The LSTS open-source communication and autonomy software: enabling networked vehicle systems to find track, and sample dynamic features of the ocean

Peer Reviewe

Early Cardiac Mitochondrial Molecular and Functional Responses to Acute Anthracycline Treatment in Wistar Rats

Doxorubicin (DOX) is an anticancer drug widely used to treat human and nonhuman tumors but the late and persistent cardio-toxicity reduces the therapeutic utility of the drug. The full mechanism(s) of DOX-induced acute, subchronic and delayed toxicity, which has a preponderant mitochondrial component, remains unclear; therefore, it is clinically relevant to identify early markers to identify patients who are predisposed to DOX-related cardiovascular toxicity. To address this, Wistar rats (16 weeks old) were treated with a single DOX dose (20 mg/kg, i.p.); then, mRNA, protein levels and functional analysis of mitochondrial endpoints were assessed 24 h later in the heart, liver, and kidney. Using an exploratory data analysis, we observed cardiac-specific alterations after DOX treatment for mitochondrial complexes III, IV, and preferentially for complex I. Conversely, the same analysis revealed complex II alterations are associated with DOX response in the liver and kidney. Interestingly, H2O2 production by the mitochondrial respiratory chain as well as loss of calcium-loading capacity, markers of subchronic toxicity, were not reliable indicators of acute DOX cardiotoxicity in this animal model. By using sequential principal component analysis and feature correlation analysis, we demonstrated for the first time alterations in sets of transcripts and proteins, but not functional measurements, that might serve as potential early acute markers of cardiac-specific mitochondrial toxicity, contributing to explain the trajectory of DOX cardiac toxicity and to develop novel interventions to minimize DOX cardiac liabilities

Interplate versus intraplate strike-slip deformed belts: examples from SW Iberia

A complete transition in tectonic style between pure thrust belts and pure strike-slip beltscan be envisaged, both in interplate and intraplate settings, by a combination of thrust and strike-slipcomponents of displacement. The accommodation of shortening components in strike-slip deforma-tion belts has been discussed recently on the basis of two alternative perspectives: (1) the “sub-horizon-tal attachment model”, where discrete strike-slip faulting of rigid blocks in the schiszosphere evolves tocontinuous movement in plastosphere through a bottom-up driving mechanism controlled by verticalcoupling across the lithosphere, and (2) the “accommodation model” that considers decoupling with-in a heterogeneous and anisotropic plastosphere. Two examples of variable shortening componentaccommodation in strike-slip deformation belts of the SW Iberia Variscides are reported and discussed.In the Tomar-Badajoz-Córdoba shear zone, an important shortening component is accommodated inflat-lying bends around the horizontal axis within a WNW-ESE flower-structure with sinistral strike-slip component; the geodynamic evolution points to an intraplate setting for this structure. In the N-S, Porto-Tomar-Ferreira do Alentejo, dextral shear zone, the shortening component is restricted torestraining bends around the vertical axis; the geodynamic evolution allows inferring a transformnature for this structure, thus indicating an interplate setting. For these examples, the “accommodationmodel” is preferred to the “sub-horizontal attachment model”info:eu-repo/semantics/publishedVersio

A projection–less approach to Rickart Jordan structures

Acknowledgments We would like to express our gratitude to the anonymous referee for many constructive comments and suggestions to improve the final form of the paper. J. Garcés and A.M. Peralta partially supported by MCIN/AEI/10.13039/501-100011033/FEDER, EU, project no. PGC2018-093332-B-I00 and Junta de Andalucía grants number A-FQM-242-UGR18 and FQM375. L. Li partially supported by NSF of China (12171251) and Tianjin Natural Science Foundation (Grant No. 19JCY-BJC30200). A.M. Peralta is also supported by the IMAG–María de Maeztu grant CEX2020-001105-M/AEI/10.13039/501100011033. H. Tahlawi supported by a grant of Scientific Research, King Saud University. Funding for open access charge: Universidad de Granada / CBUA.The main goal of this paper is to introduce and explore an appropriate notion of weakly Rickart JB⁎-triples. We introduce weakly and weakly order Rickart JB⁎-triples, and we show that a C⁎-algebra A is a weakly (order) Rickart JB⁎-triple precisely when it is a weakly Rickart C⁎-algebra. We also prove that the Peirce-2 subspace associated with any tripotent in a weakly order Rickart JB⁎-triple is a Rickart JB⁎-algebra in the sense of Ayupov and Arzikulov. By extending a classical property of Rickart C⁎-algebras, we prove that every weakly order Rickart JB⁎-triple is generated by its tripotents.Partially supported by MCIN/AEI/10.13039/501-100011033/FEDER, EU, project no. PGC2018-093332-B-I00Junta de Andalucía grants number A-FQM-242-UGR18 and FQM375Partially supported by NSF of China (12171251)Tianjin Natural Science Foundation (Grant No. 19JCY-BJC30200)IMAG–María de Maeztu grant CEX2020-001105-M/AEI/10.13039/501100011033Scientific Research, King Saud UniversityFunding for open access charge: Universidad de Granada / CBU

The genomic architecture of population divergence between subspecies of the european rabbit

This is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al.The analysis of introgression of genomic regions between divergent populations provides an excellent opportunity to determine the genetic basis of reproductive isolation during the early stages of speciation. However, hybridization and subsequent gene flow must be relatively common in order to localize individual loci that resist introgression. In this study, we used next-generation sequencing to study genome-wide patterns of genetic differentiation between two hybridizing subspecies of rabbits (Oryctolagus cuniculus algirus and O. c. cuniculus) that are known to undergo high rates of gene exchange. Our primary objective was to identify specific genes or genomic regions that have resisted introgression and are likely to confer reproductive barriers in natural conditions. On the basis of 326,000 polymorphisms, we found low to moderate overall levels of differentiation between subspecies, and fewer than 200 genomic regions dispersed throughout the genome showing high differentiation consistent with a signature of reduced gene flow. Most differentiated regions were smaller than 200 Kb and contained very few genes. Remarkably, 30 regions were each found to contain a single gene, facilitating the identification of candidate genes underlying reproductive isolation. This gene-level resolution yielded several insights into the genetic basis and architecture of reproductive isolation in rabbits. Regions of high differentiation were enriched on the X-chromosome and near centromeres. Genes lying within differentiated regions were often associated with transcription and epigenetic activities, including chromatin organization, regulation of transcription, and DNA binding. Overall, our results from a naturally hybridizing system share important commonalities with hybrid incompatibility genes identified using laboratory crosses in mice and flies, highlighting general mechanisms underlying the maintenance of reproductive barriers.This work was partially supported by POPH-QREN funds from the European Social Fund and Portuguese MCTES [postDoc grants to MC (BPD/72343/2010); JM-F (SFRH/BPD/43264/2008); JAB-A (SFRH/BPD/65464/2009), and RC (SFRH/BPD/64365/2009)], by FEDER funds through the COMPETE program and Portuguese national funds through the Fundação para a Ciência e a Tecnologia (PTDC/CVT/122943/2010; PTDC/BIA/EVF/111368/2009; POCI/CVT/61590/2004; PTDC/BIA/BDE/72304/2006; PTDC/BIA-BDE/72277/2006; CGL2009-11665; POII09-0099-2557), by a National Science Foundation international postdoctoral fellowship to JMG (OISE-0754461), by National Science Foundation and National Institutes of Health grants to MWN, and by the Max Planck Society.Peer Reviewe

On the strict topology of the multipliers of a JB∗-algebra

Universidad de Granada/CBUA. F. J. Fernandez-Polo, J. J. Garces and A. M. Peralta partially supported by grant PID2021-122126NB-C31 funded by MCIN/AEI/10.13039/501100011033 and by "ERDF A way of making Europe", Junta de Andalucia grants FQM375 and PY20_00255,and by the IMAG-Mariade Maeztu grant CEX2020-001105-M/AEI/10.13039/501100011033.L. Li partially supported by NSF of China (12171251).We introduce the Jordan-strict topology on the multiplier algebra of a JB*-algebra, a notion which was missing despite the forty years passed after the first studies on Jordan multipliers. In case that a C*-algebra A is regarded as a JB*-algebra, the J-strict topology of M(A) is precisely the well-studied C*-strict topology. We prove that every JB*-algebra U is J-strict dense in its multiplier algebra M(U), and that latter algebra is J-strict complete. We show that continuous surjective Jordan homomorphisms, triple homomorphisms, and orthogonality preserving operators between JB*-algebras admit J-strict continuous extensions to the corresponding type of operators between the multiplier algebras. We characterize J-strict continuous functionals on the multiplier algebra of a JB*-algebra U, and we establish that the dual of M(U) with respect to the J-strict topology is isometrically isomorphic to U*. We also present a first application of the J-strict topology of the multiplier algebra, by showing that under the extra hypothesis that U and B are sigma-unital JB*-algebras, every surjective Jordan *-homomorphism (respectively, triple homomorphism or continuous orthogonality preserving operator) from U onto B admits an extension to a surjective J-strict continuous Jordan *-homomorphism (respectively, triple homomorphism or continuous orthogonality preserving operator) from M(U) onto M(B).Universidad de Granada/CBUAMCIN/AEI/ PID2021-122126NB-C31"ERDF A way of making Europe"Junta de Andalucia FQM375, PY20_00255MAG-Mariade Maeztu CEX2020-001105-M/AEI/10.13039/501100011033National Natural Science Foundation of China (NSFC) 1217125

Spinning Relations: High-Speed Networks for Distributed Join Processing

By leveraging modern networking hardware (RDMA-enabled network cards), we can shift priorities in distributed database processing significantly. Complex and sophisticated mechanisms to avoid network traffic can be replaced by a scheme that takes advantag

Multipactor radiation analysis within a waveguide region based on a frequency-domain representation of the dynamics of charged particles

A technique for the accurate computation of the electromagnetic fields radiated by a charged particle moving within a parallel-plate waveguide is presented. Based on a transformation of the time-varying current density of the particle into a time-harmonic current density, this technique allows the evaluation of the radiated electromagnetic fields both in the frequency and time domains, as well as in the near- and far-field regions. For this purpose, several accelerated versions of the parallel-plate Green’s function in the frequency domain have been considered. The theory has been successfully applied to the multipactor discharge occurring within a two metal-plates region. The proposed formulation has been tested with a particle-in-cell code based on the finite- difference time-domain method, obtaining good agreement.The authors would like to thank ESA/ESTEC for having funded this research activity through the Contract “RF Breakdown in Multicarrier Systems” ͑Contract No. 19918/06/NL/GLC͒