data suggest EPA prevents hyperinsulinemia and hyperglycemia, in part, through RvE1\u27s activation of ERV1/ChemR23 in a host genetic manner. The studies underscore the need for personalized administration of RvE1 based on genetic/metabolic enzyme profiles

Generation of vortex beams by an image-rotating optical parametric oscillator,” Opt

Abstract: We generate optical vortex beams in a nanosecond optical parametric oscillator based on an image-rotating resonator. This efficient new method of vortex generation should be adaptable to pulsed or continuous lasers

Provenance of volcanic clasts from the Santa Fe Group, Culebra graben of the San Luis Basin, Colorado: A guide to tectonic evolution

Volcanic clasts incorporated in the lower portion of the Tertiary Santa Fe Group sedimentary rocks of the Culebra graben, San Luis Basin, Colorado, provide constraints on the timing of regional tectonic events by provenance determination. Based on currently exposed volcanic terrains, possible clast sources include Spanish Peaks and Mount Mestas to the east, the San Juan volcanic field to the west, and the Thirtynine Mile volcanic field, a remnant of the Central Colorado volcanic field, to the north and east of the San Luis Basin. Provenance was determined by a variety of geochemical, mineral chemical, and geochronologic data. Large porphyritic Santa Fe Group volcanic clasts are potassic with a wide compositional range from potassic trachybasalt to rhyolite. The whole-rock chemistry of the Culebra graben clasts is similar to that of the Thirtynine Mile and San Juan volcanic fields. Culebra graben amphibole and biotite chemistry is generally consistent with that of rocks of the San Juan volcanic field, but not with Spanish Peaks samples. Trace-element data of Culebra graben volcanic clasts overlap with those of the San Juan and Thirtynine Mile volcanic fields, but differ from those of the Mount Mestas. Thermobarometric calculations using mineral chemistry suggest that many Culebra graben rocks underwent a three-stage crystallization history: ∼1120 °C at 7-10 kbar, ∼1100 °C at 2.3-4.6 kbar, and hornblende formation ∼800 °C at 3 kbar. Within the Culebra graben clasts, zircon rim U-Pb geochronologic systematics as well as amphibole and biotite 40 Ar/ 39 Ar plateau data yield ages ranging from 36 to 29 Ma. These ages are consistent with ages of the Thirtynine Mile volcanic field (36-27 Ma) and the Conejos Formation of the San Juan volcanic field (35-29 Ma), but predate Spanish Peaks (ca. 27-21 Ma) and Mount Mestas (ca. 25 Ma). Based on these data, Spanish Peaks and Mount Mestas are excluded as potential source areas for the Santa Fe Group volcanic clasts in the Culebra graben. The San Juan volcanic field is also an unlikely source due to the distance from the depositional site, the inconsistent paleocurrent directions, and the pressure-temperature conditions of the rocks. The most likely scenario is that the Central Colorado volcanic field originally extended proximal to the current location of the Culebra graben and local delivery of volcanic clasts was from the north and northeast prior to the uplift of the Culebra Range and Sangre de Cristo Mountains. © 2013 The Geological Society of America. All rights reserved

Mathematical modelling of the influence of serosorting on the population-level HIV transmission impact of pre-exposure prophylaxis

Objectives: HIV pre-exposure prophylaxis (PrEP) may change serosorting patterns. We examined the influence of serosorting on the population-level HIV transmission impact of PrEP, and how impact could change if PrEP users stopped serosorting. Design: We developed a compartmental HIV transmission model parameterized with bio-behavioural and HIV surveillance data among men who have sex with men in Canada.Methods: We separately fit the model with serosorting and without serosorting (counterfactual; sero-proportionate mixing (random partner-selection proportional to availability by HIV-status)), and reproduced stable HIV epidemics with HIV-prevalence 10.3%-24.8%, undiagnosed fraction 4.9%-15.8%, and treatment coverage 82.5%-88.4%. We simulated PrEP-intervention reaching stable pre-specified coverage by year-1 and compared absolute difference in relative HIV-incidence reduction ten-years post-intervention (PrEP-impact) between: models with serosorting vs. sero-proportionate mixing; and counterfactual scenarios when PrEP users immediately stopped vs. continued serosorting. We examined sensitivity of results to PrEP-effectiveness (44%-99%; reflecting varying dosing or adherence levels) and coverage (10%-50%).Results: Models with serosorting predicted a larger PrEP-impact than models with sero-proportionate mixing under all PrEP-effectiveness and coverage assumptions (median (inter-quartile-range): 8.1%(5.5%-11.6%)). PrEP users’ stopping serosorting reduced PrEP-impact compared with when PrEP users continued serosorting: reductions in PrEP-impact were minimal (2.1%(1.4%-3.4%)) under high PrEP-effectiveness (86%-99%); however, could be considerable (10.9%(8.2%-14.1%)) under low PrEP effectiveness (44%) and high coverage (30%-50%). Conclusions: Models assuming sero-proportionate mixing may underestimate population-level HIV-incidence reductions due to PrEP. PrEP-mediated changes in serosorting could lead to programmatically-important reductions in PrEP-impact under low PrEP-effectiveness. Our findings suggest the need to monitor sexual mixing patterns to inform PrEP implementation and evaluation.<br/