Model studies of fluctuations in the background for jets in heavy ion collisions

Jets produced in high energy heavy ion collisions are quenched by the production of the quark gluon plasma. Measurements of these jets are influenced by the methods used to suppress and subtract the large, fluctuating background and the assumptions inherent in these methods. We compare the measurements of the background in Pb+Pb collisions at $\sqrt{s_{NN}}$ = 2.76 TeV by the ALICE collaboration to calculations in TennGen (a data-driven random background generator) and PYTHIA Angantyr. The standard deviation of the energy in random cones in TennGen is approximately in agreement with the form predicted in the ALICE paper, with deviations of 1-6 $\%$. The standard deviation of energy in random cones in Angantyr exceeds the same predictions by approximately 40 $\%$. Deviations in both models can be explained by the assumption that the single particle $d^2N/dydp_T$ is a Gamma distribution in the derivation of the prediction. This indicates that model comparisons are potentially sensitive to the treatment of the background

COMUNICAÇÃO ORGANIZACIONAL: ESTUDO DE CASO NO SETOR DE TI DA UFBA

A comunicação institucional na STI (Superintendência de Tecnologia da Informação da Universidade Federal da Bahia) é analisada nesse estudo de caso, em diálogo com os avanços das tecnologias digitais e as mudanças consequentes nas organizações. De modo particular, diante da transparência e compromissos sociais destacados nas instituições públicas, a comunicação ganha ares de obrigatoriedade e de estratégia de sobrevivência. A despeito da realidade que intensificou as relações multissetoriais e a interação com dezenas de milhares de usuários, a comunicação interna é destacada nesse artigo, cujo instrumento de pesquisa utiliza um questionário/entrevista aplicado aos funcionários do setor. Questões objetivas e discursivas favorecem as análises quantitativa e qualitativa. Estudos mais amplos respaldam a vinculação do tema com a realidade de uma sociedade em rede . Conclui-se que a comunicação é de fundamental importância para o setor de TI da UFBA, crença respaldada pela própria equipe da STI, fortalecida por ações de motivação e de canais de interação

Limiting intellectual property : the competition interface

PhDThis is a study of legal limits of the exercise of intellectual property, with emphasis on chip designs. In Part One, the focus is on the economics of innovation dynamics and the nature of the social bargain underlying intellectual property. It analyses the function of intellectual property and the structure of protection of chip designs under the US chip law, the IPIC Treaty and the Agreement on TRIPS. It suggests that while protection of intellectual property is designed to promote technical innovation and enhance competition in the public favour, the innovation process is carried out in conditions of increasingly imperfect competition. On these grounds, a point is made to limit the exercise of proprietary rights in the welfare/efficiency perspective. Part Two addresses the treatment of legal limitations. An analysis is made concerning the evolution of the safeguarding provisions on which unauthorised use of copyright and patent in the British legal system relies. These safeguards, structured within the intellectual property law, have gradually been developed to also rely on a resurgent competition legislation, which has been considerably used by OECD countries to order the exercise of proprietary rights. The ability of modem competition law to induce an intellectual property order, and the features of the adjudicatory process of non-voluntary licences over UK patents are also examined. From the findings the emergence of; namely, a safeguarding policy is identified. The conceptualisation of this institutional policy, aiming at efficiency and welfare objectives related to the exercise of proprietary rights, is a central theme. It shows that safeguarding provisions intrinsic to intellectual property law is insufficient to pursue these objectives, and holds that to protect intellectual property without an effective control of anti-competitive practices is a distorting and unsustainable legal policy

O Uso terapêutico de mediadores anti-inflamatórios da via do ácido araquidônico

Arachidonic acid (AA) a precursor in the formation of eicosanoids which are lipid mediators with a number of functions in human physiology and pathology. The most of the eicosanoids act as proinflammatory mediators and contribute to the development and proliferation of tumors. In this thesis we evaluated two mediators: 15-deoxy-Δ12,14-PGJ2 (15d- PGJ2) and epoxieicosatrienoic acids (EETs) both act with an opposite activity of most eicosanoids, with an anti-inflammatory and and anti-tumoral action these two distinct mediators from AA pathway were used in this thesis in two different projects. First: 15d- PGJ2, was described that to have an antiproliferative activity and to induce apoptosis in several types of tumor cells however, the effect of 15d- PGJ2 in thyroid cancer cells was unknown in this sense, we tested in vitro cultured thyroid tumor cells, here in TPC1 cells, and treated with different concentrations of 15d- PGJ2 (0 to 20 uM) the treated cells showed a decrease in proliferation and an increase in apoptosis and a decrease in IL-6 release and relative expression. These key results together demonstrate that 15d- PGJ2 can be used as a new therapy for thyroid cancer. Second: The EETs are converted to their diols by soluble epoxy hydrolase (sEH) to maintain the stability of EETs and their anti-inflammatory activity, an inhibitor (TPPU) against was used to sEH in a periodontitis model induced with Aggregatibacter actinomycetemcomitans. The oral treatment in mice with TPPU and sEH Knockout animals showed bone loss reduction accompanied by a decrease in the osteoclastogenic molecules, like RANK, RANKL and OPG, demonstrating that pharmacological inhibition of sEH may have therapeutic value in periodontitis and inflammatory diseases that involve bone resorption.Tese (Doutorado)O ácido araquidônico (AA) é precursor na formação dos eicosanoides, que são mediadores lipídicos com uma série de funções na fisiologia e patologia humana. A maioria dos eicosanoides atuam como mediadores pró-inflamatórios e contribuem para o desenvolvimento e proliferação de tumores. Nesta tese foram avaliados dois mediadores: a 15-deoxi-Δ12,14-PGJ2 (15d- PGJ2) e os ácidos Epoxieicosatrienoicos (EETs), ambos apresentam uma atividade oposta a da maioria dos eicosanoides, ou seja, com uma ação anti-inflamatória e antitumoral. Esses dois mediadores distintos da via do AA foram utilizados nesta tese em dois projetos distintos. Primeiro: A 15d- PGJ2 possui uma atividade antiproliferativa e induziu apoptose para diversos tipos de células tumorais, entretanto, o efeito da15d- PGJ2 em células de cancer da tireoide ainda estava desconhecido. Neste sentido, foram cultivadas in vitro células tumorais da tireoide, da linhagem TPC1, e tratadas com diferentes concentrações de 15d- PGJ2 (0 ate 20 μM), as células tratadas demonstraram uma diminuição na proliferação, e aumento na apoptose, e uma diminuição na liberação e expressão relativa de IL-6. Estes resultados em conjunto sugerem que a 15d- PGJ2 pode ser utilizada como uma nova terapia para o cancer da tireoide. Segundo: Os EETs são metabolizados em seus diois pela epóxi hidrolase solúvel (sEH), para manter a estabilidade dos EETs e a sua atividade antiiflamatoria, foi utilizado um inibidor (TPPU) para sEH em um modelo de periodontite induzida por Aggregatibacter actinomycetemcomitans. O tratamento oral com TPPU, assim como o uso de animais sEH Knockout, levou a uma redução na perda óssea acompanhada da diminuição de moléculas osteoclastogenicas como RANK, RANKL e OPG, demonstrando que a inibição farmacológica da sEH pode ter um valor terapêutico na periodontite e doenças inflamatórias que envolvem a reabsorção óssea

Sistema de Coleta de Dados de Acidentes de Trânsito de Joinville

TCC(graduação) - Universidade Federal de Santa Catarina. Campus Joinville. Bacharelado Interdisciplinar em Mobilidade.O Mapa da Violência, publicado pelo Governo Federal, apresenta taxas de óbito por 100 mil habitantes, decorrentes de acidentes de trânsito, em Joinville, superiores à média nacional. Em 2013, a taxa foi de 22,85 para Joinville e a média nacional foi de 20,12. Assim, o trânsito de Joinville possui dados alarmantes, sendo um dos responsáveis pela alta taxa de óbitos no município. Para se analisar os acidentes ocorridos e atuar na prevenção de novos acidentes, são necessários dados que contemplem a localização e todas as variáveis envolvidas, que possam explicar esses eventos. Nota-se que, protocolos de coleta de dados, os quais necessitam ser preenchidos a mão durante as ocorrências, tendem a ser abandonados ou preenchido sem os cuidados necessários. Sendo assim, é necessária à coleta de informações de forma sistematizada, para gerar uma base de dados confiáveis. Assim, este trabalho objetiva implementar um protocolo de coleta de dados para o planejamento urbano de Joinville, atuando nas ações dos órgãos que fazem a coleta – tais como Corpo de Bombeiros, Hospitais, etc. – a fim de garantir a confiabilidade dos dados e de centralizar as informações sobre os acidentes de trânsito. Com dados provenientes das coletas, então, pode-se fazer análises de riscos de acidentes com maior completude, confiabilidade e operacionalização

Herdabilidade estimada por diferentes métodos em quatro gerações de progênies de um cruzamento de guandu

The objective of this work was to compare different methods to estimate heritability in 30 pigeon pea families from the F3, F4, F5, and F6 generations, for nine variables. The experimental design was a randomized complete block with three replicates and 20 plants per plot. Broad-sense heritability was estimated by the analysis of variance (ANOVA) [h2b-E(MS)], restricted maximum likelihood/best linear unbiased prediction (REML/BLUP) (h2b-REML), parent-offspring regression (h2PO), and standard deviation unit (h2UP). The h2b-E(MS) and h2b-REML estimates were similar for seven of the analyzed variables. For a higher genetic control and easier selection, values of h2b-E(MS) and h2b-REML >0.70 were estimated for two variables in four generations, two variables in three generations, three variables in two generations, and one variable in one generation. Values of h2UP and h2PO >0.70 were obtained for four and five variables, respectively. The estimates via regression or parent-offspring correlation showed some values outside the expected range of 0 to 1. The ANOVA [h2b-E(MS)] and REML/BLUP [h2b-REML] methods are the best to estimate pigeon pea heritability.O objetivo deste trabalho foi comparar diferentes métodos para estimar a herdabilidade em 30 linhagens de guandu das gerações F3, F4, F5 e F6,  para nove variáveis. O delineamento experimental foi em blocos ao acaso, com três repetições e 20 plantas por parcela. Estimou-se a herdabilidade no sentido amplo por meio de análise de variância (ANOVA) [h2b-E(MS)], máxima verossimilhança restrita/melhor predição linear não viciada (REML/BLUP) (h2b-REML), regressão pai-filho (h2PO) e unidade do desvio-padrão (h2UP). As estimativas de h2b-E(MS) e h2b-REML foram de magnitude próxima para sete das variáveis analisadas. Para maior controle genético e facilidade na seleção, valores de h2b-E(MS) e h2b-REML >0,70 foram estimados para duas variáveis em quatro gerações, duas variáveis em três gerações, três variáveis em duas gerações e uma variável em uma geração. Valores de h2UP e h2PO >0,70 foram obtidos para quatro e cinco variáveis, respectivamente. As estimativas via regressão ou correlação pai-filho mostraram alguns valores fora da variação esperada de 0 a 1. Os métodos ANOVA [h2b-E(MS)] e REML/BLUP [h2b-REML] são os melhores para estimar a herdabilidade em guandu

Biotechnology and Industry 4.0: The professionals of the future

The process of developing technological research is being carried out beyond organizational boundaries, especially organizations that make intensive use of knowledge, such as Biotechnology. Considerable progress has been made in recent years in reducing costs and increasing the ease of gene sequencing and, ultimately, in activating or editing genes. In this context, discussions have been gaining prominence around Industry 4.0, in which new business models and intelligent processes for Biotechnology are evidenced. However, the challenges regarding the training and education of professionals are discussed, emphasizing the importance of a multidisciplinary education, unlike the more traditional nature of education in the areas of biology and sciences. These challenges can be partially transposed by strengthening the partnerships of universities and research centers with companies, in order to materialize in common projects, the demands of industries and the possibilities of transforming research projects into final products available to society. This paper presents a study on the impact of Industry 4.0 technologies on Biotechnology, and also presents the prospect of future professions with the influence of Industry 4.0. The results show that technologies such as artificial intelligence, robotics and 3D printing are promising in the development and advancement of Biotechnology. New automated laboratories are under development. Also, regulatory issues require a great deal of study, and business models will need to be more efficient to generate the results needed for the development of new drugs, food, and research of new products related to health

Income Content of the World Coffee Exports

Coffee is the most widely commercialized tropical product on the international market. The 2009/10 crop had an estimated value of $15.4 billion, with 93.4 million bags exported. According to the International Coffee Organization (ICO, 2011), the coffee sector employed  around 26 million people in 56 producing countries and over 100 exporting countries. But how would coffee products rank, in terms of income content, in relation to other commercialized products, and how have they evolved? To answer this question, the annual income content of 5,111 products exported by 167 countries from the period between 2000 and 2009, was calculated. Data from the UNCOMTRADE (2011), and “sophistication” indicators proposed by Hausmann and Rodrik (2003) who classify different products according to their productivity, were used. An emphasis was put on five coffee products (whole grain, roasted, decaffeinated, caffeinated, and soluble), showing the evolution of the number of exporting countries and of the “sophistication” index (income content), whose temporal variation was decomposed by the effects of competitiveness and income per capita changes. The results showed that non-roasted, non-decaffeinated, whole grain coffee is still the most commercialized product, but with the lowest income content of all coffee products, occupying the twenty-fourth worst position in terms of income content in 2009. The roasted, decaffeinated coffee presented the greatest income growth in the period, placing itself in the 3,309th position in 2009. The decomposition of the index showed that for coffee products with the most processing, the greatest cause of export sophistication growth was the Revealed Comparative Advantage effect. Products with the least amount of processing presented a loss in relative market share, with the addition of values to the production chain occurring outside those countries producing the raw materials.El café es el producto tropical más comercializado en el mercado internacional. La cosecha de 2009/10 fue estimada en 15,4 mil millones de dólares, con 93,4 millones de sacos exportados. Según la Organización Internacional del Café (ICO, 2011), el sector cafetero ha empleado alrededor de 26 millones de personas en 56 países productores y en más de 100 países exportadores. Sin embargo, ¿cómo los tipos de café podrían ser clasificados, en cuanto al ingreso, en relación a otros productos comercializados, y cómo han evolucionado? Para contestar a esta pregunta, se han calculado los ingresos anuales de 5.111 productos exportados por 167 países en el período comprendido entre 2000 y 2009. Los datos fueron obtenidos a través del UNCOMTRADE (2011), y se han utilizado los indicadores de "sofisticación" propuestos por Hausmann y Rodrik (2003) que clasifican los diferentes productos en función de sus productividades. Se hizo especial hincapié en cinco tipos de café (grano entero, tostado, descafeinado, con cafeína y soluble), que muestra la evolución del número de países exportadores y del índice de "sofisticación" (relacionado a los ingresos), cuya variación temporal se ha descompuesto por los efectos de la competitividad y por los cambios en la renta per cápita. Los resultados mostraron que el café sin tostar, con cafeína y de grano entero sigue siendo el más comercializado, pero presenta el nivel más bajo de ingreso de todos los tipos de café, ocupando el vigésimo cuarto puesto de peor nivel de ingreso en 2009. El café tostado y descafeinado presentó el mayor crecimiento de ingresos en el período, ubicándose en el puesto 3309º en 2009. La descomposición del índice mostró que para los tipos de café con mayor procesamiento, la principal causa del crecimiento de la sofisticación de las exportaciones fue el efecto de la ventaja comparativa revelada. Los productos con menor cantidad de procesamiento presentaron una pérdida de cuota relativa de mercado, con el valor añadido a la cadena de producción llevado a cabo afuera de los países productores de materias primas

Contenido de la Renta de las exportaciones mundiales de café

Coffee is the most widely commercialized tropical product on the international market. The 2009/10 crop had an estimated value of $15.4 billion, with 93.4 million bags exported. According to the International Coffee Organization (ICO, 2011), the coffee sector employed around 26 million people in 56 producing countries and over 100 exporting countries. But how would coffee products rank, in terms of income content, in relation to other commercialized products, and how have they evolved? To answer this question, the annual income content of 5,111 products exported by 167 countries from the period between 2000 and 2009, was calculated. Data from the UNCOMTRADE (2011), and “sophistication” indicators proposed by Hausmann and Rodrik (2003) who classify different products according to their productivity, were used. An emphasis was put on five coffee products (whole grain, roasted, decaffeinated, caffeinated, and soluble), showing the evolution of the number of exporting countries and of the “sophistication” index (income content), whose temporal variation was decomposed by the effects of competitiveness and income per capita changes. The results showed that non-roasted, non-decaffeinated, whole grain coffee is still the most commercialized product, but with the lowest income content of all coffee products, occupying the twenty-fourth worst position in terms of income content in 2009. The roasted, decaffeinated coffee presented the greatest income growth in the period, placing itself in the 3,309th position in 2009. The decomposition of the index showed that for coffee products with the most processing, the greatest cause of export sophistication growth was the Revealed Comparative Advantage effect. Products with the least amount of processing presented a loss in relative market share, with the addition of values to the production chain occurring outside those countries producing the raw materials.El café es el producto tropical más comercializado en el mercado internacional. La cosecha de 2009/10 fue estimada en 15,4 mil millones de dólares, con 93,4 millones de sacos exportados. Según la Organización Internacional del Café (ICO, 2011), el sector cafetero ha empleado alrededor de 26 millones de personas en 56 países productores y en más de 100 países exportadores. Sin embargo, ¿cómo los tipos de café podrían ser clasificados, en cuanto al ingreso, en relación a otros productos comercializados, y cómo han evolucionado? Para contestar a esta pregunta, se han calculado los ingresos anuales de 5.111 productos exportados por 167 países en el período comprendido entre 2000 y 2009. Los datos fueron obtenidos a través del UNCOMTRADE (2011), y se han utilizado los indicadores de "sofisticación" propuestos por Hausmann y Rodrik (2003) que clasifican los diferentes productos en función de sus productividades. Se hizo especial hincapié en cinco tipos de café (grano entero, tostado, descafeinado, con cafeína y soluble), que muestra la evolución del número de países exportadores y del índice de "sofisticación" (relacionado a los ingresos), cuya variación temporal se ha descompuesto por los efectos de la competitividad y por los cambios en la renta per cápita. Los resultados mostraron que el café sin tostar, con cafeína y de grano entero sigue siendo el más comercializado, pero presenta el nivel más bajo de ingreso de todos los tipos de café, ocupando el vigésimo cuarto puesto de peor nivel de ingreso en 2009. El café tostado y descafeinado presentó el mayor crecimiento de ingresos en el período, ubicándose en el puesto 3309º en 2009. La descomposición del índice mostró que para los tipos de café con mayor procesamiento, la principal causa del crecimiento de la sofisticación de las exportaciones fue el efecto de la ventaja comparativa revelada. Los productos con menor cantidad de procesamiento presentaron una pérdida de cuota relativa de mercado, con el valor añadido a la cadena de producción llevado a cabo afuera de los países productores de materias primas