Afrika

Ġabra ta’ poeżiji u proża li tinkludi: Kavallier ta’ Sergio Grech – Tiġrib ta’ Toni Aquilina – Kappella pprofanata ta’ Ġorġ Borg – Leħħiet ta’ Pawlu Aquilina – Fir-raqda ħadra ta’ Carmel Calleja – Epigrammi: X’dinja din! ta’ J. J. Camilleri – Karnival 1999 (Għawdex) ta’ Joe M. Attard – Ħarsti lejn l-art ta’ Ġorġ Zammit – Lill-mewt ta’ J. Zammit Tabona – Tifkira ta’ Lillian Sciberras – Lill-pitirross ta’ K. Vella Haber – Lill-irġiel miżżewġa ta’ Ġanni A. Cilia – Meta Hamlet u l-fjuri eterni jiltaqgħu ta’ Doreen Micallef – It-tren iżomm il-ħin ta’ Pawlu Aquilina – Kemm tiswa tarbija? ta’ Ġorġ Mallia – Jien naf ta’ J. J. Cremona – Odessa ta’ Charles Coleiro – L-isptar ta’ Charles Coleiro – Agunija ta’ Charles Coleiro – Milied XXI ta’ Charles Coleiro – Entużjażmu ta’ Charles Briffa – Londra ta’ Charles Briffa – Dal-ġebel kbir ta’ Emanuel Attard – Lit-Teatru Rjal ta’ Maurice Mifsud Bonnici – Fl-Ewropa magħquda ta’ Doreen Micallef – Fil-mewt ta’ Ġorġ Pisani ta’ Carm Cachia – Lejl id-19 ta’ Diċembru ta’ Charles B. Spiteri – Kont waħdi ta’ Suzanne Gatt – Imħabbti ta’ Nathalie Micallef – Xi ġralek, Ma? ta’ Oliver Friggieri – Anki t-tislima ta’ Oliver Friggieri – Fuq xifer nimxu ta’ Oliver Friggieri – Afrika ta’ Oliver Friggieri.peer-reviewe

Lil Dun Karm

Ġabra ta’ poeżiji u proża li tinkludi: Qalb ta’ Peter A. Caruana – Ċetta l-internazzjonal ta’ Wallace Ph. Gulia – Tfal Maltin ta’ C. Cassar – Meta ntefa d-dawl ta’ Joe Mejlak – Lil tfajjel jibki ta’ V. Barbara – Għanja lil San Pawl il-Baħar ta’ P. F. Sammut – L-imqass ta’ G. Z. A. – Epigrammi ta’ P. P. Saydon – Iż-żewġ arloġġi ta’ Ġ. Cardona – Li kieku... ta’ Joseph C. Sciberras – Il-Milied it-tajjeb! ta’ Ġ. Borg Pantalleresco – Raħal twelidi ta’ M. Agius – Kannizzati... ta’ Pawlu Aquilina – Quddiem id-dar fejn twieled Dun Karm ta’ Ġużè Cardona – Lil Dun Karm ta’ Pawlu Mifsud.peer-reviewe

Maternal sildenafil for severe fetal growth restriction (STRIDER): a multicentre, randomised, placebo-controlled, double-blind trial

Background Severe early-onset fetal growth restriction can lead to a range of adverse outcomes including fetal or neonatal death, neurodisability, and lifelong risks to the health of the affected child. Sildenafil, a phosphodiesterase type 5 inhibitor, potentiates the actions of nitric oxide, which leads to vasodilatation of the uterine vessels and might improve fetal growth in utero. Methods We did this superiority, placebo-controlled randomised trial in 19 fetal medicine units in the UK. We used random computer allocation (1:1) to assign women with singleton pregnancies between 22 weeks and 0 days' gestation and 29 weeks and 6 days' gestation and severe early-onset fetal growth restriction to receive either sildenafil 25 mg three times daily or placebo until 32 weeks and 0 days' gestation or delivery. We stratified women by site and by their gestational age at randomisation (before week 26 and 0 days or at week 26 and 0 days or later). We defined fetal growth restriction as a combination of estimated fetal weight or abdominal circumference below tenth percentile and absent or reversed end-diastolic blood flow in the umbilical artery on Doppler velocimetry. The primary outcome was the time from randomisation to delivery, measured in days. This study is registered with BioMed Central, number ISRCTN 39133303. Findings Between Nov 21, 2014, and July 6, 2016, we recruited 135 women and randomly assigned 70 women to sildenafil and 65 women to placebo. We found no difference in the median randomisation to delivery interval between women assigned to sildenafil (17 days [IQR 7–24]) and women assigned to placebo (18 days [8–28]; p=0·23). Livebirths (relative risk [RR] 1·06, 95% CI 0·84 to 1·33; p=0·62), fetal deaths (0·89, 0·54 to 1·45; p=0·64), neonatal deaths (1·33, 0·54 to 3·28; p=0·53), and birthweight (−14 g,–100 to 126; p=0·81) did not differ between groups. No differences were found for any other secondary outcomes. Eight serious adverse events were reported during the course of the study (six in the placebo group and two in the sildenafil group); none of these were attributed to sildenafil. Interpretation Sildenafil did not prolong pregnancy or improve pregnancy outcomes in severe early-onset fetal growth restriction and therefore it should not be prescribed for this indication outside of research studies with explicit participants' consent. Funding National Institute for Health Research and Medical Research Council

Sunetti ta’ William Shakespeare

Ġabra ta’ poeżiji u proża li tinkludi: Grand Prix ta’ Carmel Azzopardi – Pizza marinara ta’ Carmel Azzopardi – Ħajku ta’ Kit Azzopardi – Ix-xemgħa qiegħda ta’ Charles Bezzina – U taħti ramel, ramel ta’ Charles Bezzina – Vażett ta’ Ġorġ Borg – Bniedem li mhux ta’ Ġorġ Borg – Il-ħajbu ta’ Antoine Cassar – Il-mistoħbija ta’ Manwel Cassar – Għasel ta’ Carmel G. Cauchi – Dgħajsa ta’ Carmel G. Cauchi – Ħitan ta’ Alfred Degabriele – Skeletru silwett...f’realtà moħbija ta’ Stefano Farrugia – Minjatura tal-enimmi ta’ Stefano Farrugia – Mnejn jgħaddi Kristu ta’ Joe Friggieri – Rebbiegħa ta’ Reno Fenech – Blogger ta’ Charles Flores – Veġeterjana ta’ Charles Flores – Mejju ta’ Joe P. Galea – Kien hemm lejla u tmien nisa ta’ Claudia Gauci – Ħobbni ta’ Sergio Grech – Mitlufin ta’ Maria Grech Ganado – Moħħi ta’ Maria Grech Ganado – Viżjoni ta’ Maria Grech Ganado – Inkontinenza ta’ Adrian Grima – Andrew jħebb in-nar ta’ Adrian Grima – It-Tlieta, 20 ta’ Lulju 2004 ta’ Alfred Massa – Fuq l-għolja tal- Verdala ta’ Jane Micallef – Imm’issa ta’ Jane Micallef – Baby blues ta’ Immanuel Mifsud – Ġo dar sawra ta’ Immanuel Mifsud – Lil Dun Karm ta’ Maurice Mifsud Bonnici – Il-fuklar ta’ Achille Mizzi – Ut videam ta’ Achille Mizzi – Karnival solitarju ta’ Patrick Sammut – Mill-baħħ etern ta’ Joe Zammit Tabona – ...fil-ħmieġ ta’ ftit blatiet... ta’ Paul P. Borg – Bħall-qasab ta’ Steve Borg – L-aħħar żjara ta’ Victor Fenech – Ħelwa.morra 18 ta’ Ann Marie Schembri – Jack & Jill ta’ Trevor Żahra – Għadbilura ta’ Russell Davis, traduzzjoni ta’ Toni Aquilina – Sunetti ta’ William Shakespeare, traduzzjoni ta’ Oliver Friggieri.peer-reviewe

Silta mill-"Antigone" ta’ Sofokle

Ġabra ta’ poeżiji u proża li tinkludi: Ħajki ta’ Josette Attard – Din l-għanja tiegħi ta’ Rena Balzan – Fl-irdum fejn jidwi ta’ Charles Bezzina – Naqa’ biss ta’ Ġorġ Borg – Gambrinu, 7.45 a.m. ta’ Norbert Bugeja – Għadam ta’ Joseph Buttigieg – Tħarisx biss fil-wiċċ ta’ John Caruana – Petra ta’ Priscilla Cassar – Mhux iżjed dan il-pajjiż tiegħi ta’ Victor Fenech – Twieqi magħluqa ta’ Maria Grech Ganado – Joseph quddiem ir-ritratt ta’ sieħbu jitfarrak ta’ Adrian Grima – Ta’ l-ilma l-fruntieri tiegħek ta’ Simone Inguanez – Għall-kaċċa tal-grejtwajt ta’ Daniel Massa – Ftit weraq mis-Slovenja ta’ Immanuel Mifsud – Dak li kien ta’ Achille Mizzi – Wassalni ta’ Anna Pullicino – Tamiet fiergħa ta’ Patrick Sammut – Fost l-isbaħ jiem ta’ Lillian Sciberras – Kelma ta’ Marcel Zammit Marmarà – Lill-Imdina żagħżugħa ta’ Joe Zammit Tabona – Sodda ta’ l-ilma ta’ Clare Azzopardi – Kurċifiss ta’ Paul P. Borg – Mera mkissra ta’ Lina Brockdorff – No(ra)vella ta’ Joe Friggieri – L-abbati ta’ Henry Holland – L-eħrex ġurnata tal-gwerra ta’ Maurice Mifsud Bonnici – Marija ta’ Lino Spiteri – Ikla ta’ Trevor Żahra – Il-mara midinba ta’ Albert Camus, traduzzjoni ta’ Toni Aquilina – Silta mill-"Antigone" ta’ Sofokle, traduzzjoni ta’ Victor Xuereb.peer-reviewe

Nikteb...

Ġabra ta’ poeżiji u proża li tinkludi: L-iben il-ħali ta’ David Agius Muscat – Kaptan ta’ Kit Azzopardi – Il-lanterna ta’ Charles Bezzina – Li kelli mmur lura ta’ Ġorġ Borg – Firda ta’ Ġorġ Borg – Garden fairy ta’ Charles Briffa – Sejf jinfidlek ruħek ta’ Charles Briffa – Waqt ta’ Joseph Buttigieg – Vjaġġ ta’ John Caruana – Ċaqlembuta ta’ Antoine Cassar – Ħaġa tqila ta’ Carmel G. Cauchi – F’tarf il-blat ta’ Leanne Ellul – Int ta’ Victor Fenech – Pippin u l-bojja ta’ Charles Flores – L-arloġġ ta’ Joe Friggieri – Il-fjur tal-ġakaranda ta’ Joe Friggieri – Fjur tal-kaktus ta’ Joel Galea – Biss is-skiet ta’ Joel Galea – Għalissa ta’ Maria Grech Ganado – Ilsna ta’ Maria Grech Ganado – Is-sried ixoqqna fin fin ta’ Adrian Grima – Ħsieb ħalliel... ta’ Patrick Sammut – Lament lil ommi ta’ Salv Sammut – Hekk kif tinħass ġol-arja x-xitwa ta’ Lillian Sciberras – F’għajnejha, il-ħarsa siekta ta’ Clare Azzopardi – Għad jagħdab l-irdum ta’ Paul P. Borg – Forsi...xi darba ta’ Charles Casha – Faxxa ngħas ta’ Sergio Grech – Il-mejda tal-mogħdija ta’ Pierre J. Mejlak – Min jaf bi Stojan Kurepa? ta’ Immanuel Mifsud – L-eħrex jum tal-gwerra ta’ Maurice Mifsud Bonnici – Il-vażett tal-bewsiet ta’ Rita Saliba – Pjanu ta’ Trevor Żahra – Il-ħalliel ta’ Guy de Maupassant, traduzzjoni ta’ Toni Aquilina – Salvu tal-pasturi ta’ Francis Ebejer, traduzzjoni ta’ Steve Borg – Sunetti ta’ William Shakespeare, traduzzjoni ta’ Oliver Friggieri – Nikteb... ta’ Nizar Qabbani, traduzzjoni ta’ Kevin Saliba.peer-reviewe

Prenatal reflex DNA screening for trisomies 21, 18, and 13

Purpose The purpose of the study was to determine the screening performance of prenatal reflex DNA screening for trisomies 21 (T21), 18 (T18), and 13 (T13) as part of a routine service at five hospitals. Methods Women who accepted screening had a first-trimester combined test (pregnancy-associated plasma protein A, free β-human chorionic gonadotropin, nuchal translucency interpreted with maternal age). Those with a risk of having an affected pregnancy ≥1 in 800 were reflexed to a DNA sequencing test using stored plasma from the original blood sample, thereby avoiding the need to recall them. Results Of 22,812 women screened (including 106 with affected pregnancies), 2,480 (10.9%) were reflexed to DNA testing; 101/106 were detected (69/73 T21, 24/25 T18, and 8/8 T13), a 95% detection rate (95% confidence interval 89–98%) with four false positives (0.02%, 95% confidence interval 0.00–0.05%). The odds of being affected given a positive result were 25:1. Of the 105 screen-positive pregnancies, 91 (87%) had an invasive diagnostic test. Reflex DNA screening avoided up to 530 invasive diagnostic tests compared with using the combined test. Conclusion Reflex DNA screening was successfully implemented in routine care, achieving a high detection rate, low false-positive rate, and, consequently, greater safety with fewer invasive diagnostic tests than other methods of screening