A prospective, double blind randomised controlled trial on efficacy of laparoscopic uterosacral nerve ablation as an alternative of pharmacotherapy in treatment of chronic pelvic pain

Background: Chronic Pelvic Pain (CPP) is one of the commonest symptomatology in gynaecologist’s outpatient clinics. CPP has a profound impact on a woman's health and quality of life, including an economic impact through loss of working hours. Treatment for chronic pelvic pain is often unsatisfactory. Present study compares Laparoscopic Uterosacral Nerve Ablation (LUNA) with laparoscopy without pelvic denervation in patients presenting with chronic pelvic pain to our outpatient clinic.Methods: It was a Randomised Controlled Trial Study. After considering inclusion and exclusion criteria, 120 patients were selected, out of which 60 (Group I) had undergone diagnostic laparoscopy and 60 (Group II) had undergone diagnostic laparoscopy with LUNA.Results: The overall success rate for group I and group II were 80%, 78.3% and 66.6% versus 85%, 81.6%, and 83.3% at 3, 6, and 12 months, respectively. However, on subgroup analysis it was found that in patients suffering from Congestive Dysmenorrhoea, there was a significant difference in success rate of both the groups.Conclusions: It was found in present study that there was a benefit for patients with dysmenorrheal, further research in this area is desirable to reach towards a discrete conclusion regarding the benefits of LUNA in patients of CPP

Field evaluation of Indian gooseberry (Emblica officinalis) accessions for yield, fruit quality and antioxidant potential

Ten diverse promising genotypes of Indian gooseberry (Emblica officinalis Gaertn.) along with two commercial varieties, viz, NA-6 and NA-7 were evaluated during the year 2013 and 2014 for commercial potential based on tree growth and physico-chemical characteristics. Maximum plant height was recorded in genotype CISH A-19 (7.11m) and minimum in NA-6 (4.13m). Plant spread in East-West and North-South directions varied from 3.01-5.13m and 2.91-4.89m respectively, while plant girth was recorded maximum in CISH A-19 (63.88 cm). Pulp weight varied from (22.91-33.92g), recorded highest in genotype CISH A-31 (33.92g) while lowest weight was found in CISH A-17 (22.91g). Large variations in fruit shape, viz. oval round, flattened round, round, conical, flattened oblong and flattened oval was noticed amongst the genotypes. Similarly, fruit colour at maturity among different genotypes recorded as green, light green and pinkish. Fruit weight varied from 24.37 to 35.41g among the different genotypes being highest in genotype CISH A-19 (35.41g) which is significantly higher than the standard check varieties NA-6 (28.49g) and NA-7 (30.30g). No significant difference was recorded amongst the studied material with respect to standard check for fruit length and fruit diameter. Significantly higher percentage of pulp was recorded in CISH A-31 (95.60%) compared to check NA-6 (94.77%) and NA-7 (95.01%). Stone size with respect to length ranged from 1.02-1.15cm being highest in CISH-A-15 (1.15 cm) while stone width was recorded maximum in CISH A-1 and CISH A-2 (1.06cm). Stone weight varied from 1.46-1.57g being maximum recorded in CISH A-19 (1.57g) and minimum in CISH A-17 (1.46g). Considerable variation in fruit yield (26.14 to 52.50 kg/tree) from 6 years old trees were observed. Highest fruit yield was recorded in genotype CISH A-31 (52.50 kg/tree) followed by CISH A-3 (48.11 kg/tree) which is highly significant compared to standard check NA-6 (32.90 kg/tree) and NA-7 (35.76kg/tree). The chemical parameters, viz. vitamin-C content ranged from 309.66-473.13 mg/100g, TSS (9.3-10.6 0B), acidity (1.49-2.88%), total sugar content (5.66-6.89%), polyphenol content (0.633-1.427 mg/100g) and FRAP activity (102.01-235.76 mg/100g FeSO4) among different accessions evaluated. Conclusively, based on yield, associated physico-chemical traits and antioxidant value, genotype CISH A-31 found most promising and can be recommended for future commercialization

Nitsche method for Navier-Stokes equations with slip boundary conditions: Convergence analysis and VMS-LES stabilization

In this paper, we analyze the Nitsche's method for the stationary Navier-Stokes equations on Lipschitz domains under minimal regularity assumptions. Our analysis provides a robust formulation for implementing slip (i.e. Navier) boundary conditions in arbitrarily complex boundaries. The well-posedness of the discrete problem is established using the Banach Ne\v{c}as Babu\v{s}ka and the Banach fixed point theorems under standard small data assumptions, and we also provide optimal convergence rates for the approximation error. Furthermore, we propose a VMS-LES stabilized formulation, which allows the simulation of incompressible fluids at high Reynolds numbers. We validate our theory through numerous numerical tests in well established benchmark problems

Spoken language-mediated anticipatory eye-movements are modulated by reading ability - Evidence from Indian low and high literates

We investigated whether levels of reading ability attained through formal literacy are related to anticipatory language-mediated eye movements. Indian low and high literates listened to simple spoken sentences containing a target word (e.g., "door") while at the same time looking at a visual display of four objects (a target, i.e. the door, and three distractors). The spoken sentences were constructed in such a way that participants could use semantic, associative, and syntactic information from adjectives and particles (preceding the critical noun) to anticipate the visual target objects. High literates started to shift their eye gaze to the target objects well before target word onset. In the low literacy group this shift of eye gaze occurred only when the target noun (i.e. "door") was heard, more than a second later. Our findings suggest that formal literacy may be important for the fine-tuning of language-mediated anticipatory mechanisms, abilities which proficient language users can then exploit for other cognitive activities such as spoken language-mediated eye gaze. In the conclusion, we discuss three potential mechanisms of how reading acquisition and practice may contribute to the differences in predictive spoken language processing between low and high literates

Magnetoresistance behavior of a ferromagnetic shape memory alloy: Ni_1.75Mn_1.25Ga

A negative-positive-negative switching behavior of magnetoresistance (MR) with temperature is observed in a ferromagnetic shape memory alloy Ni_1.75Mn_1.25Ga. In the austenitic phase between 300 and 120 K, MR is negative due to s-d scattering. Curiously, below 120K MR is positive, while at still lower temperatures in the martensitic phase, MR is negative again. The positive MR cannot be explained by Lorentz contribution and is related to a magnetic transition. Evidence for this is obtained from ab initio density functional theory, a decrease in magnetization and resistivity upturn at 120 K. Theory shows that a ferrimagnetic state with anti-ferromagnetic alignment between the local magnetic moments of the Mn atoms is the energetically favoured ground state. In the martensitic phase, there are two competing factors that govern the MR behavior: a dominant negative trend up to the saturation field due to the decrease of electron scattering at twin and domain boundaries; and a weaker positive trend due to the ferrimagnetic nature of the magnetic state. MR exhibits a hysteresis between heating and cooling that is related to the first order nature of the martensitic phase transition.Comment: 17 pages, 5 figures. Accepted in Phys. Rev.

Critical review of Surgical treatment of Mutrashmari according to Sushruta

The Mutravaha Samsthana (Urinary system) is meant for the formation and excretion of Mutra. Mutravaha stroto dushti causes Mutrakricchra, Mutraghata, Mutrashmari etc. Mutrashmari is one of the most common and distressing maladies among the group of urinary disorders. Acharya Sushruta, the pioneer in the art and science of surgery has described widely and comprehensively about the Mutrashmari with its classification, symptomatology, aetiology, pathology, complications and its management. This is the proof for the depth of knowledge of the Acharyas on the subject of urinary disorders as a whole. Ashmari is mentioned as one of Ashta Mahagadas, so it requires great attention for its cure. early detected Ashmari can be treated with medicines because of its recent origin and small size, while an Ashmari of long-time origin is difficult to cure and large Ashmari is also an indication for surgical treatment (Shalya Chikitsa)

Lightweight novel trust based framework for IoT enabled wireless network communications

For IoT enabled networks, the security and privacy is one of the important research challenge due to open nature of wireless communications, especially for the networks like Vehicular Ad hoc Networks (VANETs). The characteristics like heterogeneity, constrained resources, scalability requirements, uncontrolled environment etc. makes the problems of security and privacy even more challenging. Additionally, the high degree of availability needs of IoT networks may compromise the integrity and confidentially of communication data. The security threats mainly performed during the operations of data routing, hence designing the secure routing protocol main research challenge for IoT networks. In this paper, to design the lightweight security algorithm the use of Named Data Networking (NDN) which provides the benefits applicable for IoT applications like built-in data provenance assurance, stateful forwarding etc. Therefore the novel security framework NDN based Cross-layer Attack Resistant Protocol (NCARP) proposed in this paper. In NCARP, we designed the cross-layer security technique to identify the malicious attackers in network to overcome the problems like routing overhead of cryptography and trust based techniques. The parameters from the physical layer, Median Access Control (MAC) layer, and routing/network layer used to compute and averages the trust score of each highly mobility nodes while detecting the attackers and establishing the communication links. The simulation results of NCARP is measured and compared in terms of precision, recall, throughput, packets dropped, and overhead rate with state-of-art solutions

Novel glioblastoma markers with diagnostic and prognostic value identified through transcriptome analysis

Purpose: Current methods of classification of astrocytoma based on histopathologic methods are often subjective and less accurate. Although patients with glioblastoma have grave prognosis, significant variability in patient outcome is observed. Therefore, the aim of this study was to identify glioblastoma diagnostic and prognostic markers through microarray analysis. Experimental Design: We carried out transcriptome analysis of 25 diffusely infiltrating astrocytoma samples [WHO grade II - diffuse astrocytoma, grade III - anaplastic astrocytoma, and grade IV - glioblastoma (GBM)] using cDNA microarrays containing 18,981 genes. Several of the markers identified were also validated by real-time reverse transcription quantitative PCR and immunohistochemical analysis on an independent set of tumor samples (n = 100). Survival analysis was carried out for two markers on another independent set of retrospective cases (n = 51). Results: We identified several differentially regulated grade-specific genes. Independent validation by real-time reverse transcription quantitative PCR analysis found growth arrest and DNA-damage-inducible α (GADD45α) and follistatin-like 1 (FSTL1) to be up-regulated in most GBMs (both primary and secondary), whereas superoxide dismutase 2 and adipocyte enhancer binding protein 1 were up-regulated in the majority of primary GBM. Further, identification of the grade-specific expression of GADD45α and FSTL1 by immunohistochemical staining reinforced our findings. Analysis of retrospective GBM cases with known survival data revealed that cytoplasmic overexpression of GADD45α conferred better survival while the coexpression of FSTL1 with p53 was associated with poor survival. Conclusions: Our study reveals that GADD45α and FSTLI are GBM-specific whereas superoxide dismutase 2 and adipocyte enhancer binding protein 1 are primary GBM-specific diagnostic markers. Whereas GADD45α overexpression confers a favorable prognosis, FSTL1 overexpression is a hallmark of poor prognosis in GBM patients