Ankyloglossia, Syndactyly and Polydactyly in the Pediatric Patient

Ankyloglossia is a congenital alteration in the development of the tongue characterized by the presence of a short or thick lingual frenulum, which leads to a limitation in its movements. There is an associative inconsistency between ankyloglossia and complications with breastfeeding, speech, swallowing, breathing, and the development of orofacial structures, and it is urgent to make more scientific research in this area. In the presence of polydactyly and syndactyly may be also present ankyloglossia. The purpose of this paper is to present two ankyloglossia cases with finger alterations, without a syndromic disease, and lead the medical team to research this topic and make an improved treatment plan for these cases.info:eu-repo/semantics/publishedVersio

Combined sticking: a new approach for finite-amplitude Coulomb frictional contact

Engineering-level accuracy of discretization methods for frictional contact originates from precise representation of discontinuous frictional and normal interaction laws and precise discrete contact techniques. In terms of discontinuous behavior in the quasi-static case, two themes are of concern: the normal interaction (i.e. impact) and the jumps in tangential directions arising from high frictional values. In terms of normal behavior, we use a smoothed complementarity relation. For the tangential behavior, we propose a simple and effective algorithm, which is based a stick predictor followed by corrections to the tangential velocity. This allows problems with impact and stick-slip behavior to be solved with an implicit code based on Newton–Raphson iterations. Three worked examples are shown with comparisons with published results. An extension to node-to-face form in 3D is also presented

Effects of the fibers distribution in the human eardrum: A biomechanical study

The eardrum separates the external ear from the middle ear and it is responsible to convert the acoustical energy into mechanical energy. It is divided by pars tensa and pars flaccida. The aim of this work is to analyze the susceptibility of the four quadrants of the pars tensa under negative pressure, to different lamina propria fibers distribution. The development of associated ear pathology, in particular the formation of retraction pockets, is also evaluated. To analyze these effects, a computational biomechanical model of the tympano-ossicular chain was constructed using computerized tomography images and based on the finite element method. Three fibers distributions in the eardrum middle layer were compared: case 1 (eardrum with a circular band of fibers surrounding all quadrants equally), case 2 (eardrum with a circular band of fibers that decreases in thickness in posterior quadrants), case 3 (eardrum without circular fibers in the posterior/superior quadrant). A static analysis was performed by applying approximately 3000Pa in the eardrum. The pars tensa of the eardrum was divided in four quadrants and the displacement of a central point of each quadrant analyzed. The largest displacements of the eardrum were obtained for the eardrum without circular fibers in the posterior/superior quadrant

Massive lower gastrointestinal bleeding from idiopathic ileocolonic varix: report of a case

Dis Colon Rectum. 2006 Apr;49(4):524-6. Massive lower gastrointestinal bleeding from idiopathic ileocolonic varix: report of a case. Lopes LM, Ramada JM, Certo MG, Pereira PR, Soares JM, Ribeiro M, Areias J, Pinho C. SourceGastroenterology Department, Hospital Geral Santo António, Porto, Portugal. [email protected] Abstract Idiopathic varices of the entire colon are very rare. We report on a 64-year-old patient with massive lower gastrointestinal hemorrhage from an extensive ileocolonic varix. Diagnosis was established by colonoscopy. The patient underwent an emergency ileocolectomy with satisfactory results. This rare case shows the importance of colonoscopy in the evaluation of patients with lower gastrointestinal hemorrhage and reminds us that sometimes the diagnosis is not what we expect. Recognition of this abnormality is important because varices may be the cause of massive lower gastrointestinal hemorrhage. PMID: 16395635 [PubMed - indexed for MEDLINE

Determination of the parameters affecting electrospun chitosan fiber size distribution and morphology

The production of chitosan nanofiber mats by electrospinning presents serious difficulties due to the lack of suitable solvents and the strong influence of processing parameters on the fiber properties. Two are the main problems to be solved: to control the properties of the solution in order to obtain large area uniform fiber mats by having a stable flow rate and to avoid sparks during the process, damaging the fiber mats. In this work chitosan electrospun mats have been prepared form solutions of trifluoroacetic acid / dichloromethane mixtures, allowing to solve the aforementioned problems. Mats with uniform fibers of submicron diameters without beads were obtained. Further, the influence of the different solution and process parameters on the mean fiber diameter and on the width of the distribution of the fiber sizes has been assessed. Solvent composition, needle diameter, applied voltage and traveling distance were the parameters considered in this study.This work is funded by FEDER funds through the "Programa Operacional Factores de Competitividade – COMPETE" and by national funds by FCT- Fundação para a Ciência e a Tecnologia, project references NANO/NMed-SD/0156/2007. V.S. thanks the FCT for the SFRH/BPD/63148/2009 grants. JLGR acknowledge the support of the Spanish Ministry of Science and Innovation through project No. MAT2010-21611-C03-01 (including the FEDER financial support) and Programa Nacional de Internacionalización de la I+D project EUI2008-00126. Funding for research in the field of Regenerative Medicine through the collaboration agreement from the Conselleria de Sanidad (Generalitat Valenciana), and the Instituto de Salud Carlos III (Ministry of Science and Innovation) is also acknowledged

Diet-induced Obesity Induces Endoplasmic Reticulum Stress And Insulin Resistance In The Amygdala Of Rats.

Insulin acts in the hypothalamus, decreasing food intake (FI) by the IR/PI3K/Akt pathway. This pathway is impaired in obese animals and endoplasmic reticulum (ER) stress and low-grade inflammation are possible mechanisms involved in this impairment. Here, we highlighted the amygdala as an important brain region for FI regulation in response to insulin. This regulation was dependent on PI3K/AKT pathway similar to the hypothalamus. Insulin was able to decrease neuropeptide Y (NPY) and increase oxytocin mRNA levels in the amygdala via PI3K, which may contribute to hypophagia. Additionally, obese rats did not reduce FI in response to insulin and AKT phosphorylation was decreased in the amygdala, suggesting insulin resistance. Insulin resistance was associated with ER stress and low-grade inflammation in this brain region. The inhibition of ER stress with PBA reverses insulin action/signaling, decreases NPY and increases oxytocin mRNA levels in the amygdala from obese rats, suggesting that ER stress is probably one of the mechanisms that induce insulin resistance in the amygdala.3443-

Predictors of Poor Neurocognitive Performance and Neuropsychological Phenotypes in Adolescents and Young Adults With Congenital Heart Disease

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