Haptic Guidance for Extended Range Telepresence

A novel navigation assistance for extended range telepresence is presented. The haptic information from the target environment is augmented with guidance commands to assist the user in reaching desired goals in the arbitrarily large target environment from the spatially restricted user environment. Furthermore, a semi-mobile haptic interface was developed, one whose lightweight design and setup configuration atop the user provide for an absolutely safe operation and high force display quality

Wide-Area Haptic Guidance: Taking the User by the Hand

In this paper, we present a novel use of haptic information in extended range telepresence, the wide-area haptic guidance. It consists of force and position signals applied to the user\u27s hand in order to improve safety, accuracy, and speed in some telepresent tasks. Wide-area haptic guidance assists the user in reaching a desired position in a remote environment of arbitrary size without degrading the feeling of presence. Several methods for haptic guidance are analyzed. With active haptic guidance, the user is guided by superimposed forces that pull him into the desired direction of motion, whereas under passive haptic guidance, the movement of the user is lightened in the preferred direction and constrained in the other directions. By using closed-loop haptic guidance instead of open-loop haptic guidance, not only is the user guided to his target but also the deviation from the desired target path is reduced. The proposed guidance methods were tested with a haptic interface specifically designed for extended range telepresence

Using a Telepresence System to Investigate Route Choice Behavior

A combination of a telepresence system and a microscopic traffic simulator is introduced. It is evaluated using a hotel evacuation scenario. Four different kinds of supporting information are compared, standard exit signs, floor plans with indicated exit routes, guiding lines on the floor and simulated agents leading the way. The results indicate that guiding lines are the most efficient way to support an evacuation but the natural behavior of following others comes very close. On another level the results are consistent with previously performed real and virtual experiments and validate the use of a telepresence system in evacuation studies. It is shown that using a microscopic traffic simulator extends the possibilities for evaluation, e.g. by adding simulated humans to the environment.Comment: Preprint of TGF11 (Traffic and Granular Flow, Moscow, September 2011) conference proceedings contributio

Using Extended Range Telepresence to Investigate Route Choice Behavior

A combination of a telepresence system and a microscopic traffic simulator is introduced. It is evaluated using a hotel evacuation scenario. Four different kinds of supporting information are compared, standard exit signs, floor plans with indicated exit routes, guiding lines on the floor and simulated agents leading the way. The results indicate that guiding lines are the most efficient way to support an evacuation but the natural behavior of following others comes very close. On another level the results are consistent with previously performed real and virtual experiments and validate the use of a telepresence system in evacuation studies. It is shown that using a microscopic traffic simulator extends the possibilities for evaluation, e.g. by adding simulated humans to the environment

A Wearable System for the Wireless Experience of Extended Range Telepresence

Extended range telepresence aims at enabling a user to experience virtual or remote environments, taking his own body movements as an input to define walking speed and viewing direction. Therefore, localization and tracking of the users pose (position and orientation) is necessary to perform a body-centered scene rendering. Visual and acoustic feedback is provided to the user by a head mounted display (HMD). To allow for free movement within the user environment, the tracking system is supposed to be user-wearable and entirely wireless. Consequently, a lightweight design is presented fea- turing small dimensions to fit into a conventional 13"laptop backpack, which satisfies the above stated demands for highly immersive extended range telepresence scenarios. Dedicated embedded hardware combined with off-the-shelf components is employed to form a robust, low-cost telepresence system that can be easily installed in any living room

La modalidad de educación a distancia y su impacto en el desempeño académico de los estudiantes en formación, inscritos en las carreras impartidas por la Facultad de Ciencias y Humanidades y la Facultad de Ciencias Naturales y Matemática de la Universidad de El Salvador, pertenecientes a la zona cuatro durante el período 2016-2017

El tema de educación a distancia en el sector público de la educación superior es relativamente joven y no se ha realizado un estudio sobre el impacto y alcances de dicha modalidad en la población estudiantil inscrita en las carreras ofertadas de la Universidad de El Salvador. Debido a que el estudio de la Modalidad de Educación a Distancia es muy amplio, profundo y complejo, esta investigación se enfocará en la formación pedagógica de los tutores que forman parte del proyecto de Modalidad a distancia de la Universidad de El Salvador, y de qué manera favorece el desempeño académico de los estudiantes en formación inscritos en las carreras impartidas por las Facultades de Ciencias y Humanidades y Ciencias Naturales y Matemática pertenecientes a las zona cuatro durante el periodo 2016-2017. El valor teórico de la investigación, ayudará a analizar las estrategias metodológicas y didácticas, que se están aplicando en la modalidad a distancia, así como proporcionar resultados significativos para los entes que impulsan la educación a distancia, de la Universidad de El Salvador; que se clasifican de la siguiente manera: Al MINED, que es el organismo impulsador. La UES, como organismo ejecutor. Los tutores que se encargan del proceso de aprendizaje y los estudiantes

EoE CONNECT, the European Registry of Clinical, Environmental, and Genetic Determinants in Eosinophilic Esophagitis:rationale, design, and study protocol of a large-scale epidemiological study in Europe

BACKGROUND: The growing prevalence of eosinophilic esophagitis (EoE) represents a considerable burden to patients and health care systems. Optimizing cost-effective management and identifying mechanisms for disease onset and progression are required. However, the paucity of large patient cohorts and heterogeneity of practice hinder the defining of optimal management of EoE. METHODS: EoE CONNECT is an ongoing, prospective registry study initiated in 2016 and currently managed by EUREOS, the European Consortium for Eosinophilic Diseases of the Gastrointestinal Tract. Patients are managed and treated by their responsible specialists independently. Data recorded using a web-based system include demographic and clinical variables; patient allergies; environmental, intrapartum, and early life exposures; and family background. Symptoms are structurally assessed at every visit; endoscopic features and histological findings are recorded for each examination. Prospective treatment data are registered sequentially, with new sequences created each time a different treatment (active principle, formulation, or dose) is administered to a patient. EoE CONNECT database is actively monitored to ensure the highest data accuracy and the highest scientific and ethical standards. RESULTS: EoE CONNECT is currently being conducted at 39 centers in Europe and enrolls patients of all ages with EoE. In its aim to increase knowledge, to date EoE CONNECT has provided evidence on the effectiveness of first- and second-line therapies for EoE in clinical practice, the ability of proton pump inhibitors to induce disease remission, and factors associated with improved response. Drug effects to reverse fibrous remodeling and endoscopic features of fibrosis in EoE have also been assessed. CONCLUSION: This prospective registry study will provide important information on the epidemiological and clinical aspects of EoE and evidence as to the real-world and long-term effectiveness and safety of therapy. These data will potentially be a vital benchmark for planning future EoE health care services in Europe

EoE CONNECT, the European Registry of Clinical, Environmental, and Genetic Determinants in Eosinophilic Esophagitis: rationale, design, and study protocol of a large-scale epidemiological study in Europe

Background: The growing prevalence of eosinophilic esophagitis (EoE) represents a considerable burden to patients and health care systems. Optimizing cost-effective management and identifying mechanisms for disease onset and progression are required. However, the paucity of large patient cohorts and heterogeneity of practice hinder the defining of optimal management of EoE. Methods: EoE CONNECT is an ongoing, prospective registry study initiated in 2016 and currently managed by EUREOS, the European Consortium for Eosinophilic Diseases of the Gastrointestinal Tract. Patients are managed and treated by their responsible specialists independently. Data recorded using a web-based system include demographic and clinical variables; patient allergies; environmental, intrapartum, and early life exposures; and family background. Symptoms are structurally assessed at every visit; endoscopic features and histological findings are recorded for each examination. Prospective treatment data are registered sequentially, with new sequences created each time a different treatment (active principle, formulation, or dose) is administered to a patient. EoE CONNECT database is actively monitored to ensure the highest data accuracy and the highest scientific and ethical standards. Results: EoE CONNECT is currently being conducted at 39 centers in Europe and enrolls patients of all ages with EoE. In its aim to increase knowledge, to date EoE CONNECT has provided evidence on the effectiveness of first- and second-line therapies for EoE in clinical practice, the ability of proton pump inhibitors to induce disease remission, and factors associated with improved response. Drug effects to reverse fibrous remodeling and endoscopic features of fibrosis in EoE have also been assessed. Conclusion: This prospective registry study will provide important information on the epidemiological and clinical aspects of EoE and evidence as to the real-world and long-term effectiveness and safety of therapy. These data will potentially be a vital benchmark for planning future EoE health care services in Europe

Accurate and timely diagnosis of Eosinophilic Esophagitis improves over time in Europe. An analysis of the EoE CONNECT Registry

BACKGROUND: Poor adherence to clinical practice guidelines for eosinophilic esophagitis (EoE) has been described and the diagnostic delay of the disease continues to be unacceptable in many settings. OBJECTIVE: To analyze the impact of improved knowledge provided by the successive international clinical practice guidelines on reducing diagnostic delay and improving the diagnostic process for European patients with EoE. METHODS: Cross‐sectional analysis of the EoE CONNECT registry based on clinical practice. Time periods defined by the publication dates of four major sets of guidelines over 10 years were considered. Patients were grouped per time period according to date of symptom onset. RESULTS: Data from 1,132 patients was analyzed and median (IQR) diagnostic delay in the whole series was 2.1 (0.7‐6.2) years. This gradually decreased over time with subsequent release of new guidelines (p < 0.001), from 12.7 years up to 2007 to 0.7 years after 2017. The proportion of patients with stricturing of mixed phenotypes at the point of EoE diagnosis also decreased over time (41.3% vs. 16%; p < 0.001), as did EREFS scores. The fibrotic sub‐score decreased from a median (IQR) of 2 (1‐2) to 0 (0‐1) when patients whose symptoms started up to 2007 and after 2017 were compared (p < 0.001). In parallel, symptoms measured with the Dysphagia Symptoms Score reduced significantly when patients with symptoms starting before 2007 and after 2012 were compared. A reduction in the number of endoscopies patients underwent before the one that achieved an EoE diagnosis, and the use of allergy testing as part of the diagnostic workout of EoE, also reduced significantly over time (p = 0.010 and p < 0.001, respectively). CONCLUSION: The diagnostic work‐up of EoE patients improved substantially over time at the European sites contributing to EoE CONNECT, with a dramatic reduction in diagnostic delay

Efficacy of Budesonide Orodispersible Tablets as Induction Therapy for Eosinophilic Esophagitis in a Randomized Placebo-Controlled Trial.

BACKGROUND & AIMS: Swallowed topical-acting corticosteroids are recommended as first-line therapy for eosinophilic esophagitis (EoE). Asthma medications not optimized for esophageal delivery are sometimes effective, although given off-label. We performed a randomized, placebo-controlled trial to assess the effectiveness and tolerability of a budesonide orodispersible tablet (BOT), which allows the drug to be delivered to the esophagus in adults with active EoE. METHODS: We performed a double-blind, parallel study of 88 adults with active EoE in Europe. Patients were randomly assigned to groups that received BOT (1 mg twice daily; n = 59) or placebo (n = 29) for 6 weeks. The primary end point was complete remission, based on clinical and histologic factors, including dysphagia and odynophagia severity ≤2 on a scale of 0-10 on each of the 7 days before the end of the double-blind phase and a peak eosinophil count <5 eosinophils/high power field. Patients who did not achieve complete remission at the end of the 6-week double-blind phase were offered 6 weeks of open-label treatment with BOT (1 mg twice daily). RESULTS: At 6 weeks, 58% of patients given BOT were in complete remission compared with no patients given placebo (P < .0001). The secondary end point of histologic remission was achieved by 93% of patients given BOT vs no patients given placebo (P < .0001). After 12 weeks, 85% of patients had achieved remission. Six-week and 12-week BOT administration were safe and well tolerated; 5% of patients who received BOT developed symptomatic, mild candida, which was easily treated with an oral antifungal agent. CONCLUSIONS: In a randomized trial of adults with active EoE, we found that budesonide oral tablets were significantly more effective than placebo in inducing clinical and histologic remission. Eudra-CT number 2014-001485-99; ClinicalTrials.gov ID NCT02434029