Galician industrial sector: perspectives in the face of a new century

Texto dispoñible en galego e españolNeste traballo analízase a evolución da industria galega nunha parte significativa da década dos noventa dende a perspectiva dunha comparación das principais variables macroeconómicas das diferentes agrupacións industriais. Esta comparación é o fundamento para a percepción das perspectivas de cada unha das agrupacións na próxima década. Os resultados revelan a evolución positiva do sector de confección de prendas de vestir e as dificultades do sector extractivo-enerxético e alimentario. De forma complementaria móstranse as diverxencias existentes nas fontes estatísticas polo que, segundo a estatística que se utilice, os resultados poderían ser ata contradictoriosEn este trabajo se analiza la evolución de la industria gallega en una parte significativa de la década de los noventa desde la perspectiva de una comparación de las principales variables macroeconómicas de las diferentes agrupaciones industriales. Esta comparación es el fundamento para la percepción de las perspectivas de cada una de las agrupaciones en la próxima década. Los resultados revelan la evolución positiva del sector de confección de prendas de vestir y las dificultades del sector extractivo-energético y alimentario. De forma complementaria se muestra las divergencias existentes en las fuentes estadísticas por lo que, según la estadística que se utilice, los resultados podrían ser hasta contradictoriosThis paper analyses the evolution of Galician industry during a significant part of the 1990s by comparing the main macroeconomic variables of the different industrial groups. That comparison is the basis to understand the perspectives of each group in the next decade. The results reveal a positive evolution of the garment industry sector and the difficulties of food and extraction-energy sectors. In a complementary way the existing divergences in the statistical sources are shown and thus in accordance with the statistical source used, the results could be even contradictoryS

The Galician Labor Market Since the Entry into Europe

Texto dispoñible en galego e españolNeste artigo reflexiónase sobre o comportamento do mercado de traballo galego desde mediados dos anos oitenta, comparándoo co do mercado español e apoiándose nos resultados das estatísticas oficiais dispoñibles. Analízase a evolución das variables claves que definen este mercado e coméntanse as peculiaridades que presentan en GaliciaEn este artículo se reflexiona sobre el comportamiento del mercado de trabajo gallego desde mediados de los años ochenta, comparándolo con el del mercado español y apoyándose en los resultados de las estadísticas oficiales disponibles. Se analiza la evolución de las variables claves que definen este mercado y se comentan las peculiaridades que presentan en GaliciaThis article reflects on Galician labor market since the mid-eighties, comparing it with the Spanish labor market, based on the results of available official statistics. We analise the evolution of the key variables that define this market and discuss the specificities presented in GaliciaS

Experimental study of hybrid-knife endoscopic submucosal dissection (ESD) versus standard ESD in a Western country

BACKGROUND: Endoscopic submucosal dissection (ESD) is an effective but time-consuming treatment for early neoplasia that requires a high level of expertise. OBJECTIVE: The objective of this study was to assess the efficacy and learning curve of gastric ESD with a hybrid knife with high pressure water jet and to compare with standard ESD. MATERIAL AND METHODS: We performed a prospective non survival animal study comparing hybrid-knife and standard gastric ESD. Variables recorded were: Number of en-bloc ESD, number of ESD with all marks included (R0), size of specimens, time and speed of dissection and adverse events. Ten endoscopists performed a total of 50 gastric ESD (30 hybrid-knife and 20 standard). RESULTS: Forty-six (92 %) ESD were en-bloc and 25 (50 %) R0 (hybrid-knife: n = 13, 44 %; standard: n = 16, 80 %; p = 0.04). Hybrid-knife ESD was faster than standard (time: 44.6 +/- 21.4 minutes vs. 68.7 +/- 33.5 minutes; p = 0.009 and velocity: 20.8 +/- 9.2 mm(2)/min vs. 14.3 +/- 9.3 mm(2)/min (p = 0.079). Adverse events were not different. There was no change in speed with any of two techniques (hybrid-knife: From 20.33 +/- 15.68 to 28.18 +/- 20.07 mm(2)/min; p = 0.615 and standard: From 6.4 +/- 0.3 to 19.48 +/- 19.21 mm(2)/min; p = 0.607). The learning curve showed a significant improvement in R0 rate in the hybrid-knife group (from 30 % to 100 %). CONCLUSION: despite the initial performance of hybrid-knife ESD is worse than standard ESD, the learning curve with hybrid knife ESD is short and is associated with a rapid improvement. The introduction of new tools to facilitate ESD should be implemented with caution in order to avoid a negative impact on the results

Creación de un nuevo recurso educativo virtual para estudiantes de grado en Farmacia

Depto. de Farmacia Galénica y Tecnología AlimentariaFac. de FarmaciaFALSEsubmitte

Endoscopic Submucosal Dissection. Sociedad Española de Endoscopia Digestiva (SEED) clinical guideline

The reason to write this guideline is to familiarize Spanish endoscopists and gastroenterologists not only with the general indications of the procedure and possible complications but also the dedicated tools

Creación de nuevo recurso educativo virtual para estudiantes de grado en Farmacia

Depto. de Farmacia Galénica y Tecnología AlimentariaFac. de FarmaciaFALSEsubmitte

Creación de un nuevo recurso educativo virtual para estudiantes de grado en Farmacia

Creación de un nuevo recurso educativo virtual para estudiantes de grado en Farmacia sobre la serialización de los medicamentos y los procesos de mezclado

Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism

© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Whole-brain radiotherapy (WBRT) is the treatment backbone for many patients with brain metastasis; however, its efficacy in preventing disease progression and the associated toxicity have questioned the clinical impact of this approach and emphasized the need for alternative treatments. Given the limited therapeutic options available for these patients and the poor understanding of the molecular mechanisms underlying the resistance of metastatic lesions to WBRT, we sought to uncover actionable targets and biomarkers that could help to refine patient selection. Through an unbiased analysis of experimental in vivo models of brain metastasis resistant to WBRT, we identified activation of the S100A9-RAGE-NF-κB-JunB pathway in brain metastases as a potential mediator of resistance in this organ. Targeting this pathway genetically or pharmacologically was sufficient to revert the WBRT resistance and increase therapeutic benefits in vivo at lower doses of radiation. In patients with primary melanoma, lung or breast adenocarcinoma developing brain metastasis, endogenous S100A9 levels in brain lesions correlated with clinical response to WBRT and underscored the potential of S100A9 levels in the blood as a noninvasive biomarker. Collectively, we provide a molecular framework to personalize WBRT and improve its efficacy through combination with a radiosensitizer that balances therapeutic benefit and toxicity.info:eu-repo/semantics/publishedVersio

O sector industrial galego: perspectivas ante un novo século

Neste traballo analízase a evolución da industria galega nunha parte significativa da década dos noventa dende a perspectiva dunha comparación das principais variables macroeconómicas das diferentes agrupacións industriais. Esta comparación é o fundamento para a percepción das perspectivas de cada unha das agrupacións na próxima década. Os resultados revelan a evolución positiva do sector de confección de prendas de vestir e as dificultades do sector extractivo-enerxético e alimentario. De forma complementaria móstranse as diverxencias existentes nas fontes estatísticas polo que, segundo a estatística que se utilice, os resultados poderían ser ata contradictorios