Morphological variability and genetic diversity of Aman rice germplasm of Bangladesh cultivated in Mymensingh region

Thirty-one Aman rice germplasm were evaluated to assess their morphological variability and genetic diversity considering ten quantitative and thirty one qualitative traits at the field experimental plot of Bangladesh Institute of Nuclear Agriculture, Mymensingh, following randomized complete block design. The germplasm showed significant differences for all the studied traits. The highest grain yield/plant was recorded in Sentu-16 whereas the lowest was found in Gaindha. The genotypic coefficient of variation (GCV) was lower than those of the corresponding phenotypic coefficient of variation (PCV) for all the traits. High PCV and GCV along with heritability, genetic advance (GA) and GA in percentage of mean were recorded for number of filled grains/panicle and number of unfilled grains/panicle. Grain yield/plant had positively significant correlation with plant height, number of total tillers/hill, number of effective tillers/hill, number of filled grains/panicle and thousand grain weight. Path co-efficient analysis suggested that grain yield/plant had positive direct effect in association with days to fifty percent flowering, number of effective tillers/hill, panicle length, number of filled grains/panicle and thousand grain weight. Principal component analysis revealed that the first three components accounted for 79.57% of cumulative variance. Cluster analyses were revealed that the studied rice germplasm organized into five clusters based on D2 values where maximum inter-cluster distance was observed between cluster II and V. Qualitative characterization by distinctness, uniformity and stability test revealed that a wide range of variation was observed among the genotypes. Therefore, this study would be useful for breeders to choose and identify the revival and preservation of beneficial genes for crop improvement

Urban governance for health and well-being: a step-by-step approach to operational research in cities

It has been estimated that, by 2050, more than two thirds of the world’s population will live in cities (5). It is known, however, that intensive urban growth increases inequity and social exclusion, which are associated with increased social, environmental, economic and health risks (6). Public policies to address social determinants are therefore essential for urban health (7, 8). Urban governance determines how effectively urban inequities and risks are addressed. Bad urban governance may harm societies, as the public policies usually fail to address social and environmental determinants (9, 10), while good urban governance promotes policies to improve health and well-being in the population (11). Cities are complex systems, however, and the same public policies may have different effects in different populations, because, beyond public policies, urban health outcomes also depend on the interactions between governance, stakeholders and the population, requiring participatory governance and consensus in policy-making (12, 13). Each context, indicator of performance and implementation strategy is also different. As the rapid global trend to urbanization continues, participatory urban governance has been a topic of increasing research and interventions to improve health outcomes. Some studies have been conducted to identify and evaluate indicators of participatory urban governance (13–16), and others have analysed the results of policies for addressing health inequity (17–21). Few studies, however, have examined participatory urban governance, public policies and health outcomes together (22)

IMPLEMENTASI KONSEP COMMUNITY BASED TOURISM DALAM PENGELOLAAN WISATA BERKELANJUTAN: STUDI DESA SUKOREJO KABUPATEN JEMBER

Sektor pariwisata merupakan aspek fundamental dalam pertumbuhan ekonomi Indonesia dan masih terus dikembangkan. Melalui pedesaan, pariwisata tumbuh dan berkembang dengan sangat baik sesuai dengan potensi yang ada di masing-masing daerah. Tak jarang, keindahan dan panorama pedesaan benar-benar menarik minat masyarakat untuk berkunjung. Sektor pariwisata juga mampu membawa manfaat yang besar, baik bagi pengelola, dunia usaha, masyarakat sekitar, maupun pemerintah desa itu sendiri. Oleh karena itu, dedikasi untuk mengangkat potensi Desa Sukorejo, Bangsalsari, Jember sangatlah penting. Potensi kanal yang sangat eksotik dengan latar belakang persawahan dan Pegunungan Argopuro bisa dijadikan destinasi wisata di Jember. Keterlibatan masyarakat, kelompok sadar pariwisata, badan usaha milik desa, usaha kecil, mikro, dan menengah di Sukorejo adalah suatu keharusan dalam memanfaatkan potensi tersebut. Cara yang dilakukan adalah dengan mengadakan audiensi dengan pemerintah setempat, melatih anggota kelompok sadar pariwisata dan badan usaha milik desa, melakukan kunjungan ke kanal, melakukan perintisan destinasi wisata, dan mempromosikan destinasi. Hasil yang dicapai adalah destinasi percontohan kanal pariwisata yang mengusung konsep pariwisata berbasis masyarakat dengan memanfaatkan potensi Sukorejo. Pengabdian ini diharapkan dapat memajukan perekonomian di Sukorejo dan menjadikan desa tersebut sebagai salah satu desa wisata di Jember

Good urban governance for health and well-being: a systematic review of barriers, facilitators and indicators

Rapid, unplanned urbanization is one of the major ecological and human challenges of the 21st century. UN Habitat predicts that, by 2050, nearly 70% of the world’s population will be living in cities, with disproportionate urban growth in low- and middle-income countries (10). While cities offer opportunities for employment and access to better public services, they also pose major health risks. Good local governance is critical for achieving the 2030 Agenda, and countries must strive to ensure that their cities are creating and improving their physical and social environments and their community resources to enable people to support each other and to develop to their maximum potential. Building on good practices in the WHO Healthy Cities programme, the World Health Organization (WHO) has identified health promotion in urban and local settings as critical to achieving the Sustainable Development Goals (SDGs) and health equity. The WHO and UN Habitat 2016 Global report on urban health concluded that good urban governance – notably the role of city governments and strong leardership – is key to ensuring health equity and the health and well-being of their citizens (10). WHO contracted the Institute of Social and Preventive Medicine, University of Bern, Switzerland, to review the evidence on two issues that are central to health promotion: achieving good governance for health and well-being, understood as participatory governance built on multisectoral action and civic engagement; and measuring the impact of governance on urban health outcomes. The aim of the systematic review was to identify barriers to and facilitators of multisectoral action and civic engagement and to suggest validated indicators and tools for assessing the processes and outcomes of participatory governance for health, equity and well-being in urban settings from published scientific evidence. Findings from the systemic review informed the development of the Urban governance for health and well-being: a step-by-step approach to conducting operational research in cities

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

A first update on mapping the human genetic architecture of COVID-19

peer reviewe

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

A Composite Index to Measure Smartness and Competitiveness of Heritage Tourism Destination and Historic Building

The key issue of this current study is related to shaping the attractiveness of heritage destinations, highlighting the significance of reuse and upgrading their historical buildings to achieve a high level of competitiveness and distinctiveness through a smart approach. Some of these cultural assets and events tend to be monotonous, and not so attractive for various categories of tourists, which negatively affects investment opportunities, tourism development, and social and economic resources. Furthermore, previous works have criticized the lack of evidence to support that the structure contains critical attributes and measurement items linked to the competitiveness of smart heritage destinations. As a result, this study aims to design and develop a composite index for evaluating these destinations and their buildings, which includes nine dimensions (attributes) and a set of key performance indicators (KPIs) of intelligent performance and competitiveness, reflecting the combination and noticing the distinct perspective between them. A mixed-methods approach was used between qualitative and quantitative methods to perform content validation on the proposed index. Furthermore, a pilot study was implemented for tourism heritage destinations to improve the quality and efficiency of the proposed index. Then, exploratory factor analysis (EFA) was used to analyze the data to develop the proposed index and measure its validity and reliability. Finally, the proposed composite index was finalized with 139 KPIs and applied to a case study (Salah El-Din Citadel). After that, we validated its utility in providing a quantitative evaluation of this heritage destination, identifying critical intervention priorities, and determining dimensions that need to be restructured. Additionally, it highlighted recommendations for future improvements to strengthen these heritage destinations to become smart heritage destinations capable of competition in the tourism sector

Social vulnerability of historic Districts: A composite measuring scale to statistically predict human-made hazards

One of the significant challenges in heritage risk assessment is concentrating on investigating physical characteristics in assessing man-made hazards and vulnerabilities without addressing the social aspects that may affect the potential rates of man-made risks on heritage buildings and surrounding historic fabric. This article aims to investigate the predictive relationship between human-made hazards in historic districts and the socio-economic weaknesses that represent Social Vulnerability of Historic Districts (SVHD). The methodology comprises a literature review for extracting the most relevant items of SVHD. Subsequently, a content validation was performed. To enhance the quality and effectiveness of the study, a pilot study was implemented for seventy-three historic districts in historic Cairo, Egypt. Then, using IBM SPSS statistics 20, exploratory factor analysis was executed to develop fewer factors of SVHD from the extracted items and establish their validity and reliability. Finally, multiple linear regression was carried using the surveyed data of human-made hazards rates occurring in the study cases. As a result, the regression analysis developed three predictive models: (the humans model, the heritage buildings model, and the context model). These models have been succussed in predicting the potential rates of human-made hazards significantly. The resulting models highlighted the importance of investigating the social component to predict human-made hazards in historic districts using a quantitative assessment tool. This would help authorities in formulating suitable strategies for the effective performance of historic districts

Implementation of a DPU-Based Intelligent Thermal Imaging Hardware Accelerator on FPGA

Thermal imaging has many applications that all leverage from the heat map that can be constructed using this type of imaging. It can be used in Internet of Things (IoT) applications to detect the features of surroundings. In such a case, Deep Neural Networks (DNNs) can be used to carry out many visual analysis tasks which can provide the system with the capacity to make decisions. However, due to their huge computational cost, such networks are recommended to exploit custom hardware platforms to accelerate their inference as well as reduce the overall energy consumption of the system. In this work, an energy adaptive system is proposed, which can intelligently configure itself based on the battery energy level. Besides achieving a maximum speed increase that equals 6.38×, the proposed system achieves significant energy that is reduced by 97.81% compared to a conventional general-purpose CPU