脳卒中後片麻痺者における歩行立脚期と遊脚期を想定した練習の即時効果

京都大学新制・論文博士博士(人間健康科学)乙第13430号論人健博第8号新制||人健||6(附属図書館)京都大学大学院医学研究科人間健康科学系専攻(主査)教授 黒木 裕士, 教授 青山 朋樹, 教授 松田 秀一学位規則第4条第2項該当Doctor of Human Health SciencesKyoto UniversityDFA

Non-ladder Extended Renormalization Group Analysis of the Dynamical Chiral Symmetry Breaking

The order parameters of dynamical chiral symmetry breaking in QCD, the dynamical mass of quarks and the chiral condensates, are evaluated by numerically solving the Non-Perturbative Renormalization Group (NPRG) equations. We employ an approximation scheme beyond ``the ladder'', that is, beyond the (improved) ladder Schwinger-Dyson equations. The chiral condensates are enhanced compared with the ladder ones, which is phenomenologically favorable. The gauge dependence of the order parameters is fairly reduced in this scheme.Comment: 18 pages, 30 eps file, 15 figures, LaTeX, slightly revised, references corrected, To be published in Prog. Theo. Phy

Validation of Short-Term Skin-Sensitizing Igg Antibodies to Egg in Atopic Dermatitis by Prausnitz-Küstner (P-K) and Oral P-K Tests

ABSTRACTWe tried to evaluate the role of IgG antibodies in the wheal and flare reaction of infantile atopic dermatitis by in vivo skin-sensitizing methods. Sera from 49 patients under 6 years of age were heated at 56°C for 30min to inactivate IgE antibodies, according to previous reports. Two-fold serial dilutions of the heated serum were injected intracutaneously in both forearms of a non-allergic recipient. One hour later, the whole egg antigen (1:1000) was injected in the serum transfer sites of an arm and the reaction was read at 15min (IgG Prausnitz-Küstner (P-K) test). Immediately afterwards, a raw hen's egg was swallowed by the recipient and the serum transfer sites of the other arm were observed for 2h (oral IgG P-K test). Three patients under 1 year of age showed an immediate wheal and flare reaction in the IgG P-K test, but none of the patients showed a positive reaction in the oral IgG P-K test. The patients with a positive IgG P-K test had an IgE radioallergosorbent test (RAST) score >4 to egg white and a positive IgE P-K titer of >28 to whole egg antigen. Two patients showed a positive reaction to the oral IgE P-K test to raw egg ingestion. Ovalbumin-specific IgG, lgG3 and lgG4 antibodies were assayed in 20 patients. IgG, and lgG3 antibodies were significantly increased in two patients with a positive IgG P-K test, while levels of the lgG4 antibody in positive patients were not significantly increased in comparison with levels in negative patients. In conclusion, these results suggest that the IgG antibody may play a role in the immediate type allergic reaction in infantile atopic dermatitis

Physics prospects of future neutrino oscillation experiments in Asia

The three neutrino model has 9 physical parameters, 3 neutrino masses, 3 mixing angles and 3 CP violating phases. Among them, neutrino oscillation experiments can probe 6 parameters: 2 mass squared differences, 3 mixing angles, and 1 CP phase. The experiments performed so far determined the magnitudes of the two mass squared differences, the sign of the smaller mass squared difference, the magnitudes of two of the three mixing angles, and the upper bound on the third mixing angle. The sign of the larger mass squared difference (the neutrino mass hierarchy pattern), the magnitude of the third mixing angle and the CP violating phase, and a two-fold ambiguity in the mixing angle that dictates the atmospheric neutrino oscillation should be determined by future oscillation experiments. In this talk, I introduce a few ideas of future long baseline neutrino oscillation experiments which make use of the super neutrino beams from J-PARC (Japan Proton Accelerator Research Complex) in Tokai village. We examine the potential of HyperKamiokande (HK), the proposed 1 Mega-ton water Cerenkov detector, and then study the fate and possible detection of the off-axis beam from J-PARC in Korea. We also show that very long baseline experiments with higher energy beams from J-PARC and a water Cerenkov calorimeter detector (BAND) proposed in Beijing can resolve the neutrino mass hierarchy, and lift all the degeneracies in the three neutrino model parameters.Comment: Talk at SEESAW 1979-2004, 23-25 February 2004, KEK. 20 pages, 17 figure

The Use of Electrospun Organic and Carbon Nanofibers in Bone Regeneration

There has been an increasing amount of research on regenerative medicine for the treatment of bone defects. Scaffolds are needed for the formation of new bone, and various scaffolding materials have been evaluated for bone regeneration. Materials with pores that allow cells to differentiate into osteocytes are preferred in scaffolds for bone regeneration, and porous materials and fibers are well suited for this application. Electrospinning is an effective method for producing a nanosized fiber by applying a high voltage to the needle tip containing a polymer solution. The use of electrospun nanofibers is being studied in the medical field, and its use as a scaffold for bone regeneration therapy has become a topic of growing interest. In this review, we will introduce the potential use of electrospun nanofiber as a scaffold for bone regenerative medicine with a focus on carbon nanofibers produced by the electrospinning method.ArticleNANOMATERIALS. 10(3):562 (2020)journal articl

Massive trapezial metastasis from gastric adenocarcinoma resected and reconstructed with a vascularized scapular bone graft: A case report

Rationale: Isolated metastasis to the hand bones is very rare. Only seven cases of metastasis to the trapezium have been reported. To the best of our knowledge, this is the first report of a single metastasis to the trapezium from a gastric adenocarcinoma. Patient concerns: A 62-year-old man presented with pain and massive swelling in the right carpometacarpal joint of the thumb. Diagnoses: The patient was diagnosed with trapezial metastasis of advanced gastric adenocarcinoma. Interventions: The patient underwent systemic chemotherapy with cisplatin and S-1, radiotherapy to the metastatic bone, and treatment with denosumab. One year later, the huge metastatic tumor was resected, and the hand was reconstructed using vascularized scapular bone. Outcomes: Eighteen months postoperatively, the patient was satisfied with the appearance of the reconstructed hand and was able to use his right thumb in activities of daily living. Lessons: Although rare, metastasis to the trapezium should be considered in patients with persistent and progressive thumb CMC joint pain.ArticleMedicine 96(50) : e9294(2017)journal articl

Examining the Validity of Efforts of the Muscular Dystrophy Medical Network in Nagano : A Questionnaire Study

Article信州医学雑誌 66(3): 205-212(2018)journal articl

Continued growth of locally aggressive fibrous dysplasia of 22 years duration after reaching adulthood: a case report

Fibrous dysplasia generally stops growing when patients reach adulthood. Locally aggressive fibrous dysplasia is an extremely rare subtype of fibrous dysplasia that is characterized by progressive enlargement after bone maturation, cortical bone destruction and soft tissue invasion but without malignant transformation. At 50 years of age, a tumor was found in the rib of a patient. The tumor gradually enlarged over time and imaging findings suggested a malignant tumor. The case was further complicated by restrictive lung disorder. Biopsies from multiple sites showed no malignant findings, and marginal resection with partial curettage was performed. The final diagnosis was locally aggressive fibrous dysplasia, and the restrictive lung disorder improved postoperatively. The natural history of the disease is also unknown. This is the first report in the literature to describe a case in which a lesion exhibited long-term growth over a period of 22 years after reaching adulthood.ArticleJournal of surgical case reports 2020(2) : rjz406(2020)journal articl

The Decay of Tau Leptons Produced in Neutrino-Nucleon Scatterings

Energy and angular distributions of the tau decay products in the CERN-to-Gran Sasso $\nu_\tau$ appearance experiments are studied for the decay modes $\tau\to\pi\nu$ and $\tau\to l\bar\nu\nu$ (l=e or mu). We find that the decay particle distributions in the laboratory frame are significantly affected by the tau polarization. Rather strong azimuthal asymmetry of $pi^-$ and $l^-$ about the tau momentum axis is predicted, which may have observable consequences even at small statistics experiments.Comment: 14 pages, 6 eps figures; comments on Fig. 1 added, Fig. 4 improved to see clearl