Some Unexplored Economics of Roaming Child Workers

Within the net of child labour, there is a section of children who live their lives on the streets, without any kind of attachment with their family and maintain their livelihood through working as informal child workers. This study is based on these children who are termed here as ‘Roaming child workers’. It came out that apart from poverty of the parents there are other socio-economic reasons which force a child to come out from the family and work as child worker in the urban areas. It also came out from field survey that after leaving home a good number of children are economically better off and even able to keep themselves above the poverty line. But still they are very vulnerable. Through this study, effort has been made to prove that average monthly expenditure on substances of these ‘Roaming working children’ increases at a decreasing rate with their average monthly income, whereas, average monthly expenditure on entertainment shares a linear relationship with average monthly income.Child Labour, Poverty and Consumption Pattern

Drivers of Credit Penetration in Eastern India

This article highlights that the eastern region of India continues to lag behind other regions in harnessing the potential of bank credit as an instrument to promote growth and development, notwithstanding concerted policy efforts to further financial inclusion in the region. While enhancing access to credit remains critical to strengthen credit penetration in the region, empirical findings suggest that factors influencing demand for credit – per capita income, level of industrial activity and availability of infrastructure such as road network and power supply – also matter

Drivers of Credit Penetration in Eastern India

This article highlights that the eastern region of India continues to lag behind other regions in harnessing the potential of bank credit as an instrument to promote growth and development, notwithstanding concerted policy efforts to further financial inclusion in the region. While enhancing access to credit remains critical to strengthen credit penetration in the region, empirical findings suggest that factors influencing demand for credit – per capita income, level of industrial activity and availability of infrastructure such as road network and power supply – also matter

Physico-chemical properties of different kind of rice water and their effect on diarrhoea causing bacteria and dandruff causing fungi

Rice water has been used for curing various ailments. The experiment was conducted to know the physico-chemical and cooking properties of six fine rice varieties. Length and breadth of the reported varieties ranges from 6–7.8mm and 4.5–5.5mm. The highest amylose (28%) was estimated in Gobindo bhog non - boiled rice followed by Sona Masori half boiled rice (24.2%) and lowest (18.6%) were Saffola arise active rice and Kerala rice. Alkali spreading value ranges from 3.0 to 3.9 of the tested varieties. Cooking time varied from 11min to 31min among the tested rice varieties. Elongation ratio of the fine rice varieties ranges from 1.5 to 2.4. Rice water of Kerala rice, Saffola arise active rice and full boiled rice had shown the significant zone of against diarrhoea causing bacteria. Overnight and 1 hr shocked rice water had shown the effective result against the dandruff causing fungi.ÂÂ

Some Unexplored Economics of Roaming Child Workers

Within the net of child labour, there is a section of children who live their lives on the streets, without any kind of attachment with their family and maintain their livelihood through working as informal child workers. This study is based on these children who are termed here as ‘Roaming child workers’. It came out that apart from poverty of the parents there are other socio-economic reasons which force a child to come out from the family and work as child worker in the urban areas. It also came out from field survey that after leaving home a good number of children are economically better off and even able to keep themselves above the poverty line. But still they are very vulnerable. Through this study, effort has been made to prove that average monthly expenditure on substances of these ‘Roaming working children’ increases at a decreasing rate with their average monthly income, whereas, average monthly expenditure on entertainment shares a linear relationship with average monthly income

Recombinant Hormones: Applications And Challenges

Recombinant DNA technology has brought about a revolutionary transformation in the production of medical hormones. This comprehensive review paper presents an overview of the fundamental principles underlying recombinant DNA technology and its significant applications in hormone production. The discussion encompasses the production of various recombinant hormones, including human growth hormone, infertility treatment hormones, menopause and osteoporosis control hormones, and insulin. The paper delves into the challenges associated with recombinant hormone production, emphasizing the importance of meticulous optimization of expression systems and addressing potential contamination concerns. Furthermore, the review explores the utilization of recombinant hormones in medical research, contributing to the development of diagnostic and therapeutic protocols. Ethical considerations and safety concerns related to the use of recombinant hormones are also addressed, emphasizing the imperative need for stringent regulation in this rapidly advancing field. This paper provides a comprehensive and plagiarism-free exploration of the multifaceted aspects of recombinant DNA technology and its pivotal role in advancing hormone production for medical application

Clinically Evaluating The Level Of Tumor Necrosis Factor-Alpha On Tissue Around Implant And Tooth

Background: Implant dentistry has become increasingly prevalent, with complications such as peri-implantitis posing challenges. Tumor necrosis factor-alpha (TNF-α) has been implicated in the inflammatory response around dental implants, akin to its role in periodontal diseases. Evaluating TNF-α levels in peri-implant tissues compared to healthy tooth tissues could provide insights into the inflammatory environment and aid in clinical management. Materials and Methods: A cross-sectional study was conducted involving 50 participants with dental implants and healthy adjacent teeth. Peri-implant mucosal samples and gingival tissue around healthy teeth were collected. TNF-α levels were quantified using enzyme-linked immunosorbent assay (ELISA) kits. Statistical analysis was performed to compare TNF-α concentrations between peri-implant tissues and healthy tooth tissues. Results: The mean TNF-α level in peri-implant tissues was found to be 120 pg/mL (standard deviation ± 25 pg/mL), whereas in healthy tooth tissues, it was 60 pg/mL (standard deviation ± 15 pg/mL). Statistical analysis revealed a significant difference (p < 0.05) in TNF-α levels between peri-implant tissues and healthy tooth tissues. Conclusion: Elevated levels of TNF-α in peri-implant tissues suggest a heightened inflammatory response compared to healthy tooth tissues. This underscores the potential role of TNF-α in peri-implantitis pathogenesis and emphasizes the importance of monitoring inflammatory biomarkers for early detection and targeted intervention in implant dentistry

Inhibitory activity of Enhydra fluctuans Lour. on calcium oxalate crystallisation through in silico and in vitro studies

The decoction of the whole plant of Enhydra fluctuans is used ethno medicinally by various tribes for the treatment of kidney stones and urinary problems. However, no scientific studies were carried out to delineate its influence on urinary stone formation and crystallisation. Hence, the present study is proposed to investigate the effect of the aqueous extract of Enhydra fluctuans extract on in vitro crystallisation of calcium oxalate. The present study also evaluated. in silico studies of the metabolites with the target proteins present in the renal calcium oxalate stone matrix. The plant material was subjected to decoction to obtain an aqueous extract. The effect of the extract on calcium oxalate crystallization was evaluated by in vitro nucleation and aggregation assays. Further, the metabolites present in E. fluctuans were mined from the existing literature and their number was found to be 35. The selected 35 metabolites of E. fluctuans were subjected to molecular docking with the 5 proteins which are known to be responsible for calcium oxalate crystal growth. Results of in vitro studies indicated that the extract (50, 100, and 200 μg/mL) and standard drug cystone (1,000 μg/mL) exhibited an inhibitory role in the nucleation process where the percentage inhibitions were 52.69, 43.47, 21.98, and 31.67 μg/mL respectively. The results of molecular docking studies revealed that 2 out of 35 metabolites i.e. Baicalein-7-O-diglucoside and 4′,5,6,7-Tetrahydroxy-8-methoxy isoflavone-7-O-beta-D- galactopyranosyl-(1→3)-O-beta-D-xylopyranosyl-(1→4)- O-alpha-L-rhamnopyranoside showed modulatory effects on the four renal stone matrix-associated protein (Human CTP: Phosphoethanolamine Cytidylyltransferase (Protein Data Bank ID: 3ELB), UDP glucose: glycoprotein glucosyltransferase 2 (Gene: UGGT2) (AlphaFold) and RIMS-binding protein 3A (Gene: RIMBP3) (AlphaFold), and Ras GTPase activating-like protein (PDB: 3FAY) based on their docking scores which indicates that they may inhibit the crystallization process. Findings from this study show that Enhydra fluctuans may be effective in the prevention of the crystallization of calcium oxalate. However, further, in vivo studies as well as molecular studies are needed to be conducted to confirm and strengthen its anti-urolithiatic activity and to elucidate the possible mechanism of action involved therein

Macromolecular design of folic acid functionalized amylopectin- albumin core-shell nanogels for improved physiological stability and colon cancer cell targeted delivery of curcumin

Nanogels have potential for encapsulating cancer therapeutics, yet their susceptibility to physiological degradation and lack of cellular specificity hinder their use as effective oral delivery vehicles. Herein, we engineered novel albumin-core with folic acid functionalized hyperbranched amylopectin shell-type nanogels, prepared through a two-step reaction and loaded with curcumin while the proteinaceous core was undergoing thermal gelation. The nanogels had a mean hydrodynamic diameter of ca. 90 nm and ζ-potential of ca. -24 mV. Encapsulation of curcumin within the nanogels was restored, up to ca. 0.05 mg mL-1, beyond which, a gradual increase in size and a decrease in ζ-potential was observed. The core-shell structures were resilient to in vitro physiological oral-gastrointestinal digestion owing to a liquid crystalline B- and V-type polymorphism in the polysaccharide shell, the latter being driven by the shell functionalization with folic acid. Additionally, these biocompatible nanogels restored stability of the encapsulated curcumin and exhibited augmented cellular uptake and retention specifically in folate receptor-positive HT29 human colon adenocarcinoma cells, inducing early-stage apoptosis. Novel insights from this study represent a promising platform for rational designing of future oral delivery systems that can surmount physiological barriers for delivering cancer therapeutics to colon cancer cells with improved stability and specificity