DAMPAK PERILAKU TURIS TERHADAP MORAL REMAJA (STUDI KASUS DI GAMPONG IBOIH KECAMATAN SUKAKARYA KOTA SABANG)

ABSTRAKPerkembangan sektor pariwisata yang terus melaju pesat memberikan pengaruh besar dalam masyarakat baik itu dampak positif maupun negatif. Dampak positif terlihat dari perkembangan perekonomian pada masyarakat Gampong Iboih Kecamatan Sukakarya Kota sabang. Dampak negatif dapat dirasakan dari perubahan moral pada remaja Gampong Iboih Kecamatan Sukakarya Kota Sabang yang terjadi akibat pergeseran budaya karena banyaknya budaya baru masuk bersama kedatangan turis-turis. Rumusan masalah pada penelitian ini adalah bagaimana dampak perilaku turis terhadap moral remaja di Gampong Iboih Kota Sabang dan bagaimana perbedaan pola perilaku remaja di daerah ada turis dengan pola perilaku remaja di daerah yang tidak ada turisnya?. Penelitian ini bertujuan untuk mengetahui dampak perilaku turis terhadap moral remaja, dan juga menganalisis bagaimana perbedaan pola perilaku remaja di daerah yang ada turis dengan pola perilaku remaja di daerah yang tidak ada turisnya. Penelitian ini menggunakan Teori Belajar Oleh Edwin H.Sutherland yang menjelaskan bahwa belajar merupakan sebuah proses perubahan didalam kepribadian manusia dan perubahan tersebut ditampakkan dalam bentuk sikap, pemahaman, dan tingkah laku individu tertentu. Metode penelitian ini menggunakan pendekatan deskriptif kualitatif dengan jumlah informan sebanyak 10 orang. Teknik pengumpulan data dilakukan dengan cara observasi dan wawancara. Hasil penelitian menjelaskan bahwa dampak dari perilaku turis terhadap moral remaja di Gampong Iboih Kota Sabang dapat terlihat dari bagaimana cara remaja berpenampilan, cara remaja berbicara dan cara remaja berinteraksi dengan teman-temannya. Perubahan yang terlihat dari segi fisik serta dampak buruk lainnya ialah sebagian remaja di Gampong Iboih lebih memilih untuk tidak sekolah agar bisa memanfaatkan peluang yang datang dari sektor pariwisata. Perubahan yang membuat perbedaan pada remaja di Gampong Iboih Kecamatan Sukakarya Kota Sabang lebih cenderung kearah budaya, perubahan yang terjadi seperti cara berpakaian remaja yang mulai terbuka, perubahan pola konsumsi yang mengakibatkan pergeseran budaya.Kata Kunci : Perilaku Turis, Moral Remaj

URB597 Administration decreases neuroinflammation and promotes autophagy in Alzheimer's disease models

In recent years, much attention has been focused on the endocannabinoid system as a therapeutic target for neurodegenerative diseases, including Alzheimer's disease (AD). The first endocannabinoid to be characterized was anandamide (N -arachidonoyl ethanolamine, AEA), which is hydrolyzed in postsynaptic neurons by the fatty acid amide hydrolase (FAAH). Notably, the post-mortem examination of brains from AD patients has revealed several alterations of the endocannabinoid system reporting a decrease in cortical AEA levels and a parallel increase in FAAH activity. On this ground, by using both cellular and a transgenic mouse model of AD, we aimed at determining whether pharmacological inhibition of FAAH via URB597 administration may affect microglia polarization and provide beneficial effects in restoring autophagic process and reducing amyloid-β (Aβ) aggregates, which are all neuropathological features of AD. The evaluation of morphological and major markers of microglial activation (iNOS and ARG-1) showed the ability of URB597 to revert microglial activation towards an anti-inflammatory condition, which was associated with the decrease of pro-inflammatory cytokines and an increase of anti-inflammatory cytokines together with the restoration of key factors involved in autophagic processes. These data were confirmed in vivo in the Tg2576 mice where the broad-spectrum action of endocannabinoids ranging from the anti-inflammatory action to the restoration of autophagic flux was demonstrated by the increase of proteins such as ATG7, Beclin1, LC3 and activation of ULK1 signaling following mTOR decrease after URB597 treatment. Moreover, treatment with URB597 decreases the expression of BACE1 through the modulation of CB2 receptors, leading to the reduction of amyloid plaques. Taken together, these data suggest that inhibition of FAAH can drive the polarization of microglia towards an anti-inflammatory phenotype and demonstrate that the modulation of the endocannabinoid system in AD, via URB597 administration, could be a potential and effective therapy not only to fight neuroinflammation but also to regulate the autophagic machinery

A multimethodological approach for the valorization of “Senatore Cappelli” wheat milling by-products as a source of bioactive compounds and nutraceutical activity

Wheat is the third most cultivated cereal in the world and represents the major contributor to human nutrition. Milling wheat by-products such as husks (17–20% of the total processing output weight), even if still containing high-value-added bioactive compounds, are often left untreated or unused, thus resulting in environmental and human health burdens. In these regards, the present study is aimed at evaluating in a multimethodological approach the nutraceutical properties of durum wheat husks belonging to the ancient cultivar “Senatore Cappelli”, thus assessing their potential as bioactive compound sources in terms of phytochemical, cytotoxic, and nutraceutical properties. By means of HPLC-FD analyses, wheat husk samples analyzed revealed a higher content of serotonin, amounting to 35% of the total BAs, and were confirmed to occur at biogenic amines quality index (BAQI) values <10 mg/100 g. In addition, spectrophotometric assays showed a signif- icant variable content in the phenolic (189.71–351.14 mg GAE/100 g) and antioxidant compounds (31.23–37.84 mg TE/100 g) within the wheat husk samples analyzed, according to the different cul- tivar areas of origin. Considering wheat husk extracts’ anti-inflammatory and antioxidant activity, in vitro analyses were performed on BV-2 murine microglia cells cultured in the presence or absence of LPS, thus evaluating their ability to promote microglia polarization towards an anti-inflammatory phenotype. Cytotoxicity assays showed that wheat extracts do not affect microglia viability. Wheat husks activity on microglial polarization was assessed by analyzing the expression of M1 and M2 markers’ mRNA by RT-PCR. Wheat husk antioxidant activity was assessed by analysis of NRF2 and SOD1 mRNA expression. Moreover, the sustainability assessment for the recovery of bioactive components from wheat by-products was carried out by applying the life cycle assessment (LCA) methodology using SimaPro v9.2.2. software

Daily Interpersonal Stress and the Stressor–Vulnerability Model of Alcohol Use

We used an experience sampling design to examine the within–person, within–day associations among interpersonal stress, negative affect, and alcohol use, and how these associations varied as a function of alcohol–outcome expectancies (AOEs), avoidance coping style, sex, and neuroticism. Ninety–eight community adult drinkers who wanted to reduce their alcohol consumption (49 women) reported for 21 days on their interpersonal stress and affect (three times per day), and alcohol use (as it occurred) using hand–held computers. Several individual difference factors interacted with daytime interpersonal stress and afternoon negative affect in predicting nighttime alcohol use, with individuals high in careless unconcern AOEs or low in impairment AOEs demonstrating stronger positive associations between daytime stress and negative affect and nighttime drinking. Daytime drinking and individual difference factors also interacted in predicting nighttime interpersonal stress, with individuals high in careless unconcern AOEs or those low in impairment AOEs or avoidance coping style demonstrating the strongest positive associations between daytime drinking and nighttime stress. The interactive effects in predicting drinking outcomes were generally limited to days on which some interpersonal stress occurred

A cryptic alien seaweed spreading in Mediterranean coastal lagoons.

1 - Introductions of exotic macroalgae have increased recently on European shores. Each introductioninvolves at least one vector of transfer. For macroalgae, the potential vectors are aquaculture(intentional or accidental introduction), fouling on hulls, ballast water, aquarium trading, fishingnets.2 - Coastal lagoons, including Venice and Thau Lagoon, developed into major hotspots of marinemacrophyte introductions in the Mediterranean Sea. Moreover, in shallow lagoons and estuaries,eutrophication processes have resulted in the development of macroalgal biomass.3 - The most characteristic species of these macroalgal communities include members of the ulvophyceangenus Ulva L. In foliose Ulvales, simple morphology and anatomy, rampant convergence, remarkabledegrees of phenotypic plasticity in response to environmental factors tend to confound attempts atidentification and make cryptic introduction difficult to detect.4 - During a survey of macroalgal biodiversity in Venice Lagoon, among the pool of exotic speciesfound, there was an Ulva differing from the Atlantic and Mediterranean species in both vegetativeand reproductive features. Detailed observations consented us to identify the taxon as Ulva pertusaKjellman, previously reported in the Mediterranean only for Thau Lagoon

KONSEP PENATAAN AREA WISATA DESA TEGALLALANG, GIANYAR SEBAGAI DAYA TARIK WISATA BARU BERNUANSA ALAM, BUDAYA, DAN SPIRITUAL

Desa Tegallalang merupakan salah satu desa dalam wilayah Kabupaten Gianyar yang memiliki banyak daya tarik wisata potensial yang akan dikembangkan sebagai suatu destinasi wisata baru. Desa ini memiliki sebaran objek-objek wisata lain yang berlokasi tidak jauh dari objek wisata Ceking Terrace yang sudah sangat terkenal itu. Daya tarik wisata baru di Desa Tegallalang tersebut antara lain berupa bangunan suci, hamparan sawah, mata air, puri, dan daya wisata tinggalan arkeologis. Hasil observasi yang telah dilakukan menunjukkan bahwa pada umumnya daya-daya tarik wisata potensial ini sesungguhnya sangat menarik dan berpeluang dijadikan sebagai daya-daya tarik wisata baru di wilayah desa ini. Hanya saja mengingat daya-daya tarik wisata yang masih tidur itu belum tertata dengan baik, maka sangat perlu kiranya dilakukan kajian tentang konsep penataan daya-daya tarik wisata potensial itu agar dapat menjadi rangkaian daya tarik wisata baru di wilayah Desa Tegallalang ini. Makalah ini memuat tentang gambaran konsep penataan area daya-daya tarik wisata baru Desa Tegallalang yang mengedepankan karakter alam, budaya, dan spiritual wilayah itu untuk dapat dipasarkan kepada para wisatawan. Hasil akhir kajian memperlihat beberapa gambaran konsep desain daya-daya tarik wisata yang dirumuskan sebagai jawaban terhadap permasalahan dan potensi yang termuat di dalamnnya

Perinatal S-Adenosylmethionine Supplementation Represses PSEN1 Expression by the Cellular Epigenetic Memory of CpG and Non-CpG Methylation in Adult TgCRD8 Mice

DNA methylation, the main epigenetic modification regulating gene expression, plays a role in the pathophysiology of neurodegeneration. Previous evidence indicates that 50 -flanking hypomethylation of PSEN1, a gene involved in the amyloidogenic pathway in Alzheimer’s dis- ease (AD), boosts the AD-like phenotype in transgenic TgCRND8 mice. Supplementation with S-adenosylmethionine (SAM), the methyl donor in the DNA methylation reactions, reverts the patho- logical phenotype. Several studies indicate that epigenetic signatures, driving the shift between normal and diseased aging, can be acquired during the first stages of life, even in utero, and manifest phenotypically later on in life. Therefore, we decided to test whether SAM supplementation during the perinatal period (i.e., supplementing the mothers from mating to weaning) could exert a protec- tive role towards AD-like symptom manifestation. We therefore compared the effect of post-weaning vs. perinatal SAM treatment in TgCRND8 mice by assessing PSEN1 methylation and expression and the development of amyloid plaques. We found that short-term perinatal supplementation was as effective as the longer post-weaning supplementation in repressing PSEN1 expression and amyloid deposition in adult mice. These results highlight the importance of epigenetic memory and methyl donor availability during early life to promote healthy aging and stress the functional role of non-CpG methylation

Identifying alien macroalgae through DNA barcoding: the case of Hypnea cornuta (Cystocloniaceae, Rhodophyta)

1 - Introduction of non-indigenous macroalgae has become a major topic in the last decades. Potential vectors are aquaculture, fouling on hulls, ballast water, aquarium trading, fishing nets.2 - Within a program of census of macroalgal alien species through DNA barcoding we found a population of previously unreported rhodophyte in Cape Peloro Lagoon and nearby marine coasts (north-eastern Sicily, Italy).3 - All collected individuals were identified as the alien species Hypnea cornuta based on morphological characters confirmed by the analysis of COI-5’ sequences