Nuove acquisizioni sull'impiego di bicicli solfonilici rigidi in sintesi organica e in studi di riconoscimento molecolare

Sulla base degli aspetti cardine descritti precedentemente e degli studi condotti su bicicli solfonilici rigidi negli ultimi anni, saranno presentati i più recenti risultati ottenuti, soprattutto per quanto concerne a) la reattività di alcheni biciclici come accettori di Michael in presenza di ammine chirali e b) la costruzione di famiglie di analoghi a scheletro [2.2.x]biciclico e benzo[2.2.1]biciclico, adatte alla elaborazione di modelli di riconoscimento chirale di tipo empirico, basati su analisi cromatografica (HPLC)

Alcheni policiclici a ponte fenilsolfonilsostituiti: versatili intermedi nella sintesi di molecole biologicamente attive

Nel campo della sintesi totale di molecole biologicamente attive, risultano di interesse, da un punto di vista sintetico-stereochimico, molecole policicliche a struttura pontata che, negli ultimi anni, sono state largamente studiate, sia come principi attivi che come intermedi sintetici. La ricerca di base si è quindi orientata verso lo studio della reattività di tali substrati e dei meccanismi che la regolano. In questi ambiti, il nostro interesse si rivolge verso lo studio della reattività di alcheni policiclici a ponte fenilsolfonilsostituiti

Composti policiclici bridged fenilsolfonilsostituiti: caratterizzazione mediante tecniche NMR e cromatografia liquida ad alte prestazioni (<i>HPLC</i>)

Da alcuni anni, il nostro gruppo di ricerca svolge studi che hanno portato alla definizione di protocolli sintetici asimmetrici per la preparazione di chetoni policiclici enantiopuri e di nuove preparazioni di alcheni, bromoderivati e aldeidi policiclici. In particolare, i nostri studi si rivolgono verso sistemi [2.2.1]biciclici, costituendo questi lo scheletro carbonioso di base in composti biologicamente attivi, di interesse in campo farmacologico e nell’industria profumiera

Sperimentazione di una proposta di didattica speciale per i giovani disabili nel nuoto

The aim of this research work is to propose a special didactics offer that can also guaranteedisabled young people the opportunity to practice swimming. The sports system,and therefore also that of swimming activities, has the duty to pursue the goal of accessibilityto all, and it is clear how important it is to structure a sports didactics strategyaimed at the sports development of disabled children with consequent positive effectson social aspects, such as inclusion and increased self-esteem and autonomy. In this regard,we will analyze the experimentation inherent a field research carried out on a sampleof 18 disabled children, over a period of 10 weeks, in order to identify the mosteffective and efficient proposal for special sports didactics both in athletic and socialterms.Lo scopo del presente lavoro di ricerca è quello di proporre un’offerta di didattica specialein grado di garantire anche ai giovani disabili l’opportunità di praticare la disciplina delnuoto. Il sistema sportivo e quindi anche quello delle attività natatorie ha il dovere di perseguirel’obiettivo dell’accessibilità per tutti, ed appare evidente quanto sia importantestrutturare una strategia di didattica sportiva che miri allo sviluppo sportivo dei bambinidiversamente abili con conseguenti ricadute positive su aspetti sociali quali l’inclusione el’incremento dell’autostima e dell’autonomia. A tal proposito si analizza la sperimentazioneinerente una ricerca sul campo condotta su un campione di 18 bambini disabili perun periodo di 10 settimane, al fine di individuare la più efficace ed efficiente proposta dididattica sportiva speciale sia in chiave atletica che sociale

Experimentation of a special didactics proposal for youth disabled in swimming

The aim of this research work is to propose a special didactics offer that can also guarantee disabled young people the opportunity to practice swimming. The sports system ,and therefore also that of swimming activities, has the duty to pursue the goal of accessibility to all, and it is clear how important it is to structure a sports didactics strategy aimed at the sports development of disabled children with consequent positive effects on social aspects, such as inclusion and increased self-esteem and autonomy. In this regard, we will analyze the experimentation inherent a field research carried out on a sample of 18 disabled children, over a period of 10 weeks, in order to identify the most effective and efficient proposal for special sports didactics both in athletic and social terms

Sorafenib, risk of bleeding and spontaneous rupture of hepatocellular carcinoma. A clinical case.

Spontaneous rupture is a rare and dramatic complication of hepatocellular carcinoma (HCC), burdened by a high mortality. Here we describe a case of a 73-year-old man, who arrived at the ER because of syncope, and acute epigastric and right upper quadrant abdominal pain. He had a history of hepatitis C-related liver cirrhosis and HCC in treatment with sorafenib. The physical examination showed a state of hemorrhagic anemia with the presence of blood in the peritoneal cavity. The patient underwent an urgent liver resection. Thirty days after surgery, he was in good general condition. Sorafenib is a multikinase inhibitor recently introduced in the therapy of patients with advanced HCC. Among the various side effects reported in patients treated with sorafenib, there is a higher risk of bleeding. In conclusion, sorafenib may increase the risk of bleeding and rupture of HCC in susceptible individuals

Association between Anthropometric Measurements and Vascular Disease: A Cross Sectional Study

The aim of this article is to assess the most studied anthropometric measurements in a population of patients with vascular disease (VD) such as chronic venous disease (CVD), carotid stenosis (CS), abdominal aortic aneurysm (AAA), and peripheral artery disease (PAD). This is a cross sectional study that recruited consecutive patients with VD (CVD, CS, AAA, PAD) referred to Vascular Surgery Units of two hospitals in the period July 2019–March 2022. Several anthropometric measurements such as height, weight, body mass index (BMI), waist circumference, waist-to-BMI, waist-to-hip ratio (WHR), A Body Shape Index (ABSI), waist-to-stature ratio (WSR) were recorded. In a one-way ANOVA test, no statistical significance for all anthropometric variables were found, but the post hoc analysis performed with Tuckey test, show significant difference for height (p-value: 0.017) and WHR (p-value: 0.005) when compared AAA and CS groups with CVD, respectively. Height seems positively associated with AAA, and negatively associated with CVD. WHR seems positively associated with CS and negatively associated with CVD. Further studies are needed to clarify the role of anthropometric measures as independent predictors for vascular disease onset, progression, and response to treatments

Wound Care Self-Efficacy Assessment of Italian Registered Nurses and Wound Care Education in Italian Nursing Education System: A Cross-Sectional Study

Wounds are a major public health challenge for nurses, and poor wound care has important implications for patients and health care systems. The aim of this study is to assess the Italian registered nurses’ (RNs) perception in the area of wound care, regarding their knowledge, tasks of care delivery, wound management, values, and attitudes, exploring also the previous specific education received during nursing education. An observational online web-based survey was used to assess learning goals and content for wound care education in undergraduate nursing education and the skills and level of self-efficacy in this area during clinical practice. The data were collected between April and May 2022. A total of 210 RNs were interviewed and divided into five national geographic areas. Northwestern RNs showed a better education about the wound care area during university courses: the rate of RNs that did not receive any training in the wound care area was lower than in other Italian geographical areas. Southern RNs presented a better knowledge about factors that expose the wound to becoming chronic, wound drains care, and the ability to assess diabetic foot. This study showed that, in Italy, education in wound care among nursing students is relatively poor, and many skills are achieved during an RN’s career in an empirical way

Familial Polyposis Coli: The Management of Desmoid Tumor Bleeding

There is currently no standard treatment for desmoid tumors (DTs) associated with familial polyposis coli (FAP). Familial adenomatous polyposis in DT patients is sometimes a life-threatening condition

Cervical dystonia patients display subclinical gait changes

Gait disorders in cervical dystonia (CD) are reported in patients under DBS or in severe cases complicated with spinal deformities