A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (Part I - Protection via specific pathways).

Neurocognitive deficits are a major source of morbidity in survivors of cardiac arrest. Treatment options that could be implemented either during cardiopulmonary resuscitation or after return of spontaneous circulation to improve these neurological deficits are limited. We conducted a literature review of treatment protocols designed to evaluate neurologic outcome and survival following cardiac arrest with associated global cerebral ischemia. The search was limited to investigational therapies that were utilized to treat global cerebral ischemia associated with cardiac arrest. In this review we discuss potential mechanisms of neurologic protection following cardiac arrest including actions of several medical gases such as xenon, argon, and nitric oxide. The 3 included mechanisms are: 1. Modulation of neuronal cell death; 2. Alteration of oxygen free radicals; and 3. Improving cerebral hemodynamics. Only a few approaches have been evaluated in limited fashion in cardiac arrest patients and results show inconclusive neuroprotective effects. Future research focusing on combined neuroprotective strategies that target multiple pathways are compelling in the setting of global brain ischemia resulting from cardiac arrest

Diffusive behavior of a greedy traveling salesman

Using Monte Carlo simulations we examine the diffusive properties of the greedy algorithm in the d-dimensional traveling salesman problem. Our results show that for d=3 and 4 the average squared distance from the origin is proportional to the number of steps t. In the d=2 case such a scaling is modified with some logarithmic corrections, which might suggest that d=2 is the critical dimension of the problem. The distribution of lengths also shows marked differences between d=2 and d>2 versions. A simple strategy adopted by the salesman might resemble strategies chosen by some foraging and hunting animals, for which anomalous diffusive behavior has recently been reported and interpreted in terms of Levy flights. Our results suggest that broad and Levy-like distributions in such systems might appear due to dimension-dependent properties of a search space.Comment: accepted in Phys. Rev.

Timing of the 2008 Outburst of SAX J1808.4-3658 with XMM-Newton: A Stable Orbital Period Derivative over Ten Years

We report on a timing analysis performed on a 62-ks long XMM-Newton observation of the accreting millisecond pulsar SAX J1808.4-3658 during the latest X-ray outburst that started on September 21, 2008. By connecting the time of arrivals of the pulses observed during the XMM observation, we derived the best-fit orbital solution and a best-fit value of the spin period for the 2008 outburst. Comparing this new set of orbital parameters and, in particular, the value of the time of ascending-node passage with the orbital parameters derived for the previous four X-ray outbursts of SAX J1808.4-3658 observed by the PCA on board RXTE, we find an updated value of the orbital period derivative, which turns out to be $\dot P_{\rm orb} = (3.89 \pm 0.15) \times 10^{-12}$ s/s. This new value of the orbital period derivative agrees with the previously reported value, demonstrating that the orbital period derivative in this source has remained stable over the past ten years. Although this timespan is not sufficient yet for confirming the secular evolution of the system, we again propose an explanation of this behavior in terms of a highly non-conservative mass transfer in this system, where the accreted mass (as derived from the X-ray luminosity during outbursts) accounts for a mere 1% of the mass lost by the companion.Comment: 4 pages, 3 figures. Final version, including editing corrections, to appear on A&A Letter

Relationships among food label use, motivation, and dietary quality.

Nutrition information on packaged foods supplies information that aids consumers in meeting the recommendations put forth in the US Dietary Guidelines for Americans such as reducing intake of solid fats and added sugars. It is important to understand how food label use is related to dietary intake. However, prior work is based only on self-reported use of food labels, making it unclear if subjective assessments are biased toward motivational influences. We assessed food label use using both self-reported and objective measures, the stage of change, and dietary quality in a sample of 392 stratified by income. Self-reported food label use was assessed using a questionnaire. Objective use was assessed using a mock shopping task in which participants viewed food labels and decided which foods to purchase. Eye movements were monitored to assess attention to nutrition information on the food labels. Individuals paid attention to nutrition information when selecting foods to buy. Self-reported and objective measures of label use showed some overlap with each other (r=0.29, p<0.001), and both predicted dietary quality (p<0.001 for both). The stage of change diminished the predictive power of subjective (p<0.09), but not objective (p<0.01), food label use. These data show both self-reported and objective measures of food label use are positively associated with dietary quality. However, self-reported measures appear to capture a greater motivational component of food label use than do more objective measures

Misunderstanding of Front-Of-Package Nutrition Information on US Food Products.

Front-of-package nutrition symbols (FOPs) are presumably readily noticeable and require minimal prior nutrition knowledge to use. Although there is evidence to support this notion, few studies have focused on Facts Up Front type symbols which are used in the US. Participants with varying levels of prior knowledge were asked to view two products and decide which was more healthful. FOPs on packages were manipulated so that one product was more healthful, allowing us to assess accuracy. Attention to nutrition information was assessed via eye tracking to determine what if any FOP information was used to make their decisions. Results showed that accuracy was below chance on half of the comparisons despite consulting FOPs. Negative correlations between attention to calories, fat, and sodium and accuracy indicated that consumers over-relied on these nutrients. Although relatively little attention was allocated to fiber and sugar, associations between attention and accuracy were positive. Attention to vitamin D showed no association to accuracy, indicating confusion surrounding what constitutes a meaningful change across products. Greater nutrition knowledge was associated with greater accuracy, even when less attention was paid. Individuals, particularly those with less knowledge, are misled by calorie, sodium, and fat information on FOPs

Large Scale Inhomogeneities from the QCD Phase Transition

We examine the first-order cosmological QCD phase transition for a large class of parameter values, previously considered unlikely. We find that the hadron bubbles can nucleate at very large distance scales, they can grow as detonations as well as deflagrations, and that the phase transition may be completed without reheating to the critical temperature. For a subset of the parameter values studied, the inhomogeneities generated at the QCD phase transition might have a noticeable effect on nucleosynthesis.Comment: 15 LaTeX pages + 6 PostScript figures appended at the end of the file, HU-TFT-94-1

Prospects for Determining the Mass Distributions of Galaxy Clusters on Large Scales Using Weak Gravitational Lensing

For more than two decades, the Navarro, Frenk, and White (NFW) model has stood the test of time; it has been used to describe the distribution of mass in galaxy clusters out to their outskirts. Stacked weak lensing measurements of clusters are now revealing the distribution of mass out to and beyond their virial radii, where the NFW model is no longer applicable. In this study we assess how well the parameterised Diemer & Kravstov (DK) density profile describes the characteristic mass distribution of galaxy clusters extracted from cosmological simulations. This is determined from stacked synthetic lensing measurements of the 50 most massive clusters extracted from the Cosmo-OWLS simulations, using the Dark Matter Only run and also the run that most closely matches observations. The characteristics of the data reflect the Weighing the Giants survey and data from the future Large Synoptic Survey Telescope (LSST). In comparison with the NFW model, the DK model favored by the stacked data, in particular for the future LSST data, where the number density of background galaxies is higher. The DK profile depends on the accretion history of clusters which is specified in the current study. Eventually however subsamples of galaxy clusters with qualities indicative of disparate accretion histories could be studied

Human platelet lysate as a potential clinical-translatable supplement to support the neurotrophic properties of human adipose-derived stem cells

Background: The autologous nerve graft, despite its donor site morbidity and unpredictable functional recovery, continues to be the gold standard in peripheral nerve repair. Rodent research studies have shown promising results with cell transplantation of human adipose-derived stem cells (hADSC) in a bioengineered conduit, as an alternative strategy for nerve regeneration. To achieve meaningful clinical translation, cell therapy must comply with biosafety. Cell extraction and expansion methods that use animal-derived products, including enzymatic adipose tissue dissociation and the use of fetal bovine serum (FBS) as a culture medium supplement, have the potential for transmission of zoonotic infectious and immunogenicity. Human-platelet-lysate (hPL) serum has been used in recent years in human cell expansion, showing reliability in clinical applications. Methods: We investigated whether hADSC can be routinely isolated and cultured in a completely xenogeneic-free way (using hPL culture medium supplement and avoiding collagenase digestion) without altering their physiology and stem properties. Outcomes in terms of stem marker expression (CD105, CD90, CD73) and the osteocyte/adipocyte differentiation capacity were compared with classical collagenase digestion and FBS-supplemented hADSC expansion. Results: We found no significant differences between the two examined extraction and culture protocols in terms of cluster differentiation (CD) marker expression and stem cell plasticity, while hADSC in hPL showed a significantly higher proliferation rate when compared with the usual FBS-Added medium. Considering the important key growth factors (particularly brain-derived growth factor (BDNF)) present in hPL, we investigated a possible neurogenic commitment of hADSC when cultured with hPL. Interestingly, hADSC cultured in hPL showed a statistically higher secretion of neurotrophic factors BDNF, glial cell-derived growth factor (GDNF), and nerve-derived growth factor (NFG) than FBS-cultured cells. When cocultured in the presence of primary neurons, hADSC which had been grown under hPL supplementation, showed significantly enhanced neurotrophic properties. Conclusions: The hPL-supplement medium could improve cell proliferation and neurotropism while maintaining stable cell properties, showing effectiveness in clinical translation and significant potential in peripheral nerve research