9 research outputs found

    Effect of 670 Nm Laser Beam on the Action Potentials of Sural Nerve in Healthy Individuals

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    Introduction: Low Level Laser (LLL) is being used in physiotherapy for pain relief in various pathologies and particularly on peripheral nerve entrapments. In the present study, the effect of LLL on the electrophysiological parameters of sural in humans was investigated. The results might be used as a basis for further clinical research in abnormal conditions. Methods and Materials: Thirty-eight normal men voluntarily participated in the current study and 670 nm LLL beam was applied to the left sural nerve at 5 points for 10 sessions. The electrophysiological parameters such as onset latency, peak latency, negative peak amplitude, peak to peak amplitude, and duration were measured before and after the application of LLL (0.5, 1.5 & 2.5 J/cm² energy density). Results: Overall, 670 nm laser beam increased the latency and reduced the nerve conduction velocity (NCV). In addition, LLL beam decreased the amplitude of action potentials. Among the various values of energy densities, application of 2.5 J/cm² had the most effective results (P < 0.001). Conclusion: These results might suggest that 670 nm laser beam could affect the latency and reduce the NCV in sural nerve of human. Probably, LLL affects the bioelectric and bioenergetic properties of the neural biomembrane. These findings might have clinical signlificance in non-surgical treatment of entrapment syndromes, such as carpal, tarsal syndromes and trigeminal entrapment in human. Further investigations are needed to elucidate the effects of LLL beam on the human peripheral nerves in pathological conditions.Keywords: Low-level laser, Sural nerve, Electrophysiology, Pai

    Effect of Estrogen Therapy on TNF-α and iNOS Gene Expression in Spinal Cord Injury Model

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    Spinal cord injury (SCI) is a crucial complication that results in neurons degeneration. The SCI lead to triggering of secondary complications such as inflammation that in turn has a key role in neurodegeneration development. The previous studies showed that TNF-α and iNOS genes expression increased significantly after SCI. As a consequence, these genes overexpression intensify the inflammation and neuron degeneration process. In the present study, 32 male Wistar rats were chased and divided into four groups of eight. The SCI were induced in three groups and another group used as a sham. The estrogen hormone used as a therapeutic agent in rats with SCI. The results showed that injection of 10 μg/kg/12h estrogen hormone reduced the TNF-α and iNOS genes expression significantly and confirmed the role of progesterone in the reduction of inflammation reduce the inflammation. The numbers of intact neurons in Estrogen group were higher than other groups and showed that progesterone has protective effects on neuron death. The BBB test was performed and demonstrated that estrogen is an effective factor in the improvement of locomotor response. Our results suggested that estrogen hormone with anti-inflammatory activity can be an efficient agent for SCI complications therapy

    Effect of Progesterone Therapy on TNF-? and iNOS Gene Expression in Spinal Cord Injury Model

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    <div><div><p>Spinal cord injury (SCI) as a destructive crash result in neurons degeneration. The SCI lead to the onset of biochemical and molecular cascades such as inflammation that in turn has a key role in neurodegeneration development. The previous studies demonstrated the role of TNF-α and iNOS genes in intensifying the process after SCI. As a consequence, these genes overexpression intensify the inflammation and neuron degeneration process. In the present study, 32 male Wistar rats were chased and divided into four groups of eight. The SCI were induced in three groups and another group used as a sham. The progesterone hormone used as a therapeutic agent in rats with SCI. The results showed that injection of 10 μg/kg/12h progesterone hormone reduced the TNF-α and iNOS gene expression significantly and confirmed the role of progesterone in the reduction of inflammation. Also, the numbers of intact neurons in progesterone group were higher than other groups that demonstrated the protective effects of progesterone on neuron death. The BBB test was performed and demonstrated that progesterone is an effective factor to the improvement of locomotor response. These results of the study confirmed the anti-inflammatory activity of progesterone hormone and suggested that it can be used as a therapeutic factor for SCI.</p></div></div
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