3,067 research outputs found
Dual-path state reconstruction scheme for propagating quantum microwaves and detector noise tomography
Quantum state reconstruction involves measurement devices that are usually
described by idealized models, but not known in full detail in experiments. For
weak propagating microwaves, the detection process requires linear amplifiers
which obscure the signal with random noise. Here, we introduce a theory which
nevertheless allows one to use these devices for measuring all quadrature
moments of propagating quantum microwaves based on cross-correlations from a
dual-path amplification setup. Simultaneously, the detector noise properties
are determined, allowing for tomography. We demonstrate the feasibility of our
novel concept by proof-of-principle experiments with classical mixtures of weak
coherent microwaves.Comment: 11 pages, 3 figure
Influencia de la expectativa sobre la orientación de la atención
Primeres Jornades de Foment de la Investigació de la FCHS (Any 1995-1996
Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1
Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS) is the leading cause of non-traumatic neurological disability in young adults. Immune mediated destruction of myelin and oligodendrocytes is considered the primary pathology of MS, but progressive axonal loss is the major cause of neurological disability. In an effort to understand microglia function during CNS inflammation, our laboratory focuses on the fractalkine/CX3CR1 signaling as a regulator of microglia neurotoxicity in various models of neurodegeneration. Fractalkine (FKN) is a transmembrane chemokine expressed in the CNS by neurons and signals through its unique receptor CX3CR1 present in microglia. During experimental autoimmune encephalomyelitis (EAE), CX3CR1 deficiency confers exacerbated disease defined by severe inflammation and neuronal loss. The CX3CR1 human polymorphism I249/M280 present in ∼20% of the population exhibits reduced adhesion for FKN conferring defective signaling whose role in microglia function and influence on neurons during MS remains unsolved. The aim of this study is to assess the effect of weaker signaling through hCX3CR1I249/M280 during EAE. We hypothesize that dysregulated microglial responses due to impaired CX3CR1 signaling enhance neuronal/axonal damage. We generated an animal model replacing the mouse CX3CR1 locus for the hCX3CR1I249/M280 variant. Upon EAE induction, these mice exhibited exacerbated EAE correlating with severe inflammation and neuronal loss. We also observed that mice with aberrant CX3CR1 signaling are unable to produce FKN and ciliary neurotrophic factor during EAE in contrast to wild type mice. Our results provide validation of defective function of the hCX3CR1I249/M280 variant and the foundation to broaden the understanding of microglia dysfunction during neuroinflammation. © 2018 Cardona et al
El altruismo en el ámbito universitario
Primeres Jornades de Foment de la Investigació de la FCHS (Any 1995-1996
What does a Text Classifier Learn about Morality? An Explainable Method for Cross-Domain Comparison of Moral Rhetoric
Moral rhetoric influences our judgement. Although social scientists recognize moral expression as domain specific, there are no systematic methods for analyzing whether a text classifier learns the domain-specific expression of moral language or not. We propose Tomea, a method to compare a supervised classifier's representation of moral rhetoric across domains. Tomea enables quantitative and qualitative comparisons of moral rhetoric via an interpretable exploration of similarities and differences across moral concepts and domains. We apply Tomea on moral narratives in thirty-five thousand tweets from seven domains. We extensively evaluate the method via a crowd study, a series of cross-domain moral classification comparisons, and a qualitative analysis of cross-domain moral expression.</p
Bounding wide composite vector resonances at the LHC
In composite Higgs models (CHMs), electroweak precision data generically push
colourless composite vector resonances to a regime where they dominantly decay
into pairs of light top partners. This greatly attenuates their traces in
canonical collider searches, tailored for narrow resonances promptly decaying
into Standard Model final states. By reinterpreting the CMS same-sign dilepton
(SS2) analysis at the Large Hadron Collider (LHC), originally designed to
search for top partners with electric charge , we demonstrate its
significant coverage over this kinematical regime. We also show the reach of
the 13 TeV run of the LHC, with various integrated luminosity options, for a
possible upgrade of the SS2 search. The top sector of CHMs is found to be
more fine-tuned in the presence of colourless composite resonances in the few
TeV range.Comment: 9 pages, 5 figures. Minor corrections for publication in JHE
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