A General Methodology for Beached Oil Spill Hazard Mapping

The current lack of a standardized approach to compute the coastal oil spill hazard due to maritime traffic accidental releases has hindered an accurate estimate of its global impact, which is paramount to manage and intercompare the associated risks. We propose here a hazard estimation approach that is based on ensemble simulations and the extraction of the relevant distributions. We demonstrate that both open ocean and beached oil concentration distributions fit a Weibull curve, a two-parameter fat-tail probability distribution function. The simulation experiments are carried out in three different areas of the northern Atlantic. An indicator that quantify the coastal oil spill hazard is proposed and applied to the study areas

Oil spill hazard bulletin

Dissemination Method: Web Product weblink: https://glamor.sincem.unibo.it The MSFD, the new Directive on Safety of offshore oil and gas operations (2013) and the European Maritime Safety Agency require robust tools for oil spill hazard mapping, from accidental to operational. In this activity WP7 and Marine Core Service products were coupled to Medslik-II oil spill model in order to produce, on request, an Oil Spill Hazard Bulletin based upon the hazard mapping data generated earlier in the project. This report contains background information and some examples of oil spill hazard bulletins for target Atlantic areas. The web-GIS Portal GLAMOR developed for Task 8.4 “Oil spill hazard mapping and disaster risk reduction best practices” is used to create the information content in the requested bulletins. Please note: bulletins are only produced on a request basis

A study on the mouldability of POM microdetails in moulding blocks using micromanufacturing technologies

The integration of micro fabrication and micro-moulding techniques contributed to the massifica-tion of microsystems in several domains of activity at feasible costs. In this study the mouldability of microdetails generated by microEDM, micromilling and laser milling in microinjection moulding blocks is assessed. For that purpose, a polyacetal for precision microparts is used to evaluate how mi-crofeatures are replicated in microinjection mould-ing. The mouldings were produced in a instru-mented micromould with two interchangeable moulding blocks, enabling the test of various mould inserts. The processing conditions were simulated with the Moldex3D commercial software. Despite the commercial success of microinjection moulding, the process involves microscale phe-nomena that make the polymer flow different from the conventional flow at the macro scale. The mi-croinjection tests and the simulation allowed the gathering of knowledge to incorporate on mathe-matical models and simulation software, enabling the filling simulations at this scale being more ac-curate. Further to the assessment of the microde-tails mouldability, the surface replication and finish-ing of the mouldings were analysed by optical and SEM microscopy.Fundação para a Ciência e a Tecnologia (FCT) - SFRH/BD/36982/200

Dissociable effects of age and Parkinson’s disease on instruction-based learning

The cognitive deficits associated with Parkinson’s disease vary across individuals and change across time, with implications for prognosis and treatment. Key outstanding challenges are to define the distinct behavioural characteristics of this disorder and develop diagnostic paradigms that can assess these sensitively in individuals. In a previous study, we measured different aspects of attentional control in Parkinson’s disease using an established fMRI switching paradigm. We observed no deficits for the aspects of attention the task was designed to examine; instead those with Parkinson’s disease learnt the operational requirements of the task more slowly. We hypothesized that a subset of people with early-to-mid stage Parkinson’s might be impaired when encoding rules for performing new tasks. Here, we directly test this hypothesis and investigate whether deficits in instruction-based learning represent a characteristic of Parkinson’s Disease. Seventeen participants with Parkinson’s disease (8 male; mean age: 61.2 years), 18 older adults (8 male; mean age: 61.3 years) and 20 younger adults (10 males; mean age: 26.7 years) undertook a simple instruction-based learning paradigm in the MRI scanner. They sorted sequences of coloured shapes according to binary discrimination rules that were updated at two-minute intervals. Unlike common reinforcement learning tasks, the rules were unambiguous, being explicitly presented; consequently, there was no requirement to monitor feedback or estimate contingencies. Despite its simplicity, a third of the Parkinson’s group, but only one older adult, showed marked increases in errors, 4 SD greater than the worst performing young adult. The pattern of errors was consistent, reflecting a tendency to misbind discrimination rules. The misbinding behaviour was coupled with reduced frontal, parietal and anterior caudate activity when rules were being encoded, but not when attention was initially oriented to the instruction slides or when discrimination trials were performed. Concomitantly, Magnetic Resonance Spectroscopy showed reduced gamma-Aminobutyric acid levels within the mid-dorsolateral prefrontal cortices of individuals who made misbinding errors. These results demonstrate, for the first time, that a subset of early-to-mid stage people with Parkinson’s show substantial deficits when binding new task rules in working memory. Given the ubiquity of instruction-based learning, these deficits are likely to impede daily living. They will also confound clinical assessment of other cognitive processes. Future work should determine the value of instruction-based learning as a sensitive early marker of cognitive decline and as a measure of responsiveness to therapy in Parkinson's disease

Mutação monoalélica no gene da tireoperoxidase em paciente com hipotireoidismo congênito com defeito total de incorporação de iodeto

The aim of this study was to identify the genetic defect of a patient with dyshormonogenetic congenital hypothyroidisms (CH) with total iodide organification defect (TIOD). A male child diagnosed with CH during neonatal screening. Laboratory tests confirmed the permanent and severe CH with TIOD (99% perchlorate release). The coding sequence of TPO, DUOX2, and DUOXA2 genes and 2957 base pairs (bp) of the TPO promoter were sequenced. Molecular analysis of patient's DNA identified the heterozygous duplication GGCC (c.1186_1187insGGCC) in exon 8 of the TPO gene. No additional mutation was detected either in the TPO gene, TPO promoter, DUOX2 or DUOXA2 genes. We have described a patient with a clear TIOD causing severe goitrous CH due to a monoallelic TPO mutation. A plausible explanation for the association between an autosomal recessive disorder with a single TPO-mutated allele is the presence of monoallelic TPO expression.O objetivo deste estudo foi identificar defeitos genéticos em paciente com hipotireoidismo congênito (HC) por disormonogênese e defeito total de incorporação de iodeto (DIIT). Neonato do sexo masculino com HC diagnosticado pelo rastreamento neonatal. Exames clínicos e radiológicos confirmaram que o paciente apresentava HC severo e permanente com DIIT (teste de perclorato: 99%). A região codificadora dos genes TPO, DUOX2, DUOXA2 e 2957 pares de bases (pb) do promotor de TPO foram sequenciados. No paciente foi identificada a duplicação em heterozigose GGCC no éxon 8 do gene TPO (c.1186_1187insGGCC). Nenhuma outra mutação foi localizada nos genes TPO, incluindo o promotor, DUOX2 ou DUOXA2. Descrevemos paciente com grave defeito de organificação de iodeto, provocando HC severo com bócio, em consequência de uma única mutação monoalélica no gene TPO. A expressão monoalélica no tecido tireoideano explicaria a associação de uma doen­ça autossômica recessiva com uma única mutação monoalélica