Neurotrauma— From Injury to Repair:Clinical Perspectives, Cellular Mechanisms and Promoting Regeneration of the Injured Brain and Spinal Cord

Traumatic injury to the brain and spinal cord (neurotrauma) is a common event across populations and often causes profound and irreversible disability. Pathophysiological responses to trauma exacerbate the damage of an index injury, propagating the loss of function that the central nervous system (CNS) cannot repair after the initial event is resolved. The way in which function is lost after injury is the consequence of a complex array of mechanisms that continue in the chronic phase post-injury to prevent effective neural repair. This review summarises the events after traumatic brain injury (TBI) and spinal cord injury (SCI), comprising a description of current clinical management strategies, a summary of known cellular and molecular mechanisms of secondary damage and their role in the prevention of repair. A discussion of current and emerging approaches to promote neuroregeneration after CNS injury is presented. The barriers to promoting repair after neurotrauma are across pathways and cell types and occur on a molecular and system level. This presents a challenge to traditional molecular pharmacological approaches to targeting single molecular pathways. It is suggested that novel approaches targeting multiple mechanisms or using combinatorial therapies may yield the sought-after recovery for future patients

Integration of Wi-Fi mobile nodes in a Web of Things Testbed

Abstract The Internet of Things (IoT) is supposed to connect billions of devices to the Internet through IP-based communications. The main goal is to foster a rapid deployment of Web-enabled everyday objects, allowing end users to manage and control smart things in a simple way, by using Web browsers. This paper focuses on the integration of Wi-Fi nodes, hosting HTTP resources, into a Web of Things Testbed (WoTT). The main novelty of the proposed approach is that the WoTT integrates new nodes by using only standard mechanisms, allowing end-users to interact with all Smart Objects without worrying about protocol-specific details

The revised perceived academic impact tool (PAIT2):A tool to assess academic dysfunction in university‐aged student‐athletes with sports‐related concussion

Research acknowledges Sports‐Related Concussion (SRC) is acutely deleterious to academic ability, but no tool has been validated to measure the effect of SRC on academic ability. The sutdy aimed to establish if the Revised Perceived Academic Impact Tool (PAIT2) is reliable and valid for assessing academic impairment following an SRC. Non‐concussed, healthy student‐athletes in higher education were recruited to the control group and completed the PAIT2 at day 0, 2, 4, 8, 14 and 19. The concussed group consisted of higher education student‐athletes participating in rugby union. The concussed group completed the PAIT2 at baseline screening during pre‐season, day 2, 4, 8 and 14 following an SRC and at return‐to‐play. The PAIT2 asks participants to rate their perceived ability on 23 academic tasks on a statement scored on a 0–6 Likert scale. Repeated measurements from the healthy group (n = 25) demonstrated PAIT2 has good internal validity (χ2(25) = 2.128 and p = 0.712) and reliability (0.880 [95% CI: 0.785–0.941]). A change of 4.631 (80% CI) can be used to indicate if academic impairment is present following an SRC. PAIT2 identified 96% of concussed student‐athletes with academic impairment at day 2, 92% at day 4, 85.71% at day 8 and 92% at day 14 and 19. PAIT2 has good reliability and internal validity for detecting those with academic impairment following SRC. The use of this tool may be of assistance to clinicians when managing student‐athletes return to learn

Factoring : Análisis de la rentabilidad del factoring para la empresa Bellilogistics en el periodo 2015

A través del presente estudio se propuso analizar la rentabilidad del factoring como financiamiento a corto plazo para la empresa BELLI LOGISTICS, en el período 2015. La empresa se encuentra en proceso de toma de decisiones ya que se le presentó una oportunidad de inversión la cual consiste en financiar a unos de sus clientes potenciales el pago de impuestos proveniente de los servicios otorgados por logística, por lo cual la gerencia financiera de la empresa está evaluando si el uso del factoring es rentable, y de esta manera poder financiar a su cliente sin presentar liquidez y poder continuar operando y generar flujos positivos. El desarrollo de este trabajo investigativo es determinar la rentabilidad del factoring, para lo cual se documentó las generalidades del factoring y su aplicación, lo que permitió detallar los antecedentes más remotos, su introducción en Nicaragua, la importancia del factoring, las ventajas, los tipos de factoring que existen, los inconvenientes que se pueden presentar al utilizar el factoring. También identificamos las normas que rigen el uso de este producto financiero, Ley 740, Ley de factoraje, se utilizó como herramienta los indicadores de rentabilidad, que permitieron dar pautas para el desarrollo del caso práctico, determinar la rentabilidad del factoring para la empresa Belli Logistics en el periodo 2015. En el cual se utilizó como referencia una empresa que por sigilo denominaremos Belli Logistics. Para el análisis de rentabilidad del factoring se realizó un estudio a los estados financieros de la empresa, lo cual determinó que el factoring es rentable, la empresa logró financiar el pago de impuestos de su cliente, y además generar un margen de ganancia. Lo cual indica que si el factoring es utilizado de manera correcta, reduce el apalancamiento, permite generar inversión, y puede utilizarse no solo para pequeñas empresas que necesitan flujo de efectivo para seguir con sus operaciones, sino que también se puede utilizar como financiamiento para generar un margen de ganancia, recuperando la inversión del producto más un margen de utilidad

Executive summary of the joint position paper on renal denervation of the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) and the European Society of Hypertension (ESH)

No abstract available

Cerebral Hemodynamic Influences in Task-Related Functional Magnetic Resonance Imaging and Near-Infrared Spectroscopy in Acute Sport-Related Concussion::A Review

One of the challenges of managing athletes with sport-related concussion (SRC) is guiding them to a safe return to play. A potential biomarker for use in the clinical assessment of recovery is the analysis of brain activation patterns during task-related functional Magnetic Resonance Imaging (fMRI). However, fMRI studies have provided conflicting results regarding what is pathological. An element that can contribute to this disagreement are hemodynamic impairments of the brain that follow a concussion. A functional neuroimaging technique based on the optical properties of brain tissue—called functional near-infrared spectroscopy (fNIRS)—can be used to evaluate SRC athletes, partially taking into consideration these brain hemodynamic impairments. However, so far, fNIRS has not been extensively used in concussion. In this critical review, there is a description of the main fMRI results involving the neocortex in acutely concussed patients, the influences of hemodynamic impairments on fMRI and fNIRS and the advantages and disadvantages of fNIRS to limit this influence

A functional connection between dyskerin and energy metabolism

The human DKC1 gene encodes dyskerin, an evolutionarily conserved nuclear protein whose overexpression represents a common trait of many types of aggressive sporadic cancers. As a crucial component of the nuclear H/ACA snoRNP complexes, dyskerin is involved in a variety of essential processes, including telomere maintenance, splicing efficiency, ribosome biogenesis, snoRNAs stabilization and stress response. Although multiple minor dyskerin splicing isoforms have been identified, their functions remain to be defined. Considering that low-abundance splice variants could contribute to the wide functional repertoire attributed to dyskerin, possibly having more specialized tasks or playing significant roles in changing cell status, we investigated in more detail the biological roles of a truncated dyskerin isoform that lacks the C-terminal nuclear localization signal and shows a prevalent cytoplasmic localization. Here we show that this dyskerin variant can boost energy metabolism and improve respiration, ultimately conferring a ROS adaptive response and a growth advantage to cells. These results reveal an unexpected involvement of DKC1 in energy metabolism, highlighting a previously underscored role in the regulation of metabolic cell homeostasis